Intramuscular lipid content is increased in obesity and decreased by weight loss

Metabolism: Clinical and Experimental

Volumn 49, Issue 4, 2000, Pages 467-472

  Goodpaster, B H ^a   Theriault, R ^a   Watkins, S C ^a   Kelley, D E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIPID ANALYSIS; MUSCLE BIOPSY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE; WEIGHT REDUCTION;

EID: 0034112806     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(00)80010-4     Document Type: Article

References (28)

1. Bogardus C. Lillioja S. Mott D.M. Relationship between degree of obesity and in vivo insulin action in man Am J Physiol 248 1985 E286 E291
2. DeFronzo R. Jacot E. Jequier E. The effect of insulin on the disposal of intravenous glucose Diabetes 30 1981 1000 1007
3. Abate N. Garg A. Peshock R.M. Relationships of generalized and regional adiposity to insulin sensitivity in men J Clin Invest 96 1995 88 98
4. Carey D.G. Jenkins A.B. Campbell L.V. Abdominal fat and insulin resistance in normal and overweight women Diabetes 45 1996 633 638
5. Despres J.-P. Abdominal obesity as important component of insulin resistance syndrome Nutrition 9 1993 452 459
6. Goodpaster B.H. Thaete F.L. Simoneau J.-A. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat Diabetes 46 1997 1579 1585
7. Pan D.A. Lillioja S. Kriketos A.D. Skeletal muscle triglyceride levels are inversely related to insulin action Diabetes 46 1997 983 988
8. Phillips D.I. Caddy S. Ilic V. Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects Metabolism 45 1996 947 950
9. Russell J.C. Shillabeer G. Bar-Tana J. Development of insulin resistance in the JCR:LA-cp rat: Role of triacylglycerols and effects of MEDICA 16 Diabetes 47 1998 770 778
10. Kelley D.E. Slasky B.S. Janosky J. Skeletal muscle density:Effects of obesity and non-insulin-dependent diabetes mellitus Am J Clin Nutr 54 1991 509 515
11. Simoneau J.-A. Colberg S.R. Thaete F.L. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women FASEB J 9 1995 273 278
12. Oakes N.D Camilleri S. Furler S.M. The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat Metabolism 46 1997 935 942
13. Shimabukuro M. Koyama K. Chen G. Direct antidiabetic effect of leptin through triglyceride depletion of tissues Proc Nat Acad Sci USA 94 1997 4637 4641
14. Colman E. Katzel L.L. Rogus E. Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance Metabolism 44 1995 1502 1508
15. Goodpaster B.H. Kelley D.E. Wing R.R. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity Diabetes 48 1999 839 847
16. Kelley D.E. Wing R. Buonocore C. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus J Clin Endocrinol Metab 77 1993 1287 1293
17. (abstr) Stein D.T. Dobbins R. Szczepaniak L. Skeletal muscle triglyceride stores are increased in insulin resistance Diabetes 46 1997 23A
18. Pedersen S.B. Børglum J.D. Schmitz O. Abdominal obesity is associated with insulin resistance and reduced glycogen synthase activity in skeletal muscle Metabolism 42 1993 998 1005
19. Hurley B.F. Nemeth P.M. Martin W.M. Muscle triglyceride utilization during exercise: Effect of training J Appl Physiol 60 1986 562 567
20. Evans W. Phinney S. Young V. Suction applied to a muscle biopsy maximizes sample size Med Sci Sports Exerc 14 1982 101 102
21. Lillie R.D. Ashburn L.L. Super-saturated solutions of fat stains in dilute isopropanol for demonstration of acute fatty degenerations not shown by the Herxheimer technique Arch Pathol 36 1943 432 440
22. Askanas V. Engel W.K. Distinct subtypes of type I fibers of human skeletal muscle Neurology 25 1975 879 887
23. Cerri C. Meola G. Scarlato G. Biochemical and morphological studies on a case of systemic camitine deficiency Acta Neuropathol Suppl 7 1981 219 220
24. VanDyke D.H. Griggs R.C. Markesbery W. Hereditary carnitine deficiency of muscle Neurology 25 1975 154 159
25. Odusote K. Karpati G. Carpenter S. An experimental morphometric study of neutral lipid accumulation in skeletal muscles Muscle Nerve 4 1981 3 9
26. Campion D.R. Shapira I.F. Allen C.E. Metabolic characteristics of skeletal muscle from lean and obese Zucker rats Growth 51 1987 397 410
27. 1H-MR-spectroscopy Magn Reson Med 37 1997 484 493
28. Wendling P.S Peters S.J. Heigenhauser G.J. Variability of triacylglycerol content in human skeletal muscle biopsy samples J Appl Physiol 81 1996 1150 1155