Intramyocellular Lipid Is Associated with Resistance to in Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle

Diabetes

Volumn 50, Issue 10, 2001, Pages 2337-2343

  Virkamäki, Antti ^a,b   Korsheninnikova, Elena ^a   Seppälä Lindroos, Anneli ^a   Vehkavaara, Satu ^a   Goto, Takashi ^a   Halavaara, Juha ^a   Häkkinen, Anna Maija ^a   Yki Järvinen, Hannele ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; TYROSINE;

ADULT; ARTICLE; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; MALE; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TYROSINE;

EID: 0035487317     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.10.2337     Document Type: Article

References (61)

1. DeFronzo RA, Ferrannini E: Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194, 1991
2. Howard BV: Insulin resistance and lipid metabolism. Am J Cardiol 84:28J-32J, 1999
3. Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH: Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 278:E941-E948, 2000
4. Phillips DI, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R: Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45:947-950, 1996
5. Krssak M, Falk PK, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI: Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116, 1999
6. Forouhi NG, Jenkinson G, Thomas EL, Mullick S, Mierisova S, Bhonsle U, McKeigue PM, Bell JD: Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia 42:932-935, 1999
7. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU: Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119, 1999
8. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH: Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988, 1997
9. Manco M, Mingrone G, Greco AV, Capristo E, Gniuli D, De Gaetano A, Gasbarrini G: Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism 49:220-224, 2000
10. Goodpaster BH, Thaete FL, Kelley DE: Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 71:885-892, 2000
11. Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, Vanzulli A, Testolin G, Pozza G, Del Maschio A, Luzi L: Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606, 1999
12. Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI: Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 275:8456-8460, 2000
13. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML: Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105:271-278, 2000
14. Yki-Jarvinen H: Sex and insulin sensitivity. Metabolism 33:1011-1015, 1984
15. Brechtel K, Dahl DP, Machann J, Bachmann OP, Wenzel I, Maier T, Claussen CD, Haring HU, Jacob S, Schick F: Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-MRS study. Magn Reson Med 45:179-183, 2001
16. Kelley DE, Mandarino LJ: Fuel selection in human skeletal muscle in insulin resistance: a reexamination (Review). Diabetes 49:677-683, 2000
17. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789, 1963
18. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253-259, 1999
19. Hawkins M, Barzilai N, Liu R, Hu M, Chen W, Rossetti L: Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest 99:2173-2182, 1997
20. Ellis BA, Poynten A, Lowy AJ, Furler SM, Chisholm DJ, Kraegen EW, Cooney GJ: Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol Metab 279: E554-E560, 2000
21. Wititsuwannakul D, Kim KH: Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase. J Biol Chem 252:7812-7817, 1977
22. Thompson AL, Cooney GJ: Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance. Diabetes 49:1761-1765, 2000
23. Boesch C, Kreis R: Observation of intramyocellular lipids by 1H-magnetic resonance spectroscopy. Ann N Y Acad Sci 904:25-31, 2000
24. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O: Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 29:158-167, 1993
25. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT: Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276:E977-E989, 1999
26. de Beer R, van den Boogaart A, van Ormondt D, Pijnappel WW, den Hollander JA, Marien AJ, Luyten PR: Application of time-domain fitting in the quantification of in vivo 1H spectroscopic imaging data sets. NMR Biomed 5:171-178, 1992
27. Ryysy L, Hakkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, Yki-Jarvinen H: Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49:749-758, 2000
28. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
29. Vuorinen-Markkola H, Koivisto VA, Yki-Jarvinen H: Mechanisms of hyperglycemia-induced insulin resistance in whole body and skeletal muscle of type I diabetic patients. Diabetes 41:571-580, 1992
30. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
31. Kadish AH, Litle RL, Sternberg JC: A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption. Clin Chem 14:116-131, 1968
32. Miles J, Glasscock R, Aikens J, Gerich J, Haymond M: A microfluorometric method for the determination of free fatty acids in plasma. J Lipid Res 24:96-99, 1983
33. McGowan MW, Artiss JD, Strandbergh DR, Zak B: A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 29:538-542, 1983
34. Utriainen T, Nuutila P, Takala T. Vicini P, Ruotsalainen U, Ronnemaa T, Tolvanen T, Raitakari M, Haaparanta M, Kirvela O, Cobelli C, Yki-Jarvinen H: Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus. J Clin Invest 100:777-785, 1997
35. Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579-1585, 1997
36. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U: Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest 72:1150-1162, 1983
37. Yki-Jarvinen H, Koivisto VA: Effects of body composition on insulin sensitivity. Diabetes 32:965-969, 1983
38. Horowitz JF, Klein S: Lipid metabolism during endurance exercise. Am J Clin Nutr 72:558S-563S, 2000
39. Jansson E, Kaijser L: Substrate utilization and enzymes in skeletal muscle of extremely endurance-trained men. J Appl Physiol 62:999-1005, 1987
40. Holloszy JO: Biochemical adaptations in muscle: effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem 242:2278-2282, 1967
41. Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA: Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 279:E1039-E1044, 2000
42. Raben A, Mygind E, Astrup A: Lower activity of oxidative key enzymes and smaller fiber areas in skeletal muscle of postobese women. Am J Physiol 275:E487-E494, 1998
43. Simoneau JA, Bouchard C: Genetic determinism of fiber type proportion in human skeletal muscle. FASEB J 9:1091-1095, 1995
44. Essen-Gustavsson B, Tesch PA: Glycogen and triglyceride utilization in relation to muscle metabolic characteristics in men performing heavy-resistance exercise. Eur J Appl Physiol Occup Physiol 61:5-10, 1990
45. Hurley BF, Nemeth PM, Martin WH, Hagberg JM, Dalsky GP, Holloszy JO: Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60:562-567, 1986
46. Lithell H, Orlander J, Schele R. Sjodin B, Karlsson J: Changes in lipoprotein-lipase activity and lipid stores in human skeletal muscle with prolonged heavy exercise. Acta Physiol Scand 107:257-261, 1979
47. Sweet W, Schroeder F: Lipid domains and enzyme activity. In Lipid Domains and the Relationship to Membrane Function. Aloia RC, Curtain CC, Gordon LM, Eds. New York, Alan R. Liss, 1988, p. 17-42
48. Curtain CC, Gordon LM, Aloia RC: Lipid domains in biological membranes: conceptual development and significance. In Lipid Domains and the Relationship to Membrane Function. Aloia RC, Curtain CC, Gordon LM, Eds. New York, Alan R Liss, 1988, p. 1-15
49. Taylor CR, Hoppeler H, Kennedy C, Valenski T, Roberts TJ, Weyand P: High fat diet improves aerobic performance by building mitochondria (Abstract). Physiologist 37: 1994
50. 3H-(R)-2-bromopalmitate. Diabetes 49:1427-1433, 2000
51. Patti ME, Virkamaki A, Landaker EJ, Kahn CR, Yki-Jarvinen H: Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes 48:1562-1571, 1999
52. Goldstein BJ, Ahmad F, Ding W, Li PM, Zhang WR: Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 182:91-99, 1998
53. Kellerer M, Lammers R, Haring HU: Insulin signal transduction: possible mechanisms for insulin resistance. Exp Clin Endocrinol Diabetes 107:97-106, 1999
54. Ruderman NB, Saha AK, Vavvas D, Witters LA: Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 276:E1-E18, 1999
55. Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW: Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Adv Exp Med Biol 441:263-270, 1998
56. Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI: Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade. Diabetes 48:1270-1274, 1999
57. Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL: Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49:1353-1358, 2000
58. Kelley DE, Goodpaster B, Wing RR, Simoneau JA: Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130-E1141, 1999
59. Straczkowski M, Kowalska I, Gorski J, Kinalska I: The effect of a single bout of exhaustive exercise on muscle carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus. Acta Diabetol 37:47-53, 2000
60. Krssak M, Petersen KF, Bergeron R, Price T, Laurent D, Rothman DL, Roden M, Shulman GI: Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab 85:748-754, 2000
61. Kakuma T, Lee Y, Higa M, Wang Z, Pan W, Shimomura I, Unger RH: Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Prof Natl Acad Sci U S A 97:8536-8541, 2000