Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity

Diabetes

Volumn 49, Issue 8, 2000, Pages 1353-1358

  Itani, S I ^a   Zhou, Q ^a   Pories, W J ^a   MacDonald, K G ^a   Dohm, G L ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE C;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME POLYMORPHISM; FEMALE; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECTUS ABDOMINIS MUSCLE; SKELETAL MUSCLE;

EID: 0033861608     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.8.1353     Document Type: Article

References (25)

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3. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity
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5. Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase
6. Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors
7. Activation of protein kinase C inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1
8. Protein kinase C isoforms βI and βII inhibit the tyrosine kinase activity of the insulin receptor
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14. Dephosphorylation increases insulin-stimulated receptor kinase activity in skeletal muscle of obese Zucker rats
15. An in vitro human muscle preparation suitable for metabolic studies: Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
16. Effect of phorbol ester on PKC-ξ
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21. Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: An alteration not due to hyperglycemia
22. Chronic activation of protein kinase C in soleus muscle and other tissues if insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats
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