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Volumn 28, Issue 12, 2011, Pages 1463-1475

Insulin resistance and pathological brain ageing

Author keywords

Brain; Insulin resistance

Indexed keywords

INSULIN; PLACEBO; ROSIGLITAZONE; SOMATOMEDIN C;

EID: 81355151398     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2011.03464.x     Document Type: Review
Times cited : (135)

References (182)
  • 1
    • 0030664286 scopus 로고    scopus 로고
    • Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin
    • Banks WA, Jaspan JB, Huang W, Kastin AJ. Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 1997; 18: 1423-1429.
    • (1997) Peptides , vol.18 , pp. 1423-1429
    • Banks, W.A.1    Jaspan, J.B.2    Huang, W.3    Kastin, A.J.4
  • 3
    • 0027361094 scopus 로고
    • Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
    • Baura GD, Foster DM, Porte D Jr, Kahn SE, Bergman RN, Cobelli C et al. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest 1993; 92: 1824-1830.
    • (1993) J Clin Invest , vol.92 , pp. 1824-1830
    • Baura, G.D.1    Foster, D.M.2    Porte Jr, D.3    Kahn, S.E.4    Bergman, R.N.5    Cobelli, C.6
  • 4
    • 0025279593 scopus 로고
    • Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats
    • Schwartz MW, Figlewicz DF, Kahn SE, Baskin DG, Greenwood MR, Porte D Jr. Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats. Peptides 1990; 11: 467-472.
    • (1990) Peptides , vol.11 , pp. 467-472
    • Schwartz, M.W.1    Figlewicz, D.F.2    Kahn, S.E.3    Baskin, D.G.4    Greenwood, M.R.5    Porte Jr, D.6
  • 6
    • 0033197996 scopus 로고    scopus 로고
    • The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
    • Abbott MA, Wells DG, Fallon JR. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci 1999; 19: 7300-7308.
    • (1999) J Neurosci , vol.19 , pp. 7300-7308
    • Abbott, M.A.1    Wells, D.G.2    Fallon, J.R.3
  • 7
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • Havrankova J, Roth J, Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 1978; 272: 827-829.
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 9
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects
    • Unger JW, Livingston JN, Moss AM. Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog Neurobiol 1991; 36: 343-362.
    • (1991) Prog Neurobiol , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 10
    • 0038177803 scopus 로고    scopus 로고
    • Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype
    • Craft S, Asthana S, Cook DG, Baker LD, Cherrier M, Purganan K et al. Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype. Psychoneuroendocrinology 2003; 28: 809-822.
    • (2003) Psychoneuroendocrinology , vol.28 , pp. 809-822
    • Craft, S.1    Asthana, S.2    Cook, D.G.3    Baker, L.D.4    Cherrier, M.5    Purganan, K.6
  • 14
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
    • Reger MA, Watson GS, Frey WH 2nd, Baker LD, Cholerton B, Keeling ML et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 2006; 27: 451-458.
    • (2006) Neurobiol Aging , vol.27 , pp. 451-458
    • Reger, M.A.1    Watson, G.S.2    Frey 2nd, W.H.3    Baker, L.D.4    Cholerton, B.5    Keeling, M.L.6
  • 15
    • 0033521130 scopus 로고    scopus 로고
    • Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
    • Zhao W, Chen H, Xu H, Moore E, Meiri N, Quon MJ et al. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 1999; 274: 34893-34902.
    • (1999) J Biol Chem , vol.274 , pp. 34893-34902
    • Zhao, W.1    Chen, H.2    Xu, H.3    Moore, E.4    Meiri, N.5    Quon, M.J.6
  • 16
    • 0036895563 scopus 로고    scopus 로고
    • The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study
    • Bingham EM, Hopkins D, Smith D, Pernet A, Hallett W, Reed L et al. The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study. Diabetes 2002; 51: 3384-3390.
    • (2002) Diabetes , vol.51 , pp. 3384-3390
    • Bingham, E.M.1    Hopkins, D.2    Smith, D.3    Pernet, A.4    Hallett, W.5    Reed, L.6
  • 17
    • 0035956883 scopus 로고    scopus 로고
    • Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
    • Reagan LP, Gorovits N, Hoskin EK, Alves SE, Katz EB, Grillo CA et al. Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats. Proc Natl Acad Sci U S A 2001; 98: 2820-2825.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2820-2825
    • Reagan, L.P.1    Gorovits, N.2    Hoskin, E.K.3    Alves, S.E.4    Katz, E.B.5    Grillo, C.A.6
  • 18
    • 0033664539 scopus 로고    scopus 로고
    • Insulin receptors and insulin action in the brain: review and clinical implications
    • Schulingkamp RJ, Pagano TC, Hung D, Raffa RB. Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci Biobehav Rev 2000; 24: 855-872.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 855-872
    • Schulingkamp, R.J.1    Pagano, T.C.2    Hung, D.3    Raffa, R.B.4
  • 20
    • 0033199378 scopus 로고    scopus 로고
    • Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain
    • Apelt J, Mehlhorn G, Schliebs R. Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain. J Neurosci Res 1999; 57: 693-705.
    • (1999) J Neurosci Res , vol.57 , pp. 693-705
    • Apelt, J.1    Mehlhorn, G.2    Schliebs, R.3
  • 21
    • 0027321678 scopus 로고
    • Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system
    • Brant AM, Jess TJ, Milligan G, Brown CM, Gould GW. Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system. Biochem Biophys Res Commun 1993; 192: 1297-1302.
    • (1993) Biochem Biophys Res Commun , vol.192 , pp. 1297-1302
    • Brant, A.M.1    Jess, T.J.2    Milligan, G.3    Brown, C.M.4    Gould, G.W.5
  • 22
    • 0032487335 scopus 로고    scopus 로고
    • Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system
    • El Messari S, Leloup C, Quignon M, Brisorgueil MJ, Penicaud L, Arluison M. Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system. J Comp Neurol 1998; 399: 492-512.
    • (1998) J Comp Neurol , vol.399 , pp. 492-512
    • El Messari, S.1    Leloup, C.2    Quignon, M.3    Brisorgueil, M.J.4    Penicaud, L.5    Arluison, M.6
  • 23
    • 0028890116 scopus 로고
    • Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism?
    • Livingstone C, Lyall H, Gould GW. Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism? Mol Cell Endocrinol 1995; 107: 67-70.
    • (1995) Mol Cell Endocrinol , vol.107 , pp. 67-70
    • Livingstone, C.1    Lyall, H.2    Gould, G.W.3
  • 24
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 2001; 177: 125-134.
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 25
    • 0035853124 scopus 로고    scopus 로고
    • Insulin promotes rapid delivery of N-methyl-D-aspartate receptors to the cell surface by exocytosis
    • Skeberdis VA, Lan J, Zheng X, Zukin RS, Bennett MV. Insulin promotes rapid delivery of N-methyl-D-aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A 2001; 98: 3561-3566.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3561-3566
    • Skeberdis, V.A.1    Lan, J.2    Zheng, X.3    Zukin, R.S.4    Bennett, M.V.5
  • 26
    • 0027400795 scopus 로고
    • Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus
    • Figlewicz DP, Szot P, Israel PA, Payne C, Dorsa DM. Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus. Brain Res 1993; 602: 161-164.
    • (1993) Brain Res , vol.602 , pp. 161-164
    • Figlewicz, D.P.1    Szot, P.2    Israel, P.A.3    Payne, C.4    Dorsa, D.M.5
  • 27
    • 0032863618 scopus 로고    scopus 로고
    • Effects of post-training administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism
    • Kopf SR, Baratti CM. Effects of post-training administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism. Neurobiol Learn Mem 1999; 71: 50-61.
    • (1999) Neurobiol Learn Mem , vol.71 , pp. 50-61
    • Kopf, S.R.1    Baratti, C.M.2
  • 28
    • 0035706134 scopus 로고    scopus 로고
    • Glucose treatment reduces memory deficits in young adult rats fed high-fat diets
    • Greenwood CE, Winocur G. Glucose treatment reduces memory deficits in young adult rats fed high-fat diets. Neurobiol Learn Mem 2001; 75: 179-189.
    • (2001) Neurobiol Learn Mem , vol.75 , pp. 179-189
    • Greenwood, C.E.1    Winocur, G.2
  • 30
    • 0037452760 scopus 로고    scopus 로고
    • Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
    • Convit A, Wolf OT, Tarshish C, de Leon MJ. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci U S A 2003; 100: 2019-2022.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2019-2022
    • Convit, A.1    Wolf, O.T.2    Tarshish, C.3    de Leon, M.J.4
  • 31
    • 0036311771 scopus 로고    scopus 로고
    • The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
    • Hoyer S. The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review. J Neural Transm 2002; 109: 991-1002.
    • (2002) J Neural Transm , vol.109 , pp. 991-1002
    • Hoyer, S.1
  • 33
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
    • Rivera E, Goldin A, Fulmer N, Tavares R, Wands J, de la Monte S. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimer's Disease 2005; 8: 247-268.
    • (2005) J Alzheimer's Disease , vol.8 , pp. 247-268
    • Rivera, E.1    Goldin, A.2    Fulmer, N.3    Tavares, R.4    Wands, J.5    de la Monte, S.6
  • 34
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    • Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P et al. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001; 21: 2561-2570.
    • (2001) J Neurosci , vol.21 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3    Gross, R.S.4    Beal, M.F.5    Greengard, P.6
  • 35
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M, Mehta T, Selkoe DJ. Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 2007; 282: 33305-33312.
    • (2007) J Biol Chem , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 36
    • 60549084867 scopus 로고    scopus 로고
    • Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers
    • De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers. Proc Natl Acad Sci U S A 2009; 106: 1971-1976.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1971-1976
    • De Felice, F.G.1    Vieira, M.N.2    Bomfim, T.R.3    Decker, H.4    Velasco, P.T.5    Lambert, M.P.6
  • 37
    • 58549102356 scopus 로고    scopus 로고
    • Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation
    • Lee CC, Kuo YM, Huang CC, Hsu KS. Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation. Neurobiol Aging 2009; 30: 377-387.
    • (2009) Neurobiol Aging , vol.30 , pp. 377-387
    • Lee, C.C.1    Kuo, Y.M.2    Huang, C.C.3    Hsu, K.S.4
  • 38
    • 10944228564 scopus 로고    scopus 로고
    • Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention
    • Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ et al. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci 2004; 24: 11120-11126.
    • (2004) J Neurosci , vol.24 , pp. 11120-11126
    • Zhao, L.1    Teter, B.2    Morihara, T.3    Lim, G.P.4    Ambegaokar, S.S.5    Ubeda, O.J.6
  • 40
    • 0028176821 scopus 로고
    • Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
    • Kurochkin IV, Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 1994; 345: 33-37.
    • (1994) FEBS Lett , vol.345 , pp. 33-37
    • Kurochkin, I.V.1    Goto, S.2
  • 41
    • 0031044352 scopus 로고    scopus 로고
    • Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme
    • McDermott JR, Gibson AM. Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. Neurochem Res 1997; 22: 49-56.
    • (1997) Neurochem Res , vol.22 , pp. 49-56
    • McDermott, J.R.1    Gibson, A.M.2
  • 42
    • 0000398342 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
    • Qiu W, Walsh D, Ye Z, Vekrellis K, Zhang J, Podlisny M et al. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem 1998; 273: 32730-32738.
    • (1998) J Biol Chem , vol.273 , pp. 32730-32738
    • Qiu, W.1    Walsh, D.2    Ye, Z.3    Vekrellis, K.4    Zhang, J.5    Podlisny, M.6
  • 43
    • 0037192120 scopus 로고    scopus 로고
    • Differential effects of proteases involved in intracellular degradation of amyloid β-protein between detergent-soluble and -insoluble pools in CHO-695 cells
    • Sudoh S, Frosch MP, Wolf BA. Differential effects of proteases involved in intracellular degradation of amyloid β-protein between detergent-soluble and -insoluble pools in CHO-695 cells. Biochemistry 2002; 41: 1091-1099.
    • (2002) Biochemistry , vol.41 , pp. 1091-1099
    • Sudoh, S.1    Frosch, M.P.2    Wolf, B.A.3
  • 44
    • 0037219221 scopus 로고    scopus 로고
    • Reduced hippocampal insulin-degrading enzyme in late-onsheimer's disease is associated with the apolipoprotein E-ε4 allele
    • Cook DG, Leverenz JB, McMillan PJ, Kulstad JJ, Ericksen S, Roth RA et al. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-ε4 allele. Am J Pathol 2003; 162: 313-319.
    • (2003) Am J Pathol , vol.162 , pp. 313-319
    • Cook, D.G.1    Leverenz, J.B.2    McMillan, P.J.3    Kulstad, J.J.4    Ericksen, S.5    Roth, R.A.6
  • 45
    • 0037390039 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    • Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 2003; 100: 4162-4167.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4162-4167
    • Farris, W.1    Mansourian, S.2    Chang, Y.3    Lindsley, L.4    Eckman, E.A.5    Frosch, M.P.6
  • 46
    • 0034038036 scopus 로고    scopus 로고
    • Degradation of soluble amyloid B-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
    • Perez A, Morelli L, Cresto JC, Castano EM. Degradation of soluble amyloid B-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem Res 2000; 25: 247-255.
    • (2000) Neurochem Res , vol.25 , pp. 247-255
    • Perez, A.1    Morelli, L.2    Cresto, J.C.3    Castano, E.M.4
  • 47
    • 0031456345 scopus 로고    scopus 로고
    • Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays
    • Banks WA, Jaspan JB, Kastin AJ. Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 1997; 18: 1257-1262.
    • (1997) Peptides , vol.18 , pp. 1257-1262
    • Banks, W.A.1    Jaspan, J.B.2    Kastin, A.J.3
  • 48
    • 0027223525 scopus 로고
    • Basal and hyperinsulinemia-induced immunoreactive hypothalamic insulin changes in lean and genetically obese Zucker rats revealed by microdialysis
    • Gerozissis K, Orosco M, Rouch C, Nicolaidis S. Basal and hyperinsulinemia-induced immunoreactive hypothalamic insulin changes in lean and genetically obese Zucker rats revealed by microdialysis. Brain Res 1993; 611: 258-263.
    • (1993) Brain Res , vol.611 , pp. 258-263
    • Gerozissis, K.1    Orosco, M.2    Rouch, C.3    Nicolaidis, S.4
  • 49
    • 0033857975 scopus 로고    scopus 로고
    • Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs
    • Kaiyala KJ, Prigeon RL, Kahn SE, Woods SC, Schwartz MW. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes 2000; 49: 1525-1533.
    • (2000) Diabetes , vol.49 , pp. 1525-1533
    • Kaiyala, K.J.1    Prigeon, R.L.2    Kahn, S.E.3    Woods, S.C.4    Schwartz, M.W.5
  • 50
    • 4644286910 scopus 로고    scopus 로고
    • Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    • Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 2004; 18: 902-904.
    • (2004) FASEB J , vol.18 , pp. 902-904
    • Ho, L.1    Qin, W.2    Pompl, P.N.3    Xiang, Z.4    Wang, J.5    Zhao, Z.6
  • 51
    • 37549035051 scopus 로고    scopus 로고
    • Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
    • Cao D, Lu H, Lewis TL, Li L. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 2007; 282: 36275-36282.
    • (2007) J Biol Chem , vol.282 , pp. 36275-36282
    • Cao, D.1    Lu, H.2    Lewis, T.L.3    Li, L.4
  • 52
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
    • Hong M, Lee V. Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 1997; 272: 19547-19553.
    • (1997) J Biol Chem , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.2
  • 54
    • 0043127453 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
    • Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003; 23: 7084-7092.
    • (2003) J Neurosci , vol.23 , pp. 7084-7092
    • Schubert, M.1    Brazil, D.P.2    Burks, D.J.3    Kushner, J.A.4    Ye, J.5    Flint, C.L.6
  • 55
    • 77953285468 scopus 로고    scopus 로고
    • Insulin resistance, diabetes and cognitive function: consequences for preventative strategies
    • Bourdel-Marchasson I, Lapre E, Laksir H, Puget E. Insulin resistance, diabetes and cognitive function: consequences for preventative strategies. Diabetes Metab 2010; 36: 173-181.
    • (2010) Diabetes Metab , vol.36 , pp. 173-181
    • Bourdel-Marchasson, I.1    Lapre, E.2    Laksir, H.3    Puget, E.4
  • 57
    • 1542373533 scopus 로고    scopus 로고
    • Prospective study of type 2 diabetes and cognitive decline in women aged 70-81years
    • Logroscino G, Kang JH, Grodstein F. Prospective study of type 2 diabetes and cognitive decline in women aged 70-81years. Br Med J 2004; 328: 548.
    • (2004) Br Med J , vol.328 , pp. 548
    • Logroscino, G.1    Kang, J.H.2    Grodstein, F.3
  • 58
    • 4043164114 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study
    • Hassing LB, Grant MD, Hofer SM, Pedersen NL, Nilsson SE, Berg S et al. Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study. J Int Neuropsychol Soc 2004; 10: 599-607.
    • (2004) J Int Neuropsychol Soc , vol.10 , pp. 599-607
    • Hassing, L.B.1    Grant, M.D.2    Hofer, S.M.3    Pedersen, N.L.4    Nilsson, S.E.5    Berg, S.6
  • 59
    • 4043104808 scopus 로고    scopus 로고
    • Co-morbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study
    • Hassing LB, Hofer SM, Nilsson SE, Berg S, Pedersen NL, McClearn G et al. Co-morbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing 2004; 33: 355-361.
    • (2004) Age Ageing , vol.33 , pp. 355-361
    • Hassing, L.B.1    Hofer, S.M.2    Nilsson, S.E.3    Berg, S.4    Pedersen, N.L.5    McClearn, G.6
  • 60
    • 3042589342 scopus 로고    scopus 로고
    • Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort
    • Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med 2004; 164: 1327-1333.
    • (2004) Arch Intern Med , vol.164 , pp. 1327-1333
    • Kanaya, A.M.1    Barrett-Connor, E.2    Gildengorin, G.3    Yaffe, K.4
  • 62
    • 0142011103 scopus 로고    scopus 로고
    • Diabetes mellitus and cognitive performance in older women
    • Crooks VC, Buckwalter JG, Petitti DB. Diabetes mellitus and cognitive performance in older women. Ann Epidemiol 2003; 13: 613-619.
    • (2003) Ann Epidemiol , vol.13 , pp. 613-619
    • Crooks, V.C.1    Buckwalter, J.G.2    Petitti, D.B.3
  • 63
    • 0032707190 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus, cognitive impairment and dementia
    • Stewart R, Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med 1999; 16: 93-112.
    • (1999) Diabet Med , vol.16 , pp. 93-112
    • Stewart, R.1    Liolitsa, D.2
  • 65
    • 42249094013 scopus 로고    scopus 로고
    • Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective
    • Luchsinger JA. Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective. Eur J Pharmacol 2008; 585: 119-129.
    • (2008) Eur J Pharmacol , vol.585 , pp. 119-129
    • Luchsinger, J.A.1
  • 68
    • 0036227542 scopus 로고    scopus 로고
    • Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    • Peila R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 2002; 51: 1256-1262.
    • (2002) Diabetes , vol.51 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 72
    • 0030663143 scopus 로고    scopus 로고
    • The risk of dementia among persons with diabetes mellitus: a population-based cohort study
    • Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O'Brien PC et al. The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann N Y Acad Sci 1997; 826: 422-427.
    • (1997) Ann N Y Acad Sci , vol.826 , pp. 422-427
    • Leibson, C.L.1    Rocca, W.A.2    Hanson, V.A.3    Cha, R.4    Kokmen, E.5    O'Brien, P.C.6
  • 73
    • 2442424380 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
    • Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004; 61: 661-666.
    • (2004) Arch Neurol , vol.61 , pp. 661-666
    • Arvanitakis, Z.1    Wilson, R.S.2    Bienias, J.L.3    Evans, D.A.4    Bennett, D.A.5
  • 75
    • 66249126971 scopus 로고    scopus 로고
    • Metabolic links between diabetes and Alzheimer's disease
    • Maher PA, Schubert DR. Metabolic links between diabetes and Alzheimer's disease. Expert Rev Neurother 2009; 9: 617-630.
    • (2009) Expert Rev Neurother , vol.9 , pp. 617-630
    • Maher, P.A.1    Schubert, D.R.2
  • 76
    • 42249089508 scopus 로고    scopus 로고
    • Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review
    • Kloppenborg RP, van den Berg E, Kappelle LJ, Biessels GJ. Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. Eur J Pharmacol 2008; 585: 97-108.
    • (2008) Eur J Pharmacol , vol.585 , pp. 97-108
    • Kloppenborg, R.P.1    van den Berg, E.2    Kappelle, L.J.3    Biessels, G.J.4
  • 77
    • 54049136095 scopus 로고    scopus 로고
    • Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
    • Beeri MS, Schmeidler J, Silverman JM, Gandy S, Wysocki M, Hannigan CM et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 2008; 71: 750-757.
    • (2008) Neurology , vol.71 , pp. 750-757
    • Beeri, M.S.1    Schmeidler, J.2    Silverman, J.M.3    Gandy, S.4    Wysocki, M.5    Hannigan, C.M.6
  • 79
    • 33748781703 scopus 로고    scopus 로고
    • Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma
    • Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J et al. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis 2006; 24: 114-127.
    • (2006) Neurobiol Dis , vol.24 , pp. 114-127
    • Burgess, B.L.1    McIsaac, S.A.2    Naus, K.E.3    Chan, J.Y.4    Tansley, G.H.5    Yang, J.6
  • 80
    • 47749100053 scopus 로고    scopus 로고
    • Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment
    • Mamo JC, Jian L, James AP, Flicker L, Esselmann H, Wiltfang J. Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment. Ann Clin Biochem 2008; 45: 395-403.
    • (2008) Ann Clin Biochem , vol.45 , pp. 395-403
    • Mamo, J.C.1    Jian, L.2    James, A.P.3    Flicker, L.4    Esselmann, H.5    Wiltfang, J.6
  • 81
    • 38849086036 scopus 로고    scopus 로고
    • Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
    • Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A et al. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest 2008; 118: 671-682.
    • (2008) J Clin Invest , vol.118 , pp. 671-682
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3    Kim, J.4    Li, A.5    Knoten, A.6
  • 82
    • 42149122012 scopus 로고    scopus 로고
    • Functional role of lipoprotein receptors in Alzheimer's disease
    • Jaeger S, Pietrzik CU. Functional role of lipoprotein receptors in Alzheimer's disease. Curr Alzheimer Res 2008; 5: 15-25.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 15-25
    • Jaeger, S.1    Pietrzik, C.U.2
  • 83
    • 4043154232 scopus 로고    scopus 로고
    • Plasma beta-amyloid (A beta) 40 concentration, lipid status and age in humans
    • Smith CC, Betteridge DJ. Plasma beta-amyloid (A beta) 40 concentration, lipid status and age in humans. Neurosci Lett 2004; 367: 48-50.
    • (2004) Neurosci Lett , vol.367 , pp. 48-50
    • Smith, C.C.1    Betteridge, D.J.2
  • 84
    • 48649110601 scopus 로고    scopus 로고
    • Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis
    • Anstey KJ, Lipnicki DM, Low LF. Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis. Am J Geriatr Psychiatry 2008; 16: 343-354.
    • (2008) Am J Geriatr Psychiatry , vol.16 , pp. 343-354
    • Anstey, K.J.1    Lipnicki, D.M.2    Low, L.F.3
  • 85
    • 17644412919 scopus 로고    scopus 로고
    • Impact of plasma lipids and time on memory performance in healthy elderly without dementia
    • Reitz C, Luchsinger J, Tang MX, Manly J, Mayeux R. Impact of plasma lipids and time on memory performance in healthy elderly without dementia. Neurology 2005; 64: 1378-1383.
    • (2005) Neurology , vol.64 , pp. 1378-1383
    • Reitz, C.1    Luchsinger, J.2    Tang, M.X.3    Manly, J.4    Mayeux, R.5
  • 86
    • 79953733579 scopus 로고    scopus 로고
    • Plasma cholesterol and risk for late-onsheimer's disease
    • Cedazo-Minguez A, Ismail MA, Mateos L. Plasma cholesterol and risk for late-onset Alzheimer's disease. Expert Rev Neurother 2011; 11: 495-498.
    • (2011) Expert Rev Neurother , vol.11 , pp. 495-498
    • Cedazo-Minguez, A.1    Ismail, M.A.2    Mateos, L.3
  • 87
    • 33745948085 scopus 로고    scopus 로고
    • Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases
    • Cersosimo E, DeFronzo RA. Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases. Diabetes Metab Res Rev 2006; 22: 423-436.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 423-436
    • Cersosimo, E.1    DeFronzo, R.A.2
  • 88
    • 78649675160 scopus 로고    scopus 로고
    • Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with obesity-related metabolic syndrome
    • Schinzari F, Tesauro M, Rovella V, Galli A, Mores N, Porzio O et al. Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with obesity-related metabolic syndrome. Am J Physiol Endocrinol Metab 2010; 299: E947-E952.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Schinzari, F.1    Tesauro, M.2    Rovella, V.3    Galli, A.4    Mores, N.5    Porzio, O.6
  • 90
    • 57749186455 scopus 로고    scopus 로고
    • Prevalence of insulin resistance and related risk factors for cardiovascular disease in patients with essential hypertension
    • Lima NK, Abbasi F, Lamendola C, Reaven GM. Prevalence of insulin resistance and related risk factors for cardiovascular disease in patients with essential hypertension. Am J Hypertens 2009; 22: 106-111.
    • (2009) Am J Hypertens , vol.22 , pp. 106-111
    • Lima, N.K.1    Abbasi, F.2    Lamendola, C.3    Reaven, G.M.4
  • 91
    • 44349096287 scopus 로고    scopus 로고
    • Hypertension and cerebrovascular dysfunction
    • Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab 2008; 7: 476-484.
    • (2008) Cell Metab , vol.7 , pp. 476-484
    • Iadecola, C.1    Davisson, R.L.2
  • 92
    • 0035897938 scopus 로고    scopus 로고
    • Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    • Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K et al. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. Br Med J 2001; 322: 1447-1451.
    • (2001) Br Med J , vol.322 , pp. 1447-1451
    • Kivipelto, M.1    Helkala, E.L.2    Laakso, M.P.3    Hanninen, T.4    Hallikainen, M.5    Alhainen, K.6
  • 93
    • 79959704345 scopus 로고    scopus 로고
    • Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama Study
    • Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J et al. Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama Study. Hypertension 2011; 58: 22-28.
    • (2011) Hypertension , vol.58 , pp. 22-28
    • Ninomiya, T.1    Ohara, T.2    Hirakawa, Y.3    Yoshida, D.4    Doi, Y.5    Hata, J.6
  • 94
    • 0034594470 scopus 로고    scopus 로고
    • Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study
    • Petrovitch H, White LR, Izmirilian G, Ross GW, Havlik RJ, Markesbery W et al. Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study. Neurobiol Aging 2000; 21: 57-62.
    • (2000) Neurobiol Aging , vol.21 , pp. 57-62
    • Petrovitch, H.1    White, L.R.2    Izmirilian, G.3    Ross, G.W.4    Havlik, R.J.5    Markesbery, W.6
  • 96
    • 60949108829 scopus 로고    scopus 로고
    • Blood pressure and the risk for dementia: a double edged sword
    • Kennelly SP, Lawlor BA, Kenny RA. Blood pressure and the risk for dementia: a double edged sword. Ageing Res Rev 2009; 8: 61-70.
    • (2009) Ageing Res Rev , vol.8 , pp. 61-70
    • Kennelly, S.P.1    Lawlor, B.A.2    Kenny, R.A.3
  • 99
    • 0038606277 scopus 로고    scopus 로고
    • High dietary fat promotes syndrome X in nonobese rats
    • Axen KV, Dikeakos A, Sclafani A. High dietary fat promotes syndrome X in nonobese rats. J Nutr 2003; 133: 2244-2249.
    • (2003) J Nutr , vol.133 , pp. 2244-2249
    • Axen, K.V.1    Dikeakos, A.2    Sclafani, A.3
  • 100
    • 0036712472 scopus 로고    scopus 로고
    • The influence of different fats and fatty acids on obesity, insulin resistance and inflammation
    • Bray GA, Lovejoy JC, Smith SR, DeLany JP, Lefevre M, Hwang D et al. The influence of different fats and fatty acids on obesity, insulin resistance and inflammation. J Nutr 2002; 132: 2488-2491.
    • (2002) J Nutr , vol.132 , pp. 2488-2491
    • Bray, G.A.1    Lovejoy, J.C.2    Smith, S.R.3    DeLany, J.P.4    Lefevre, M.5    Hwang, D.6
  • 102
    • 0035081372 scopus 로고    scopus 로고
    • Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study
    • Vessby B, Unsitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 2001; 44: 312-319.
    • (2001) Diabetologia , vol.44 , pp. 312-319
    • Vessby, B.1    Unsitupa, M.2    Hermansen, K.3    Riccardi, G.4    Rivellese, A.A.5    Tapsell, L.C.6
  • 103
    • 51749118278 scopus 로고    scopus 로고
    • Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids
    • López S BB, Pacheco YM, Villar J, Abia R, Muriana FJ. Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. Am J Clin Nutr 2008; 88: 638-644.
    • (2008) Am J Clin Nutr , vol.88 , pp. 638-644
    • López, S.B.1    Pacheco, Y.M.2    Villar, J.3    Abia, R.4    Muriana, F.J.5
  • 104
    • 0036276967 scopus 로고    scopus 로고
    • The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream)
    • Piers LS, Walker KZ, Stoney RM, Soares MJ, O'Dea K. The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream). Int J Obes Relat Metab Disord 2002; 26: 814-821.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 814-821
    • Piers, L.S.1    Walker, K.Z.2    Stoney, R.M.3    Soares, M.J.4    O'Dea, K.5
  • 105
    • 26444463825 scopus 로고    scopus 로고
    • Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    • Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kareholt I, Winblad B et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005; 62: 1556-1560.
    • (2005) Arch Neurol , vol.62 , pp. 1556-1560
    • Kivipelto, M.1    Ngandu, T.2    Fratiglioni, L.3    Viitanen, M.4    Kareholt, I.5    Winblad, B.6
  • 108
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists
    • Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists. J Clin Invest 2000; 106: 467-472.
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 109
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
    • Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J Neurosci 2000; 20: 558-567.
    • (2000) J Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 110
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001; 169: 453-459.
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 111
    • 0034623141 scopus 로고    scopus 로고
    • Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways
    • Paik JH, Ju JH, Lee JY, Boudreau MD, Hwang DH. Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J Biol Chem 2000; 275: 28173-28179.
    • (2000) J Biol Chem , vol.275 , pp. 28173-28179
    • Paik, J.H.1    Ju, J.H.2    Lee, J.Y.3    Boudreau, M.D.4    Hwang, D.H.5
  • 113
    • 1542313910 scopus 로고    scopus 로고
    • Anti-inflammatory and antiproliferative actions of PPAR-γ agonists on T lymphocytes derived from MS patients
    • Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, Heneka MT. Anti-inflammatory and antiproliferative actions of PPAR-γ agonists on T lymphocytes derived from MS patients. J Leukoc Biol 2004; 75: 478-485.
    • (2004) J Leukoc Biol , vol.75 , pp. 478-485
    • Schmidt, S.1    Moric, E.2    Schmidt, M.3    Sastre, M.4    Feinstein, D.L.5    Heneka, M.T.6
  • 114
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR γ)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR γ). J Biol Chem 1995; 270: 12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 115
    • 9644268167 scopus 로고    scopus 로고
    • Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease
    • Pedersen WA, Flynn ER. Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Dis 2004; 17: 500-506.
    • (2004) Neurobiol Dis , vol.17 , pp. 500-506
    • Pedersen, W.A.1    Flynn, E.R.2
  • 116
    • 33644592598 scopus 로고    scopus 로고
    • Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
    • Watson GS, Cholerton BA, Reger MA, Baker LD, Plymate SR, Asthana S et al. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 2005; 13: 950-958.
    • (2005) Am J Geriatr Psychiatry , vol.13 , pp. 950-958
    • Watson, G.S.1    Cholerton, B.A.2    Reger, M.A.3    Baker, L.D.4    Plymate, S.R.5    Asthana, S.6
  • 117
    • 0034012731 scopus 로고    scopus 로고
    • Intracerebroventricular insulin enhances memory in a passive-avoidance task
    • Park CR, Seeley RJ, Craft S, Woods SC. Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol Behav 2000; 68: 509-514.
    • (2000) Physiol Behav , vol.68 , pp. 509-514
    • Park, C.R.1    Seeley, R.J.2    Craft, S.3    Woods, S.C.4
  • 118
    • 56549112905 scopus 로고    scopus 로고
    • Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
    • Francis GJ, Martinez JA, Liu WQ, Xu K, Ayer A, Fine J et al. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008; 131: 3311-3334.
    • (2008) Brain , vol.131 , pp. 3311-3334
    • Francis, G.J.1    Martinez, J.A.2    Liu, W.Q.3    Xu, K.4    Ayer, A.5    Fine, J.6
  • 119
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127: 481-496.
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey 2nd, W.H.4
  • 121
    • 0037802511 scopus 로고    scopus 로고
    • Intranasal delivery: bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord
    • Frey WH 2nd. Intranasal delivery: bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord. Drug Deliv Technol 2002; 2: 46-49.
    • (2002) Drug Deliv Technol , vol.2 , pp. 46-49
    • Frey 2nd, W.H.1
  • 122
    • 0036896831 scopus 로고    scopus 로고
    • Nasal drug delivery: new developments and strategies
    • Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today 2002; 7: 1184-1189.
    • (2002) Drug Discov Today , vol.7 , pp. 1184-1189
    • Illum, L.1
  • 123
    • 0033014163 scopus 로고    scopus 로고
    • Central nervous system effects of intranasally administered insulin during euglycemia in men
    • Kern W, Born J, Schreiber H, Fehm HL. Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes 1999; 48: 557-563.
    • (1999) Diabetes , vol.48 , pp. 557-563
    • Kern, W.1    Born, J.2    Schreiber, H.3    Fehm, H.L.4
  • 124
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
    • Reger MA, Watson GS, Frey WH II, Baker LD, Cholerton B, Keeling ML et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 2006; 27: 451-458.
    • (2006) Neurobiol Aging , vol.27 , pp. 451-458
    • Reger, M.A.1    Watson, G.S.2    Frey II, W.H.3    Baker, L.D.4    Cholerton, B.5    Keeling, M.L.6
  • 126
    • 42049089751 scopus 로고    scopus 로고
    • Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    • Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab 2008; 93: 1339-1344.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1339-1344
    • Benedict, C.1    Kern, W.2    Schultes, B.3    Born, J.4    Hallschmid, M.5
  • 127
    • 81355140743 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer Disease and amnestic mild cognitive impairment: a pilot clinical trial
    • Epub ahead of print].
    • Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A et al. Intranasal insulin therapy for Alzheimer Disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2011; [Epub ahead of print].
    • (2011) Arch Neurol
    • Craft, S.1    Baker, L.D.2    Montine, T.J.3    Minoshima, S.4    Watson, G.S.5    Claxton, A.6
  • 128
    • 0037423144 scopus 로고    scopus 로고
    • Obesity and the environment: where do we go from here?
    • Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here? Science 2003; 299: 853-855.
    • (2003) Science , vol.299 , pp. 853-855
    • Hill, J.O.1    Wyatt, H.R.2    Reed, G.W.3    Peters, J.C.4
  • 129
  • 130
    • 0021918027 scopus 로고
    • Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes
    • Salzman R, Manson JE, Griffing GT, Kimmerle R, Ruderman N, McCall A et al. Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes. N Engl J Med 1985; 312: 1078-1084.
    • (1985) N Engl J Med , vol.312 , pp. 1078-1084
    • Salzman, R.1    Manson, J.E.2    Griffing, G.T.3    Kimmerle, R.4    Ruderman, N.5    McCall, A.6
  • 132
    • 77949322655 scopus 로고    scopus 로고
    • Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms
    • Solfrizzi V, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Vendemiale G et al. Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. Ageing Res Rev 2010; 9: 184-199.
    • (2010) Ageing Res Rev , vol.9 , pp. 184-199
    • Solfrizzi, V.1    Frisardi, V.2    Capurso, C.3    D'Introno, A.4    Colacicco, A.M.5    Vendemiale, G.6
  • 133
    • 77957289008 scopus 로고    scopus 로고
    • Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms
    • Panza F, Frisardi V, Capurso C, Imbimbo BP, Vendemiale G, Santamato A et al. Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms. J Alzheimers Dis 2010; 21: 691-724.
    • (2010) J Alzheimers Dis , vol.21 , pp. 691-724
    • Panza, F.1    Frisardi, V.2    Capurso, C.3    Imbimbo, B.P.4    Vendemiale, G.5    Santamato, A.6
  • 134
    • 79952483902 scopus 로고    scopus 로고
    • Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity
    • Kanoski SE, Davidson TL. Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav 2011; 103: 59-68.
    • (2011) Physiol Behav , vol.103 , pp. 59-68
    • Kanoski, S.E.1    Davidson, T.L.2
  • 135
    • 0035372336 scopus 로고    scopus 로고
    • Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Aβ) and apoE/Aβ complexes on protein kinase C-alpha (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
    • Cedazo-Minguez A, Wiehager B, Winblad B, Huttinger M, Cowburn RF. Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Aβ) and apoE/Aβ complexes on protein kinase C-alpha (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Neurochem Int 2001; 38: 615-625.
    • (2001) Neurochem Int , vol.38 , pp. 615-625
    • Cedazo-Minguez, A.1    Wiehager, B.2    Winblad, B.3    Huttinger, M.4    Cowburn, R.F.5
  • 136
    • 77956026310 scopus 로고    scopus 로고
    • Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases
    • Schroeder JE, Richardson JC, Virley DJ. Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases. Biochim Biophys Acta 2010; 1802: 840-846.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 840-846
    • Schroeder, J.E.1    Richardson, J.C.2    Virley, D.J.3
  • 138
    • 77953736212 scopus 로고    scopus 로고
    • Diet and neurocognition: review of evidence and methodological considerations
    • Smith PJ, Blumenthal JA. Diet and neurocognition: review of evidence and methodological considerations. Curr Aging Sci 2010; 3: 57-66.
    • (2010) Curr Aging Sci , vol.3 , pp. 57-66
    • Smith, P.J.1    Blumenthal, J.A.2
  • 140
    • 33749633921 scopus 로고    scopus 로고
    • Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
    • Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, Basun H, Faxen-Irving G, Garlind A et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 2006; 63: 1402-1408.
    • (2006) Arch Neurol , vol.63 , pp. 1402-1408
    • Freund-Levi, Y.1    Eriksdotter-Jonhagen, M.2    Cederholm, T.3    Basun, H.4    Faxen-Irving, G.5    Garlind, A.6
  • 145
    • 78650827898 scopus 로고    scopus 로고
    • Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    • Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A et al. Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. J Alzheimers Dis 2010; 22: 569-579.
    • (2010) J Alzheimers Dis , vol.22 , pp. 569-579
    • Baker, L.D.1    Frank, L.L.2    Foster-Schubert, K.3    Green, P.S.4    Wilkinson, C.W.5    McTiernan, A.6
  • 146
    • 79251551381 scopus 로고    scopus 로고
    • Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties
    • Teixeira-Lemos E, Nunes S, Teixeira F, Reis F. Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol 2011; 10: 12.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 12
    • Teixeira-Lemos, E.1    Nunes, S.2    Teixeira, F.3    Reis, F.4
  • 147
    • 79952093796 scopus 로고    scopus 로고
    • Physical exercise alleviates debilities of normal aging and Alzheimer's disease
    • Archer T. Physical exercise alleviates debilities of normal aging and Alzheimer's disease. Acta Neurol Scand 2011; 123: 221-238.
    • (2011) Acta Neurol Scand , vol.123 , pp. 221-238
    • Archer, T.1
  • 149
    • 57349148171 scopus 로고    scopus 로고
    • Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: independence from changes in dynamic autoregulation and reactivity
    • Ainslie PN, Hamlin M, Hellemans J, Rasmussen P, Ogoh S. Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: independence from changes in dynamic autoregulation and reactivity. Am J Physiol Regul Integr Comp Physiol 2008; 295: R1613-R1622.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Ainslie, P.N.1    Hamlin, M.2    Hellemans, J.3    Rasmussen, P.4    Ogoh, S.5
  • 150
    • 3042719532 scopus 로고    scopus 로고
    • Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    • Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004; 52: 1098-1104.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1098-1104
    • Colbert, L.H.1    Visser, M.2    Simonsick, E.M.3    Tracy, R.P.4    Newman, A.B.5    Kritchevsky, S.B.6
  • 151
    • 42649110683 scopus 로고    scopus 로고
    • Association between arterial elasticity, C-reactive protein and maximal oxygen consumption in well-trained cadets during three days extreme physical load: a pilot study
    • Kampus P, Kals J, Unt E, Zilmer K, Eha J, Teesalu R et al. Association between arterial elasticity, C-reactive protein and maximal oxygen consumption in well-trained cadets during three days extreme physical load: a pilot study. Physiol Meas 2008; 29: 429-437.
    • (2008) Physiol Meas , vol.29 , pp. 429-437
    • Kampus, P.1    Kals, J.2    Unt, E.3    Zilmer, K.4    Eha, J.5    Teesalu, R.6
  • 152
    • 56749180855 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
    • Gomez-Pinilla F, Vaynman S, Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 2008; 28: 2278-2287.
    • (2008) Eur J Neurosci , vol.28 , pp. 2278-2287
    • Gomez-Pinilla, F.1    Vaynman, S.2    Ying, Z.3
  • 153
    • 79751487496 scopus 로고    scopus 로고
    • Intensity of recreational physical activity throughout life and later life cognitive functioning in women
    • Tierney MC, Moineddin R, Morra A, Manson J, Blake J. Intensity of recreational physical activity throughout life and later life cognitive functioning in women. J Alzheimers Dis 2010; 22: 1331-1338.
    • (2010) J Alzheimers Dis , vol.22 , pp. 1331-1338
    • Tierney, M.C.1    Moineddin, R.2    Morra, A.3    Manson, J.4    Blake, J.5
  • 155
  • 157
    • 78650179908 scopus 로고    scopus 로고
    • Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: role of hippocampus
    • Maniam J, Morris MJ. Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: role of hippocampus. Psychoneuroendocrinology 2010; 35: 1553-1564.
    • (2010) Psychoneuroendocrinology , vol.35 , pp. 1553-1564
    • Maniam, J.1    Morris, M.J.2
  • 158
    • 0025766828 scopus 로고
    • Usual vs. successful aging: some notes on experiential factors
    • discussion: 352-325.
    • Black JE, Isaacs KR, Greenough WT. Usual vs. successful aging: some notes on experiential factors. Neurobiol Aging 1991; 12: 325-328 discussion: 352-325.
    • (1991) Neurobiol Aging , vol.12 , pp. 325-328
    • Black, J.E.1    Isaacs, K.R.2    Greenough, W.T.3
  • 159
    • 77954322943 scopus 로고    scopus 로고
    • Physical activity over the life course and its association with cognitive performance and impairment in old age
    • Middleton LE, Barnes DE, Lui LY, Yaffe K. Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc 2010; 58: 1322-1326.
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1322-1326
    • Middleton, L.E.1    Barnes, D.E.2    Lui, L.Y.3    Yaffe, K.4
  • 160
    • 78649790037 scopus 로고    scopus 로고
    • 'Executive' functions and normal aging: selective impairment in conditional exclusion compared to abstraction and inhibition
    • Silver H, Goodman C, Gur RC, Gur RE, Bilker WB. 'Executive' functions and normal aging: selective impairment in conditional exclusion compared to abstraction and inhibition. Dement Geriatr Cogn Disord 2011; 31: 53-62.
    • (2011) Dement Geriatr Cogn Disord , vol.31 , pp. 53-62
    • Silver, H.1    Goodman, C.2    Gur, R.C.3    Gur, R.E.4    Bilker, W.B.5
  • 161
    • 79958757046 scopus 로고    scopus 로고
    • Attention, working memory and grammaticality judgment in normal young adults
    • Smith PA. Attention, working memory and grammaticality judgment in normal young adults. J Speech Lang Hear Res 2011; 54: 918-931.
    • (2011) J Speech Lang Hear Res , vol.54 , pp. 918-931
    • Smith, P.A.1
  • 162
    • 71549116412 scopus 로고    scopus 로고
    • The relationship between episodic long-term memory and white matter integrity in normal aging
    • Charlton RA, Barrick TR, Markus HS, Morris RG. The relationship between episodic long-term memory and white matter integrity in normal aging. Neuropsychologia 2010; 48: 114-122.
    • (2010) Neuropsychologia , vol.48 , pp. 114-122
    • Charlton, R.A.1    Barrick, T.R.2    Markus, H.S.3    Morris, R.G.4
  • 164
    • 59849089967 scopus 로고    scopus 로고
    • The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review
    • van Uffelen JG, Chin APMJ, Hopman-Rock M, van Mechelen W. The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review. Clin J Sport Med 2008; 18: 486-500.
    • (2008) Clin J Sport Med , vol.18 , pp. 486-500
    • van Uffelen, J.G.1    Chin, A.P.M.J.2    Hopman-Rock, M.3    van Mechelen, W.4
  • 166
    • 43049155954 scopus 로고    scopus 로고
    • Prevention of CIND by physical activity: different impact on VCI-ND compared with MCI
    • Middleton L, Kirkland S, Rockwood K. Prevention of CIND by physical activity: different impact on VCI-ND compared with MCI. J Neurol Sci 2008; 269: 80-84.
    • (2008) J Neurol Sci , vol.269 , pp. 80-84
    • Middleton, L.1    Kirkland, S.2    Rockwood, K.3
  • 168
    • 33644800309 scopus 로고    scopus 로고
    • Exercise is associated with reduced risk for incident dementia among persons 65years of age and older
    • Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P et al. Exercise is associated with reduced risk for incident dementia among persons 65years of age and older. Ann Intern Med 2006; 144: 73-81.
    • (2006) Ann Intern Med , vol.144 , pp. 73-81
    • Larson, E.B.1    Wang, L.2    Bowen, J.D.3    McCormick, W.C.4    Teri, L.5    Crane, P.6
  • 169
    • 0034922575 scopus 로고    scopus 로고
    • A prospective study of physical activity and cognitive decline in elderly women: women who walk
    • Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med 2001; 161: 1703-1708.
    • (2001) Arch Intern Med , vol.161 , pp. 1703-1708
    • Yaffe, K.1    Barnes, D.2    Nevitt, M.3    Lui, L.Y.4    Covinsky, K.5
  • 175
    • 79952611070 scopus 로고    scopus 로고
    • Impact of age on critical closing pressure of the cerebral circulation during dynamic exercise in humans
    • Ogoh S, Fisher JP, Young CN, Fadel PJ. Impact of age on critical closing pressure of the cerebral circulation during dynamic exercise in humans. Exp Physiol 2011; 96: 417-425.
    • (2011) Exp Physiol , vol.96 , pp. 417-425
    • Ogoh, S.1    Fisher, J.P.2    Young, C.N.3    Fadel, P.J.4
  • 176
    • 0038050784 scopus 로고    scopus 로고
    • Fitness effects on the cognitive function of older adults: a meta-analytic study
    • Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci 2003; 14: 125-130.
    • (2003) Psychol Sci , vol.14 , pp. 125-130
    • Colcombe, S.1    Kramer, A.F.2
  • 177
    • 81355140744 scopus 로고    scopus 로고
    • Non-pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI)
    • Epub ahead of print].
    • Teixeira CV, Gobbi LT, Corazza DI, Stella F, Costa JL, Gobbi S. Non-pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI). Arch Gerontol Geriatr 2011; [Epub ahead of print].
    • (2011) Arch Gerontol Geriatr
    • Teixeira, C.V.1    Gobbi, L.T.2    Corazza, D.I.3    Stella, F.4    Costa, J.L.5    Gobbi, S.6
  • 178
    • 21444458336 scopus 로고    scopus 로고
    • Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease
    • discussion: 255-262.
    • Morris JC, Cummings J. Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease. J Alzheimers Dis 2005; 7: 235-239 discussion: 255-262.
    • (2005) J Alzheimers Dis , vol.7 , pp. 235-239
    • Morris, J.C.1    Cummings, J.2
  • 179
    • 50949110086 scopus 로고    scopus 로고
    • Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    • Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. J Am Med Assoc 2008; 300: 1027-1037.
    • (2008) J Am Med Assoc , vol.300 , pp. 1027-1037
    • Lautenschlager, N.T.1    Cox, K.L.2    Flicker, L.3    Foster, J.K.4    van Bockxmeer, F.M.5    Xiao, J.6
  • 180
    • 79951895634 scopus 로고    scopus 로고
    • Structured exercise does not stabilize cognitive function in individuals with mild cognitive impairment residing in a structured living facility
    • Miller LA, Spitznagel MB, Busko S, Potter V, Juvancic-Heltzel J, Istenes N et al. Structured exercise does not stabilize cognitive function in individuals with mild cognitive impairment residing in a structured living facility. Int J Neurosci 2011; 121: 218-223.
    • (2011) Int J Neurosci , vol.121 , pp. 218-223
    • Miller, L.A.1    Spitznagel, M.B.2    Busko, S.3    Potter, V.4    Juvancic-Heltzel, J.5    Istenes, N.6
  • 182
    • 67650470231 scopus 로고    scopus 로고
    • Walking the line: a randomised trial on the effects of a short-term walking programme on cognition in dementia
    • Eggermont LH, Swaab DF, Hol EM, Scherder EJ. Walking the line: a randomised trial on the effects of a short-term walking programme on cognition in dementia. J Neurol Neurosurg Psychiatry 2009; 80: 802-804.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 802-804
    • Eggermont, L.H.1    Swaab, D.F.2    Hol, E.M.3    Scherder, E.J.4


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