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Volumn 96, Issue 2, 2016, Pages 156-167

Wnt/β-catenin signaling in kidney injury and repair: A double-edged sword

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CALVASCULIN; CASEIN KINASE I; CHEMOKINE; CYCLIN A; CYCLIN D1; CYTOKINE; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE; GROWTH FACTOR; IMMUNOREACTIVE INSULIN; LIGAND; MATRILYSIN; MULTIPROTEIN COMPLEX; PLASMINOGEN ACTIVATOR INHIBITOR 1; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; WNT PROTEIN;

EID: 84955615234     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.153     Document Type: Article
Times cited : (160)

References (128)
  • 1
    • 84907996792 scopus 로고    scopus 로고
    • Mechanisms of epithelial repair and regeneration after acute kidney injury
    • Berger K, Moeller MJ. Mechanisms of epithelial repair and regeneration after acute kidney injury. Semin Nephrol 2014;34:394-403.
    • (2014) Semin Nephrol , vol.34 , pp. 394-403
    • Berger, K.1    Moeller, M.J.2
  • 2
    • 84895560010 scopus 로고    scopus 로고
    • Regeneration of injured renal tubules
    • Yoshida M, Honma S. Regeneration of injured renal tubules. J Pharmacol Sci 2014;124:117-122.
    • (2014) J Pharmacol Sci , vol.124 , pp. 117-122
    • Yoshida, M.1    Honma, S.2
  • 3
    • 45849144386 scopus 로고    scopus 로고
    • Wnt signaling in kidney development and disease
    • Pulkkinen K, Murugan S, Vainio S. Wnt signaling in kidney development and disease. Organogenesis 2008;4:55-59.
    • (2008) Organogenesis , vol.4 , pp. 55-59
    • Pulkkinen, K.1    Murugan, S.2    Vainio, S.3
  • 4
    • 79957821845 scopus 로고    scopus 로고
    • The severity of acute kidney injury predicts progression to chronic kidney disease
    • Chawla LS, Amdur RL, Amodeo S et al. The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 2011;79:1361-1369.
    • (2011) Kidney Int , vol.79 , pp. 1361-1369
    • Chawla, L.S.1    Amdur, R.L.2    Amodeo, S.3
  • 5
    • 79953175649 scopus 로고    scopus 로고
    • Pathophysiology of ischemic acute kidney injury
    • Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol 2011;7:189-200.
    • (2011) Nat Rev Nephrol , vol.7 , pp. 189-200
    • Sharfuddin, A.A.1    Molitoris, B.A.2
  • 6
    • 84922248283 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta orchestrates microtubule remodeling in compensatory glomerular adaptation to podocyte depletion
    • Xu W, Ge Y, Liu Z et al. Glycogen synthase kinase 3beta orchestrates microtubule remodeling in compensatory glomerular adaptation to podocyte depletion. J Biol Chem 2015;290:1348-1363.
    • (2015) J Biol Chem , vol.290 , pp. 1348-1363
    • Xu, W.1    Ge, Y.2    Liu, Z.3
  • 7
    • 84902166317 scopus 로고    scopus 로고
    • KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria
    • Hayashi K, Sasamura H, Nakamura M et al. KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria. J Clin Invest 2014;124:2523-2537.
    • (2014) J Clin Invest , vol.124 , pp. 2523-2537
    • Hayashi, K.1    Sasamura, H.2    Nakamura, M.3
  • 8
    • 33846886531 scopus 로고    scopus 로고
    • Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat
    • Hayden MR, Chowdhury NA, Cooper SA et al. Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat. Am J Physiol Renal Physiol 2007;292:F861-F867.
    • (2007) Am J Physiol Renal Physiol , vol.292 , pp. F861-F867
    • Hayden, M.R.1    Chowdhury, N.A.2    Cooper, S.A.3
  • 9
    • 0043022151 scopus 로고    scopus 로고
    • Mechanisms of repair after kidney injury
    • Mene P, Polci R, Festuccia F. Mechanisms of repair after kidney injury. J Nephrol 2003;16:186-195.
    • (2003) J Nephrol , vol.16 , pp. 186-195
    • Mene, P.1    Polci, R.2    Festuccia, F.3
  • 10
    • 84929129947 scopus 로고    scopus 로고
    • Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD
    • Ferenbach DA, Bonventre JV. Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD. Nat Rev Nephrol 2015;11:264-276.
    • (2015) Nat Rev Nephrol , vol.11 , pp. 264-276
    • Ferenbach, D.A.1    Bonventre, J.V.2
  • 11
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • Yang L, Besschetnova TY, Brooks CR et al. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010;16:535-543.
    • (2010) Nat Med , vol.16 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3
  • 12
    • 77954594721 scopus 로고    scopus 로고
    • Pathophysiology of AKI: Injury and normal and abnormal repair
    • Bonventre JV. Pathophysiology of AKI: injury and normal and abnormal repair. Contrib Nephrol 2010;165:9-17.
    • (2010) Contrib Nephrol , vol.165 , pp. 9-17
    • Bonventre, J.V.1
  • 13
    • 84920949774 scopus 로고    scopus 로고
    • Wnt signaling in kidney tubulointerstitium during disease
    • Maarouf OH, Ikeda Y, Humphreys BD. Wnt signaling in kidney tubulointerstitium during disease. Histol Histopathol 2015;30: 163-171.
    • (2015) Histol Histopathol , vol.30 , pp. 163-171
    • Maarouf, O.H.1    Ikeda, Y.2    Humphreys, B.D.3
  • 14
    • 84940451305 scopus 로고    scopus 로고
    • Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease
    • Zhou L, Liu Y. Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease. Nat Rev Nephrol 2015;11:535-545.
    • (2015) Nat Rev Nephrol , vol.11 , pp. 535-545
    • Zhou, L.1    Liu, Y.2
  • 15
    • 84908499000 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and kidney fibrosis
    • Tan RJ, Zhou D, Zhou L et al. Wnt/β-catenin signaling and kidney fibrosis. Kidney Int Suppl 2014;4:84-90.
    • (2014) Kidney Int Suppl , vol.4 , pp. 84-90
    • Tan, R.J.1    Zhou, D.2    Zhou, L.3
  • 16
    • 84860633548 scopus 로고    scopus 로고
    • Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis
    • Ding H, Zhou D, Hao S et al. Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis. J Am Soc Nephrol 2012;23:801-813.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 801-813
    • Ding, H.1    Zhou, D.2    Hao, S.3
  • 17
    • 77957857754 scopus 로고    scopus 로고
    • Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders
    • Lasagni L, Ballerini L, Angelotti ML et al. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells 2010;28: 1674-1685.
    • (2010) Stem Cells , vol.28 , pp. 1674-1685
    • Lasagni, L.1    Ballerini, L.2    Angelotti, M.L.3
  • 18
    • 0036156658 scopus 로고    scopus 로고
    • Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice
    • Dai C, Yang J, Liu Y. Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice. J Am Soc Nephrol 2002;13:411-422.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 411-422
    • Dai, C.1    Yang, J.2    Liu, Y.3
  • 20
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis-A look outside the nucleus
    • Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 2000;287:1606-1609.
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 21
    • 69949172478 scopus 로고    scopus 로고
    • Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
    • Lancaster MA, Louie CM, Silhavy JL et al. Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med 2009;15:1046-1054.
    • (2009) Nat Med , vol.15 , pp. 1046-1054
    • Lancaster, M.A.1    Louie, C.M.2    Silhavy, J.L.3
  • 22
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Angers S, Moon RT. Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 2009;10:468-477.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 23
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell 2012;149:1192-1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 24
    • 84865261784 scopus 로고    scopus 로고
    • Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice
    • Zhou D, Li Y, Lin L et al. Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice. Kidney Int 2012;82: 537-547.
    • (2012) Kidney Int , vol.82 , pp. 537-547
    • Zhou, D.1    Li, Y.2    Lin, L.3
  • 25
    • 77749246063 scopus 로고    scopus 로고
    • Macrophage Wnt7b is critical for kidney repair and regeneration
    • Lin SL, Li B, Rao S et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci USA 2010;107:4194-4199.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4194-4199
    • Lin, S.L.1    Li, B.2    Rao, S.3
  • 26
    • 65249134946 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling promotes renal interstitial fibrosis
    • He W, Dai C, Li Y et al. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009;20:765-776.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 765-776
    • He, W.1    Dai, C.2    Li, Y.3
  • 27
    • 69849089270 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria
    • Dai C, Stolz DB, Kiss LP et al. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 2009;20: 1997-2008.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1997-2008
    • Dai, C.1    Stolz, D.B.2    Kiss, L.P.3
  • 28
    • 28444468088 scopus 로고    scopus 로고
    • Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    • Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005;16:2373-2384.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2373-2384
    • Surendran, K.1    Schiavi, S.2    Hruska, K.A.3
  • 29
    • 78651384347 scopus 로고    scopus 로고
    • Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury
    • He W, Kang YS, Dai C et al. Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 2011;22:90-103.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 90-103
    • He, W.1    Kang, Y.S.2    Dai, C.3
  • 30
    • 80052335469 scopus 로고    scopus 로고
    • Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis
    • Hao S, He W, Li Y et al. Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 2011;22: 1642-1653.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1642-1653
    • Hao, S.1    He, W.2    Li, Y.3
  • 31
    • 84884306401 scopus 로고    scopus 로고
    • Wnt4/beta-catenin signaling in medullary kidney myofibroblasts
    • DiRocco DP, Kobayashi A, Taketo MM et al. Wnt4/beta-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 2013;24:1399-1412.
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1399-1412
    • Dirocco, D.P.1    Kobayashi, A.2    Taketo, M.M.3
  • 32
    • 85020438785 scopus 로고    scopus 로고
    • Sustained activation of Wnt/β-catenin signaling drives AKI to CKD progression
    • Xiao L, Zhou D, Tan RJ et al. Sustained activation of Wnt/β-catenin signaling drives AKI to CKD progression. J Am Soc Nephrol 2015; doi: 10.1681/ASN.2015040449.
    • (2015) J Am Soc Nephrol
    • Xiao, L.1    Zhou, D.2    Tan, R.J.3
  • 33
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 34
    • 84871093351 scopus 로고    scopus 로고
    • Wnt signalling in kidney diseases: Dual roles in renal injury and repair
    • Kawakami T, Ren S, Duffield JS. Wnt signalling in kidney diseases: dual roles in renal injury and repair. J Pathol 2013;229:221-231.
    • (2013) J Pathol , vol.229 , pp. 221-231
    • Kawakami, T.1    Ren, S.2    Duffield, J.S.3
  • 35
    • 84870657185 scopus 로고    scopus 로고
    • Wntless in Wnt secretion: Molecular, cellular and genetic aspects
    • Das S, Yu S, Sakamori R et al. Wntless in Wnt secretion: molecular, cellular and genetic aspects. Front Biol 2012;7:587-593.
    • (2012) Front Biol , vol.7 , pp. 587-593
    • Das, S.1    Yu, S.2    Sakamori, R.3
  • 36
    • 45849117967 scopus 로고    scopus 로고
    • Wnt signal transduction pathways
    • Komiya Y, Habas R. Wnt signal transduction pathways. Organogenesis 2008;4:68-75.
    • (2008) Organogenesis , vol.4 , pp. 68-75
    • Komiya, Y.1    Habas, R.2
  • 37
    • 2142790592 scopus 로고    scopus 로고
    • The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family
    • Tanaka K, Okabayashi K, Asashima M et al. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem 2000;267:4300-4311.
    • (2000) Eur J Biochem , vol.267 , pp. 4300-4311
    • Tanaka, K.1    Okabayashi, K.2    Asashima, M.3
  • 38
    • 77956942286 scopus 로고    scopus 로고
    • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
    • Coombs GS, Yu J, Canning CA et al. WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci 2010;123:3357-3367.
    • (2010) J Cell Sci , vol.123 , pp. 3357-3367
    • Coombs, G.S.1    Yu, J.2    Canning, C.A.3
  • 39
    • 46249102044 scopus 로고    scopus 로고
    • In vivo role of lipid adducts on Wingless
    • Franch-Marro X, Wendler F, Griffith J et al. In vivo role of lipid adducts on Wingless. J Cell Sci 2008;121:1587-1592.
    • (2008) J Cell Sci , vol.121 , pp. 1587-1592
    • Franch-Marro, X.1    Wendler, F.2    Griffith, J.3
  • 40
    • 33646134826 scopus 로고    scopus 로고
    • Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
    • Banziger C, Soldini D, Schutt C et al. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 2006;125:509-522.
    • (2006) Cell , vol.125 , pp. 509-522
    • Banziger, C.1    Soldini, D.2    Schutt, C.3
  • 41
    • 33646123992 scopus 로고    scopus 로고
    • Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
    • Bartscherer K, Pelte N, Ingelfinger D et al. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 2006;125:523-533.
    • (2006) Cell , vol.125 , pp. 523-533
    • Bartscherer, K.1    Pelte, N.2    Ingelfinger, D.3
  • 42
    • 33846138014 scopus 로고    scopus 로고
    • Sprinter: A novel transmembrane protein required for Wg secretion and signaling
    • Goodman RM, Thombre S, Firtina Z et al. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development 2006;133:4901-4911.
    • (2006) Development , vol.133 , pp. 4901-4911
    • Goodman, R.M.1    Thombre, S.2    Firtina, Z.3
  • 43
    • 33947521050 scopus 로고    scopus 로고
    • Helping wingless take flight: How WNT proteins are secreted
    • Hausmann G, Banziger C, Basler K. Helping wingless take flight: how WNT proteins are secreted. Nat Rev Mol Cell Biol 2007;8:331-336.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 331-336
    • Hausmann, G.1    Banziger, C.2    Basler, K.3
  • 44
    • 33646124944 scopus 로고    scopus 로고
    • A dedicated Wnt secretion factor
    • Ching W, Nusse R. A dedicated Wnt secretion factor. Cell 2006;125: 432-433.
    • (2006) Cell , vol.125 , pp. 432-433
    • Ching, W.1    Nusse, R.2
  • 45
    • 37749040775 scopus 로고    scopus 로고
    • The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network
    • Belenkaya TY, Wu Y, Tang X et al. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev Cell 2008;14:120-131.
    • (2008) Dev Cell , vol.14 , pp. 120-131
    • Belenkaya, T.Y.1    Wu, Y.2    Tang, X.3
  • 46
    • 77956139240 scopus 로고    scopus 로고
    • Dual roles of Drosophila glypican Dally-like in Wingless/Wnt signaling and distribution
    • Wu Y, Belenkaya TY, Lin X. Dual roles of Drosophila glypican Dally-like in Wingless/Wnt signaling and distribution. Methods Enzymol 2010;480:33-50.
    • (2010) Methods Enzymol , vol.480 , pp. 33-50
    • Wu, Y.1    Belenkaya, T.Y.2    Lin, X.3
  • 47
    • 43049138477 scopus 로고    scopus 로고
    • Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis
    • Gallet A, Staccini-Lavenant L, Therond PP. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. Dev Cell 2008;14:712-725.
    • (2008) Dev Cell , vol.14 , pp. 712-725
    • Gallet, A.1    Staccini-Lavenant, L.2    Therond, P.P.3
  • 48
    • 84877090354 scopus 로고    scopus 로고
    • Loss of Klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling
    • Zhou L, Li Y, Zhou D et al. Loss of Klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling. J Am Soc Nephrol 2013;24:771-785.
    • (2013) J Am Soc Nephrol , vol.24 , pp. 771-785
    • Zhou, L.1    Li, Y.2    Zhou, D.3
  • 49
    • 11144317908 scopus 로고    scopus 로고
    • Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
    • De Langhe SP, Sala FG, Del Moral PM et al. Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol 2005;277: 316-331.
    • (2005) Dev Biol , vol.277 , pp. 316-331
    • De Langhe, S.P.1    Sala, F.G.2    Del Moral, P.M.3
  • 50
    • 84877131537 scopus 로고    scopus 로고
    • Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/beta-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis
    • Das DS, Wadhwa N, Kunj N et al. Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/beta-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis. PLoS One 2013;8:e63603.
    • (2013) PLoS One , vol.8 , pp. e63603
    • Das, D.S.1    Wadhwa, N.2    Kunj, N.3
  • 51
    • 0037155185 scopus 로고    scopus 로고
    • Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled
    • Li L, Mao J, Sun L et al. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 2002;277:5977-5981.
    • (2002) J Biol Chem , vol.277 , pp. 5977-5981
    • Li, L.1    Mao, J.2    Sun, L.3
  • 52
    • 0242704649 scopus 로고    scopus 로고
    • Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors
    • Schweizer L, Varmus H. Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol 2003;4:4.
    • (2003) BMC Cell Biol , vol.4 , pp. 4
    • Schweizer, L.1    Varmus, H.2
  • 53
    • 77958462847 scopus 로고    scopus 로고
    • Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1
    • Kikuchi K, Niikura Y, Kitagawa K et al. Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1. EMBO J 2010;29:3470-3483.
    • (2010) EMBO J , vol.29 , pp. 3470-3483
    • Kikuchi, K.1    Niikura, Y.2    Kitagawa, K.3
  • 54
    • 56749104928 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature
    • Stenman JM, Rajagopal J, Carroll TJ et al. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008;322:1247-1250.
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1    Rajagopal, J.2    Carroll, T.J.3
  • 55
    • 77649129121 scopus 로고    scopus 로고
    • GSK3: A multifaceted kinase in Wnt signaling
    • Wu D, Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci 2010;35:161-168.
    • (2010) Trends Biochem Sci , vol.35 , pp. 161-168
    • Wu, D.1    Pan, W.2
  • 56
    • 84868665485 scopus 로고    scopus 로고
    • Wnt regulation of planar cell polarity (PCP)
    • Gao B. Wnt regulation of planar cell polarity (PCP). Curr Top Dev Biol 2012;101:263-295.
    • (2012) Curr Top Dev Biol , vol.101 , pp. 263-295
    • Gao, B.1
  • 57
    • 84900297244 scopus 로고    scopus 로고
    • Beta-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation
    • Seitz K, Dursch V, Harnos J et al. beta-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. PLoS One 2014;9: e87132.
    • (2014) PLoS One , vol.9 , pp. e87132
    • Seitz, K.1    Dursch, V.2    Harnos, J.3
  • 58
    • 58749110357 scopus 로고    scopus 로고
    • Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma
    • Dissanayake SK, Weeraratna AT. Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma. Methods Mol Biol 2008;468:157-172.
    • (2008) Methods Mol Biol , vol.468 , pp. 157-172
    • Dissanayake, S.K.1    Weeraratna, A.T.2
  • 59
    • 84908290096 scopus 로고    scopus 로고
    • A river runs through it: How autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling
    • Gomez-Cambronero J, Kantonen S. A river runs through it: how autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling. J Leukoc Biol 2014;96:779-784.
    • (2014) J Leukoc Biol , vol.96 , pp. 779-784
    • Gomez-Cambronero, J.1    Kantonen, S.2
  • 60
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003;5:367-377.
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 61
    • 84896694895 scopus 로고    scopus 로고
    • Coordination of kidney organogenesis by Wnt signaling
    • Halt K, Vainio S. Coordination of kidney organogenesis by Wnt signaling. Pediatr Nephrol 2014;29:737-744.
    • (2014) Pediatr Nephrol , vol.29 , pp. 737-744
    • Halt, K.1    Vainio, S.2
  • 62
    • 0037408544 scopus 로고    scopus 로고
    • Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats
    • Terada Y, Tanaka H, Okado T et al. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol 2003;14:1223-1233.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1223-1233
    • Terada, Y.1    Tanaka, H.2    Okado, T.3
  • 63
    • 69849095662 scopus 로고    scopus 로고
    • Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax
    • Wang Z, Havasi A, Gall JM et al. Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol 2009;20: 1919-1928.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1919-1928
    • Wang, Z.1    Havasi, A.2    Gall, J.M.3
  • 64
    • 84937883412 scopus 로고    scopus 로고
    • WNT agonist decreases tissue damage and improves renal function after ischemia-reperfusion
    • Kuncewitch M, Yang WL, Corbo L et al. WNT agonist decreases tissue damage and improves renal function after ischemia-reperfusion. Shock 2015;43:268-275.
    • (2015) Shock , vol.43 , pp. 268-275
    • Kuncewitch, M.1    Yang, W.L.2    Corbo, L.3
  • 65
    • 33644638349 scopus 로고    scopus 로고
    • Renal fibrosis: New insights into the pathogenesis and therapeutics
    • Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 2006;69:213-217.
    • (2006) Kidney Int , vol.69 , pp. 213-217
    • Liu, Y.1
  • 66
    • 78149298226 scopus 로고    scopus 로고
    • Mechanisms of tubulointerstitial fibrosis
    • Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010;21:1819-1834.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1819-1834
    • Zeisberg, M.1    Neilson, E.G.2
  • 67
    • 82355190219 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of renal fibrosis
    • Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 2011;7:684-696.
    • (2011) Nat Rev Nephrol , vol.7 , pp. 684-696
    • Liu, Y.1
  • 68
    • 84947704122 scopus 로고    scopus 로고
    • Klotho ameliorates kidney injury and fibrosis by targeting the renin-angiotensin system
    • Zhou L, Mo H, Miao J et al. Klotho ameliorates kidney injury and fibrosis by targeting the renin-angiotensin system. Am J Pathol 2015;185:3211-3223.
    • (2015) Am J Pathol , vol.185 , pp. 3211-3223
    • Zhou, L.1    Mo, H.2    Miao, J.3
  • 69
    • 84863049577 scopus 로고    scopus 로고
    • Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy
    • Zhou T, He X, Cheng R et al. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia 2012;55:255-266.
    • (2012) Diabetologia , vol.55 , pp. 255-266
    • Zhou, T.1    He, X.2    Cheng, R.3
  • 70
    • 84896126899 scopus 로고    scopus 로고
    • A glimpse of the pathogenetic mechanisms of Wnt/beta-catenin signaling in diabetic nephropathy
    • Xiao L, Wang M, Yang S et al. A glimpse of the pathogenetic mechanisms of Wnt/beta-catenin signaling in diabetic nephropathy. Biomed Res Int 2013;2013:987064.
    • (2013) Biomed Res Int , vol.2013 , pp. 987064
    • Xiao, L.1    Wang, M.2    Yang, S.3
  • 71
    • 84881458007 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/beta-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria
    • Jiang L, Xu L, Song Y et al. Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/beta-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria. J Biol Chem 2013;288:23368-23379.
    • (2013) J Biol Chem , vol.288 , pp. 23368-23379
    • Jiang, L.1    Xu, L.2    Song, Y.3
  • 72
    • 84855537673 scopus 로고    scopus 로고
    • Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling
    • Shkreli M, Sarin KY, Pech MF et al. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med 2012;18:111-119.
    • (2012) Nat Med , vol.18 , pp. 111-119
    • Shkreli, M.1    Sarin, K.Y.2    Pech, M.F.3
  • 73
    • 77955418239 scopus 로고    scopus 로고
    • Cystic kidney disease: The role of Wnt signaling
    • Lancaster MA, Gleeson JG. Cystic kidney disease: the role of Wnt signaling. Trends Mol Med 2010;16:349-360.
    • (2010) Trends Mol Med , vol.16 , pp. 349-360
    • Lancaster, M.A.1    Gleeson, J.G.2
  • 74
    • 58149496651 scopus 로고    scopus 로고
    • Increased expression of secreted frizzled-related protein 4 in polycystic kidneys
    • Romaker D, Puetz M, Teschner S et al. Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol 2009;20:48-56.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 48-56
    • Romaker, D.1    Puetz, M.2    Teschner, S.3
  • 75
    • 79960425136 scopus 로고    scopus 로고
    • Wnt/-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival
    • Kato H, Gruenwald A, Suh JH et al. Wnt/-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 2011;286:26003-26015.
    • (2011) J Biol Chem , vol.286 , pp. 26003-26015
    • Kato, H.1    Gruenwald, A.2    Suh, J.H.3
  • 76
    • 84924060445 scopus 로고    scopus 로고
    • Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease
    • Zhou L, Li Y, He W et al. Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease. J Am Soc Nephrol 2015;26:677-691.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 677-691
    • Zhou, L.1    Li, Y.2    He, W.3
  • 77
    • 84924090632 scopus 로고    scopus 로고
    • Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling
    • Zhou L, Li Y, Hao S et al. Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling. J Am Soc Nephrol 2015;26:107-120.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 107-120
    • Zhou, L.1    Li, Y.2    Hao, S.3
  • 78
    • 77955175704 scopus 로고    scopus 로고
    • Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy
    • Cox SN, Sallustio F, Serino G et al. Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy. Kidney Int 2010;78:396-407.
    • (2010) Kidney Int , vol.78 , pp. 396-407
    • Cox, S.N.1    Sallustio, F.2    Serino, G.3
  • 79
    • 75149137022 scopus 로고    scopus 로고
    • Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction
    • Lin CL, Wang JY, Ko JY et al. Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. J Am Soc Nephrol 2010;21:124-135.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 124-135
    • Lin, C.L.1    Wang, J.Y.2    Ko, J.Y.3
  • 80
    • 80051848854 scopus 로고    scopus 로고
    • Association analysis of canonical Wnt signalling genes in diabetic nephropathy
    • Kavanagh DH, Savage DA, Patterson CC et al. Association analysis of canonical Wnt signalling genes in diabetic nephropathy. PLoS One 2011;6:e23904.
    • (2011) PLoS One , vol.6 , pp. e23904
    • Kavanagh, D.H.1    Savage, D.A.2    Patterson, C.C.3
  • 81
    • 84879064665 scopus 로고    scopus 로고
    • Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy
    • Kavanagh DH, Savage DA, Patterson CC et al. Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy. BMC Nephrol 2013;14:126.
    • (2013) BMC Nephrol , vol.14 , pp. 126
    • Kavanagh, D.H.1    Savage, D.A.2    Patterson, C.C.3
  • 82
    • 84898635998 scopus 로고    scopus 로고
    • Aberrant activation of the WNT/beta-catenin signaling pathway in lupus nephritis
    • Wang XD, Huang XF, Yan QR et al. Aberrant activation of the WNT/beta-catenin signaling pathway in lupus nephritis. PLoS One 2014;9: e84852.
    • (2014) PLoS One , vol.9 , pp. e84852
    • Wang, X.D.1    Huang, X.F.2    Yan, Q.R.3
  • 83
    • 84893818867 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway
    • Gu Z, Tan W, Feng G et al. Wnt/beta-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway. Mol Cell Biochem 2014;387:27-37.
    • (2014) Mol Cell Biochem , vol.387 , pp. 27-37
    • Gu, Z.1    Tan, W.2    Feng, G.3
  • 84
    • 10744226531 scopus 로고    scopus 로고
    • Glomerular crescents predominantly express cadherin-catenin complex in pauci-immune-type crescentic glomerulonephritis
    • Usui J, Kanemoto K, Tomari S et al. Glomerular crescents predominantly express cadherin-catenin complex in pauci-immune-type crescentic glomerulonephritis. Histopathology 2003; 43: 173-179.
    • (2003) Histopathology , vol.43 , pp. 173-179
    • Usui, J.1    Kanemoto, K.2    Tomari, S.3
  • 85
    • 79959811780 scopus 로고    scopus 로고
    • WNT/beta-catenin signaling in poly-cystic kidney disease
    • Wuebken A, Schmidt-Ott KM. WNT/beta-catenin signaling in poly-cystic kidney disease. Kidney Int 2011;80:135-138.
    • (2011) Kidney Int , vol.80 , pp. 135-138
    • Wuebken, A.1    Schmidt-Ott, K.M.2
  • 86
    • 34248187071 scopus 로고    scopus 로고
    • Wnt signaling in polycystic kidney disease
    • Benzing T, Simons M, Walz G. Wnt signaling in polycystic kidney disease. J Am Soc Nephrol 2007;18:1389-1398.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1389-1398
    • Benzing, T.1    Simons, M.2    Walz, G.3
  • 87
    • 67649878597 scopus 로고    scopus 로고
    • Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
    • Karner CM, Chirumamilla R, Aoki S et al. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 2009;41:793-799.
    • (2009) Nat Genet , vol.41 , pp. 793-799
    • Karner, C.M.1    Chirumamilla, R.2    Aoki, S.3
  • 88
    • 72049109742 scopus 로고    scopus 로고
    • Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin
    • Kim I, Ding T, Fu Y et al. Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin. J Am Soc Nephrol 2009;20:2556-2569.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2556-2569
    • Kim, I.1    Ding, T.2    Fu, Y.3
  • 89
    • 84923346326 scopus 로고    scopus 로고
    • Biomarkers of AKI: A review of mechanistic relevance and potential therapeutic implications
    • Alge JL, Arthur JM. Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications. Clin J Am Soc Nephrol 2015;10:147-155.
    • (2015) Clin J Am Soc Nephrol , vol.10 , pp. 147-155
    • Alge, J.L.1    Arthur, J.M.2
  • 90
    • 84890555428 scopus 로고    scopus 로고
    • Pathophysiology and management of septic acute kidney injury
    • Romanovsky A, Morgan C, Bagshaw SM. Pathophysiology and management of septic acute kidney injury. Pediatr Nephrol 2014;29: 1-12.
    • (2014) Pediatr Nephrol , vol.29 , pp. 1-12
    • Romanovsky, A.1    Morgan, C.2    Bagshaw, S.M.3
  • 92
    • 80555157523 scopus 로고    scopus 로고
    • Cellular pathophysiology of ischemic acute kidney injury
    • Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011;121:4210-4221.
    • (2011) J Clin Invest , vol.121 , pp. 4210-4221
    • Bonventre, J.V.1    Yang, L.2
  • 93
    • 84879078766 scopus 로고    scopus 로고
    • Physiological biomarkers of acute kidney injury: A conceptual approach to improving outcomes
    • Okusa MD, Jaber BL, Doran P et al. Physiological biomarkers of acute kidney injury: a conceptual approach to improving outcomes. Contrib Nephrol 2013;182:65-81.
    • (2013) Contrib Nephrol , vol.182 , pp. 65-81
    • Okusa, M.D.1    Jaber, B.L.2    Doran, P.3
  • 95
    • 20144378863 scopus 로고    scopus 로고
    • Transient myofibroblast differentiation of interstitial fibroblastic cells relevant to tubular dilatation in uranyl acetate-induced acute renal failure in rats
    • Fujigaki Y, Muranaka Y, Sun D et al. Transient myofibroblast differentiation of interstitial fibroblastic cells relevant to tubular dilatation in uranyl acetate-induced acute renal failure in rats. Virchows Arch 2005;446:164-176.
    • (2005) Virchows Arch , vol.446 , pp. 164-176
    • Fujigaki, Y.1    Muranaka, Y.2    Sun, D.3
  • 96
    • 84959860026 scopus 로고    scopus 로고
    • Paracrine Wnt1 drives interstitial fibrosis without inflammation by tubulointerstitial cross-talk
    • Maarouf OH, Aravamudhan A, Rangarajan D et al. Paracrine Wnt1 drives interstitial fibrosis without inflammation by tubulointerstitial cross-talk. J Am Soc Nephrol 2015; doi: 10.1681/ASN.2014121188.
    • (2015) J Am Soc Nephrol
    • Maarouf, O.H.1    Aravamudhan, A.2    Rangarajan, D.3
  • 97
    • 84878694323 scopus 로고    scopus 로고
    • Kidney tubular beta-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication
    • Zhou D, Tan RJ, Zhou L et al. Kidney tubular beta-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Sci Rep 2013;3:1878.
    • (2013) Sci Rep , vol.3 , pp. 1878
    • Zhou, D.1    Tan, R.J.2    Zhou, L.3
  • 98
    • 84921790719 scopus 로고    scopus 로고
    • Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury
    • Zhou D, Li Y, Zhou L et al. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. J Am Soc Nephrol 2014;25:2187-2200.
    • (2014) J Am Soc Nephrol , vol.25 , pp. 2187-2200
    • Zhou, D.1    Li, Y.2    Zhou, L.3
  • 99
    • 84883455006 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury
    • Zhou D, Tan RJ, Lin L et al. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int 2013;84:509-520.
    • (2013) Kidney Int , vol.84 , pp. 509-520
    • Zhou, D.1    Tan, R.J.2    Lin, L.3
  • 100
    • 0036531819 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    • Monga SP, Mars WM, Pediaditakis P et al. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 2002;62: 2064-2071.
    • (2002) Cancer Res , vol.62 , pp. 2064-2071
    • Monga, S.P.1    Mars, W.M.2    Pediaditakis, P.3
  • 101
    • 84901060533 scopus 로고    scopus 로고
    • Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling
    • Koraishy FM, Silva C, Mason S et al. Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling. J Biol Chem 2014;289:14341-14350.
    • (2014) J Biol Chem , vol.289 , pp. 14341-14350
    • Koraishy, F.M.1    Silva, C.2    Mason, S.3
  • 102
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004;303:1483-1487.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 103
    • 2442642567 scopus 로고    scopus 로고
    • Matrilysin (MMP-7) expression in renal tubular damage: Association with Wnt4
    • Surendran K, Simon TC, Liapis H et al. Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int 2004;65: 2212-2222.
    • (2004) Kidney Int , vol.65 , pp. 2212-2222
    • Surendran, K.1    Simon, T.C.2    Liapis, H.3
  • 104
    • 84903643715 scopus 로고    scopus 로고
    • SHH, WNT, and NOTCH pathways in medulloblastoma: When cancer stem cells maintain self-renewal and differentiation properties
    • Cordeiro BM, Oliveira ID, Alves MT et al. SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties. Childs Nerv Syst 2014;30: 1165-1172.
    • (2014) Childs Nerv Syst , vol.30 , pp. 1165-1172
    • Cordeiro, B.M.1    Oliveira, I.D.2    Alves, M.T.3
  • 105
    • 84902477979 scopus 로고    scopus 로고
    • Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse
    • Winkler T, Mahoney EJ, Sinner D et al. Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse. PLoS One 2014;9:e98444.
    • (2014) PLoS One , vol.9 , pp. e98444
    • Winkler, T.1    Mahoney, E.J.2    Sinner, D.3
  • 106
    • 84937197833 scopus 로고    scopus 로고
    • Wnt and Notch signaling pathway involved in wound healing by targeting separately c-Myc and Hes1
    • Shi Y, Shu B, Yang R et al. Wnt and Notch signaling pathway involved in wound healing by targeting separately c-Myc and Hes1. Stem Cell Res Ther 2015;6:120.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 120
    • Shi, Y.1    Shu, B.2    Yang, R.3
  • 107
    • 84936107738 scopus 로고    scopus 로고
    • A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, smoothened
    • Stasiulewicz M, Gray S, Mastromina I et al. A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, smoothened. Development 2015;142: 2291-2303.
    • (2015) Development , vol.142 , pp. 2291-2303
    • Stasiulewicz, M.1    Gray, S.2    Mastromina, I.3
  • 108
    • 0033809912 scopus 로고    scopus 로고
    • Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats
    • Sun DF, Fujigaki Y, Fujimoto T et al. Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats. Am J Pathol 2000;157:1321-1335.
    • (2000) Am J Pathol , vol.157 , pp. 1321-1335
    • Sun, D.F.1    Fujigaki, Y.2    Fujimoto, T.3
  • 109
    • 84863115179 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD
    • He W, Tan RJ, Li Y et al. Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD. J Am Soc Nephrol 2012;23:294-304.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 294-304
    • He, W.1    Tan, R.J.2    Li, Y.3
  • 110
    • 84861850705 scopus 로고    scopus 로고
    • Matrix metalloproteinases in kidney homeostasis and disease
    • Tan RJ, Liu Y. Matrix metalloproteinases in kidney homeostasis and disease. Am J Physiol Renal Physiol 2012;302:F1351-F1361.
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F1351-F1361
    • Tan, R.J.1    Liu, Y.2
  • 111
    • 77952685728 scopus 로고    scopus 로고
    • Enhanced progenitor cell recruitment and endothelial repair after selective endothelial injury of the mouse kidney
    • Hohenstein B, Kuo MC, Addabbo F et al. Enhanced progenitor cell recruitment and endothelial repair after selective endothelial injury of the mouse kidney. Am J Physiol Renal Physiol 2010;298:F1504-F1514.
    • (2010) Am J Physiol Renal Physiol , vol.298 , pp. F1504-F1514
    • Hohenstein, B.1    Kuo, M.C.2    Addabbo, F.3
  • 112
    • 84930177865 scopus 로고    scopus 로고
    • The administration of erythropoietin attenuates kidney injury induced by ischemia/reperfusion with increased activation of Wnt/beta-catenin signaling
    • Chen X, Wang CC, Song SM et al. The administration of erythropoietin attenuates kidney injury induced by ischemia/reperfusion with increased activation of Wnt/beta-catenin signaling. J Formosan Med Asso 2015;114:430-437.
    • (2015) J Formosan Med Asso , vol.114 , pp. 430-437
    • Chen, X.1    Wang, C.C.2    Song, S.M.3
  • 113
    • 80053210046 scopus 로고    scopus 로고
    • Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice
    • Outtz HH, Tattersall IW, Kofler NM et al. Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. Blood 2011;118: 3436-3439.
    • (2011) Blood , vol.118 , pp. 3436-3439
    • Outtz, H.H.1    Tattersall, I.W.2    Kofler, N.M.3
  • 114
    • 0037443760 scopus 로고    scopus 로고
    • IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    • Li A, Dubey S, Varney ML et al. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003;170:3369-3376.
    • (2003) J Immunol , vol.170 , pp. 3369-3376
    • Li, A.1    Dubey, S.2    Varney, M.L.3
  • 115
    • 37549051776 scopus 로고    scopus 로고
    • Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro
    • Fan Y, Ye J, Shen F et al. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab 2008;28:90-98.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 90-98
    • Fan, Y.1    Ye, J.2    Shen, F.3
  • 116
    • 24044500959 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells
    • Masckauchan TN, Shawber CJ, Funahashi Y et al. Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis 2005;8:43-51.
    • (2005) Angiogenesis , vol.8 , pp. 43-51
    • Masckauchan, T.N.1    Shawber, C.J.2    Funahashi, Y.3
  • 117
    • 84911959577 scopus 로고    scopus 로고
    • Interleukin-6 drives melanoma cell motility through p38alpha-MAPK-dependent up-regulation of WNT5A expression
    • Linnskog R, Jonsson G, Axelsson L et al. Interleukin-6 drives melanoma cell motility through p38alpha-MAPK-dependent up-regulation of WNT5A expression. Mol Oncol 2014;8:1365-1378.
    • (2014) Mol Oncol , vol.8 , pp. 1365-1378
    • Linnskog, R.1    Jonsson, G.2    Axelsson, L.3
  • 118
    • 0033012871 scopus 로고    scopus 로고
    • Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression
    • Diez-Roux G, Argilla M, Makarenkova H et al. Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression. Development 1999;126:2141-2147.
    • (1999) Development , vol.126 , pp. 2141-2147
    • Diez-Roux, G.1    Argilla, M.2    Makarenkova, H.3
  • 119
    • 25144451336 scopus 로고    scopus 로고
    • WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
    • Lobov IB, Rao S, Carroll TJ et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 2005;437:417-421.
    • (2005) Nature , vol.437 , pp. 417-421
    • Lobov, I.B.1    Rao, S.2    Carroll, T.J.3
  • 120
    • 84865262751 scopus 로고    scopus 로고
    • Role changes of beta-catenin in kidney injury and repair
    • Peng J, Dong Z. Role changes of beta-catenin in kidney injury and repair. Kidney Int 2012;82:509-511.
    • (2012) Kidney Int , vol.82 , pp. 509-511
    • Peng, J.1    Dong, Z.2
  • 121
    • 84894060402 scopus 로고    scopus 로고
    • The link between acute kidney injury and chronic kidney disease
    • Belayer LY, Palevsky PM. The link between acute kidney injury and chronic kidney disease. Curr Opin Nephrol Hypertens 2014;23: 149-154.
    • (2014) Curr Opin Nephrol Hypertens , vol.23 , pp. 149-154
    • Belayer, L.Y.1    Palevsky, P.M.2
  • 122
    • 84873121387 scopus 로고    scopus 로고
    • Chronic kidney disease following acute kidney injury-risk and outcomes
    • Leung KC, Tonelli M, James MT. Chronic kidney disease following acute kidney injury-risk and outcomes. Nat Rev Nephrol 2013;9: 77-85.
    • (2013) Nat Rev Nephrol , vol.9 , pp. 77-85
    • Leung, K.C.1    Tonelli, M.2    James, M.T.3
  • 124
    • 84865273555 scopus 로고    scopus 로고
    • Acute kidney injury and chronic kidney disease: An integrated clinical syndrome
    • Chawla LS, Kimmel PL. Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int 2012;82:516-524.
    • (2012) Kidney Int , vol.82 , pp. 516-524
    • Chawla, L.S.1    Kimmel, P.L.2
  • 125
    • 77955286565 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/β-catenin signaling
    • He W, Tan R, Dai C et al. Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/β-catenin signaling. J Biol Chem 2010;285:24665-24675.
    • (2010) J Biol Chem , vol.285 , pp. 24665-24675
    • He, W.1    Tan, R.2    Dai, C.3
  • 126
    • 84871335138 scopus 로고    scopus 로고
    • Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling
    • Satoh M, Nagasu H, Morita Y et al. Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol 2012;303:F1641-F1651.
    • (2012) Am J Physiol Renal Physiol , vol.303 , pp. F1641-F1651
    • Satoh, M.1    Nagasu, H.2    Morita, Y.3
  • 127
    • 77953530356 scopus 로고    scopus 로고
    • β-Catenin mediates adriamycin-induced albuminuria and podocyte injury in the adult mouse kidneys
    • Heikkila E, Juhila J, Lassila M et al. β-Catenin mediates adriamycin-induced albuminuria and podocyte injury in the adult mouse kidneys. Nephrol Dial Transplant 2010;25:2437-2446.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 2437-2446
    • Heikkila, E.1    Juhila, J.2    Lassila, M.3
  • 128
    • 81155150123 scopus 로고    scopus 로고
    • Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria
    • Wang D, Dai C, Li Y et al. Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria. Kidney Int 2011;80:1159-1169.
    • (2011) Kidney Int , vol.80 , pp. 1159-1169
    • Wang, D.1    Dai, C.2    Li, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.