WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

Journal of Cell Science

Volumn 123, Issue 19, 2010, Pages 3357-3367

  Coombs, Gary S ^a   Yu, Jia ^a   Canning, Claire A ^b   Veltri, Charles A ^c   Covey, Tracy M ^a   Cheong, Jit K ^a   Utomo, Velani ^a   Banerjee, Nikhil ^d   Zhang, Zong Hong ^e   Jadulco, Raquel C ^c   Concepcion, Gisela P ^f   Bugni, Tim S ^c   Harper, Mary Kay ^c   Mihalek, Ivana ^e   Jones, C Michael ^b   Ireland, Chris M ^c   Virshup, David M ^a  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e BIOINFORMATICS INSTITUTE   (Singapore)

^f University of the Philippines Diliman   (Philippines)

Author keywords

Acidification; Palmitate; Secretion; WLS; Wnt

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN; BETA CATENIN; CONCANAMYCIN A; PALMITIC ACID; SERINE; WNT3A PROTEIN;

ACIDIFICATION; ACYLATION; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CELL VACUOLE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; XENOPUS LAEVIS;

ACYLATION; ADENOSINE TRIPHOSPHATASES; ANIMALS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROLIDES; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SERINE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; VACUOLES; WNT PROTEINS; XENOPUS;

EID: 77956942286     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.072132     Document Type: Article

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