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Volumn 9, Issue 6, 2014, Pages

Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; WNT PROTEIN; SHH PROTEIN, MOUSE;

EID: 84902477979     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098444     Document Type: Article
Times cited : (51)

References (62)
  • 1
    • 79959360699 scopus 로고    scopus 로고
    • Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs
    • Choi KS, Harfe BD (2011) Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A 108: 9484-9489.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9484-9489
    • Choi, K.S.1    Harfe, B.D.2
  • 2
    • 65549151759 scopus 로고    scopus 로고
    • Postnatal growth, differentiation, and aging of the mouse intervertebral disc
    • Phila Pa 1976
    • Dahia CL, Mahoney EJ, Durrani AA, Wylie C (2009) Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine (Phila Pa 1976) 34: 447-455.
    • (2009) Spine , vol.34 , pp. 447-455
    • Dahia, C.L.1    Mahoney, E.J.2    Durrani, A.A.3    Wylie, C.4
  • 4
    • 0021147075 scopus 로고
    • Morphologic changes in annulus fibrosus during aging. An ultrastructural study in rats
    • Phila Pa 1976
    • Postacchini F, Bellocci M, Massobrio M (1984) Morphologic changes in annulus fibrosus during aging. An ultrastructural study in rats. Spine (Phila Pa 1976) 9: 596-603.
    • (1984) Spine , vol.9 , pp. 596-603
    • Postacchini, F.1    Bellocci, M.2    Massobrio, M.3
  • 5
    • 0000798831 scopus 로고
    • Nerve rot compression associated with narrowing of the lumbar spinal canal
    • Epstein JA, Epstein BS, Lavine L (1962) Nerve rot compression associated with narrowing of the lumbar spinal canal. J Neurol Neurosurg Psychiatry 25: 165-176.
    • (1962) J Neurol Neurosurg Psychiatry , vol.25 , pp. 165-176
    • Epstein, J.A.1    Epstein, B.S.2    Lavine, L.3
  • 6
    • 0345583880 scopus 로고    scopus 로고
    • Differential diagnosis and management of spinal nerve root-related pain
    • Sizer PSJr, Phelps V, Dedrick G, Matthijs O (2002) Differential diagnosis and management of spinal nerve root-related pain. Pain Pract 2: 98-121.
    • (2002) Pain Pract , vol.2 , pp. 98-121
    • Sizer Jr., P.S.1    Phelps, V.2    Dedrick, G.3    Matthijs, O.4
  • 7
    • 65549088017 scopus 로고    scopus 로고
    • Intercellular signaling pathways active during intervertebral disc growth, differentiation, and aging
    • Phila Pa 1976
    • Dahia CL, Mahoney EJ, Durrani AA, Wylie C (2009) Intercellular signaling pathways active during intervertebral disc growth, differentiation, and aging. Spine (Phila Pa 1976) 34: 456-462.
    • (2009) Spine , vol.34 , pp. 456-462
    • Dahia, C.L.1    Mahoney, E.J.2    Durrani, A.A.3    Wylie, C.4
  • 8
    • 84860465584 scopus 로고    scopus 로고
    • Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc
    • Dahia CL, Mahoney E, Wylie C (2012) Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One 7: e35944.
    • (2012) PLoS One , vol.7
    • Dahia, C.L.1    Mahoney, E.2    Wylie, C.3
  • 10
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • DOI 10.1038/nm979
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10: 55-63. (Pubitemid 38524699)
    • (2004) Nature Medicine , vol.10 , Issue.1 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 11
    • 70349695861 scopus 로고    scopus 로고
    • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    • Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461: 614-620.
    • (2009) Nature , vol.461 , pp. 614-620
    • Huang, S.M.1    Mishina, Y.M.2    Liu, S.3    Cheung, A.4    Stegmeier, F.5
  • 12
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg HM (2003) Developmental regulation of the growth plate. Nature 423: 332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 13
    • 0035230123 scopus 로고    scopus 로고
    • The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate
    • discussion 152-147
    • Kronenberg HM, Chung U (2001) The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate. Novartis Found Symp 232: 144-152; discussion 152-147.
    • (2001) Novartis Found Symp , vol.232 , pp. 144-152
    • Kronenberg, H.M.1    Chung, U.2
  • 14
    • 84878354129 scopus 로고    scopus 로고
    • Wntless is required for peripheral lung differentiation and pulmonary vascular development
    • Cornett B, Snowball J, Varisco BM, Lang R, Whitsett J, et al. (2013) Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev Biol 379: 38-52.
    • (2013) Dev Biol , vol.379 , pp. 38-52
    • Cornett, B.1    Snowball, J.2    Varisco, B.M.3    Lang, R.4    Whitsett, J.5
  • 15
    • 33646134826 scopus 로고    scopus 로고
    • Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
    • Banziger C, Soldini D, Schutt C, Zipperlen P, Hausmann G, et al. (2006) Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 125: 509-522.
    • (2006) Cell , vol.125 , pp. 509-522
    • Banziger, C.1    Soldini, D.2    Schutt, C.3    Zipperlen, P.4    Hausmann, G.5
  • 16
    • 33748702122 scopus 로고    scopus 로고
    • The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes
    • DOI 10.1016/j.chembiol.2006.08.004, PII S107455210600295X
    • Tseng AS, Engel FB, Keating MT (2006) The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol 13: 957-963. (Pubitemid 44389934)
    • (2006) Chemistry and Biology , vol.13 , Issue.9 , pp. 957-963
    • Tseng, A.-S.1    Engel, F.B.2    Keating, M.T.3
  • 17
    • 84863560929 scopus 로고    scopus 로고
    • Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
    • Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, et al. (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A 109: E1848-1857.
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • Lian, X.1    Hsiao, C.2    Wilson, G.3    Zhu, K.4    Hazeltine, L.B.5
  • 18
    • 77956564468 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
    • Ahn Y, Sanderson BW, Klein OD, Krumlauf R (2010) Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137: 3221-3231.
    • (2010) Development , vol.137 , pp. 3221-3231
    • Ahn, Y.1    Sanderson, B.W.2    Klein, O.D.3    Krumlauf, R.4
  • 19
    • 79955411359 scopus 로고    scopus 로고
    • Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth
    • Cho SW, Kwak S, Woolley TE, Lee MJ, Kim EJ, et al. (2011) Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development 138: 1807-1816.
    • (2011) Development , vol.138 , pp. 1807-1816
    • Cho, S.W.1    Kwak, S.2    Woolley, T.E.3    Lee, M.J.4    Kim, E.J.5
  • 20
    • 84874642648 scopus 로고    scopus 로고
    • Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate
    • Martinez-Ferre A, Navarro-Garberi M, Bueno C, Martinez S (2013) Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate. J Neurosci 33: 3967-3980.
    • (2013) J Neurosci , vol.33 , pp. 3967-3980
    • Martinez-Ferre, A.1    Navarro-Garberi, M.2    Bueno, C.3    Martinez, S.4
  • 22
    • 84866788742 scopus 로고    scopus 로고
    • beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus
    • Bluske KK, Vue TY, Kawakami Y, Taketo MM, Yoshikawa K, et al. (2012) beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development 139: 2692-2702.
    • (2012) Development , vol.139 , pp. 2692-2702
    • Bluske, K.K.1    Vue, T.Y.2    Kawakami, Y.3    Taketo, M.M.4    Yoshikawa, K.5
  • 23
    • 33750301324 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
    • DOI 10.1242/dev.02546
    • Mak KK, Chen MH, Day TF, Chuang PT, Yang Y (2006) Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development 133: 3695-3707. (Pubitemid 44614291)
    • (2006) Development , vol.133 , Issue.18 , pp. 3695-3707
    • Mak, K.K.1    Chen, M.-H.2    Day, T.F.3    Chuang, P.-T.4    Yang, Y.5
  • 24
    • 70349895668 scopus 로고    scopus 로고
    • Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation
    • Alvarez-Medina R, Le Dreau G, Ros M, Marti E (2009) Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation. Development 136: 3301-3309.
    • (2009) Development , vol.136 , pp. 3301-3309
    • Alvarez-Medina, R.1    Le Dreau, G.2    Ros, M.3    Marti, E.4
  • 25
    • 57149118250 scopus 로고    scopus 로고
    • Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation
    • Choi KS, Cohn MJ, Harfe BD (2008) Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn 237: 3953-3958.
    • (2008) Dev Dyn , vol.237 , pp. 3953-3958
    • Choi, K.S.1    Cohn, M.J.2    Harfe, B.D.3
  • 26
    • 24344488971 scopus 로고    scopus 로고
    • Molecular signaling in intervertebral disk development
    • DOI 10.1016/j.orthres.2005.03.008, PII S0736026605000902
    • DiPaola CP, Farmer JC, Manova K, Niswander LA (2005) Molecular signaling in intervertebral disk development. J Orthop Res 23: 1112-1119. (Pubitemid 41245436)
    • (2005) Journal of Orthopaedic Research , vol.23 , Issue.5 , pp. 1112-1119
    • DiPaola, C.P.1    Farmer, J.C.2    Manova, K.3    Niswander, L.A.4
  • 27
    • 77953483355 scopus 로고    scopus 로고
    • BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: Role of MAPKs
    • Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, et al. (2010) BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res 25: 1179-1190.
    • (2010) J Bone Miner Res , vol.25 , pp. 1179-1190
    • Hiyama, A.1    Gogate, S.S.2    Gajghate, S.3    Mochida, J.4    Shapiro, I.M.5
  • 28
    • 77957688083 scopus 로고    scopus 로고
    • Enhancement of intervertebral disc cell senescence by WNT/beta-catenin signaling-induced matrix metalloproteinase expression
    • Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, et al. (2010) Enhancement of intervertebral disc cell senescence by WNT/beta-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum 62: 3036-3047.
    • (2010) Arthritis Rheum , vol.62 , pp. 3036-3047
    • Hiyama, A.1    Sakai, D.2    Risbud, M.V.3    Tanaka, M.4    Arai, F.5
  • 29
    • 79955069743 scopus 로고    scopus 로고
    • Intervertebral disc development is regulated by Wnt/beta-catenin signaling
    • Phila Pa 1976
    • Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, et al. (2011) Intervertebral disc development is regulated by Wnt/beta-catenin signaling. Spine (Phila Pa 1976) 36: E513-518.
    • (2011) Spine , vol.36
    • Kondo, N.1    Yuasa, T.2    Shimono, K.3    Tung, W.4    Okabe, T.5
  • 30
    • 33646442480 scopus 로고    scopus 로고
    • Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling
    • Phila Pa 1976
    • Risbud MV, Di Martino A, Guttapalli A, Seghatoleslami R, Denaro V, et al. (2006) Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine (Phila Pa 1976) 31: 884-890.
    • (2006) Spine , vol.31 , pp. 884-890
    • Risbud, M.V.1    Di Martino, A.2    Guttapalli, A.3    Seghatoleslami, R.4    Denaro, V.5
  • 31
    • 77950424020 scopus 로고    scopus 로고
    • Molecular profiling of the developing mouse axial skeleton: A role for Tgfbr2 in the development of the intervertebral disc
    • Sohn P, Cox M, Chen D, Serra R (2010) Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc. BMC Dev Biol 10: 29.
    • (2010) BMC Dev Biol , vol.10 , pp. 29
    • Sohn, P.1    Cox, M.2    Chen, D.3    Serra, R.4
  • 32
    • 58149129547 scopus 로고    scopus 로고
    • Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway
    • Phila Pa 1976
    • Zhang H, Lin CY (2008) Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway. Spine (Phila Pa 1976) 33: E525-531.
    • (2008) Spine , vol.33
    • Zhang, H.1    Lin, C.Y.2
  • 33
    • 84878179789 scopus 로고    scopus 로고
    • Endogenous TGF-beta activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-kappaB activation
    • Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, et al. (2013) Endogenous TGF-beta activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-kappaB activation. J Orthop Res 31: 1144-1149.
    • (2013) J Orthop Res , vol.31 , pp. 1144-1149
    • Zhu, Y.1    Ohba, T.2    Ando, T.3    Fujita, K.4    Koyama, K.5
  • 34
    • 79951780686 scopus 로고    scopus 로고
    • The relationship between the Wnt/beta-catenin and TGF-beta/BMP signals in the intervertebral disc cell
    • Hiyama A, Sakai D, Tanaka M, Arai F, Nakajima D, et al. (2011) The relationship between the Wnt/beta-catenin and TGF-beta/BMP signals in the intervertebral disc cell. J Cell Physiol 226: 1139-1148.
    • (2011) J Cell Physiol , vol.226 , pp. 1139-1148
    • Hiyama, A.1    Sakai, D.2    Tanaka, M.3    Arai, F.4    Nakajima, D.5
  • 35
    • 84872943178 scopus 로고    scopus 로고
    • Gene expression profiling of early intervertebral disc degeneration reveals a downregulation of canonical Wnt signaling and caveolin-1 expression: Implications for development of regenerative strategies
    • Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, et al. (2013) Gene expression profiling of early intervertebral disc degeneration reveals a downregulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Res Ther 15: R23.
    • (2013) Arthritis Res Ther , vol.15
    • Smolders, L.A.1    Meij, B.P.2    Onis, D.3    Riemers, F.M.4    Bergknut, N.5
  • 36
    • 84859628684 scopus 로고    scopus 로고
    • Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration
    • Smolders LA, Meij BP, Riemers FM, Licht R, Wubbolts R, et al. (2012) Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration. J Orthop Res 30: 950-957.
    • (2012) J Orthop Res , vol.30 , pp. 950-957
    • Smolders, L.A.1    Meij, B.P.2    Riemers, F.M.3    Licht, R.4    Wubbolts, R.5
  • 37
    • 80455141423 scopus 로고    scopus 로고
    • Specific inhibitory protein Dkk-1 blocking Wnt/beta-catenin signaling pathway improve protectives effect on the extracellular matrix
    • Ye S, Wang J, Yang S, Xu W, Xie M, et al. (2011) Specific inhibitory protein Dkk-1 blocking Wnt/beta-catenin signaling pathway improve protectives effect on the extracellular matrix. J Huazhong Univ Sci Technolog Med Sci 31: 657-662.
    • (2011) J Huazhong Univ Sci Technolog Med Sci , vol.31 , pp. 657-662
    • Ye, S.1    Wang, J.2    Yang, S.3    Xu, W.4    Xie, M.5
  • 40
    • 57349146621 scopus 로고    scopus 로고
    • A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression
    • Yochum GS, Cleland R, Goodman RH (2008) A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol 28: 7368-7379.
    • (2008) Mol Cell Biol , vol.28 , pp. 7368-7379
    • Yochum, G.S.1    Cleland, R.2    Goodman, R.H.3
  • 43
    • 84870855799 scopus 로고    scopus 로고
    • Tankyrase-targeted therapeutics: Expanding opportunities in the PARP family
    • Riffell JL, Lord CJ, Ashworth A (2012) Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov 11: 923-936.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 923-936
    • Riffell, J.L.1    Lord, C.J.2    Ashworth, A.3
  • 44
    • 84886375160 scopus 로고    scopus 로고
    • Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells
    • Vadlakonda L, Pasupuleti M, Pallu R (2013) Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells. Front Oncol 3: 85.
    • (2013) Front Oncol , vol.3 , pp. 85
    • Vadlakonda, L.1    Pasupuleti, M.2    Pallu, R.3
  • 45
    • 84873109431 scopus 로고    scopus 로고
    • Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1alpha
    • Wang Z, Zhang X, Chen S, Wang D, Wu J, et al. (2013) Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1alpha. PLoS One 8: e55471.
    • (2013) PLoS One , vol.8
    • Wang, Z.1    Zhang, X.2    Chen, S.3    Wang, D.4    Wu, J.5
  • 47
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • DOI 10.1042/BJ20021535
    • Bain J, McLauchlan H, Elliott M, Cohen P (2003) The specificities of protein kinase inhibitors: an update. Biochem J 371: 199-204. (Pubitemid 36458094)
    • (2003) Biochemical Journal , vol.371 , Issue.1 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 48
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 50
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, et al. (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276: 36734-36741.
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5
  • 51
    • 3042635178 scopus 로고    scopus 로고
    • GSK3 inhibitors: Development and therapeutic potential
    • Cohen P, Goedert M (2004) GSK3 inhibitors: development and therapeutic potential. Nat Rev Drug Discov 3: 479-487. (Pubitemid 38807530)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.6 , pp. 479-487
    • Cohen, P.1    Goedert, M.2
  • 52
    • 84889084088 scopus 로고    scopus 로고
    • Differential phenotypic behaviors of human degenerative nucleus pulposus cells under normoxic and hypoxic conditions: Influence of oxygen concentration during isolation, expansion, and cultivation
    • Yang SH, Hu MH, Sun YH, Lin FH (2013) Differential phenotypic behaviors of human degenerative nucleus pulposus cells under normoxic and hypoxic conditions: influence of oxygen concentration during isolation, expansion, and cultivation. Spine J.
    • (2013) Spine J
    • Yang, S.H.1    Hu, M.H.2    Sun, Y.H.3    Lin, F.H.4
  • 53
    • 42149196270 scopus 로고    scopus 로고
    • Stem cell-mediated regeneration of the intervertebral disc: Cellular and molecular challenge
    • Jandial R, Aryan HE, Park J, Taylor WT, Snyder EY (2008) Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge. Neurosurg Focus 24: E21.
    • (2008) Neurosurg Focus , vol.24
    • Jandial, R.1    Aryan, H.E.2    Park, J.3    Taylor, W.T.4    Snyder, E.Y.5
  • 54
    • 84896795857 scopus 로고    scopus 로고
    • Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapiesfor intervertebral disc degeneration
    • Rodrigues-Pinto R, Richardson SM, Hoyland JA (2013) Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapiesfor intervertebral disc degeneration. Bone Joint Res 2: 169-178.
    • (2013) Bone Joint Res , vol.2 , pp. 169-178
    • Rodrigues-Pinto, R.1    Richardson, S.M.2    Hoyland, J.A.3
  • 55
    • 44649175659 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc
    • Fujita N, Imai J, Suzuki T, Yamada M, Ninomiya K, et al. (2008) Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc. Biochem Biophys Res Commun 372: 367-372.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 367-372
    • Fujita, N.1    Imai, J.2    Suzuki, T.3    Yamada, M.4    Ninomiya, K.5
  • 56
    • 36148934197 scopus 로고    scopus 로고
    • PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways
    • DOI 10.1007/s00586-007-0408-9
    • Pratsinis H, Kletsas D (2007) PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways. Eur Spine J 16: 1858-1866. (Pubitemid 350105321)
    • (2007) European Spine Journal , vol.16 , Issue.11 , pp. 1858-1866
    • Pratsinis, H.1    Kletsas, D.2
  • 57
    • 33947181438 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: Implications for cell-based transplantation therapy
    • Phila Pa 1976
    • Tsai TT, Guttapalli A, Oguz E, Chen LH, Vaccaro AR, et al. (2007) Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy. Spine (Phila Pa 1976) 32: 495-502.
    • (2007) Spine , vol.32 , pp. 495-502
    • Tsai, T.T.1    Guttapalli, A.2    Oguz, E.3    Chen, L.H.4    Vaccaro, A.R.5
  • 58
    • 29744447597 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 7: R732-745.
    • (2005) Arthritis Res Ther , vol.7
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 59
    • 29744453149 scopus 로고    scopus 로고
    • Expression of receptors for putative anabolic growth factors in human intervertebral disc: Implications for repair and regeneration of the disc
    • DOI 10.1002/path.1862
    • Le Maitre CL, Richardson SM, Baird P, Freemont AJ, Hoyland JA (2005) Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. J Pathol 207: 445-452. (Pubitemid 43025693)
    • (2005) Journal of Pathology , vol.207 , Issue.4 , pp. 445-452
    • Le, M.C.L.1    Richardson, S.M.A.2    Baird, P.3    Freemont, A.J.4    Hoyland, J.A.5
  • 60
    • 77957350032 scopus 로고    scopus 로고
    • Generation of mice with a conditional null allele for Wntless
    • Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA (2010) Generation of mice with a conditional null allele for Wntless. Genesis 48: 554-558.
    • (2010) Genesis , vol.48 , pp. 554-558
    • Carpenter, A.C.1    Rao, S.2    Wells, J.M.3    Campbell, K.4    Lang, R.A.5
  • 61
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • DOI 10.1016/j.cell.2004.07.024, PII S0092867404007123
    • Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118: 517-528. (Pubitemid 39485670)
    • (2004) Cell , vol.118 , Issue.4 , pp. 517-528
    • Harfe, B.D.1    Scherz, P.J.2    Nissim, S.3    Tian, H.4    McMahon, A.P.5    Tabin, C.J.6
  • 62
    • 64149097786 scopus 로고    scopus 로고
    • The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments
    • Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, et al. (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55: 611-622.
    • (2009) Clin Chem , vol.55 , pp. 611-622
    • Bustin, S.A.1    Benes, V.2    Garson, J.A.3    Hellemans, J.4    Huggett, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.