Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy

BMC Nephrology

Volumn 14, Issue 1, 2013, Pages

  Kavanagh, David H ^a   Savage, David A ^b   Patterson, Christopher C ^a   McKnight, Amy Jayne ^a   Crean, John K ^c   Maxwell, Alexander P ^a   McKay, Gareth J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b BELFAST CITY HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Association study; Diabetic nephropathy; End stage renal disease; WNT signalling pathway

Indexed keywords

BETA CATENIN; CREATININE; GLYCOGEN SYNTHASE KINASE 3BETA; HEMOGLOBIN A1C; WNT PROTEIN; WNT6 PROTEIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; COPY NUMBER VARIATION; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DIASTOLIC BLOOD PRESSURE; DISEASE DURATION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GLOMERULUS FILTRATION RATE; HAPLOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; PHENOTYPE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

ADULT; DIABETIC NEPHROPATHIES; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; WNT SIGNALING PATHWAY;

EID: 84879064665     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-14-126     Document Type: Article

References (28)

1. Chapter 1 UK RRT incidence in 2010: national and centre-specific analyses. Gilg J, Castledine C, Fogarty D, Nephron Clin Pract 2012 120 Suppl 1 1 27 22964563
2. CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Surendran K, Simon TC, Am J Physiol Renal Physiol 2003 284 653 662 12475749
3. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. Surendran K, Schiavi S, Hruska KA, J Am Soc Nephrol 2005 16 2373 2384 10.1681/ASN.2004110949 15944336
4. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y, J Am Soc Nephrol 2009 20 765 776 10.1681/ASN.2008060566 19297557
5. Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. Lin CL, Wang JY, Ko JY, Huang YT, Kuo YH, Wang FS, J Am Soc Nephrol 2010 21 124 135 10.1681/ASN.2008101059 20019166
6. Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. Kato H, Gruenwald A, Suh JH, et al. J Biol Chem 2011 286 26003 26015 10.1074/jbc.M111.223164 21613219
7. CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy. Rooney B, O'Donovan H, Gaffney A, et al. FEBS Lett 2011 585 531 538 10.1016/j.febslet. 2011.01.004 21237163
8. Sustained Wnt/β-Catenin Signaling Rescues High Glucose Induction of Transforming Growth Factor-β1-Mediated Renal Fibrosis. Ho C, Lee PH, Hsu YC, Wang FS, Huang YT, Lin CL, Am J Med Sci 2012 344 374 382 22270399
9. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Zhou T, He X, Cheng R, et al. Diabetologia 2012 55 255 266 10.1007/s00125-011-2314-2 22016045
10. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Hart M, Concordet JP, Lassot I, et al. Curr Biol 1999 9 207 210 10.1016/S0960-9822(99)80091-8 10074433
11. Wnt signaling and cancer. Polakis P, Genes Dev 2000 14 1837 1851 10921899
12. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Grant SFA, Thorleifsson G, Reynisdottir I, et al. Nat Genet 2006 38 320 323 10.1038/ng1732 16415884
13. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Saxena R, Gianniny L, Burtt NP, et al. Diabetes 2006 55 2890 2895 10.2337/db06-0381 17003358
14. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Steinberg S, de Jong S, Andreassen OA, et al. Human Mol Genet 2011 20 4076 4081 10.1093/hmg/ddr325
15. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Habas R, Dawid IB, He X, Gen Dev 2003 17 295 309 10.1101/gad.1022203
16. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Veeman MT, Axelrod JD, Moon RT, Dev Cell 2003 5 367 377 10.1016/S1534-5807(03)00266-1 12967557
17. Dishevelled and Wnt signaling: is the nucleus the final frontier? Habas R, Dawid IB, J Biol 2005 4 2 10.1186/jbiol22 15720723
18. New insights into epithelial-mesenchymal transition in kidney fibrosis. Liu Y, J Am Soc Nephrol 2010 21 212 222 10.1681/ASN.2008121226 20019167
19. Mesenchymal transition in kidney collecting duct epithelial cells. Ivanova L, Butt MJ, Matsell DG, Am J Physiol Renal Physiol 2008 294 1238 1248 10.1152/ajprenal.00326.2007 18322023
20. GSK-3-specific inhibitor-supplemented hESC medium prevents the epithelial-mesenchymal transition process and the up-regulation of matrix metalloproteinases in hESCs cultured in feeder-free conditions. Ullmann U, Gilles C, De Rycke M, Van de Velde H, Sermon K, Liebaers I, Mol Hum Reprod 2008 14 169 179 10.1093/molehr/gan001 18263607
21. A ssociation analysis of canonical Wnt signalling genes in diabetic nephropathy. Kavanagh DH, Savage DA, Patterson CC, et al. PLoS One 2011 6 23904 10.1371/journal.pone.0023904 21876774
22. New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes. Sandholm N, Salem RM, McKnight AJ, et al. PLoS Genet 2012 8 1002921 10.1371/journal.pgen.1002921 23028342
23. Association analysis of Notch pathway signalling genes in diabetic nephropathy. Kavanagh D, McKay GJ, Patterson CC, McKnight AJ, Maxwell AP, Savage DA, Diabetologia 2011 54 334 338 10.1007/s00125-010-1978-3 21103979
24. Regression of microalbuminuria in type 1 diabetes. Perkins BA, Ficociello LH, Silva KH, Finkelstein DM, Warram JH, Krolewski AS, N Engl J Med 2003 348 2285 2293 10.1056/NEJMoa021835 12788992
25. The structure of haplotype blocks in the human genome. Gabriel SB, Schaffner SF, Nguyen H, et al. Science 2002 296 2225 2229 10.1126/science. 1069424 12029063
26. PLINK: a tool set for whole-genome association and population-based linkage analyses. Purcell S, Neale B, Todd-Brown K, et al. Am J Human Genet 2007 81 559 575 10.1086/519795
27. A versatile gene-based test for genome-wide association studies. Liu JZ, McRae AF, Nyholt DR, et al. Am J Hum Genet 2010 87 139 145 10.1016/j.ajhg.2010. 06.009 20598278
28. Association study designs for complex diseases. Cardon LR, Bell JI, Nat Rev Genet 2001 2 91 99 11253062