메뉴 건너뛰기




Volumn 21, Issue 11, 2010, Pages 1819-1834

Mechanisms of tubulointerstitial fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; PLASMIN; STROMELYSIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 78149298226     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010080793     Document Type: Short Survey
Times cited : (753)

References (286)
  • 1
    • 0025865188 scopus 로고
    • Mechanisms of tubulointerstitial fibrosis
    • Kuncio GS, Neilson EG, Haverty T: Mechanisms of tubulointerstitial fibrosis. Kidney Int 39: 550-556, 1991
    • (1991) Kidney Int , vol.39 , pp. 550-556
    • Kuncio, G.S.1    Neilson, E.G.2    Haverty, T.3
  • 2
    • 32944464939 scopus 로고    scopus 로고
    • Toward a unified theory of renal progression
    • Harris RC, Neilson EG: Toward a unified theory of renal progression. Annu Rev Med 57: 365-380, 2006
    • (2006) Annu Rev Med , vol.57 , pp. 365-380
    • Harris, R.C.1    Neilson, E.G.2
  • 3
    • 0014885804 scopus 로고
    • Structural-functional correlations in renal disease. II. The correlations
    • Schainuck LI, Striker GE, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. II. The correlations. Hum Pathol 1: 631-641, 1970
    • (1970) Hum Pathol , vol.1 , pp. 631-641
    • Schainuck, L.I.1    Striker, G.E.2    Cutler, R.E.3    Benditt, E.P.4
  • 4
    • 0017687126 scopus 로고
    • Neunhoeffer: Serum creatinine concentration and renal interstitial volume. Analysis of correlations in endocapillary (acute) glomerulonephritis and in moderately severe mesangioproliferative glomerulonephritis
    • Bohle A, Bader R, Grund KE, Mackensen S, Neunhoeffer: Serum creatinine concentration and renal interstitial volume. Analysis of correlations in endocapillary (acute) glomerulonephritis and in moderately severe mesangioproliferative glomerulonephritis. Virchows Arch A Pathol Anat Histol 375: 87-96, 1977
    • (1977) Virchows Arch A Pathol Anat Histol , vol.375 , pp. 87-96
    • Bohle, A.1    Bader, R.2    Grund, K.E.3    Mackensen, S.4
  • 6
    • 0018370363 scopus 로고
    • The role of the interstitium of the renal cortex in renal disease
    • Bohle A, Christ H, Grund KE, Mackensen S: The role of the interstitium of the renal cortex in renal disease. Contrib Nephrol 16: 109-114, 1979
    • (1979) Contrib Nephrol , vol.16 , pp. 109-114
    • Bohle, A.1    Christ, H.2    Grund, K.E.3    Mackensen, S.4
  • 7
    • 77952971675 scopus 로고    scopus 로고
    • The clinical importance of nephron mass
    • Luyckx VA, Brenner BM: The clinical importance of nephron mass. J Am Soc Nephrol 21: 898-910, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 898-910
    • Luyckx, V.A.1    Brenner, B.M.2
  • 8
    • 0030893720 scopus 로고    scopus 로고
    • Renal function in the elderly: Impact of hypertension and cardiac function
    • Fliser D, Franek E, Joest M, Block S, Mutschler E, Ritz E: Renal function in the elderly: Impact of hypertension and cardiac function. Kidney Int 51: 1196-1204, 1997
    • (1997) Kidney Int , vol.51 , pp. 1196-1204
    • Fliser, D.1    Franek, E.2    Joest, M.3    Block, S.4    Mutschler, E.5    Ritz, E.6
  • 9
    • 73449112003 scopus 로고    scopus 로고
    • Ageing and the glomerular filtration rate: Truths and consequences
    • Glassock RJ, Winearls C: Ageing and the glomerular filtration rate: Truths and consequences. Trans Am Clin Climatol Assoc 120: 419-428, 2009
    • (2009) Trans Am Clin Climatol Assoc , vol.120 , pp. 419-428
    • Glassock, R.J.1    Winearls, C.2
  • 10
    • 76549236600 scopus 로고
    • Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males
    • Davies DF, Shock NW: Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 29: 496-507, 1950
    • (1950) J Clin Invest , vol.29 , pp. 496-507
    • Davies, D.F.1    Shock, N.W.2
  • 11
    • 0028961697 scopus 로고
    • Aging-associated changes in renal extracellular matrix
    • Abrass CK, Adcox MJ, Raugi GJ: Aging-associated changes in renal extracellular matrix. Am J Pathol 146: 742-752, 1995
    • (1995) Am J Pathol , vol.146 , pp. 742-752
    • Abrass, C.K.1    Adcox, M.J.2    Raugi, G.J.3
  • 12
    • 0031901227 scopus 로고    scopus 로고
    • The aging kidney: Insights from experimental studies
    • Baylis C, Corman B: The aging kidney: Insights from experimental studies. J Am Soc Nephrol 9: 699-709, 1998
    • (1998) J Am Soc Nephrol , vol.9 , pp. 699-709
    • Baylis, C.1    Corman, B.2
  • 16
    • 77956534990 scopus 로고    scopus 로고
    • Cell senescence in the aging kidney
    • Yang H, Fogo AB: Cell senescence in the aging kidney. J Am Soc Nephrol 21: 1436-1439, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1436-1439
    • Yang, H.1    Fogo, A.B.2
  • 18
    • 77949349091 scopus 로고    scopus 로고
    • Telomere shortening and regenerative capacity after acute kidney injury
    • Wills LP, Schnellmann RG: Telomere shortening and regenerative capacity after acute kidney injury. J Am Soc Nephrol 21: 202-204, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 202-204
    • Wills, L.P.1    Schnellmann, R.G.2
  • 19
    • 55749100670 scopus 로고    scopus 로고
    • Epigenetics, development, and the kidney
    • Dressler GR: Epigenetics, development, and the kidney. J Am Soc Nephrol 19: 2060-2067, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2060-2067
    • Dressler, G.R.1
  • 21
    • 77952561383 scopus 로고    scopus 로고
    • Glomerular epithelial stem cells: The good, the bad, and the ugly
    • in press
    • Lasagni L, Romagnani P: Glomerular epithelial stem cells: The good, the bad, and the ugly. J Am Soc Nephrol 2010, in press
    • (2010) J Am Soc Nephrol
    • Lasagni, L.1    Romagnani, P.2
  • 23
    • 57149105572 scopus 로고    scopus 로고
    • Zag expression during aging suppresses proliferation after kidney injury
    • Schmitt R, Marlier A, Cantley LG: Zag expression during aging suppresses proliferation after kidney injury. J Am Soc Nephrol 19: 2375-2383, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2375-2383
    • Schmitt, R.1    Marlier, A.2    Cantley, L.G.3
  • 24
    • 77949882555 scopus 로고    scopus 로고
    • Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: The roles of fetuin-A, adiponectin, and AMPK
    • Ix JH, Sharma K: Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: The roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol 21: 406-412, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 406-412
    • Ix, J.H.1    Sharma, K.2
  • 27
    • 0021017787 scopus 로고
    • Ultrastructural analysis of human proximal tubules and cortical interstitium in chronic renal disease
    • Moller JC, Skriver E, Olsen S, Maunsbach AB: Ultrastructural analysis of human proximal tubules and cortical interstitium in chronic renal disease. Virchows Arch A Pathol Anat Histopathol 402: 209-237, 1984
    • (1984) Virchows Arch A Pathol Anat Histopathol , vol.402 , pp. 209-237
    • Moller, J.C.1    Skriver, E.2    Olsen, S.3    Maunsbach, A.B.4
  • 28
    • 0031952093 scopus 로고    scopus 로고
    • Tubulointerstitial disease in aging: Evidence for underlying peritubular capillary damage, a potential role for renal ischemia
    • Thomas SE, Anderson S, Gordon KL, Oyama TT, Shankland SJ, Johnson RJ: Tubulointerstitial disease in aging: Evidence for underlying peritubular capillary damage, a potential role for renal ischemia. J Am Soc Nephrol 9: 231-242, 1998
    • (1998) J Am Soc Nephrol , vol.9 , pp. 231-242
    • Thomas, S.E.1    Anderson, S.2    Gordon, K.L.3    Oyama, T.T.4    Shankland, S.J.5    Johnson, R.J.6
  • 29
    • 72049124334 scopus 로고    scopus 로고
    • The PPARgamma agonist pioglitazone ameliorates agingrelated progressive renal injury
    • Yang HC, Deleuze S, Zuo Y, Potthoff SA, Ma LJ, Fogo AB: The PPARgamma agonist pioglitazone ameliorates agingrelated progressive renal injury. J Am Soc Nephrol 20: 2380-2388, 2009
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2380-2388
    • Yang, H.C.1    Deleuze, S.2    Zuo, Y.3    Potthoff, S.A.4    Ma, L.J.5    Fogo, A.B.6
  • 30
    • 58149127646 scopus 로고    scopus 로고
    • PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta
    • Kawai T, Masaki T, Doi S, Arakawa T, Yokoyama Y, Doi T, Kohno N, Yorioka N: PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Lab Invest 89: 47-58, 2009
    • (2009) Lab Invest , vol.89 , pp. 47-58
    • Kawai, T.1    Masaki, T.2    Doi, S.3    Arakawa, T.4    Yokoyama, Y.5    Doi, T.6    Kohno, N.7    Yorioka, N.8
  • 32
    • 49649085000 scopus 로고    scopus 로고
    • The aggravating mechanisms of aldosterone on kidney fibrosis
    • Remuzzi G, Cattaneo D, Perico N: The aggravating mechanisms of aldosterone on kidney fibrosis. J Am Soc Nephrol 19: 1459-1462, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1459-1462
    • Remuzzi, G.1    Cattaneo, D.2    Perico, N.3
  • 34
    • 38149011216 scopus 로고    scopus 로고
    • Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury
    • Tu X, Chen X, Xie Y, Shi S, Wang J, Chen Y, Li J: Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury. J Am Soc Nephrol 19: 77-83, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 77-83
    • Tu, X.1    Chen, X.2    Xie, Y.3    Shi, S.4    Wang, J.5    Chen, Y.6    Li, J.7
  • 35
    • 0030419494 scopus 로고    scopus 로고
    • Molecular insights into renal interstitial fibrosis
    • Eddy AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7: 2495-2508, 1996
    • (1996) J Am Soc Nephrol , vol.7 , pp. 2495-2508
    • Eddy, A.A.1
  • 36
    • 0024094112 scopus 로고
    • Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis
    • Haverty TP, Kelly CJ, Hines WH, Amenta PS, Watanabe M, Harper RA, Kefalides NA, Neilson EG: Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol 107: 1359-1368, 1988
    • (1988) J Cell Biol , vol.107 , pp. 1359-1368
    • Haverty, T.P.1    Kelly, C.J.2    Hines, W.H.3    Amenta, P.S.4    Watanabe, M.5    Harper, R.A.6    Kefalides, N.A.7    Neilson, E.G.8
  • 38
    • 0036781472 scopus 로고    scopus 로고
    • Fibronectin splice variants-prognostic markers for the stage of renal interstitial fibrosis in the rat
    • Eismann U, Sommer M, Kosmehl H, Appenroth D, Fleck C, Stein G: Fibronectin splice variants-prognostic markers for the stage of renal interstitial fibrosis in the rat. Nephron 92: 379-388, 2002
    • (2002) Nephron , vol.92 , pp. 379-388
    • Eismann, U.1    Sommer, M.2    Kosmehl, H.3    Appenroth, D.4    Fleck, C.5    Stein, G.6
  • 39
    • 0031948169 scopus 로고    scopus 로고
    • Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring
    • Hewitson TD, Darby IA, Bisucci T, Jones CL, Becker GJ:Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring. J Am Soc Nephrol 9: 632-642, 1998
    • (1998) J Am Soc Nephrol , vol.9 , pp. 632-642
    • Hewitson, T.D.1    Darby, I.A.2    Bisucci, T.3    Jones, C.L.4    Becker, G.J.5
  • 40
    • 66449119643 scopus 로고    scopus 로고
    • Renal tubulointerstitial fibrosis: Common but never simple
    • Hewitson TD: Renal tubulointerstitial fibrosis: Common but never simple. Am J Physiol Renal Physiol 296: F1239-F1244, 2009
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Hewitson, T.D.1
  • 41
    • 77957750664 scopus 로고    scopus 로고
    • Focus on collagen: In vitro systems to study fibrogenesis and antifibrosis state of the art
    • Chen CZ, Raghunath M: Focus on collagen: In vitro systems to study fibrogenesis and antifibrosis state of the art. Fibrogenesis Tissue Repair 2: 7, 2009
    • (2009) Fibrogenesis Tissue Repair , vol.2 , pp. 7
    • Chen, C.Z.1    Raghunath, M.2
  • 42
    • 33748550344 scopus 로고    scopus 로고
    • Dynamics of assembly and reorganization of extracellular matrix proteins
    • Dallas SL, Chen Q, Sivakumar P: Dynamics of assembly and reorganization of extracellular matrix proteins. Curr Top Dev Biol 75: 1-24, 2006
    • (2006) Curr Top Dev Biol , vol.75 , pp. 1-24
    • Dallas, S.L.1    Chen, Q.2    Sivakumar, P.3
  • 43
    • 50849145156 scopus 로고    scopus 로고
    • Collagen fibrillogenesis: Fibronectin, integrins, and minor collagens as organizers and nucleators
    • Kadler KE, Hill A, Canty-Laird EG: Collagen fibrillogenesis: Fibronectin, integrins, and minor collagens as organizers and nucleators. Curr Opin Cell Biol 20: 495-501, 2008
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 495-501
    • Kadler, K.E.1    Hill, A.2    Canty-Laird, E.G.3
  • 44
    • 72449202606 scopus 로고    scopus 로고
    • The role of SPARC in extracellular matrix assembly
    • Bradshaw AD: The role of SPARC in extracellular matrix assembly. J Cell Commun Signal 2009
    • (2009) J Cell Commun Signal
    • Bradshaw, A.D.1
  • 45
    • 33751235286 scopus 로고    scopus 로고
    • The 10+4 microfibril structure of thin cartilage fibrils
    • Holmes DF, Kadler KE: The 10+4 microfibril structure of thin cartilage fibrils. Proc Natl Acad Sci U S A 103: 17249-17254, 2006
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17249-17254
    • Holmes, D.F.1    Kadler, K.E.2
  • 46
    • 0035022957 scopus 로고    scopus 로고
    • SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
    • Bradshaw AD, Sage EH: SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest 107: 1049-1054, 2001
    • (2001) J Clin Invest , vol.107 , pp. 1049-1054
    • Bradshaw, A.D.1    Sage, E.H.2
  • 47
    • 0027297962 scopus 로고
    • SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway
    • Tremble PM, Lane TF, Sage EH, Werb Z: SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway. J Cell Biol 121: 1433-1444, 1993
    • (1993) J Cell Biol , vol.121 , pp. 1433-1444
    • Tremble, P.M.1    Lane, T.F.2    Sage, E.H.3    Werb, Z.4
  • 49
    • 77949351029 scopus 로고    scopus 로고
    • New insights into epithelial-mesenchymal transition in kidney fibrosis
    • Liu Y: New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 212-222
    • Liu, Y.1
  • 51
    • 52049087551 scopus 로고    scopus 로고
    • Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
    • Zeisberg M, Kalluri R: Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis. Front Biosci 13: 6991-6998, 2008
    • (2008) Front Biosci , vol.13 , pp. 6991-6998
    • Zeisberg, M.1    Kalluri, R.2
  • 52
    • 0021684196 scopus 로고
    • Spontaneous interstitial nephritis in kdkd mice. I. An experimental model of autoimmune renal disease
    • Neilson EG, McCafferty E, Feldman A, Clayman MD, Zakheim B, Korngold R: Spontaneous interstitial nephritis in kdkd mice. I. An experimental model of autoimmune renal disease. J Immunol 133: 2560-2565, 1984
    • (1984) J Immunol , vol.133 , pp. 2560-2565
    • Neilson, E.G.1    McCafferty, E.2    Feldman, A.3    Clayman, M.D.4    Zakheim, B.5    Korngold, R.6
  • 55
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin SL, Kisseleva T, Brenner DA, Duffield JS: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173: 1617-1627, 2008
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 57
    • 33846850183 scopus 로고    scopus 로고
    • The collagen-specific molecular chaperone HSP47: Is there a role in fibrosis?
    • Taguchi T, Razzaque MS: The collagen-specific molecular chaperone HSP47: Is there a role in fibrosis? Trends Mol Med 13: 45-53, 2007
    • (2007) Trends Mol Med , vol.13 , pp. 45-53
    • Taguchi, T.1    Razzaque, M.S.2
  • 58
    • 0033865917 scopus 로고    scopus 로고
    • Progressive renal fibrosis in routine polycystic kidney disease: An immunohistochemical observation
    • DOI 10.1046/j.1523-1755.2000.00205.x
    • Okada H, Ban S, Nagao S, Takahashi H, Suzuki H, Neilson EG: Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation. Kidney Int 58: 587-597, 2000 (Pubitemid 30620008)
    • (2000) Kidney International , vol.58 , Issue.2 , pp. 587-597
    • Okada, H.1    Ban, S.2    Nagao, S.3    Takahashi, H.4    Suzuki, H.5    Neilson, E.G.6
  • 61
    • 0034981126 scopus 로고    scopus 로고
    • Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts
    • Iwano M, Fischer A, Okada H, Plieth D, Xue C, Danoff TM, Neilson EG: Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts. Mol Ther 3: 149-159, 2001
    • (2001) Mol Ther , vol.3 , pp. 149-159
    • Iwano, M.1    Fischer, A.2    Okada, H.3    Plieth, D.4    Xue, C.5    Danoff, T.M.6    Neilson, E.G.7
  • 62
    • 33646509272 scopus 로고    scopus 로고
    • Fibroblast migration and collagen deposition during dermal wound healing: Mathematical modelling and clinical implications
    • McDougall S, Dallon J, Sherratt J, Maini P: Fibroblast migration and collagen deposition during dermal wound healing: Mathematical modelling and clinical implications. Philos Transact A Math Phys Eng Sci 364: 1385-1405, 2006
    • (2006) Philos Transact A Math Phys Eng Sci , vol.364 , pp. 1385-1405
    • McDougall, S.1    Dallon, J.2    Sherratt, J.3    Maini, P.4
  • 63
    • 0025946070 scopus 로고
    • Immunohistochemical localization of growth factors in fetal wound healing
    • Whitby DJ, Ferguson MW: Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 147: 207-215, 1991
    • (1991) Dev Biol , vol.147 , pp. 207-215
    • Whitby, D.J.1    Ferguson, M.W.2
  • 66
    • 70349337337 scopus 로고    scopus 로고
    • MicroRNAs and their role in progressive kidney diseases
    • Kato M, Arce L, Natarajan R: MicroRNAs and their role in progressive kidney diseases. Clin J Am Soc Nephrol 4: 1255-1266, 2009
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 1255-1266
    • Kato, M.1    Arce, L.2    Natarajan, R.3
  • 67
    • 69449107940 scopus 로고    scopus 로고
    • Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury
    • Noh H, Oh EY, Seo JY, Yu MR, Kim YO, Ha H, Lee HB: Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Am J Physiol Renal Physiol 297: F729-F739, 2009
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Noh, H.1    Oh, E.Y.2    Seo, J.Y.3    Yu, M.R.4    Kim, Y.O.5    Ha, H.6    Lee, H.B.7
  • 69
    • 75749131647 scopus 로고    scopus 로고
    • Narrative review: Fibrotic diseases: Cellular and molecular mechanisms and novel therapies
    • Rosenbloom J, Castro SV, Jimenez SA: Narrative review: Fibrotic diseases: Cellular and molecular mechanisms and novel therapies. Ann Intern Med 152: 159-166, 2010
    • (2010) Ann Intern Med , vol.152 , pp. 159-166
    • Rosenbloom, J.1    Castro, S.V.2    Jimenez, S.A.3
  • 70
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn TA: Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210, 2008
    • (2008) J Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 71
    • 0031601718 scopus 로고    scopus 로고
    • Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis
    • Border WA, Noble NA: Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis. Hypertension 31: 181-188, 1998
    • (1998) Hypertension , vol.31 , pp. 181-188
    • Border, W.A.1    Noble, N.A.2
  • 73
    • 33750741932 scopus 로고    scopus 로고
    • Renin-angiotensin-aldosterone system and progression of renal disease
    • Ruster C, Wolf G: Renin-angiotensin-aldosterone system and progression of renal disease. J Am Soc Nephrol 17: 2985-2991, 2006
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2985-2991
    • Ruster, C.1    Wolf, G.2
  • 74
    • 0025277164 scopus 로고
    • Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1
    • Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 346: 371-374, 1990
    • (1990) Nature , vol.346 , pp. 371-374
    • Border, W.A.1    Okuda, S.2    Languino, L.R.3    Sporn, M.B.4    Ruoslahti, E.5
  • 75
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN: Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45: 522-530, 1996
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 77
    • 0029905441 scopus 로고    scopus 로고
    • Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
    • Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA: Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 2: 418-423, 1996
    • (1996) Nat Med , vol.2 , pp. 418-423
    • Isaka, Y.1    Brees, D.K.2    Ikegaya, K.3    Kaneda, Y.4    Imai, E.5    Noble, N.A.6    Border, W.A.7
  • 78
    • 0034608948 scopus 로고    scopus 로고
    • Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti-transforming growth factor-beta antibody in db/db diabetic mice
    • Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti-transforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci U S A 97: 8015-8020, 2000
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 8015-8020
    • Ziyadeh, F.N.1    Hoffman, B.B.2    Han, D.C.3    Iglesias-De La Cruz, M.C.4    Hong, S.W.5    Isono, M.6    Chen, S.7    McGowan, T.A.8    Sharma, K.9
  • 79
    • 0037677200 scopus 로고    scopus 로고
    • The thrombospondin 1-TGF-beta axis in fibrotic renal disease
    • Hugo C: The thrombospondin 1-TGF-beta axis in fibrotic renal disease. Nephrol Dial Transplant 18: 1241-1245, 2003
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 1241-1245
    • Hugo, C.1
  • 80
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968, 2003
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6    Kalluri, R.7
  • 82
    • 77955595272 scopus 로고    scopus 로고
    • TGFβ signaling and the renal tubular epithelial cell: Too much, too little, and just right
    • Kopp JB: TGFβ signaling and the renal tubular epithelial cell: Too much, too little, and just right. J Am Soc Nephrol 21: 1241-1243, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1241-1243
    • Kopp, J.B.1
  • 83
    • 4444304939 scopus 로고    scopus 로고
    • Regulation of matrix biology by matrix metalloproteinases
    • Mott JD, Werb Z: Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol 16: 558-564, 2004
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 558-564
    • Mott, J.D.1    Werb, Z.2
  • 84
    • 0038582623 scopus 로고    scopus 로고
    • Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation
    • Cheng S, Lovett DH: Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 162: 1937-1949, 2003
    • (2003) Am J Pathol , vol.162 , pp. 1937-1949
    • Cheng, S.1    Lovett, D.H.2
  • 85
    • 69249156451 scopus 로고    scopus 로고
    • Secreted versus membrane-anchored collagenases: Relative roles in fibroblast-dependent collagenolysis and invasion
    • Sabeh F, Li XY, Saunders TL, Rowe RG, Weiss SJ: Secreted versus membrane-anchored collagenases: Relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem 284: 23001-23011, 2009
    • (2009) J Biol Chem , vol.284 , pp. 23001-23011
    • Sabeh, F.1    Li, X.Y.2    Saunders, T.L.3    Rowe, R.G.4    Weiss, S.J.5
  • 87
    • 51849139372 scopus 로고    scopus 로고
    • Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: Therapeutic perspectives
    • Ronco P, Chatziantoniou C: Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: therapeutic perspectives. Kidney Int 74: 873-878, 2008
    • (2008) Kidney Int , vol.74 , pp. 873-878
    • Ronco, P.1    Chatziantoniou, C.2
  • 89
    • 33845576431 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 and basement membrane integrity: A unifying mechanism for progressive renal injury
    • Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH: Matrix metalloproteinase 2 and basement membrane integrity: A unifying mechanism for progressive renal injury. FASEB J 20: 1898-1900, 2006
    • (2006) FASEB J , vol.20 , pp. 1898-1900
    • Cheng, S.1    Pollock, A.S.2    Mahimkar, R.3    Olson, J.L.4    Lovett, D.H.5
  • 91
    • 73949087260 scopus 로고    scopus 로고
    • Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1
    • Ota I, Li XY, Hu Y, Weiss SJ: Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proc Natl Acad Sci U S A 106: 20318-20323, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20318-20323
    • Ota, I.1    Li, X.Y.2    Hu, Y.3    Weiss, S.J.4
  • 93
    • 33750716519 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 in chronic kidney disease: Evidence and mechanisms of action
    • Eddy AA, Fogo AB: Plasminogen activator inhibitor-1 in chronic kidney disease: Evidence and mechanisms of action. J AmSoc Nephrol 17: 2999-3012, 2006
    • (2006) J AmSoc Nephrol , vol.17 , pp. 2999-3012
    • Eddy, A.A.1    Fogo, A.B.2
  • 94
    • 0036068351 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 and the kidney
    • Eddy AA: Plasminogen activator inhibitor-1 and the kidney. Am J Physiol Renal Physiol 283: F209-F220, 2002
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Eddy, A.A.1
  • 95
    • 0022380602 scopus 로고
    • Cleavage of bovine skin type III collagen by proteolytic enzymes. Relative resistance of the fibrillar form
    • Birkedal-Hansen H, Taylor RE, Bhown AS, Katz J, Lin HY, Wells BR: Cleavage of bovine skin type III collagen by proteolytic enzymes. Relative resistance of the fibrillar form. J Biol Chem 260: 16411-16417, 1985
    • (1985) J Biol Chem , vol.260 , pp. 16411-16417
    • Birkedal-Hansen, H.1    Taylor, R.E.2    Bhown, A.S.3    Katz, J.4    Lin, H.Y.5    Wells, B.R.6
  • 96
    • 0030957218 scopus 로고    scopus 로고
    • Activation mechanisms of matrix metalloproteinases
    • Nagase H: Activation mechanisms of matrix metalloproteinases. Biol Chem 378: 151-160, 1997
    • (1997) Biol Chem , vol.378 , pp. 151-160
    • Nagase, H.1
  • 97
    • 33947233187 scopus 로고    scopus 로고
    • Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: Role of plasminactivated signals
    • Zhang G, Kernan KA, Collins SJ, Cai X, Lopez-Guisa JM, Degen JL, Shvil Y, Eddy AA: Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasminactivated signals. J Am Soc Nephrol 18: 846-859, 2007
    • (2007) J Am Soc Nephrol , vol.18 , pp. 846-859
    • Zhang, G.1    Kernan, K.A.2    Collins, S.J.3    Cai, X.4    Lopez-Guisa, J.M.5    Degen, J.L.6    Shvil, Y.7    Eddy, A.A.8
  • 98
    • 0036854980 scopus 로고    scopus 로고
    • Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
    • Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, Nejak K, Liu Y: Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 110: 1525-1538, 2002
    • (2002) J Clin Invest , vol.110 , pp. 1525-1538
    • Yang, J.1    Shultz, R.W.2    Mars, W.M.3    Wegner, R.E.4    Li, Y.5    Dai, C.6    Nejak, K.7    Liu, Y.8
  • 100
    • 34248229142 scopus 로고    scopus 로고
    • Angiotensin II activates plasminogen activator inhibitor-I promoter in renal tubular epithelial cells via the AT1 receptor
    • Fintha A, Sebe A, Masszi A, Terebessy T, Huszar T, Rosivall L, Mucsi I: Angiotensin II activates plasminogen activator inhibitor-I promoter in renal tubular epithelial cells via the AT1 receptor. Acta Physiol Hung 94: 19-30, 2007
    • (2007) Acta Physiol Hung , vol.94 , pp. 19-30
    • Fintha, A.1    Sebe, A.2    Masszi, A.3    Terebessy, T.4    Huszar, T.5    Rosivall, L.6    Mucsi, I.7
  • 103
    • 32844468585 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease
    • Krag S, Danielsen CC, Carmeliet P, Nyengaard J, Wogensen L: Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease. Kidney Int 68: 2651-2666, 2005
    • (2005) Kidney Int , vol.68 , pp. 2651-2666
    • Krag, S.1    Danielsen, C.C.2    Carmeliet, P.3    Nyengaard, J.4    Wogensen, L.5
  • 105
    • 34347375050 scopus 로고    scopus 로고
    • Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    • Sugimoto H, Grahovac G, Zeisberg M, Kalluri R: Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 56: 1825-1833, 2007
    • (2007) Diabetes , vol.56 , pp. 1825-1833
    • Sugimoto, H.1    Grahovac, G.2    Zeisberg, M.3    Kalluri, R.4
  • 106
    • 0142182731 scopus 로고    scopus 로고
    • Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats
    • Adamczak M, Gross ML, Krtil J, Koch A, Tyralla K, Amann K, Ritz E: Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats. J Am Soc Nephrol 14: 2833-2842, 2003
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2833-2842
    • Adamczak, M.1    Gross, M.L.2    Krtil, J.3    Koch, A.4    Tyralla, K.5    Amann, K.6    Ritz, E.7
  • 107
    • 35348951024 scopus 로고    scopus 로고
    • Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction
    • Thornhill BA, Forbes MS, Marcinko ES, Chevalier RL: Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction. Kidney Int 72: 1103-1112, 2007
    • (2007) Kidney Int , vol.72 , pp. 1103-1112
    • Thornhill, B.A.1    Forbes, M.S.2    Marcinko, E.S.3    Chevalier, R.L.4
  • 108
    • 8944249294 scopus 로고    scopus 로고
    • Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling
    • Everts V, van der Zee E, Creemers L, Beertsen W: Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling. Histochem J 28: 229-245, 1996
    • (1996) Histochem J , vol.28 , pp. 229-245
    • Everts, V.1    Van Der Zee, E.2    Creemers, L.3    Beertsen, W.4
  • 109
    • 56349170391 scopus 로고    scopus 로고
    • Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart
    • Hilliard LM, Russo LM, Comper WD: Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart. Am J Nephrol 29: 454-464, 2009
    • (2009) Am J Nephrol , vol.29 , pp. 454-464
    • Hilliard, L.M.1    Russo, L.M.2    Comper, W.D.3
  • 110
    • 34247899236 scopus 로고    scopus 로고
    • Cathepsin g is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys
    • Shimoda N, Fukazawa N, Nonomura K, Fairchild RL: Cathepsin g is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys. Am J Pathol 170: 930-940, 2007
    • (2007) Am J Pathol , vol.170 , pp. 930-940
    • Shimoda, N.1    Fukazawa, N.2    Nonomura, K.3    Fairchild, R.L.4
  • 114
    • 34948849039 scopus 로고    scopus 로고
    • Dendritic cells in the kidney
    • John R, Nelson PJ: Dendritic cells in the kidney. J Am Soc Nephrol 18: 2628-2635, 2007
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2628-2635
    • John, R.1    Nelson, P.J.2
  • 115
    • 0033025978 scopus 로고    scopus 로고
    • Cellular immunity and the tubulointerstitium
    • Kelly CJ: Cellular immunity and the tubulointerstitium. Semin Nephrol 19: 182-187, 1999
    • (1999) Semin Nephrol , vol.19 , pp. 182-187
    • Kelly, C.J.1
  • 116
    • 39749178268 scopus 로고    scopus 로고
    • Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease
    • Lebleu VS, Sugimoto H, Miller CA, Gattone VH, 2nd, Kalluri R: Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease. Lab Invest 88: 284-292, 2008
    • (2008) Lab Invest , vol.88 , pp. 284-292
    • Lebleu, V.S.1    Sugimoto, H.2    Miller, C.A.3    Gattone II, V.H.4    Kalluri, R.5
  • 117
    • 26944492287 scopus 로고    scopus 로고
    • Macrophages and progressive tubulointerstitial disease
    • Sean Eardley K, Cockwell P: Macrophages and progressive tubulointerstitial disease. Kidney Int 68: 437-455, 2005
    • (2005) Kidney Int , vol.68 , pp. 437-455
    • Sean Eardley, K.1    Cockwell, P.2
  • 118
    • 57149091790 scopus 로고    scopus 로고
    • Role of mast cells in progressive renal diseases
    • Holdsworth SR, Summers SA: Role of mast cells in progressive renal diseases. J Am Soc Nephrol 19: 2254-2261, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2254-2261
    • Holdsworth, S.R.1    Summers, S.A.2
  • 123
    • 0023164647 scopus 로고
    • Prostaglandin E1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis
    • Kelly CJ, Zurier RB, Krakauer KA, Blanchard N, Neilson EG: Prostaglandin E1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis. J Clin Invest 79: 782-789, 1987
    • (1987) J Clin Invest , vol.79 , pp. 782-789
    • Kelly, C.J.1    Zurier, R.B.2    Krakauer, K.A.3    Blanchard, N.4    Neilson, E.G.5
  • 124
    • 60749095669 scopus 로고    scopus 로고
    • Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes
    • Ascon M, Ascon DB, Liu M, Cheadle C, Sarkar C, Racusen L, Hassoun HT, Rabb H: Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int 75: 526-535, 2009
    • (2009) Kidney Int , vol.75 , pp. 526-535
    • Ascon, M.1    Ascon, D.B.2    Liu, M.3    Cheadle, C.4    Sarkar, C.5    Racusen, L.6    Hassoun, H.T.7    Rabb, H.8
  • 125
    • 33750950627 scopus 로고    scopus 로고
    • Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: A possible mechanism linking early injury and progressive renal disease?
    • Burne-Taney MJ, Liu M, Ascon D, Molls RR, Racusen L, Rabb H: Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: A possible mechanism linking early injury and progressive renal disease? Am J Physiol Renal Physiol 291: F981-F986, 2006
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Burne-Taney, M.J.1    Liu, M.2    Ascon, D.3    Molls, R.R.4    Racusen, L.5    Rabb, H.6
  • 128
    • 39349086389 scopus 로고    scopus 로고
    • B cells and tertiary lymphoid organs in renal inflammation
    • Segerer S, Schlondorff D: B cells and tertiary lymphoid organs in renal inflammation. Kidney Int 73: 533-537, 2008
    • (2008) Kidney Int , vol.73 , pp. 533-537
    • Segerer, S.1    Schlondorff, D.2
  • 129
    • 55849103960 scopus 로고    scopus 로고
    • Macrophage diversity in renal injury and repair
    • Ricardo SD, van Goor H, Eddy AA: Macrophage diversity in renal injury and repair. J Clin Invest 118: 3522-3530, 2008
    • (2008) J Clin Invest , vol.118 , pp. 3522-3530
    • Ricardo, S.D.1    Van Goor, H.2    Eddy, A.A.3
  • 130
    • 49849099578 scopus 로고    scopus 로고
    • Macrophage phenotype and renal fibrosis in obstructive nephropathy
    • Nishida M, Hamaoka K: Macrophage phenotype and renal fibrosis in obstructive nephropathy. Nephron Exp Nephrol 110: e31-e36, 2008
    • (2008) Nephron Exp Nephrol , vol.110
    • Nishida, M.1    Hamaoka, K.2
  • 131
    • 42449105787 scopus 로고    scopus 로고
    • Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury
    • Ko GJ, Boo CS, Jo SK, Cho WY, Kim HK: Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury. Nephrol Dial Transplant 23: 842-852, 2008
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 842-852
    • Ko, G.J.1    Boo, C.S.2    Jo, S.K.3    Cho, W.Y.4    Kim, H.K.5
  • 135
    • 2442668849 scopus 로고    scopus 로고
    • Role of mast cells in the development of renal fibrosis: Use of mast cell-deficient rats
    • Miyazawa S, Hotta O, Doi N, Natori Y, Nishikawa K, Natori Y: Role of mast cells in the development of renal fibrosis: Use of mast cell-deficient rats. Kidney Int 65: 2228-2237, 2004
    • (2004) Kidney Int , vol.65 , pp. 2228-2237
    • Miyazawa, S.1    Hotta, O.2    Doi, N.3    Natori, Y.4    Nishikawa, K.5    Natori, Y.6
  • 138
    • 17744382183 scopus 로고    scopus 로고
    • Antibody blockade of TNF-alpha reduces inflammation and scarring in experimental crescentic glomerulonephritis
    • Khan SB, Cook HT, Bhangal G, Smith J, Tam FW, Pusey CD: Antibody blockade of TNF-alpha reduces inflammation and scarring in experimental crescentic glomerulonephritis. Kidney Int 67: 1812-1820, 2005
    • (2005) Kidney Int , vol.67 , pp. 1812-1820
    • Khan, S.B.1    Cook, H.T.2    Bhangal, G.3    Smith, J.4    Tam, F.W.5    Pusey, C.D.6
  • 139
    • 0025733932 scopus 로고
    • Characterization of human renal fibroblasts in health and disease: I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis
    • Muller GA, Rodemann HP: Characterization of human renal fibroblasts in health and disease: I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis. Am J Kidney Dis 17: 680-683, 1991
    • (1991) Am J Kidney Dis , vol.17 , pp. 680-683
    • Muller, G.A.1    Rodemann, H.P.2
  • 140
    • 0025816170 scopus 로고
    • Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis
    • Rodemann HP, Muller GA: Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. Am J Kidney Dis 17: 684-686, 1991
    • (1991) Am J Kidney Dis , vol.17 , pp. 684-686
    • Rodemann, H.P.1    Muller, G.A.2
  • 141
    • 48749122527 scopus 로고    scopus 로고
    • The renal cortical interstitium: Morphological and functional aspects
    • Kaissling B, Le Hir M: The renal cortical interstitium: morphological and functional aspects. Histochem Cell Biol 130: 247-262, 2008
    • (2008) Histochem Cell Biol , vol.130 , pp. 247-262
    • Kaissling, B.1    Le Hir, M.2
  • 142
    • 68549091057 scopus 로고    scopus 로고
    • Fibroblast activation and myofibroblast generation in obstructive nephropathy
    • Grande MT, Lopez-Novoa JM: Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol 5: 319-328, 2009
    • (2009) Nat Rev Nephrol , vol.5 , pp. 319-328
    • Grande, M.T.1    Lopez-Novoa, J.M.2
  • 145
    • 0023440740 scopus 로고
    • Clonal heterogeneity in fibroblast phenotype: Implications for the control of epithelial-mesenchymal interactions
    • Schor SL, Schor AM: Clonal heterogeneity in fibroblast phenotype: Implications for the control of epithelial-mesenchymal interactions. Bioessays 7: 200-204, 1987
    • (1987) Bioessays , vol.7 , pp. 200-204
    • Schor, S.L.1    Schor, A.M.2
  • 146
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 147
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG: Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437, 2009
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 148
    • 67649202158 scopus 로고    scopus 로고
    • Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells
    • Hutchison N, Hendry BM, Sharpe CC: Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells. Cell Signal 21: 1522-1531, 2009
    • (2009) Cell Signal , vol.21 , pp. 1522-1531
    • Hutchison, N.1    Hendry, B.M.2    Sharpe, C.C.3
  • 151
    • 33644830593 scopus 로고    scopus 로고
    • Mechanisms of disease: Fibroblasts - A new look at an old problem
    • Neilson EG: Mechanisms of disease: Fibroblasts - a new look at an old problem. Nat Clin Pract Nephrol 2: 101-108, 2006
    • (2006) Nat Clin Pract Nephrol , vol.2 , pp. 101-108
    • Neilson, E.G.1
  • 153
    • 0034323610 scopus 로고    scopus 로고
    • Role of fibroblast activation in inducing interstitial fibrosis
    • Zeisberg M, Strutz F, Muller GA: Role of fibroblast activation in inducing interstitial fibrosis. J Nephrol 13 [Suppl 3]: S111-S120, 2000
    • (2000) J Nephrol , vol.13 , Issue.SUPPL. 3
    • Zeisberg, M.1    Strutz, F.2    Muller, G.A.3
  • 154
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • Gabbiani G: The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200: 500-503, 2003
    • (2003) J Pathol , vol.200 , pp. 500-503
    • Gabbiani, G.1
  • 155
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • Hay ED: The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn 233: 706-720, 2005
    • (2005) Dev Dyn , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 156
    • 33845981877 scopus 로고    scopus 로고
    • Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis
    • Takeji M, Moriyama T, Oseto S, Kawada N, Hori M, Imai E, Miwa T: Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis. J Biol Chem 281: 40193-40200, 2006
    • (2006) J Biol Chem , vol.281 , pp. 40193-40200
    • Takeji, M.1    Moriyama, T.2    Oseto, S.3    Kawada, N.4    Hori, M.5    Imai, E.6    Miwa, T.7
  • 158
    • 21544440606 scopus 로고    scopus 로고
    • Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys
    • Le Hir M, Hegyi I, Cueni-Loffing D, Loffing J, Kaissling B: Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem Cell Biol 123: 335-346, 2005
    • (2005) Histochem Cell Biol , vol.123 , pp. 335-346
    • Le Hir, M.1    Hegyi, I.2    Cueni-Loffing, D.3    Loffing, J.4    Kaissling, B.5
  • 159
    • 77950565076 scopus 로고    scopus 로고
    • Autophagy is a component of epithelial cell fate in obstructive uropathy
    • Li L, Zepeda-Orozco D, Black R, Lin F: Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176: 1767-1778, 2010
    • (2010) Am J Pathol , vol.176 , pp. 1767-1778
    • Li, L.1    Zepeda-Orozco, D.2    Black, R.3    Lin, F.4
  • 160
    • 77955602944 scopus 로고    scopus 로고
    • Resolved: EMT produces fibroblasts in the kidney
    • Zeisberg M, Duffield JS: Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 21: 1247-1253, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1247-1253
    • Zeisberg, M.1    Duffield, J.S.2
  • 161
    • 23044457914 scopus 로고    scopus 로고
    • Antibodies against macrophages that overlap in specificity with fibroblasts
    • Inoue T, Plieth D, Venkov CD, Xu C, Neilson EG: Antibodies against macrophages that overlap in specificity with fibroblasts. Kidney Int 67: 2488-2493, 2005
    • (2005) Kidney Int , vol.67 , pp. 2488-2493
    • Inoue, T.1    Plieth, D.2    Venkov, C.D.3    Xu, C.4    Neilson, E.G.5
  • 163
    • 38149107161 scopus 로고    scopus 로고
    • A new look at platelet-derived growth factor in renal disease
    • Floege J, Eitner F, Alpers CE: A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol 19: 12-23, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 12-23
    • Floege, J.1    Eitner, F.2    Alpers, C.E.3
  • 167
    • 29644432271 scopus 로고    scopus 로고
    • The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature
    • Wilm B, Ipenberg A, Hastie ND, Burch JB, Bader DM: The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. Development 132: 5317-5328, 2005
    • (2005) Development , vol.132 , pp. 5317-5328
    • Wilm, B.1    Ipenberg, A.2    Hastie, N.D.3    Burch, J.B.4    Bader, D.M.5
  • 168
    • 55949133275 scopus 로고    scopus 로고
    • Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development
    • Que J, Wilm B, Hasegawa H, Wang F, Bader D, Hogan BL: Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A 105: 16626-16630, 2008
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16626-16630
    • Que, J.1    Wilm, B.2    Hasegawa, H.3    Wang, F.4    Bader, D.5    Hogan, B.L.6
  • 171
    • 2442655244 scopus 로고    scopus 로고
    • Suppression of cyclosporine a nephrotoxicity in vivo by transforming growth factor beta receptor-immunoglobulin G chimeric protein
    • Xin J, Homma T, Matsusaka T, Ma J, Isaka Y, Imai E, Ichikawa I: Suppression of cyclosporine a nephrotoxicity in vivo by transforming growth factor beta receptor-immunoglobulin G chimeric protein. Transplantation 77: 1433-1442, 2004
    • (2004) Transplantation , vol.77 , pp. 1433-1442
    • Xin, J.1    Homma, T.2    Matsusaka, T.3    Ma, J.4    Isaka, Y.5    Imai, E.6    Ichikawa, I.7
  • 173
    • 0034946204 scopus 로고    scopus 로고
    • Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats
    • Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM, Brown L: Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br J Pharmacol 133: 687-694, 2001
    • (2001) Br J Pharmacol , vol.133 , pp. 687-694
    • Miric, G.1    Dallemagne, C.2    Endre, Z.3    Margolin, S.4    Taylor, S.M.5    Brown, L.6
  • 176
    • 44449167108 scopus 로고    scopus 로고
    • Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats
    • Waanders F, van den Berg E, Nagai R, van Veen I, Navis G, van Goor H: Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats. Nephrol Dial Transplant 23: 518-524, 2008
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 518-524
    • Waanders, F.1    Van Den Berg, E.2    Nagai, R.3    Van Veen, I.4    Navis, G.5    Van Goor, H.6
  • 177
    • 33748939751 scopus 로고    scopus 로고
    • IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
    • Moon JA, Kim HT, Cho IS, Sheen YY, Kim DK: IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int 70: 1234-1243, 2006
    • (2006) Kidney Int , vol.70 , pp. 1234-1243
    • Moon, J.A.1    Kim, H.T.2    Cho, I.S.3    Sheen, Y.Y.4    Kim, D.K.5
  • 178
    • 33845242306 scopus 로고    scopus 로고
    • Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy
    • Tan X, Li Y, Liu Y: Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol 17: 3382-3393, 2006
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3382-3393
    • Tan, X.1    Li, Y.2    Liu, Y.3
  • 180
    • 0347004648 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blockade attenuates renal fibrogenesis in an immune-mediated nephritic kidney through counter-activation of angiotensin II type 2 receptor
    • Okada H, Watanabe Y, Inoue T, Kobayashi T, Kikuta T, Kanno Y, Ban S, Suzuki H: Angiotensin II type 1 receptor blockade attenuates renal fibrogenesis in an immune-mediated nephritic kidney through counter-activation of angiotensin II type 2 receptor. Biochem Biophys Res Commun 314: 403-408, 2004
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 403-408
    • Okada, H.1    Watanabe, Y.2    Inoue, T.3    Kobayashi, T.4    Kikuta, T.5    Kanno, Y.6    Ban, S.7    Suzuki, H.8
  • 181
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV: Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16: 535-543, 2010
    • (2010) Nat Med , vol.16 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3    Shah, J.V.4    Bonventre, J.V.5
  • 183
    • 0034567759 scopus 로고    scopus 로고
    • Proteinuria and progression of chronic renal disease
    • Wang S, LaPage J, Hirschberg R: Proteinuria and progression of chronic renal disease. Kidney Blood Press Res 23: 167-169, 2000
    • (2000) Kidney Blood Press Res , vol.23 , pp. 167-169
    • Wang, S.1    LaPage, J.2    Hirschberg, R.3
  • 184
    • 53449102533 scopus 로고    scopus 로고
    • The molecular interactions between filtered proteins and proximal tubular cells in proteinuria
    • Baines RJ, Brunskill NJ: The molecular interactions between filtered proteins and proximal tubular cells in proteinuria. Nephron Exp Nephrol 110: e67-e71, 2008
    • (2008) Nephron Exp Nephrol , vol.110
    • Baines, R.J.1    Brunskill, N.J.2
  • 185
    • 51849083714 scopus 로고    scopus 로고
    • Overview of factors contributing to the pathophysiology of progressive renal disease
    • Schlondorff DO: Overview of factors contributing to the pathophysiology of progressive renal disease. Kidney Int 74: 860-866, 2008
    • (2008) Kidney Int , vol.74 , pp. 860-866
    • Schlondorff, D.O.1
  • 186
    • 0029121069 scopus 로고
    • The pathogenesis of tubulointerstitial disease associated with glomerulonephritis: The glomerular cytokine theory
    • Pichler R, Giachelli C, Young B, Alpers CE, Couser WG, Johnson RJ: The pathogenesis of tubulointerstitial disease associated with glomerulonephritis: The glomerular cytokine theory. Miner Electrolyte Metab 21: 317-327, 1995
    • (1995) Miner Electrolyte Metab , vol.21 , pp. 317-327
    • Pichler, R.1    Giachelli, C.2    Young, B.3    Alpers, C.E.4    Couser, W.G.5    Johnson, R.J.6
  • 187
    • 12144264180 scopus 로고    scopus 로고
    • Proteinuria and growth factors in the development of tubulointerstitial injury and scarring in kidney disease
    • Hirschberg R, Wang S: Proteinuria and growth factors in the development of tubulointerstitial injury and scarring in kidney disease. Curr Opin Nephrol Hypertens 14: 43-52, 2005
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 43-52
    • Hirschberg, R.1    Wang, S.2
  • 189
    • 73849089954 scopus 로고    scopus 로고
    • Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney
    • Rohatgi R, Flores D: Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney. Curr Opin Nephrol Hypertens 19: 65-71, 2010
    • (2010) Curr Opin Nephrol Hypertens , vol.19 , pp. 65-71
    • Rohatgi, R.1    Flores, D.2
  • 191
    • 33750736645 scopus 로고    scopus 로고
    • How does proteinuria cause progressive renal damage?
    • Abbate M, Zoja C, Remuzzi G: How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17: 2974-2984, 2006
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2974-2984
    • Abbate, M.1    Zoja, C.2    Remuzzi, G.3
  • 194
    • 37349046018 scopus 로고    scopus 로고
    • Nuclear factor-kappaB as a hormonal intracellular signaling molecule: Focus on angiotensin II-induced cardiovascular and renal injury
    • Li XC, Zhuo JL: Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury. Curr Opin Nephrol Hypertens 17: 37-43, 2008
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 37-43
    • Li, X.C.1    Zhuo, J.L.2
  • 196
    • 63849087686 scopus 로고    scopus 로고
    • The role of chemokines in progressive renal disease
    • Zoja C, Garcia PB, Remuzzi G: The role of chemokines in progressive renal disease. Front Biosci 14: 1815-1822, 2009
    • (2009) Front Biosci , vol.14 , pp. 1815-1822
    • Zoja, C.1    Garcia, P.B.2    Remuzzi, G.3
  • 200
    • 15444362469 scopus 로고    scopus 로고
    • Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES
    • Gong R, Rifai A, Tolbert EM, Biswas P, Centracchio JN, Dworkin LD: Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES. J Am Soc Nephrol 15: 2868-2881, 2004
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2868-2881
    • Gong, R.1    Rifai, A.2    Tolbert, E.M.3    Biswas, P.4    Centracchio, J.N.5    Dworkin, L.D.6
  • 202
    • 42649120148 scopus 로고    scopus 로고
    • Smad7 as a therapeutic agent for chronic kidney diseases
    • Lan HY: Smad7 as a therapeutic agent for chronic kidney diseases. Front Biosci 13: 4984-4992, 2008
    • (2008) Front Biosci , vol.13 , pp. 4984-4992
    • Lan, H.Y.1
  • 203
    • 54749105918 scopus 로고    scopus 로고
    • Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling
    • Tan X, Wen X, Liu Y: Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am Soc Nephrol 19: 1741-1752, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1741-1752
    • Tan, X.1    Wen, X.2    Liu, Y.3
  • 207
    • 63149162780 scopus 로고    scopus 로고
    • Transcriptional regulation of NF-kappaB by ring type decoy oligodeoxynucleotide in an animal model of nephropathy
    • Kim KH, Lee ES, Cha SH, Park JH, Park JS, Chang YC, Park KK: Transcriptional regulation of NF-kappaB by ring type decoy oligodeoxynucleotide in an animal model of nephropathy. Exp Mol Pathol 86: 114-120, 2009
    • (2009) Exp Mol Pathol , vol.86 , pp. 114-120
    • Kim, K.H.1    Lee, E.S.2    Cha, S.H.3    Park, J.H.4    Park, J.S.5    Chang, Y.C.6    Park, K.K.7
  • 209
    • 39049085896 scopus 로고    scopus 로고
    • Generation and evolution of atubular glomeruli in the progression of renal disorders
    • Chevalier RL, Forbes MS: Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 19: 197-206, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 197-206
    • Chevalier, R.L.1    Forbes, M.S.2
  • 210
    • 0027955050 scopus 로고
    • Tubular atrophy in the end-stage kidney: A lectin and immunohistochemical study
    • Nadasdy T, Laszik Z, Blick KE, Johnson DL, Silva FG: Tubular atrophy in the end-stage kidney: A lectin and immunohistochemical study. Hum Pathol 25: 22-28, 1994
    • (1994) Hum Pathol , vol.25 , pp. 22-28
    • Nadasdy, T.1    Laszik, Z.2    Blick, K.E.3    Johnson, D.L.4    Silva, F.G.5
  • 211
    • 33644789780 scopus 로고    scopus 로고
    • Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction
    • Docherty NG, O'Sullivan OE, Healy DA, Fitzpatrick JM, Watson RW: Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction. Am J Physiol Renal Physiol 290: F4-F13, 2006
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Docherty, N.G.1    O'Sullivan, O.E.2    Healy, D.A.3    Fitzpatrick, J.M.4    Watson, R.W.5
  • 213
    • 34447264295 scopus 로고    scopus 로고
    • Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia
    • Neilson EG: Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia. J Am Soc Nephrol 18: 1995-1998, 2007
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1995-1998
    • Neilson, E.G.1
  • 214
    • 33847016930 scopus 로고    scopus 로고
    • Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells
    • Chase LG, Ulloa-Montoya F, Kidder BL, Verfaillie CM: Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56: 3-7, 2007
    • (2007) Diabetes , vol.56 , pp. 3-7
    • Chase, L.G.1    Ulloa-Montoya, F.2    Kidder, B.L.3    Verfaillie, C.M.4
  • 216
    • 77953769774 scopus 로고    scopus 로고
    • Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    • Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R: Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 285: 20202-20212, 2010
    • (2010) J Biol Chem , vol.285 , pp. 20202-20212
    • Flier, S.N.1    Tanjore, H.2    Kokkotou, E.G.3    Sugimoto, H.4    Zeisberg, M.5    Kalluri, R.6
  • 217
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R: Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282: 23337-23347, 2007
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6    Kalluri, R.7
  • 221
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R: Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67: 10123-10128, 2007
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 222
    • 56349114070 scopus 로고    scopus 로고
    • Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells
    • Kokudo T, Suzuki Y, Yoshimatsu Y, Yamazaki T, Watabe T, Miyazono K: Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci 121: 3317-33124, 2008
    • (2008) J Cell Sci , vol.121 , pp. 3317-33124
    • Kokudo, T.1    Suzuki, Y.2    Yoshimatsu, Y.3    Yamazaki, T.4    Watabe, T.5    Miyazono, K.6
  • 223
    • 20544462075 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis
    • Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF: Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis. Am J Transplant 5: 1367-1374, 2005
    • (2005) Am J Transplant , vol.5 , pp. 1367-1374
    • Vongwiwatana, A.1    Tasanarong, A.2    Rayner, D.C.3    Melk, A.4    Halloran, P.F.5
  • 224
    • 0942276287 scopus 로고    scopus 로고
    • Chronic renal allograft dysfunction: The role of T cell-mediated tubular epithelial to mesenchymal cell transition
    • Robertson H, Ali S, McDonnell BJ, Burt AD, Kirby JA: Chronic renal allograft dysfunction: The role of T cell-mediated tubular epithelial to mesenchymal cell transition. J Am Soc Nephrol 15: 390-397, 2004
    • (2004) J Am Soc Nephrol , vol.15 , pp. 390-397
    • Robertson, H.1    Ali, S.2    McDonnell, B.J.3    Burt, A.D.4    Kirby, J.A.5
  • 227
    • 58149504281 scopus 로고    scopus 로고
    • Nephronophthisis: Disease mechanisms of a ciliopathy
    • Hildebrandt F, Attanasio M, Otto E: Nephronophthisis: Disease mechanisms of a ciliopathy. J Am Soc Nephrol 20: 23-35, 2009
    • (2009) J Am Soc Nephrol , vol.20 , pp. 23-35
    • Hildebrandt, F.1    Attanasio, M.2    Otto, E.3
  • 228
    • 67349114001 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition
    • Sun S, Ning X, Zhang Y, Lu Y, Nie Y, Han S, Liu L, Du R, Xia L, He L, Fan D: Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition. Kidney Int 75: 1278-1287, 2009
    • (2009) Kidney Int , vol.75 , pp. 1278-1287
    • Sun, S.1    Ning, X.2    Zhang, Y.3    Lu, Y.4    Nie, Y.5    Han, S.6    Liu, L.7    Du, R.8    Xia, L.9    He, L.10    Fan, D.11
  • 230
    • 69849113833 scopus 로고    scopus 로고
    • HIF in kidney disease and development
    • Gunaratnam L, Bonventre JV: HIF in kidney disease and development. J Am Soc Nephrol 20: 1877-1887, 2009
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1877-1887
    • Gunaratnam, L.1    Bonventre, J.V.2
  • 231
  • 235
    • 77952991468 scopus 로고    scopus 로고
    • Vitamin d receptor attenuates renal fibrosis by suppressing the renin-angiotensin system
    • Zhang Y, Kong J, Deb DK, Chang A, Li YC: Vitamin d receptor attenuates renal fibrosis by suppressing the renin-angiotensin system. J Am Soc Nephrol 21: 966-973, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 966-973
    • Zhang, Y.1    Kong, J.2    Deb, D.K.3    Chang, A.4    Li, Y.C.5
  • 237
    • 33751582928 scopus 로고    scopus 로고
    • Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
    • Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J, Nieto MA: Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J 25: 5603-5613, 2006
    • (2006) EMBO J , vol.25 , pp. 5603-5613
    • Boutet, A.1    De Frutos, C.A.2    Maxwell, P.H.3    Mayol, M.J.4    Romero, J.5    Nieto, M.A.6
  • 238
    • 34250856260 scopus 로고    scopus 로고
    • Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney
    • Kida Y, Asahina K, Teraoka H, Gitelman I, Sato T: Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J Histochem Cytochem 55: 661-673, 2007
    • (2007) J Histochem Cytochem , vol.55 , pp. 661-673
    • Kida, Y.1    Asahina, K.2    Teraoka, H.3    Gitelman, I.4    Sato, T.5
  • 240
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 241
    • 0036138824 scopus 로고    scopus 로고
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
    • Yang J, Liu Y: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 13: 96-107, 2002
    • (2002) J Am Soc Nephrol , vol.13 , pp. 96-107
    • Yang, J.1    Liu, Y.2
  • 242
  • 243
    • 69849100333 scopus 로고    scopus 로고
    • Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis
    • Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y: Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 20: 1907-1918, 2009
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1907-1918
    • Li, Y.1    Tan, X.2    Dai, C.3    Stolz, D.B.4    Wang, D.5    Liu, Y.6
  • 244
    • 70349792513 scopus 로고    scopus 로고
    • Therapeutic effect of Y-27632 on chronic allograft nephropathy in rats
    • Liu M, Gu M, Wu Y, Zhu P, Zhang W, Yin C, Zhang WJ: Therapeutic effect of Y-27632 on chronic allograft nephropathy in rats. J Surg Res 157: e117-e127, 2009
    • (2009) J Surg Res , vol.157
    • Liu, M.1    Gu, M.2    Wu, Y.3    Zhu, P.4    Zhang, W.5    Yin, C.6    Zhang, W.J.7
  • 246
    • 77956553923 scopus 로고    scopus 로고
    • Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression
    • Gai Z, Zhou G, Gui T, Itoh S, Oikawa K, Uetani K, Muragaki Y: Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression. J Am Soc Nephrol 21: 1468-1476, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1468-1476
    • Gai, Z.1    Zhou, G.2    Gui, T.3    Itoh, S.4    Oikawa, K.5    Uetani, K.6    Muragaki, Y.7
  • 248
    • 72049105867 scopus 로고    scopus 로고
    • The role of the mammalian target of rapamycin (mTOR) in renal disease
    • Lieberthal W, Levine JS: The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 20: 2493-2502, 2009
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2493-2502
    • Lieberthal, W.1    Levine, J.S.2
  • 250
    • 0035156004 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition prevents glomerular-tubule disconnection and atrophy in passive Heymann nephritis, an effect not observed with a calcium antagonist
    • Benigni A, Gagliardini E, Remuzzi A, Corna D, Remuzzi G: Angiotensin-converting enzyme inhibition prevents glomerular-tubule disconnection and atrophy in passive Heymann nephritis, an effect not observed with a calcium antagonist. Am J Pathol 159: 1743-1750, 2001
    • (2001) Am J Pathol , vol.159 , pp. 1743-1750
    • Benigni, A.1    Gagliardini, E.2    Remuzzi, A.3    Corna, D.4    Remuzzi, G.5
  • 253
    • 33644849158 scopus 로고    scopus 로고
    • Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia
    • Kim D, Dressler GR: Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol 16: 3527-3534, 2005
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3527-3534
    • Kim, D.1    Dressler, G.R.2
  • 255
    • 70349641568 scopus 로고    scopus 로고
    • Postischemic inflammatory syndrome: A critical mechanism of progression in diabetic nephropathy
    • Kelly KJ, Burford JL, Dominguez JH: Postischemic inflammatory syndrome: A critical mechanism of progression in diabetic nephropathy. Am J Physiol Renal Physiol 297: F923-F931, 2009
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Kelly, K.J.1    Burford, J.L.2    Dominguez, J.H.3
  • 256
    • 4043077114 scopus 로고    scopus 로고
    • Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive nephropathy
    • Basile DP: Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive nephropathy. Curr Opin Nephrol Hypertens 13: 1-7, 2004
    • (2004) Curr Opin Nephrol Hypertens , vol.13 , pp. 1-7
    • Basile, D.P.1
  • 259
    • 73549092294 scopus 로고    scopus 로고
    • Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice
    • Li J, Qu X, Bertram JF: Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am J Pathol 175: 1380-1388, 2009
    • (2009) Am J Pathol , vol.175 , pp. 1380-1388
    • Li, J.1    Qu, X.2    Bertram, J.F.3
  • 260
    • 51849094304 scopus 로고    scopus 로고
    • Chronic hypoxia as a mechanism of progression of chronic kidney diseases: From hypothesis to novel therapeutics
    • Fine LG, Norman JT: Chronic hypoxia as a mechanism of progression of chronic kidney diseases: From hypothesis to novel therapeutics. Kidney Int 74: 867-872, 2008
    • (2008) Kidney Int , vol.74 , pp. 867-872
    • Fine, L.G.1    Norman, J.T.2
  • 261
    • 36849049298 scopus 로고    scopus 로고
    • Hypoxia and the HIF system in kidney disease
    • Nangaku M, Eckardt KU: Hypoxia and the HIF system in kidney disease. J Mol Med 85: 1325-1330, 2007
    • (2007) J Mol Med , vol.85 , pp. 1325-1330
    • Nangaku, M.1    Eckardt, K.U.2
  • 262
    • 0345258415 scopus 로고    scopus 로고
    • Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action
    • Norman JT, Stidwill R, Singer M, Fine LG: Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action. Nephron Physiol 94: 39-46, 2003
    • (2003) Nephron Physiol , vol.94 , pp. 39-46
    • Norman, J.T.1    Stidwill, R.2    Singer, M.3    Fine, L.G.4
  • 263
    • 71049181486 scopus 로고    scopus 로고
    • Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats
    • Fujimoto S, Satoh M, Nagasu H, Horike H, Sasaki T, Kashihara N: Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats. Nephrol Dial Transplant 24: 3651-3658, 2009
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3651-3658
    • Fujimoto, S.1    Satoh, M.2    Nagasu, H.3    Horike, H.4    Sasaki, T.5    Kashihara, N.6
  • 264
    • 33746803789 scopus 로고    scopus 로고
    • Role of endothelin and endothelin receptor antagonists in renal disease
    • Neuhofer W, Pittrow D: Role of endothelin and endothelin receptor antagonists in renal disease. Eur J Clin Invest 36 [Suppl 3]: 78-88, 2006
    • (2006) Eur J Clin Invest , vol.36 , Issue.SUPPL. 3 , pp. 78-88
    • Neuhofer, W.1    Pittrow, D.2
  • 267
    • 33845370437 scopus 로고    scopus 로고
    • Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension
    • Long DA, Mu W, Price KL, Roncal C, Schreiner GF, Woolf AS, Johnson RJ: Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension. Am J Physiol Renal Physiol 291: F1248-F1254, 2006
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Long, D.A.1    Mu, W.2    Price, K.L.3    Roncal, C.4    Schreiner, G.F.5    Woolf, A.S.6    Johnson, R.J.7
  • 268
    • 0142244847 scopus 로고    scopus 로고
    • Risk factors for chronic kidney disease: A prospective study of 23,534 men and women in Washington County, Maryland
    • Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J: Risk factors for chronic kidney disease: A prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol 14: 2934-2941, 2003
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2934-2941
    • Haroun, M.K.1    Jaar, B.G.2    Hoffman, S.C.3    Comstock, G.W.4    Klag, M.J.5    Coresh, J.6
  • 271
    • 55749102265 scopus 로고    scopus 로고
    • X inactivation, female mosaicism, and sex differences in renal diseases
    • Migeon BR: X inactivation, female mosaicism, and sex differences in renal diseases. J Am Soc Nephrol 19: 2052-2059, 2008
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2052-2059
    • Migeon, B.R.1
  • 284
    • 60149088848 scopus 로고    scopus 로고
    • Origins and Mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ: Origins and Mechanisms of miRNAs and siRNAs. Cell 136: 642-655, 2009
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 285
    • 77955611511 scopus 로고    scopus 로고
    • miR-192 Mediates TGF-{beta}/Smad3-Driven Renal Fibrosis
    • Chung AC, Huang XR, Meng X, Lan HY: miR-192 Mediates TGF-{beta}/Smad3- Driven Renal Fibrosis. J Am Soc Nephrol 21: 1317-1325, 2010
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1317-1325
    • Chung, A.C.1    Huang, X.R.2    Meng, X.3    Lan, H.Y.4
  • 286
    • 33847682663 scopus 로고    scopus 로고
    • MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors
    • Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi JJ, Natarajan R: MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A 104: 3432-3437, 2007
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3432-3437
    • Kato, M.1    Zhang, J.2    Wang, M.3    Lanting, L.4    Yuan, H.5    Rossi, J.J.6    Natarajan, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.