Pathophysiology of AKI: Injury and normal and abnormal repair

Contributions to Nephrology

Volumn 165, Issue , 2010, Pages 9-17

  Bonventre, Joseph V ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1;

ACUTE KIDNEY FAILURE; ANIMAL; ARTICLE; GENETICS; HUMAN; INFLAMMATION; INJURY; KIDNEY; KIDNEY CIRCULATION; KIDNEY TUBULE; LEUKOCYTE; MICROVILLUS; MOUSE; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANIMALS; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; KIDNEY FAILURE, ACUTE; KIDNEY TUBULES; LEUKOCYTES; MICE; MICE, KNOCKOUT; MICROVILLI; RENAL CIRCULATION; RENAL INSUFFICIENCY, ACUTE; REPERFUSION INJURY; VASOCONSTRICTION;

EID: 77954594721     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000313738     Document Type: Article

References (34)

1. Zuk A, Bonventre JV, Brown D, Matlin KS: Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 1998;275: C711-C731.
2. Thadhani R, Pascual M, Bonventre JV: Acute renal failure. N Engl J Med 1996;334:1448-1460.
3. Zuk A, Bonventre JV, Matlin KS: Expression of fibronectin splice variants in the postischemic rat kidney. Am J Physiol 2001;280: F1037-F1053.
4. Heyman SN, Rosenberger C, Rosen S: Experimental ischemia-reperfusion: biases and myths - the proximal vs. distal hypoxic tubular injury debate revisited. Kidney Int 2009;77:9-16.
5. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV: Kidney injury molecule-1: a novel biomarker for human renal proximal tubule injury. Kidney Int 2002;62:237-244.
6. Vaidya VS, Waikar SS, Ferguson MA, Collings FB, Sunderland K, Gioules C, Bradwin G, Matsouaka R, Betensky RA, Curhan GC, Bonventre JV: Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci 2008;1:200-208.
7. Conger J: Hemodynamic factors in acute renal failure. Adv Ren Replace Ther 1997;4(suppl 1):25-37.
8. Conger JD: Vascular abnormalities in the maintenance of acute renal failure. Circ Shock 1983;11:235-244.
9. Kwon O, Hong SM, Ramesh G: Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion. Am J Physiol 2009;296: F25-F33.
10. Park KM, Chen A, Bonventre JV: Prevention of kidney ischemia/reperfusion- induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 2001;276:11870-11876.
11. Basile DP, Fredrich K, Chelladurai B, Leonard EC, Parrish AR: Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Am J Physiol 2008;294: F928-F936.
12. Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Recalde A, Duriez M, Levy BI, Lutgens E, Mallat Z, Silvestre JS: Regulatory T cells modulate postischemic neovascularization. Circulation 2009;120:1415-1425.
13. Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S: Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005;115:2894-2903.
14. Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC: Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PloS One 2008;3: e3596.
15. Kelly KJ, Williams WW, Colvin RB, Bonventre JV: Antibody to intercellular adhesion molecule-1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 1994;91:812-816.
16. Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV: Intercellular adhesion molecule-1-deficient mice are protected against renal ischemia. J Clin Invest 1996;97:1056-1063.
17. Sanz MJ, Johnston B, Issekutz A, Kubes P: Endothelin causes P-selectin-dependent leukocyte rolling and adhesion within rat mesenteric microvessels. Am J Physiol 1999;277: H1823-H30.
18. Linas S, Whittenburg D, Repine JE: Nitric oxide prevents neutrophil-mediated acute renal failure. Am J Physiol 1997;272:F48-F54.
19. Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD: IL-17 produced by neutrophils regulates IFN-γ-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest 2010;120:331-342.
20. Rabb H, Daniels F, O'Donnell M, Haq M, Saba SR, Keane W, Tang WW: Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol 2000;279: F525-F531.
21. Park P, Haas M, Cunningham PN, Bao L, Alexander JJ, Quigg RJ: Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol 2002;282: F352-F357.
22. Burne-Taney MJ, Yokota-Ikeda N, Rabb H: Effects of combined T-and B-cell deficiency on murine ischemia reperfusion injury. Am J Transplant 2005;5:1186-1193.
23. Gandolfo MT, Jang HR, Bagnasco SM, Ko GJ, Agreda P, Satpute SR, Crow MT, King LS, Rabb H: Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int 2009;76:717-729.
24. Ricardo SD, van Goor H, Eddy AA: Macrophage diversity in renal injury and repair. J Clin Invest 2008;118:3522-3530.
25. Li L, Huang L, Sung SS, Vergis AL, Rosin DL, Rose CE Jr, Lobo PI, Okusa MD: The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int 2008;74:1526-1537.
26. John R, Nelson PJ: Dendritic cells in the kidney. J Am Soc Nephrol 2007;18:2628-2635.
27. Reis e Sousa C: Dendritic cells in a mature age. Nat Rev Immunol 2006;6:476-483.
28. Homeister JW, Lucchesi BR: Complement activation and inhibition in myocardial ischemia and reperfusion injury. Annu Rev Pharmacol Toxicol 1994;34:17-40.
29. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV: Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008;2:284-291.
30. Forbes JM, Hewitson TD, Becker GJ, Jones CL: Ischemic acute renal failure: long-term histology of cell and matrix changes in the rat. Kidney Int 2000;57:2375-2385.
31. Macedo E, Bouchard J, Mehta RL: Renal recovery following acute kidney injury. Curr Opin Crit Care 2008;14:660-665.
32. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS: Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010;176:85-97.
33. Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV: Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010 (in press).
34. Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, Collins AJ: Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 2009;20:223-228.