Wnt agonist decreases tissue damage and improves renal function after ischemia-reperfusion

Shock

Volumn 43, Issue 3, 2015, Pages 268-275

  Kuncewitch, Michael ^a   Yang, Weng Lang ^a,b   Corbo, Lana ^a,b   Khader, Adam ^a   Nicastro, Jeffrey ^a   Coppa, Gene F ^a   Wang, Ping ^a,b  

^a DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Oxidative stress; Proliferation; Renal ischemia reperfusion; Wnt agonist; Wnt catenin

Indexed keywords

2 AMINO 4 [3,4 (METHYLENEDIOXY)BENZYLAMINO] 6 (3 METHOXYPHENYL)PYRIMIDINE; 3 NITROTYROSINE; 4 HYDROXYNONENAL; ASPARTATE AMINOTRANSFERASE; BETA CATENIN; CREATININE; CYCLIN D1; DIMETHYL SULFOXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KI 67 ANTIGEN; LACTATE DEHYDROGENASE; MYELOPEROXIDASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; WNT PROTEIN; CTNNB1 PROTEIN, RAT; MESSENGER RNA; NOS2 PROTEIN, RAT; PROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY CLAMP; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE TARGETING; HISTOPATHOLOGY; KIDNEY BLOOD VESSEL; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; KIDNEY TUBULE CELL; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; REPERFUSION INJURY; SHAM PROCEDURE; TISSUE REGENERATION; VASCULAR PEDICLE; WNT SIGNALING PATHWAY; ACUTE KIDNEY INJURY; AGONISTS; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REGENERATION; SHOCK; SPRAGUE DAWLEY RAT;

ACUTE KIDNEY INJURY; ANIMALS; BETA CATENIN; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; KIDNEY; MALE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PROTECTIVE AGENTS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; REPERFUSION INJURY; RNA, MESSENGER; SHOCK; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84937883412     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000293     Document Type: Article

References (35)

1. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, et al.: Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294(7):813Y818, 2005.
2. Thadhani R, Pascual M, Bonventre JV: Acute renal failure. N Engl J Med 334(22):1448Y1460, 1996.
3. Nankivell BJ, Alexander SI: Rejection of the kidney allograft. N Engl J Med 363(15):1451Y1462, 2010.
4. Grinyo JM: Role of ischemia-reperfusion injury in the development of chronic renal allograft damage. Transplant Proc 33(7Y8):3741Y3742, 2001.
5. Bagul A, Frost JH, Drage M: Stem cells and their role in renal ischaemia reperfusion injury. Am J Nephrol 37(1):16Y29, 2013.
6. Clevers H: Wnt/beta-catenin signaling in development and disease. Cell 127(3):469Y480, 2006.
7. Zhou D, Li Y, Lin L, Zhou L, Igarashi P, Liu Y: Tubule-specific ablation of endogenous beta-catenin aggravates acute kidney injury in mice. Kidney Int 82(5):537Y547, 2012.
8. Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG: A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl 44(13): 1987Y1990, 2005.
9. Kuncewitch M, Yang WL, Molmenti E, Nicastro J, Coppa GF, Wang P: Wnt agonist attenuates liver injury and improves survival after hepatic ischemia/ reperfusion. Shock 39(1):3Y10, 2013.
10. Feilleux-Duche S, Garlatti M, Aggerbeck M, Poyard M, Bouguet J, Hanoune J, Barouki R: Cell-specific regulation of cytosolic aspartate aminotransferase by glucocorticoids in the rat kidney. Am J Physiol 265(5 pt 1):C1298YC1305, 1993.
11. Heyman SN, Rosen S, Epstein FH, Spokes K, Brezis ML: Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int 45(4):981Y985, 1994.
12. Chatterjee PK, Patel NS, Sivarajah A, Kvale EO, Dugo L, Cuzzocrea S, Brown PA, Stewart KN, Mota-Filipe H, Britti D, et al.: GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int 63(3):853Y865, 2003.
13. Idrovo JP, Yang WL, Matsuda A, Nicastro J, Coppa GF, Wang P: Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury. Shock 37(1): 39Y46, 2012.
14. Scholzen T, Gerdes J: The Ki-67 protein: from the known and the unknown. J Cell Physiol 182(3):311Y322, 2000.
15. Uchida K: 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 42(4):318Y343, 2003.
16. US Department of Health and Human Services. National Kidney and Urologic Diseases Information Clearinghouse, Kidney Diseases Statistics for the United States. 2012. Available from: http://kidney.niddk.nih.gov/KUDiseases/pubs/ kustats/index.aspx#8. Accessed August 20, 2014.
17. Wenzel RP, Edmond MB: Severe sepsis-national estimates. Crit Care Med 29(7):1472Y1474, 2001.
18. Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC: Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308(5725):1181Y1184, 2005.
19. Hoogeboom D, Burgering BM: Should I stay or should I go: beta-catenin decides under stress. Biochim Biophys Acta 1796(2):63Y74, 2009.
20. Sabbagh Y, Graciolli FG, O'Brien S, Tang W, dos Reis LM, Ryan S, Phillips L, Boulanger J, Song W, Bracken C, et al.: Repression of osteocyte Wnt/betacatenin signaling is an early event in the progression of renal osteodystrophy. J Bone Miner Res 27(8):1757Y1772, 2012.
21. Kaidi A, Williams AC, Paraskeva C: Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol 9(2):210Y217, 2007.
22. Shin SY, Chin BR, Lee YH, Kim JH: Involvement of glycogen synthase kinase-3beta in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity. Cell Signal 18(5):601Y607, 2006.
23. Terada Y, Tanaka H, Okado T, Shimamura H, Inoshita S, Kuwahara M, Sasaki S: Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol 14(5):1223Y1233, 2003.
24. Bonventre JV, Weinberg JM: Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14(8):2199Y2210, 2003.
25. Chen G, Akintola AD, Catania JM, Covington MD, Dean DD, Trzeciakowski JP, Burghardt RC, Parrish AR: Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity. Cell Commun Adhes 14(4):111Y123, 2007.
26. Feng Z, Ting J, Alfonso Z, Strem BM, Fraser JK, Rutenberg J, Kuo HC, Pinkernell K: Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia-reperfusion-induced acute kidney injury. Nephrol Dial Transplant 25(12):3874Y3884, 2010.
27. Chatterjee PK, Patel NS, Kvale EO, Cuzzocrea S, Brown PA, Stewart KN, Mota-Filipe H, Thiemermann C: Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int 61(3):862Y871, 2002.
28. Walker LM, Walker PD, Imam SZ, Ali SF, Mayeux PR: Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine. J Pharmacol Exp Ther 295(1):417Y422, 2000.
29. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 121(11):4210Y4221, 2011.
30. Di Paola R, Genovese T, Impellizzeri D, Ahmad A, Cuzzocrea S, Esposito E: The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-alphaR1: a comparison with infliximab treatment. Eur J Pharmacol 700(1Y3):134Y146, 2013.
31. Matthijsen RA, Huugen D, Hoebers NT, de Vries B, Peutz-Kootstra CJ, Aratani Y, DahaMR, Tervaert JW, Buurman WA, Heeringa P:Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion. Am J Pathol 171(6):1743Y1752, 2007.
32. Malle E, Buch T, Grone HJ: Myeloperoxidase in kidney disease. Kidney Int 64(6):1956Y1967, 2003.
33. Vinas JL, Sola A, Jung M, Mastora C, Vinuesa E, Pi F, Hotter G: Inhibitory action of Wnt target gene osteopontin on mitochondrial cytochrome c release determines renal ischemic resistance. Am J Physiol Renal Physiol 299(1): F234YF242, 2010.
34. Cho YD, Kim WJ, Yoon WJ, Woo KM, Baek JH, Lee G, Kim GS, Ryoo HM: Wnt3a stimulates Mepe, matrix extracellular phosphoglycoprotein, expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression. J Cell Physiol 227(6):2287Y2296, 2012.
35. Dugo L, Abdelrahman M, Murch O, Mazzon E, Cuzzocrea S, Thiemermann C: Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation. Shock 25(5):485Y491, 2006.