Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice

Journal of the American Society of Nephrology

Volumn 13, Issue 2, 2002, Pages 411-422

  Dai, Chunsun ^a   Yang, Junwei ^a   Liu, Youhua ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FOLIC ACID; PLASMID DNA; PROTEIN BCL XL; PROTEIN KINASE B; SCATTER FACTOR;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENE THERAPY; KIDNEY TUBULE; MALE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; TISSUE REGENERATION; TISSUE REPAIR;

EID: 0036156658     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Acute renal failure. I. Relative importance of proximal vs. distal tubular injury
2. Emerging therapies for acute renal failure
3. Acute renal failure in the new millennium: Time to consider combination therapy
4. Therapeutic use of growth factors in renal failure
5. Acute renal failure: Growth factors, cell therapy, and gene therapy
6. Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair
7. The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis
8. Emerging multipotent aspects of hepatocyte growth factor
9. Liver regeneration
10. Hepatocyte growth factor in renal failure: Promise and reality
11. Hepatocyte growth factor in renal regeneration, renal disease and potential therapeutics
12. Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats
13. Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice
14. Hepatocyte growth factor increases in injured organs and functions as an organotrophic factor in rats with experimental acute pancreatitis
15. Up-regulation of hepatocyte growth factor receptor: An amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure
16. Uptake and distribution of hepatocyte growth factor in normal and regenerating adult rat liver
17. Gene transfer in the kidney
18. New paradigm of gene therapy: Skeletal-muscle-targeting gene therapy for kidney disease
19. Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth
20. Constitutive expression of HGF modulates renal epithelial cell phenotype and induces c-met and fibronectin expression
21. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
22. Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways
23. Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice
24. Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury
25. Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury
26. Cellular survival: A play in three Akts
27. p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
28. Elevated akt activity protects the prostate cancer cell line INCAP from trail-induced apoptosis
29. Relationship between expression of Bcl-2 genes and growth factor in ischemic acute renal failure in the rat
30. Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death
31. Potential role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells
32. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms
33. Hepatocyte growth factor, but not insulin-like growth factor I, protects podocytes against cyclosporin A-induced apoptosis
34. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
35. The biochemistry of apoptosis
36. A matter of life and cell death
37. Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells
38. The Bcl-2 protein family: Arbiters of cell survival
39. Necrosis and apoptosis in acute renal failure
40. Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure