메뉴 건너뛰기




Volumn 387, Issue 1-2, 2014, Pages 27-37

Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway

Author keywords

Bone marrow mesenchymal stem cells (BM MSCs); p53 p21 pathway; Senescence; Systemic lupus erythematosus (SLE); Wnt Catenin signaling

Indexed keywords

ADOLESCENT; ADULT; BETA CATENIN; BONE MARROW CELLS; CASE-CONTROL STUDIES; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MESENCHYMAL STROMAL CELLS; TUMOR SUPPRESSOR PROTEIN P53; WNT SIGNALING PATHWAY; YOUNG ADULT;

EID: 84893818867     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1866-5     Document Type: Article
Times cited : (79)

References (33)
  • 1
    • 84859389832 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • 22312827
    • Julkunen H (2012) Systemic lupus erythematosus. Duodecim 128:51-61
    • (2012) Duodecim , vol.128 , pp. 51-61
    • Julkunen, H.1
  • 2
    • 84864865405 scopus 로고    scopus 로고
    • Decreased microRNA-142-3p/5p expression causes CD4 + T cell activation and B cell hyperstimulation in systemic lupus erythematosus
    • 1:CAS:528:DC%2BC38Xht1GrsbjP 22549634 10.1002/art.34505
    • Ding S, Liang Y, Zhao M, Liang G, Long H, Zhao S, Wang Y, Yin H, Zhang P, Zhang Q, Lu Q (2012) Decreased microRNA-142-3p/5p expression causes CD4 + T cell activation and B cell hyperstimulation in systemic lupus erythematosus. Arthritis Rheum 64:2953-2963
    • (2012) Arthritis Rheum , vol.64 , pp. 2953-2963
    • Ding, S.1    Liang, Y.2    Zhao, M.3    Liang, G.4    Long, H.5    Zhao, S.6    Wang, Y.7    Yin, H.8    Zhang, P.9    Zhang, Q.10    Lu, Q.11
  • 3
    • 77957845081 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells: Historical overview and concepts
    • 1:CAS:528:DC%2BC3cXhtFehu7%2FP 20565251 10.1089/hum.2010.115
    • Charbord P (2010) Bone marrow mesenchymal stem cells: historical overview and concepts. Hum Gene Ther 21:1045-1056
    • (2010) Hum Gene Ther , vol.21 , pp. 1045-1056
    • Charbord, P.1
  • 4
    • 22244488719 scopus 로고    scopus 로고
    • Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice
    • DOI 10.1089/dna.2005.24.458
    • Deng W, Han Q, Liao L, You S, Deng H, Zhao RC (2005) Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice. DNA Cell Biol 24:458-463 (Pubitemid 40994557)
    • (2005) DNA and Cell Biology , vol.24 , Issue.7 , pp. 458-463
    • Deng, W.1    Han, Q.2    Liao, L.3    You, S.4    Deng, H.5    Zhao, R.C.H.6
  • 5
    • 84885121179 scopus 로고    scopus 로고
    • EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells
    • [Epub ahead of print]
    • Nguyen TM, Arthur A, Hayball JD, Gronthos S (2013) EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Stem Cells Dev. [Epub ahead of print]
    • (2013) Stem Cells Dev.
    • Nguyen, T.M.1    Arthur, A.2    Hayball, J.D.3    Gronthos, S.4
  • 6
    • 77955451557 scopus 로고    scopus 로고
    • Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: A pilot clinical study
    • 20650877 10.1136/ard.2009.123463
    • Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S, Hou Y, Zeng X, Gilkeson GS, Sun L (2010) Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 69:1423-1429
    • (2010) Ann Rheum Dis , vol.69 , pp. 1423-1429
    • Liang, J.1    Zhang, H.2    Hua, B.3    Wang, H.4    Lu, L.5    Shi, S.6    Hou, Y.7    Zeng, X.8    Gilkeson, G.S.9    Sun, L.10
  • 7
    • 77951143265 scopus 로고    scopus 로고
    • Allogenic bone-marrow-derived mesenchymal stem cells transplantation as a novel therapy for systemic lupus erythematosus
    • 1:CAS:528:DC%2BC3cXksFCgt74%3D 20345339 10.1517/14712591003769816
    • Zhang H, Zeng X, Sun L (2010) Allogenic bone-marrow-derived mesenchymal stem cells transplantation as a novel therapy for systemic lupus erythematosus. Expert Opin Biol Ther 10:701-709
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 701-709
    • Zhang, H.1    Zeng, X.2    Sun, L.3
  • 8
    • 77749279645 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients
    • 1:STN:280:DC%2BC3c7isFWhsQ%3D%3D 19919974 10.1177/0961203309348983
    • Carrion F, Nova E, Ruiz C, Diaz F, Inostroza C, Rojo D, Mönckeberg G, Figueroa FE (2010) Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Lupus 19:317-322
    • (2010) Lupus , vol.19 , pp. 317-322
    • Carrion, F.1    Nova, E.2    Ruiz, C.3    Diaz, F.4    Inostroza, C.5    Rojo, D.6    Mönckeberg, G.7    Figueroa, F.E.8
  • 9
    • 84867905846 scopus 로고    scopus 로고
    • Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice
    • 1:CAS:528:DC%2BC38XhsFKnsrzE 23041504 10.1016/j.clim.2012.08.012
    • Gu F, Molano I, Ruiz P, Sun L, Gilkeson GS (2012) Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice. Clin Immunol 145:142-152
    • (2012) Clin Immunol , vol.145 , pp. 142-152
    • Gu, F.1    Molano, I.2    Ruiz, P.3    Sun, L.4    Gilkeson, G.S.5
  • 10
    • 33847374613 scopus 로고    scopus 로고
    • Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
    • DOI 10.1177/0961203306075793
    • Sun LY, Zhang HY, Feng XB, Hou YY, Lu LW, Fan LM (2007) Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 16:121-128 (Pubitemid 46347934)
    • (2007) Lupus , vol.16 , Issue.2 , pp. 121-128
    • Sun, L.Y.1    Zhang, H.Y.2    Feng, X.B.3    Hou, Y.Y.4    Lu, L.W.5    Fan, L.M.6
  • 11
    • 77952921223 scopus 로고    scopus 로고
    • Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus
    • 1:STN:280:DC%2BC3czntlSgtg%3D%3D 20511276 10.1177/0961203309361482
    • Nie Y, Lau C, Lie A, Chan G, Mok M (2010) Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 19:850-859
    • (2010) Lupus , vol.19 , pp. 850-859
    • Nie, Y.1    Lau, C.2    Lie, A.3    Chan, G.4    Mok, M.5
  • 12
    • 84865722353 scopus 로고    scopus 로고
    • Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
    • 1:CAS:528:DC%2BC38Xht1yntr7L 22375903 10.1089/scd.2011.0447
    • Li X, Liu L, Meng D, Wang D, Zhang J, Shi D, Liu H, Xu H, Lu L, Sun L (2012) Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Stem Cells Dev 21:2387-2394
    • (2012) Stem Cells Dev , vol.21 , pp. 2387-2394
    • Li, X.1    Liu, L.2    Meng, D.3    Wang, D.4    Zhang, J.5    Shi, D.6    Liu, H.7    Xu, H.8    Lu, L.9    Sun, L.10
  • 13
    • 84866095966 scopus 로고    scopus 로고
    • Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus
    • 3433142 22966240 10.1155/2012/826182
    • Tang Y, Ma X, Zhang H, Gu Z, Hou Y, Gilkeson GS, Lu L, Zeng X, Sun L (2012) Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus. Clin Dev Immunol 2012:826182
    • (2012) Clin Dev Immunol , vol.2012 , pp. 826182
    • Tang, Y.1    Ma, X.2    Zhang, H.3    Gu, Z.4    Hou, Y.5    Gilkeson, G.S.6    Lu, L.7    Zeng, X.8    Sun, L.9
  • 14
    • 84865620125 scopus 로고    scopus 로고
    • Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
    • 1:CAS:528:DC%2BC38XhsVCnsr%2FK 22820504 10.1016/j.cellsig.2012.07.012
    • Gu Z, Cao X, Jiang J, Li L, Da Z, Liu H, Cheng C (2012) Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients. Cell Signal 24:2307-2314
    • (2012) Cell Signal , vol.24 , pp. 2307-2314
    • Gu, Z.1    Cao, X.2    Jiang, J.3    Li, L.4    Da, Z.5    Liu, H.6    Cheng, C.7
  • 15
    • 84881389384 scopus 로고    scopus 로고
    • The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway
    • 1:CAS:528:DC%2BC3sXhtFamsLzO 23553737 10.1002/jcb.24557
    • Jim Leu SJ, Sung JS, Chen MY, Chen CW, Cheng JY, Wang TY, Wang JJ (2013) The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway. J Cell Biochem 114:2082-2093
    • (2013) J Cell Biochem , vol.114 , pp. 2082-2093
    • Jim Leu, S.J.1    Sung, J.S.2    Chen, M.Y.3    Chen, C.W.4    Cheng, J.Y.5    Wang, T.Y.6    Wang, J.J.7
  • 16
    • 84902283529 scopus 로고    scopus 로고
    • Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: In vivo and in vitro evidence
    • [Epub ahead of print]
    • Poulsen RC, Watts AC, Murphy RJ, Snelling SJ, Carr AJ, Hulley PA (2013) Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence. Ann Rheum Dis.[Epub ahead of print]
    • (2013) Ann Rheum Dis.
    • Poulsen, R.C.1    Watts, A.C.2    Murphy, R.J.3    Snelling, S.J.4    Carr, A.J.5    Hulley, P.A.6
  • 17
    • 0029049680 scopus 로고
    • Aging and cellular senescence
    • 1:STN:280:DyaK2MzktFOqtw%3D%3D 7616677 10.3143/geriatrics.32.259
    • Fujiwara Y (1995) Aging and cellular senescence. Nihon Ronen Igakkai Zasshi 32:259-265
    • (1995) Nihon Ronen Igakkai Zasshi , vol.32 , pp. 259-265
    • Fujiwara, Y.1
  • 18
    • 84885666355 scopus 로고    scopus 로고
    • P53/p21 pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
    • 3787636 24151513
    • Gu Z, Jiang J, Tan W, Xia Y, Cao H, Meng Y, Da Z, Liu H, Cheng C (2013) p53/p21 pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients. Clin Dev Immunol 2013:134243
    • (2013) Clin Dev Immunol , vol.2013 , pp. 134243
    • Gu, Z.1    Jiang, J.2    Tan, W.3    Xia, Y.4    Cao, H.5    Meng, Y.6    Da, Z.7    Liu, H.8    Cheng, C.9
  • 19
    • 84869204233 scopus 로고    scopus 로고
    • Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin
    • 1:CAS:528:DC%2BC3sXht1Ois7g%3D 22972485
    • Hahnvajanawong C, Ketnimit S, Pattanapanyasat K, Anantachoke N, Sripa B, Pinmai K, Seubwai W, Reutrakul V (2012) Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin. Biol Pharm Bull 35:1914-1925
    • (2012) Biol Pharm Bull , vol.35 , pp. 1914-1925
    • Hahnvajanawong, C.1    Ketnimit, S.2    Pattanapanyasat, K.3    Anantachoke, N.4    Sripa, B.5    Pinmai, K.6    Seubwai, W.7    Reutrakul, V.8
  • 20
    • 84886375160 scopus 로고    scopus 로고
    • Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells
    • 3624606 23596569
    • Vadlakonda L, Pasupuleti M, Pallu R (2013) Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells. Front Oncol 3:85
    • (2013) Front Oncol , vol.3 , pp. 85
    • Vadlakonda, L.1    Pasupuleti, M.2    Pallu, R.3
  • 21
    • 84878986499 scopus 로고    scopus 로고
    • Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis
    • 1:CAS:528:DC%2BC3sXptFCntrk%3D 23404993 10.1093/carcin/bgt058
    • Wang X, Bai H, Zhang X, Liu J, Cao P, Liao N, Zhang W, Wang Z, Hai C (2013) Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. Carcinogenesis 34:1323-1330
    • (2013) Carcinogenesis , vol.34 , pp. 1323-1330
    • Wang, X.1    Bai, H.2    Zhang, X.3    Liu, J.4    Cao, P.5    Liao, N.6    Zhang, W.7    Wang, Z.8    Hai, C.9
  • 22
    • 79959340540 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
    • 1:CAS:528:DC%2BC3MXotFalsLk%3D 3119703 21712954 10.1371/journal.pone. 0021397
    • Zhang DY, Wang HJ, Tan YZ (2011) Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway. PLoS ONE 6:e21397
    • (2011) PLoS ONE , vol.6 , pp. 21397
    • Zhang, D.Y.1    Wang, H.J.2    Tan, Y.Z.3
  • 23
    • 84860596892 scopus 로고    scopus 로고
    • Role of Wnt/beta-catenin signaling in aging of mesenchymal stem cells of rats
    • 1:CAS:528:DC%2BC38XitV2ku7s%3D 22190524
    • Xiang XX, Chen L, Wang JH, Zhang YB, Zhang DY (2011) Role of Wnt/beta-catenin signaling in aging of mesenchymal stem cells of rats. Zhejiang Da Xue Xue Bao Yi Xue Ban 40:630-640
    • (2011) Zhejiang da Xue Xue Bao Yi Xue Ban , vol.40 , pp. 630-640
    • Xiang, X.X.1    Chen, L.2    Wang, J.H.3    Zhang, Y.B.4    Zhang, D.Y.5
  • 25
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • DOI 10.1038/nature03319
    • Reya T, Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434:843-850 (Pubitemid 40558990)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 26
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-Catenin Signaling in Development and Disease
    • DOI 10.1016/j.cell.2006.10.018, PII S0092867406013444
    • Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127:469-480 (Pubitemid 44647433)
    • (2006) Cell , vol.127 , Issue.3 , pp. 469-480
    • Clevers, H.1
  • 27
    • 0035801388 scopus 로고    scopus 로고
    • Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
    • DOI 10.1093/emboj/20.17.4912
    • Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M (2001) Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J 20:4912-4922 (Pubitemid 32848643)
    • (2001) EMBO Journal , vol.20 , Issue.17 , pp. 4912-4922
    • Damalas, A.1    Kahan, S.2    Shtutman, M.3    Ben-Ze'ev, A.4    Oren, M.5
  • 28
    • 40749092119 scopus 로고    scopus 로고
    • Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
    • 1:CAS:528:DC%2BD1cXivVajtLg%3D 2258783 18160717 10.1128/MCB.01360-07
    • Xu M, Yu Q, Subrahmanyam R, Difilippantonio MJ, Ried T, Sen JM (2008) Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol 28:1713-1723
    • (2008) Mol Cell Biol , vol.28 , pp. 1713-1723
    • Xu, M.1    Yu, Q.2    Subrahmanyam, R.3    Difilippantonio, M.J.4    Ried, T.5    Sen, J.M.6
  • 29
    • 0035854803 scopus 로고    scopus 로고
    • Lithium Inhibits Cell Cycle Progression and Induces Stabilization of p53 in Bovine Aortic Endothelial Cells
    • DOI 10.1074/jbc.M101188200
    • Mao CD, Hoang P, DiCorleto PE (2001) Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells. J Biol Chem 276:26180-26188 (Pubitemid 37412831)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.28 , pp. 26180-26188
    • Mao, C.D.1    Hoang, P.2    DiCorleto, P.E.3
  • 30
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
    • 1:CAS:528:DC%2BC3cXpvVensA%3D%3D
    • Demidenko ZN, Blagosklonny MV (2009) Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging (Albany NY) 1:1008-1016
    • (2009) Aging (Albany NY) , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 31
    • 80053063127 scopus 로고    scopus 로고
    • Maintaining embryonic stem cell pluripotency with Wnt signaling
    • 1:CAS:528:DC%2BC3MXhsV2nt7nK 21903672 10.1242/dev.066209
    • Sokol SY (2011) Maintaining embryonic stem cell pluripotency with Wnt signaling. Development 138:4341-4350
    • (2011) Development , vol.138 , pp. 4341-4350
    • Sokol, S.Y.1
  • 32
    • 34547924424 scopus 로고    scopus 로고
    • Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    • DOI 10.1126/science.1144090
    • Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA (2007) Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317:807-810 (Pubitemid 47257918)
    • (2007) Science , vol.317 , Issue.5839 , pp. 807-810
    • Brack, A.S.1    Conboy, M.J.2    Roy, S.3    Lee, M.4    Kuo, C.J.5    Keller, C.6    Rando, T.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.