Increased expression of secreted frizzled-related protein 4 in polycystic kidneys

Journal of the American Society of Nephrology

Volumn 20, Issue 1, 2009, Pages 48-56

  Romaker, Daniel ^a   Puetz, Michael ^a   Teschner, Sven ^a   Donauer, Johannes ^a   Geyer, Marcel ^a   Gerke, Peter ^a   Rumberger, Brigitta ^a   Dworniczak, Bernd ^b   Pennekamp, Petra ^b   Buchholz, Björn ^c   Neumann, H P H ^a   Kumar, Rajiv ^d   Gloy, Joachim ^a   Eckardt, Kai Uwe ^c   Walz, Gerd ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Department of Human Genetics ^*  (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; SECRETED FRIZZLED RELATED PROTEIN 4; VASOPRESSIN RECEPTOR ANTAGONIST; VASOPRESSIN V2 RECEPTOR; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CYST FLUID; DISEASE COURSE; DISEASE MARKER; EMBRYO; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY EPITHELIUM; KIDNEY PARENCHYMA; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; MOUSE; NONHUMAN; PATIENT MONITORING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; PROTEIN URINE LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ZEBRA FISH;

EID: 58149496651     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008040345     Document Type: Article

References (52)

1. Grantham JJ: The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: Recent advances. Am J Kidney Dis 28: 788-803, 1996
2. Wilson PD: Polycystic kidney disease. N Engl J Med 350: 151-164, 2004
3. Woo D: Apoptosis and loss of renal tissue in polycystic kidney diseases. N Engl J Med 333: 18-25, 1995
4. Wilson PD: Epithelial cell polarity and disease. Am J Physiol 272: F434-F442, 1997
5. Jones SE, Jomary C: Secreted Frizzled-related proteins: Searching for relationships and patterns. Bioessays 24: 811-820, 2002
6. Kawano Y, Kypta R: Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116: 2627-2634, 2003
7. Dennis S, Aikawa M, Szeto W, d'Amore PA, Papkoff J: A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling. J Cell Sci 112: 3815-3820, 1999
8. Benzing T, Simons M, Walz G: Wnt signaling in polycystic kidney disease. J Am Soc Nephrol 18: 1389-1398, 2007
9. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA: Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem 274: 16180-16187, 1999
10. Saadi-Kheddouci S, Berrebi D, Romagnolo B, Cluzeaud F, Peuchmaur M, Kahn A, Vandewalle A, Perret C: Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. Oncogene 20: 5972-5981, 2001
11. Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO: Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem 280: 3938-3945, 2005
12. Schieren G, Rumberger B, Klein M, Kreutz C, Wilpert J, Geyer M, Faller D, Timmer J, Quack I, Rump LC, Walz G, Donauer J: Gene profiling of polycystic kidneys. Nephrol Dial Transplant 21: 1816-1824, 2006
13. Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B: The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol 12: 938-943, 2002
14. Olbrich H, Fliegauf M, Hoefele J, Kispert A, Otto E, Volz A, Wolf MT, Sasmaz G, Trauer U, Reinhardt R, Sudbrak R, Antignac C, Gretz N, Walz G, Schermer B, Benzing T, Hildebrandt F, Omran H: Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapetoretinal degeneration and hepatic fibrosis. Nat Genet 34: 455-459, 2003
15. Grantham JJ, Ye M, Gattone VH 2nd, Sullivan LP: In vitro fluid secretion by epithelium from polycystic kidneys. J Clin Invest 95: 195-202, 1995
16. Yamaguchi T, Nagao S, Takahashi H, Ye M, Grantham JJ: Cyst fluid from a murine model of polycystic kidney disease stimulates fluid secretion, cyclic adenosine monophosphate accumulation, and cell proliferation by Madin-Darby canine kidney cells in vitro. Am J Kidney Dis 25: 471-477, 1995
17. Yam JW, Chan KW, Wong VK, Hsiao WL: Transcriptional activity of the promoter region of rat frizzled-related protein gene. Biochem Biophys Res Commun 286: 94-100, 2001
18. Wong VK, Yam JW, Hsiao WL: Cloning and characterization of the promoter region of the mouse frizzled-related protein 4 gene. Biol Chem 384: 1147-1154, 2003
19. Gattone VH 2nd, Wang X, Harris PC, Torres VE: Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat Med 9: 1323-1326, 2003
20. Torres VE, Wang X, Qian Q, Somlo S, Harris PC, Gattone VH 2nd: Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med 10: 363-364, 2004
21. Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O: Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Lab Invest 79: 439-447, 1999
22. Drummond IA: Kidney development and disease in the zebrafish. J Am Soc Nephrol 16: 299-304, 2005
23. Perner B, Englert C, Bollig F: The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Dev Biol 309: 87-96, 2007
24. Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N: A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131: 4085-4093, 2004
25. Fu X, Wang Y, Schetle N, Gao H, Putz M, von Gersdorff G, Walz G, Kramer-Zucker AG: The subcellular localization of TRPP2 modulates its function. J Am Soc Nephrol 19: 1342-1351, 2008
26. Yoshino K, Rubin JS, Higinbotham KG, Uren A, Anest V, Plisov SY, Perantoni AO: Secreted Frizzled-related proteins can regulate metanephric development. Mech Dev 102: 45-55, 2001
27. Lee HX, Ambrosio AL, Reversade B, De Robertis EM: Embryonic dorsal-ventral signaling: Secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell 124: 147-159, 2006
28. He J, Sheng T, Stelter AA, Li C, Zhang X, Sinha M, Luxon BA, Xie J: Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J Biol Chem 281: 35598-35602, 2006
29. Zhou Z, Wang J, Han X, Zhou J, Linder S: Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. Int J Cancer 78: 95-99, 1998
30. Ellies DL, Church V, Francis-West P, Lumsden A: The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain. Development 127: 5285-5295, 2000
31. Jones SE, Jomary C, Grist J, Stewart HJ, Neal MJ: Modulated expression of secreted frizzled-related proteins in human retinal degeneration. Neuroreport 11: 3963-3967, 2000
32. Schumann H, Holtz J, Zerkowski HR, Hatzfeld M: Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. Cardiovasc Res 45: 720-728, 2000
33. Dufourcq P, Couffinhal T, Ezan J, Barandon L, Moreau C, Daret D, Duplaa C: FrzA, a secreted frizzled related protein, induced angiogenic response. Circulation 106: 3097-3103, 2002
34. Ko J, Ryu KS, Lee YH, Na DS, Kim YS, Oh YM, Kim IS, Kim JW: Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. Exp Cell Res 280: 280-287, 2002
35. Drake JM, Friis RR, Dharmarajan AM: The role of sFRP4, a secreted frizzled-related protein, in ovulation. Apoptosis 8: 389-397, 2003
36. Lacher MD, Siegenthaler A, Jager R, Yan X, Hett S, Xuan L, Saurer S, Lareu RR, Dharmarajan AM, Friis R: Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution. Cell Death Differ 10: 528-538, 2003
37. Bodine PV, Billiard J, Moran RA, Ponce-de-Leon H, McLarney S, Mangine A, Scrimo MJ, Bhat RA, Stauffer B, Green J, Stein GS, Lian JB, Komm BS: The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. J Cell Biochem 96, 1212-1230, 2005
38. Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG: A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13: 1490-1495, 2007
39. Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, Jablons DM: Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene 23: 6672-6676, 2004
40. Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36: 417-422, 2004
41. Urakami S, Shiina H, Enokida H, Hirata H, Kawamoto K, Kawakami T, Kikuno N, Tanaka Y, Majid S, Nakagawa M, Igawa M, Dahiya R: Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA. Clin Cancer Res 12: 6989-6997, 2006
42. Lee JL, Chang CJ, Chueh LL, Lin CT: Expression of secreted frizzled-related protein 2 in a primary canine mammary tumor cell line: A candidate tumor marker for mammary tumor cells. In Vitro Cell Dev Biol Anim 39, 221-227, 2003
43. Lee JL, Chang CJ, Wu SY, Sargan DR, Lin CT: Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands. Breast Cancer Res Treat 84: 139-149, 2004
44. Fliegauf M, Benzing T, Omran H: When cilia go bad: Cilia defects and ciliopathies. Nat Rev Mol Cell Biol 8: 880-893, 2007
45. Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, Beachy PA, Beales PL, Demartino GN, Fisher S, Badano JL, Katsanis N: Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet 39: 1350-1360, 2007
46. Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Reiter JF: Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol 10: 70-76, 2008
47. Barandon L, Couffinhal T, Ezan J, Dufourcq P, Costet P, Alzieu P, Leroux L, Moreau C, Dare D, Duplaa C: Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. Circulation 108: 2282-2289, 2003
48. Schneider I, Houston DW, Rebagliati MR, Slusarski DC: Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterning. Development 135: 75-84, 2008
49. Adachi J, Kumar C, Zhang Y, Olsen JV, Mann M: The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol 7: R80, 2006
50. Berndt T, Craig TA, Bowe AE, Vassiliadis J, Reczek D, Finnegan R, Jan De Beur SM, Schiavi SC, Kumar R: Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 112: 785-794, 2003
51. Donauer J, Rumberger B, Klein M, Faller D, Wilpert J, Sparna T, Schieren G, Rohrbach R, Dern P, Timmer J, Pisarski P, Kirste G, Walz G: Expression profiling on chronically rejected transplant kidneys. Transplantation 76: 539-547, 2003
52. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Kronig C, Schermer B, Benzing T, Cabello OA, Jenny A, Mlodzik M, Polok B, Driever W, Obara T, Walz G: Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 37: 537-543, 2005