Wnt signalling in kidney diseases: Dual roles in renal injury and repair

Journal of Pathology

Volumn 229, Issue 2, 2013, Pages 221-231

  Kawakami, Takahisa ^a   Ren, Shuyu ^a   Duffield, Jeremy S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

catenin; acute kidney injury; diabetic nephropathy; fibrosis; macrophage; podocyte; polycystic kidney disease; regeneration; Wnt

Indexed keywords

BETA CATENIN;

ACUTE KIDNEY FAILURE; DIABETIC NEPHROPATHY; FIBROSING ALVEOLITIS; HUMAN; KIDNEY; KIDNEY DISEASE; KIDNEY POLYCYSTIC DISEASE; MACROPHAGE; MESANGIUM CELL; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; REGENERATION; REVIEW; WNT SIGNALING PATHWAY;

ACUTE KIDNEY INJURY; ANIMALS; HUMANS; KIDNEY; KIDNEY DISEASES; MACROPHAGES; POLYCYSTIC KIDNEY DISEASES; REGENERATION; WNT SIGNALING PATHWAY;

EID: 84871093351     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4121     Document Type: Review

References (64)

1. Nusse R, van Ooyen A, Cox D, et al,. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 1984; 307: 131-136. (Pubitemid 14132897)
2. Rijsewijk F, Schuermann M, Wagenaar E, et al,. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 1987; 50: 649-657.
3. Kinzler KW, Nilbert MC, Su LK, et al,. Identification of FAP locus genes from chromosome 5q21. Science 1991; 253: 661-665. (Pubitemid 21917199)
4. Nishisho I, Nakamura Y, Miyoshi Y, et al,. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991; 253: 665-669. (Pubitemid 21917200)
5. Reya T, Clevers H,. Wnt signalling in stem cells and cancer. Nature 2005; 434: 843-850. (Pubitemid 40558990)
6. Schmidt-Ott KM, Barasch J,. WNT/β-catenin signaling in nephron progenitors and their epithelial progeny. Kidney Int 2008; 74: 1004-1008.
7. Pietila I, Ellwanger K, Railo A, et al,. Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7β signalling. Dev Biol 2011; 353: 50-60.
8. Takada R, Satomi Y, Kurata T, et al,. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell 2006; 11: 791-801. (Pubitemid 44804277)
9. Clevers H, Nusse R,. Wnt/beta-Catenin Signaling and Disease. Cell 2012; 149: 1192-1205.
10. Bhanot P, Brink M, Samos CH, et al,. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 1996; 382: 225-230.
11. Wehrli M, Dougan ST, Caldwell K, et al,. Arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 2000; 407: 527-530.
12. Siegfried E, Chou TB, Perrimon N., Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 1992; 71: 1167- 1179. (Pubitemid 23016551)
13. Peifer M, Sweeton D, Casey M, et al,. Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 1994; 120: 369-380. (Pubitemid 24042404)
14. Ikeda S, Kishida S, Yamamoto H, et al,. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin. EMBO J 1998; 17: 1371-1384. (Pubitemid 28105516)
15. Rubinfeld B, Souza B, Albert I, et al,. Association of the APC gene product with β-catenin. Science 1993; 262: 1731-1734. (Pubitemid 24030096)
16. Noordermeer J, Klingensmith J, Perrimon N, et al,. Dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature 1994; 367: 80-83.
17. Peters JM, McKay RM, McKay JP, et al,. Casein kinase I transduces Wnt signals. Nature 1999; 401: 345-350. (Pubitemid 29454951)
18. Aberle H, Bauer A, Stappert J, et al,. β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997; 16: 3797-3804.
19. Jiang J, Struhl G,. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 1998; 391: 493-496. (Pubitemid 28086550)
20. He X, Semenov M, Tamai K, et al,. LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development 2004; 131: 1663-1677. (Pubitemid 38559836)
21. Tamai K, Semenov M, Kato Y, et al,. LDL-receptor-related proteins in Wnt signal transduction. Nature 2000; 407: 530-535.
22. Li VS, Ng SS, Boersema PJ, et al,. Wnt signaling through Inhibition of β-catenin degradation in an intact Axin1 complex. Cell 2012; 149: 1245-1256.
23. Behrens J, von Kries JP, Kuhl M, et al,. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 1996; 382: 638-642. (Pubitemid 26268958)
24. Glinka A, Wu W, Delius H, et al,. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998; 391: 357-362. (Pubitemid 28093502)
25. Rattner A, Hsieh JC, Smallwood PM, et al,. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci USA 1997; 94: 2859-2863. (Pubitemid 27157229)
26. Pennica D, Swanson TA, Welsh JW, et al,. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci USA 1998; 95: 14717-14722. (Pubitemid 29003696)
27. Pece S, Chiariello M, Murga C, et al,. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem 1999; 274: 19347-19351.
28. Kohn AD, Moon RT,. Wnt and calcium signaling: β-catenin-independent pathways. Cell Calcium 2005; 38: 439-446. (Pubitemid 41283282)
29. Carroll TJ, Das A,. Planar cell polarity in kidney development and disease. Organogenesis 2011; 7: 180-190.
30. Minami Y, Oishi I, Endo M, et al,. Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev Dyn 2010; 239: 1-15.
31. Fradkin LG, Dura JM, Noordermeer JN,. Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci 2010; 33: 84-92.
32. Mehta RL, Kellum JA, Shah SV, et al,. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31.
33. Waikar SS, Liu KD, Chertow GM,. The incidence and prognostic significance of acute kidney injury. Curr Opin Nephrol Hypertens 2007; 16: 227-236. (Pubitemid 46608530)
34. Lin SL, Li B, Rao S, et al,. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci USA 2010; 107: 4194-4199.
35. Terada Y, Tanaka H, Okado T, et al,. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol 2003; 14: 1223-1233. (Pubitemid 36514664)
36. Surendran K, Simon TC, Liapis H, et al,. Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int 2004; 65: 2212-2222. (Pubitemid 38670007)
37. Zhou D, Li Y, Lin L, et al,. Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney Int 2012; 82: 537-547.
38. Matsui I, Ito T, Kurihara H, et al,. Snail, a transcriptional regulator, represses nephrin expression in glomerular epithelial cells of nephrotic rats. Lab Invest 2007; 87: 273-283. (Pubitemid 46353945)
39. Dai C, Stolz DB, Kiss LP, et al,. Wnt/β-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 2009; 20: 1997-2008.
40. Kato H, Gruenwald A, Suh JH, et al,. Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 2011; 286: 26003-26015.
41. Teixeira Vde P, Blattner SM, Li M, et al,. Functional consequences of integrin-linked kinase activation in podocyte damage. Kidney Int 2005; 67: 514-523. (Pubitemid 40139843)
42. Heikkila E, Juhila J, Lassila M, et al,. β-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys. Nephrol Dial Transpl 2010; 25: 2437-2446.
43. Kim MS, Yoon SK, Bollig F, et al,. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. J Biol Chem 2010; 285: 14585-14593.
44. Alpers CE, Hudkins KL,. Mouse models of diabetic nephropathy. Curr Opin Nephrol Hypertens 2011; 20: 278-284.
45. Lin CL, Wang JY, Huang YT, et al,. Wnt/β-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol 2006; 17: 2812-2820.
46. Lin CL, Cheng H, Tung CW, et al,. Simvastatin reverses high glucose-induced apoptosis of mesangial cells via modulation of Wnt signaling pathway. Am J Nephrol 2008; 28: 290-297.
47. Rooney B, O'Donovan H, Gaffney A, et al,. CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy. FEBS Lett 2011; 585: 531-538.
48. Duffield JS, Humphreys BD,. Origin of new cells in the adult kidney: results from genetic labeling techniques. Kidney Int 2011; 79: 494-501.
49. Kida Y, Duffield JS,. Pivotal role of pericytes in kidney fibrosis. Clin Exp Pharmacol Physiol 2011; 38: 467-473.
50. Schrimpf C, Duffield JS,. Mechanisms of fibrosis: the role of the pericyte. Curr Opin Nephrol Hypertens 2011; 20: 297-305.
51. Surendran K, Schiavi S, Hruska KA,. Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16: 2373-2384. (Pubitemid 41725055)
52. He W, Dai C, Li Y, et al,. Wnt/β-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009; 20: 765-776.
53. He W, Kang YS, Dai C, et al,. Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 2011; 22: 90-103.
54. 3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling. J Cell Biol 2001; 154: 369-387. (Pubitemid 34286147)
55. Lam AP, Gottardi CJ., β-Catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol 2011; 23: 562-567.
56. Wuebken A, Schmidt-Ott KM,. WNT/β-catenin signaling in polycystic kidney disease. Kidney Int 2011; 80: 135-138.
57. Saadi-Kheddouci S, Berrebi D, Romagnolo B, et al,. Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the β-catenin gene. Oncogene 2001; 20: 5972-5981. (Pubitemid 32955039)
58. Qian CN, Knol J, Igarashi P, et al,. Cystic renal neoplasia following conditional inactivation of APC in mouse renal tubular epithelium. J Biol Chem 2005; 280: 3938-3945. (Pubitemid 40223863)
59. Kim I, Ding T, Fu Y, et al,. Conditional mutation of Pkd2 causes cystogenesis and upregulates β-catenin. J Am Soc Nephrol 2009; 20: 2556-2569.
60. Miller MM, Iglesias DM, Zhang Z, et al,. T cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease. Kidney Int 2011; 80: 146-153.
61. Lancaster MA, Louie CM, Silhavy JL, et al,. Impaired Wnt-β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med 2009; 15: 1046-1054.
62. Mao B, Wu W, Davidson G, et al,. Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling. Nature 2002; 417: 664-667. (Pubitemid 34614827)
63. Mao B, Niehrs C,. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 2003; 302: 179-183. (Pubitemid 36078410)
64. Mao B, Wu W, Li Y, et al,. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001; 411: 321-325. (Pubitemid 32467039)