메뉴 건너뛰기




Volumn , Issue , 2014, Pages 207-230

Hepatitis C

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84955070241     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-319-02096-9_15     Document Type: Chapter
Times cited : (1)

References (232)
  • 1
    • 78751621217 scopus 로고    scopus 로고
    • Evolving epidemiology of hepatitis c virus
    • Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect. 2011;17:107-15.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 107-115
    • Lavanchy, D.1
  • 2
    • 54549127290 scopus 로고    scopus 로고
    • Surveillance and epidemiology of hepatitis b and c in europe—a review
    • Rantala M, van de Laar MJ. Surveillance and epidemiology of hepatitis B and C in Europe—a review. Eurosorveillance. 2008; 13(4-6). http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=18880; http://ecdc.europa.eu/en/publications/Publications/TER_100914_Hep_B_C%20_EU_neighbourhood. pdf
    • (2008) Eurosorveillance , vol.13 , Issue.4-6
    • Rantala, M.1    Van De Laar, M.J.2
  • 3
    • 77954761711 scopus 로고    scopus 로고
    • Acute hepatitis c in hiv-infected men who have sex with men: An emerging sexually transmitted infection
    • van de Laar TJ, Matthews GV, Prins M, Danta M. Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection. AIDS. 2010;24:1799-812.
    • (2010) AIDS , vol.24 , pp. 1799-1812
    • Van De Laar, T.J.1    Matthews, G.V.2    Prins, M.3    Danta, M.4
  • 4
    • 0347302936 scopus 로고    scopus 로고
    • The global burden of disease attributable to contaminated injections given in health care settings
    • Hauri AM, Armstrong GL, Hutin YJ. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS. 2004;15:7-16.
    • (2004) Int J STD AIDS , vol.15 , pp. 7-16
    • Hauri, A.M.1    Armstrong, G.L.2    Hutin, Y.J.3
  • 5
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in il28b and spontaneous clearance of hepatitis c virus
    • Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O’Huigin C, Kidd J, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461:798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3    Qi, Y.4    Ge, D.5    O’huigin, C.6    Kidd, J.7
  • 7
    • 36348950196 scopus 로고    scopus 로고
    • Hepatitic c genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: A seventeen-year prospective cohort study
    • Bruno S, Crosignani A, Maisonneuve P, Rossi S, Silini E, Mondelli MU. Hepatitic C genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study. Hepatology. 2007; 46(5):1350-6.
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1350-1356
    • Bruno, S.1    Crosignani, A.2    Maisonneuve, P.3    Rossi, S.4    Silini, E.5    Mondelli, M.U.6
  • 8
    • 67349105629 scopus 로고    scopus 로고
    • Hepatitis c virus genotype 1b as a risk factor for hepatocellular carcinoma development: A meta-analysis
    • Raimondi S, Bruno S, Mondelli MU, Maisonneuve P. Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis. J Hepatol. 2009;50:1142-54.
    • (2009) J Hepatol , vol.50 , pp. 1142-1154
    • Raimondi, S.1    Bruno, S.2    Mondelli, M.U.3    Maisonneuve, P.4
  • 10
    • 14544284040 scopus 로고    scopus 로고
    • Hepatitis c reactivation in patients with chronic infection with genotype 1b and 2c: A retrospective cohort study of 206 untreated patients
    • Rumi MG, De Filippi F, La Vecchia C, Donato MF, Gallus S, Del Ninno E, Colombo M. Hepatitis C reactivation in patients with chronic infection with genotype 1b and 2c: a retrospective cohort study of 206 untreated patients. Gut. 2005;54(3):402-6.
    • (2005) Gut , vol.54 , Issue.3 , pp. 402-406
    • Rumi, M.G.1    De Filippi, F.2    La Vecchia, C.3    Donato, M.F.4    Gallus, S.5    Del Ninno, E.6    Colombo, M.7
  • 11
    • 84863663083 scopus 로고    scopus 로고
    • Hcv genotype are differently prone to the development of resistance to linear and macrocyclic protease inhibitors
    • Cento V, Mirabelli C, Salpini R, Dimonte S, Artese A, Costa G, Mercurio F, et al. HCV genotype are differently prone to the development of resistance to linear and macrocyclic protease inhibitors. PLos One. 2012;7:e39652.
    • (2012) Plos One , vol.7
    • Cento, V.1    Mirabelli, C.2    Salpini, R.3    Dimonte, S.4    Artese, A.5    Costa, G.6    Mercurio, F.7
  • 12
    • 79951669627 scopus 로고    scopus 로고
    • Hepatitis c virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies
    • Zeisel MB, Fofana I, Fafi-Kremer S, Baumert TF. Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies. J Hepatol. 2011;54:566-76.
    • (2011) J Hepatol , vol.54 , pp. 566-576
    • Zeisel, M.B.1    Fofana, I.2    Fafi-Kremer, S.3    Baumert, T.F.4
  • 13
    • 19044396066 scopus 로고    scopus 로고
    • Characterization of low- and very low-density hepatitis c virus rna-containing particles
    • Andrè P, Komurian-Pradel F, Deforges S, Perret M, Berland JL, Sodoyer M, Pol S, et al. Characterization of low- and very low-density hepatitis C virus RNA-containing particles. J Virol. 2002;76(14):6919-28.
    • (2002) J Virol , vol.76 , Issue.14 , pp. 6919-6928
    • Andrè, P.1    Komurian-Pradel, F.2    Deforges, S.3    Perret, M.4    Berland, J.L.5    Sodoyer, M.6    Pol, S.7
  • 15
    • 84866943211 scopus 로고    scopus 로고
    • The p7 protein of hepatitis c virus forms structurally plastic, minimalist ion channels
    • Chandler DE, Penin F, Schulten K, Chipot C. The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels. PLoS Comput Biol. 2012;8:e1002702.
    • (2012) Plos Comput Biol , vol.8
    • Chandler, D.E.1    Penin, F.2    Schulten, K.3    Chipot, C.4
  • 16
    • 78951472458 scopus 로고    scopus 로고
    • Hepatitis c virus ns2 coordinates virus particle assembly through physical interactions with the e1-e2 glycoprotein and ns3-ns4a enzyme complexes
    • Stapleford KA, Lindenbach BD. Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol. 2011;85:1706-17.
    • (2011) J Virol , vol.85 , pp. 1706-1717
    • Stapleford, K.A.1    Lindenbach, B.D.2
  • 18
    • 77649175920 scopus 로고    scopus 로고
    • Hepatitis c virus nonstruc-tural protein 4b: A journey into unexplored territory
    • Gouttenoire J, Penin F, Moradpour D. Hepatitis C virus nonstruc-tural protein 4B: a journey into unexplored territory. Rev Med Virol. 2010;20:117-29.
    • (2010) Rev Med Virol , vol.20 , pp. 117-129
    • Gouttenoire, J.1    Penin, F.2    Moradpour, D.3
  • 20
    • 50549094817 scopus 로고    scopus 로고
    • Acute hepatitis c: Current status and remaining challenges
    • Santantonio T, Wiegand J, Gerlach JT. Acute hepatitis C: current status and remaining challenges. J Hepatol. 2008;49:625-33.
    • (2008) J Hepatol , vol.49 , pp. 625-633
    • Santantonio, T.1    Wiegand, J.2    Gerlach, J.T.3
  • 21
    • 0037222767 scopus 로고    scopus 로고
    • Spontaneous viral clearance in patients with acute hepatitis c can be predicted by repeated measurements of serum viral load
    • Hofer H, Watkins-Riedel T, Janata O, Penner E, Holzmann H, Steindl-Munda P, Gangi A, et al. Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load. Hepatology. 2003;37:60-4.
    • (2003) Hepatology , vol.37 , pp. 60-64
    • Hofer, H.1    Watkins-Riedel, T.2    Janata, O.3    Penner, E.4    Holzmann, H.5    Steindl-Munda, P.6    Gangi, A.7
  • 22
    • 82955163230 scopus 로고    scopus 로고
    • Ribavirin for the treatment of chronic hepatitis c virus infection: A review of the proposed mechanisms of action
    • Paeshuyse J, Dallmeier K, Neyts J. Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action. Curr Opin Virol. 2011;1:590-8.
    • (2011) Curr Opin Virol , vol.1 , pp. 590-598
    • Paeshuyse, J.1    Dallmeier, K.2    Neyts, J.3
  • 24
    • 84855242247 scopus 로고    scopus 로고
    • What’s new in hcv genotype 2 treatment
    • Mangia A, Mottola L. What’s new in HCV genotype 2 treatment. Liver Int. 2012;32 Suppl 1:135-40.
    • (2012) Liver Int , vol.32 , pp. 135-140
    • Mangia, A.1    Mottola, L.2
  • 25
    • 84855240877 scopus 로고    scopus 로고
    • Treatment of patients with genotype 3 chronic hepatitis c—current and future therapies
    • Sarin SK, Kumar CK. Treatment of patients with genotype 3 chronic hepatitis C—current and future therapies. Liver Int. 2012;32 Suppl 1:141-5.
    • (2012) Liver Int , vol.32 , pp. 141-145
    • Sarin, S.K.1    Kumar, C.K.2
  • 26
  • 27
    • 84860322902 scopus 로고    scopus 로고
    • New direct-acting antiviral agents for the treatment of hepatitis c virus infection and perspectives
    • Welsch C, Jesudian A, Zeuzem S, Jacobson I. New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives. Gut. 2012;61 Suppl 1:136-46.
    • (2012) Gut , vol.61 , pp. 136-146
    • Welsch, C.1    Jesudian, A.2    Zeuzem, S.3    Jacobson, I.4
  • 28
    • 58049193003 scopus 로고    scopus 로고
    • Microbe sensing, positive feedback loops and the pathogenesis of inflammator diseases
    • Beutler B. Microbe sensing, positive feedback loops and the pathogenesis of inflammator diseases. Immunol Rev. 2009; 227:248-63.
    • (2009) Immunol Rev , vol.227 , pp. 248-263
    • Beutler, B.1
  • 29
    • 63649108380 scopus 로고    scopus 로고
    • The roles of tlrs, rlrs, and nlrs in pathogen recognition
    • Kawai T, Akira S. The roles of TLRs, RLRs, and NLRs in pathogen recognition. Int Immunol. 2009;21:317-37.
    • (2009) Int Immunol , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 31
    • 34347259525 scopus 로고    scopus 로고
    • Il-28 and il-29: Newcomers to the interferon family
    • Uze G, Monneron D. IL-28 and IL-29: newcomers to the interferon family. Biochimie. 2007;89:729-34.
    • (2007) Biochimie , vol.89 , pp. 729-734
    • Uze, G.1    Monneron, D.2
  • 32
    • 34548418137 scopus 로고    scopus 로고
    • Toll-like receptor 1 and 6 are involved in tlt2-mediated macrophage activation by hepatitis c virus core and ns3 protein
    • Chang S, Dolganiuc A, Szabo G. Toll-like receptor 1 and 6 are involved in TLT2-mediated macrophage activation by hepatitis C virus core and NS3 protein. J Leukoc Biol. 2007;82:479-87.
    • (2007) J Leukoc Biol , vol.82 , pp. 479-487
    • Chang, S.1    Dolganiuc, A.2    Szabo, G.3
  • 34
    • 84881517083 scopus 로고    scopus 로고
    • Human type 2 myeloid dendritic cells produce interferon-x and amplify interferon-a in response to hepatitis c virus infection
    • Zhang S, Kodys K, Li K, Szabo G. Human type 2 myeloid dendritic cells produce interferon-X and amplify interferon-a in response to hepatitis C virus infection. Gastroenterology. 2013;144:414-25. http://dx.xoi.org/10.1053/j.gastro.2012.10.034
    • (2013) Gastroenterology , vol.144 , pp. 414-425
    • Zhang, S.1    Kodys, K.2    Li, K.3    Szabo, G.4
  • 35
    • 84870567022 scopus 로고    scopus 로고
    • Il-29 is the dominant type iii interferon produced by hepatocytes during acute hepatitis c virus infection
    • Park H, Serti E, Eke O, Muchmore B, Prokunina-Olsson L, Capone S, Folgori A, Rehermann B. IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection. Hepatology. 2012;56:2060-70. http://dx.xoi.org/10.1002/hep.25897
    • (2012) Hepatology , vol.56 , pp. 2060-2070
    • Park, H.1    Serti, E.2    Eke, O.3    Muchmore, B.4    Prokunina-Olsson, L.5    Capone, S.6    Folgori, A.7    Rehermann, B.8
  • 36
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in il28b predicts hepatitis c treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461(7262): 399-401.
    • (2009) Nature , vol.461 , Issue.7262 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3    Simon, J.S.4    Shianna, K.V.5    Urban, T.J.6    Heinzen, E.L.7
  • 37
    • 33947730807 scopus 로고    scopus 로고
    • The newest interleukins: Recent additions to the ever-growing cytokine family
    • Chen Q, Carroll HP, Gadina M. The newest interleukins: recent additions to the ever-growing cytokine family. Vitam Horm. 2006;74:207-28.
    • (2006) Vitam Horm , vol.74 , pp. 207-228
    • Chen, Q.1    Carroll, H.P.2    Gadina, M.3
  • 40
    • 34547116656 scopus 로고    scopus 로고
    • Type i interferon receptors: Biochemistry and biological functions
    • de Weerd NA, Samarajiwa SA, Hertzog PJ. Type I interferon receptors: biochemistry and biological functions. J Biol Chem. 2007;282:20053-7.
    • (2007) J Biol Chem , vol.282 , pp. 20053-20057
    • De Weerd, N.A.1    Samarajiwa, S.A.2    Hertzog, P.J.3
  • 41
    • 80055038932 scopus 로고    scopus 로고
    • Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28b genotype in patients with chronic hepatitis c
    • Golden-Mason L, Bambha KM, Cheng L, Howell CD, Taylor MW, Clark PJ, Afdhal N, et al. Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology. 2011;54(5):1559-69.
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1559-1569
    • Golden-Mason, L.1    Bambha, K.M.2    Cheng, L.3    Howell, C.D.4    Taylor, M.W.5    Clark, P.J.6    Afdhal, N.7
  • 42
    • 0034948009 scopus 로고    scopus 로고
    • Dna microarray analysis of chimpanzee liver during acute resolving hepatitis c virus infection
    • Bigger CB, Brasky KM, Lanford RE. DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol. 2001;75:7059-66.
    • (2001) J Virol , vol.75 , pp. 7059-7066
    • Bigger, C.B.1    Brasky, K.M.2    Lanford, R.E.3
  • 44
    • 58149526773 scopus 로고    scopus 로고
    • Differential expression of the cxcr3 ligands in chronic hepatitis c virus (Hcv) infection and their modulation by hcv in vitro
    • Helbig KJ, Ruszkiewicz A, Lanford RE, Berzsenyi MD, Harley HA, McColl SR, Beard MR. Differential expression of the CXCR3 ligands in chronic hepatitis C virus (HCV) infection and their modulation by HCV in vitro. J Virol. 2009;83:836-46.
    • (2009) J Virol , vol.83 , pp. 836-846
    • Helbig, K.J.1    Ruszkiewicz, A.2    Lanford, R.E.3    Berzsenyi, M.D.4    Harley, H.A.5    Mc Coll, S.R.6    Beard, M.R.7
  • 45
    • 34548850886 scopus 로고    scopus 로고
    • Chemokines in hepatitis c virus infection:Pathogenesis, prognosis and therapeutics
    • Wald O, Weiss ID, Galun E, Peled A. Chemokines in hepatitis C virus infection:pathogenesis, prognosis and therapeutics. Cytokine. 2007;39:50-62.
    • (2007) Cytokine , vol.39 , pp. 50-62
    • Wald, O.1    Weiss, I.D.2    Galun, E.3    Peled, A.4
  • 46
    • 34347336666 scopus 로고    scopus 로고
    • The role of chemokines as inflammatory mediators in chronic hepatitis c infection
    • Zeremski M, Petrovic LM, Talai AH. The role of chemokines as inflammatory mediators in chronic hepatitis C infection. J Viral Hepat. 2007;14:675-87.
    • (2007) J Viral Hepat , vol.14 , pp. 675-687
    • Zeremski, M.1    Petrovic, L.M.2    Talai, A.H.3
  • 48
    • 1642371355 scopus 로고    scopus 로고
    • Increased circulating and intrahepatic t-cell-specific chemokines in chronic hepatitis c: Relationship with the type of virological response to peginterferon plus ribavirin combination therapy
    • Apolinario A, Diago M, Lo Iacono O, Lorente R, Perez C, Majano PL, Clemente G, et al. Increased circulating and intrahepatic T-cell-specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy. Aliment Pharmacol Ther. 2004;19:551-62.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 551-562
    • Apolinario, A.1    Diago, M.2    Lo Iacono, O.3    Lorente, R.4    Perez, C.5    Majano, P.L.6    Clemente, G.7
  • 50
    • 33749017951 scopus 로고    scopus 로고
    • Interferon (Ifn)-gamma-inducible protein-10: Association with histological results, viral kinetics, and outcome during treatment with pegylated ifn-alpha 2a and ribavirin for chronic hepatitis c virus infection
    • Romero AI, Lagging M, Westin J, Dhillon AP, Pawlotsky JM, Neumann AU, Ferrari C, et al. Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection. J Infect Dis. 2006;194:895-903.
    • (2006) J Infect Dis , vol.194 , pp. 895-903
    • Romero, A.I.1    Lagging, M.2    Westin, J.3    Dhillon, A.P.4    Pawlotsky, J.M.5    Neumann, A.U.6    Ferrari, C.7
  • 51
    • 33144462713 scopus 로고    scopus 로고
    • Association of pretreatment serum interferon inducible protein 10 levels with sustained virological response to peginterferon plus ribavirin therapy in genotype 1 infected patients with chronic hepatitis c
    • Diago M, Castellano G, Garcia-Samaniego J, Perez C, Fernandez I, Romero M, Iacono OL, et al. Association of pretreatment serum interferon inducible protein 10 levels with sustained virological response to peginterferon plus ribavirin therapy in genotype 1 infected patients with chronic hepatitis C. Gut. 2006;55:374-9.
    • (2006) Gut , vol.55 , pp. 374-379
    • Diago, M.1    Castellano, G.2    Garcia-Samaniego, J.3    Perez, C.4    Fernandez, I.5    Romero, M.6    Iacono, O.L.7
  • 52
    • 0035111193 scopus 로고    scopus 로고
    • Increase of chemokine interferon-inducible protein-10 (Ip-10) in the serum of patients with autoimmune liver diseases and increase of its mrna expression in hepatocytes
    • Nishioji K, Okanoue T, Itoh Y, Narumi S, Sakamoto M, Nakamura H, Morita A, et al. Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes. Clin Exp Immunol. 2001;123:271-9.
    • (2001) Clin Exp Immunol , vol.123 , pp. 271-279
    • Nishioji, K.1    Okanoue, T.2    Itoh, Y.3    Narumi, S.4    Sakamoto, M.5    Nakamura, H.6    Morita, A.7
  • 53
    • 0035723756 scopus 로고    scopus 로고
    • Clinical significance of elevated serum interferon-inducible protein-10 levels in hepatitis c virus carriers with persistently normal serum transaminase levels
    • Itoh Y, Morita A, Nishioji K, Narumi S, Toyama T, Daimon Y, Nakamura H, et al. Clinical significance of elevated serum interferon-inducible protein-10 levels in hepatitis C virus carriers with persistently normal serum transaminase levels. J Viral Hepat. 2001;8:341-8.
    • (2001) J Viral Hepat , vol.8 , pp. 341-348
    • Itoh, Y.1    Morita, A.2    Nishioji, K.3    Narumi, S.4    Toyama, T.5    Daimon, Y.6    Nakamura, H.7
  • 54
    • 33344476398 scopus 로고    scopus 로고
    • Caterpillers, pyrin and hereditary immunological disorders
    • Ting JP, Kastner DL, Hoffman HM. CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol. 2006;6: 183-5.
    • (2006) Nat Rev Immunol , vol.6 , pp. 183-185
    • Ting, J.P.1    Kastner, D.L.2    Hoffman, H.M.3
  • 55
  • 56
    • 78149332071 scopus 로고    scopus 로고
    • Interleukin-1p, c-x-c motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis
    • Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, et al. Interleukin-1p, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis. J Interferon Cytokine Res. 2010;30:835-42.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 835-842
    • Antonelli, A.1    Ferri, C.2    Ferrari, S.M.3    De Marco, S.4    Di Domenicantonio, A.5    Centanni, M.6    Pupilli, C.7
  • 57
    • 25844504659 scopus 로고    scopus 로고
    • The concentration of sfasl, ice and il1beta in the serum and the liver tissue of chronic hcv infected patients
    • Lapinski TW. The concentration of sFasL, ICE and IL1beta in the serum and the liver tissue of chronic HCV infected patients. Hepatogastroenterology. 2005;52:1479-83.
    • (2005) Hepatogastroenterology , vol.52 , pp. 1479-1483
    • Lapinski, T.W.1
  • 58
    • 84955093984 scopus 로고    scopus 로고
    • Hepatic inflammation and disease severity during hepatitis c virus infection is linked with macrophage il-1p production through the nlrp3 inflammasome
    • Venice, 5-9 Oct 2012. Oral Presentation O.09. Abstract book
    • Negash A, Crochet N, Ramos HJ, Doehle B, Lau D, Papic N, Curt H, et al. Hepatic inflammation and disease severity during hepatitis C virus infection is linked with macrophage IL-1p production through the NLRP3 inflammasome. In: 19th International symposium on hepatitis C virus and related viruses, Venice, 5-9 Oct 2012. Oral Presentation O.09. Abstract book. www.hcv2012.org
    • 19Th International Symposium on Hepatitis C Virus and Related Viruses
    • Negash, A.1    Crochet, N.2    Ramos, H.J.3    Doehle, B.4    Lau, D.5    Papic, N.6    Curt, H.7
  • 60
    • 77953601881 scopus 로고    scopus 로고
    • Regulation of innate immune responses by autophagy-related proteins
    • Saitoh T, Akira S. Regulation of innate immune responses by autophagy-related proteins. J Cell Biol. 2010;189(6):925-35.
    • (2010) J Cell Biol , vol.189 , Issue.6 , pp. 925-935
    • Saitoh, T.1    Akira, S.2
  • 61
    • 73849087396 scopus 로고    scopus 로고
    • Autophagy in viral replication and pathogenesis
    • Sir D, Ou JH. Autophagy in viral replication and pathogenesis. Mol Cells. 2010;29(1):1-7.
    • (2010) Mol Cells , vol.29 , Issue.1 , pp. 1-7
    • Sir, D.1    Ou, J.H.2
  • 62
    • 0036314483 scopus 로고    scopus 로고
    • Hepatitis c virus subgenomic rep-licons induce endoplasmic reticulum stress activating an intracellular signaling pathway
    • Tardif KD, Mori K, Siddiqui A. Hepatitis C virus subgenomic rep-licons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol. 2002;76(15):7453-9.
    • (2002) J Virol , vol.76 , Issue.15 , pp. 7453-7459
    • Tardif, K.D.1    Mori, K.2    Siddiqui, A.3
  • 64
    • 54449101892 scopus 로고    scopus 로고
    • Induction of incomplete autophagic response by hepatitis c virus via the unfolded protein response
    • Sir D, Chen WL, Choi J, Wakita T, Yen TS, Ou JH. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology. 2008;48(4):1054-61.
    • (2008) Hepatology , vol.48 , Issue.4 , pp. 1054-1061
    • Sir, D.1    Chen, W.L.2    Choi, J.3    Wakita, T.4    Yen, T.S.5    Ou, J.H.6
  • 65
    • 79955689690 scopus 로고    scopus 로고
    • Autophagy: A novel guardian of hcv against innate immune response
    • Ke PY, Chen SS. Autophagy: a novel guardian of HCV against innate immune response. Autophagy. 2011;7(5):533-5.
    • (2011) Autophagy , vol.7 , Issue.5 , pp. 533-535
    • Ke, P.Y.1    Chen, S.S.2
  • 66
    • 79251512287 scopus 로고    scopus 로고
    • Knockdown of autophagy enhances the innate immune response in hepatitis c virus-infected hepatocytes
    • Shrivastava S, Raychoudhuri A, Steele R, Ray R, Ray RB. Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology. 2011; 53(2):406-14.
    • (2011) Hepatology , vol.53 , Issue.2 , pp. 406-414
    • Shrivastava, S.1    Raychoudhuri, A.2    Steele, R.3    Ray, R.4    Ray, R.B.5
  • 67
    • 22544481160 scopus 로고    scopus 로고
    • Stealth and cunning: Hepatitis b and hepatitis c viruses
    • Wieland SF, Chisari FV. Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol. 2005;79:9369-80.
    • (2005) J Virol , vol.79 , pp. 9369-9380
    • Wieland, S.F.1    Chisari, F.V.2
  • 68
    • 33744828747 scopus 로고    scopus 로고
    • Inhibition of dsrna-induced signaling in hepatitis c virus-infected cells by ns3 protease-dependent and -independent mechanisms
    • Cheng G, Zhong J, Chisari FV. Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms. Proc Natl Acad Sci U S A. 2006;103:8499-504.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 8499-8504
    • Cheng, G.1    Zhong, J.2    Chisari, F.V.3
  • 70
    • 20144379712 scopus 로고    scopus 로고
    • Molecular determinants of trif proteolysis mediated by the hepatitis c virus ns3/4a protease
    • Ferreon JC, Ferreon AC, Li K, Lemon SM. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J Biol Chem. 2005;280:20483-92.
    • (2005) J Biol Chem , vol.280 , pp. 20483-20492
    • Ferreon, J.C.1    Ferreon, A.C.2    Li, K.3    Lemon, S.M.4
  • 71
    • 56549116047 scopus 로고    scopus 로고
    • Toll-like receptor and rig-i-like receptor signaling
    • Kawai T, Akira S. Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci. 2008;1143:1-20.
    • (2008) Ann N Y Acad Sci , vol.1143 , pp. 1-20
    • Kawai, T.1    Akira, S.2
  • 72
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis c virus ns3/4a proteasemediated cleavage of the toll-like receptor 3 adaptor protein trif
    • Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, et al. Immune evasion by hepatitis C virus NS3/4A proteasemediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005;102:2992-7.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3    Nakamura, M.4    Ferreon, A.C.5    Ikeda, M.6    Ray, S.C.7
  • 73
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the rig-i antiviral pathway and is targeted by hepatitis c virus
    • Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature. 2005;437:1167-72.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 74
    • 20044379559 scopus 로고    scopus 로고
    • Control of antiviral defenses through hepatitis c virus disruption of retinoic acid-inducible gene-i signaling
    • Foy E, Li K, Sumpter Jr R, Loo YM, Johnson CL, Wang C, Fish PM, et al. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A. 2005;102:2986-91.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2986-2991
    • Foy, E.1    Li, K.2    Sumpter, R.3    Loo, Y.M.4    Johnson, C.L.5    Wang, C.6    Fish, P.M.7
  • 75
    • 34250643546 scopus 로고    scopus 로고
    • The interferon inducing pathways and the hepatitis c virus
    • Meurs EF, Breiman A. The interferon inducing pathways and the hepatitis C virus. World J Gastroentrol. 2007;13(17):2446-54.
    • (2007) World J Gastroentrol , vol.13 , Issue.17 , pp. 2446-2454
    • Meurs, E.F.1    Breiman, A.2
  • 76
    • 77950603105 scopus 로고    scopus 로고
    • Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis c correlates with a reduced activation of the endogenous interferon system
    • Bellecave P, Sarasin-Filipowicz M, Donze O, Kennel A, Gouttenoire J, Meylan E, Terracciano L, et al. Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology. 2010;51(14): 1127-36.
    • (2010) Hepatology , vol.51 , Issue.14 , pp. 1127-1136
    • Bellecave, P.1    Sarasin-Filipowicz, M.2    Donze, O.3    Kennel, A.4    Gouttenoire, J.5    Meylan, E.6    Terracciano, L.7
  • 77
    • 36348936640 scopus 로고    scopus 로고
    • Hepatitis c virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy
    • Binder M, Kochs G, Bartenschlager R, Lohmann V. Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology. 2007;46(5): 1365-74.
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1365-1374
    • Binder, M.1    Kochs, G.2    Bartenschlager, R.3    Lohmann, V.4
  • 78
    • 0037362931 scopus 로고    scopus 로고
    • Ifn-alpha antagonistic activity of hcv core protein involves induction of suppressor of cytokine signaling-3
    • Bode JG, Ludwig S, Ehrhardt C, Albrecht U, Erhardt A, Shaper F, Heinrich PC, et al. IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3. FASEB J. 2003;17(3):488-90.
    • (2003) FASEB J , vol.17 , Issue.3 , pp. 488-490
    • Bode, J.G.1    Ludwig, S.2    Ehrhardt, C.3    Albrecht, U.4    Erhardt, A.5    Shaper, F.6    Heinrich, P.C.7
  • 79
    • 11144342298 scopus 로고    scopus 로고
    • Virus core protein down-regulates transcription of interferon-induced antiviral genes
    • de Lucas S, Bartolome J, Carreno V. Hepatitis C virus core protein down-regulates transcription of interferon-induced antiviral genes. J Infect Dis. 2005;191(1):93-9.
    • (2005) J Infect Dis , vol.191 , Issue.1 , pp. 93-99
    • De Lucas, S.1    Bartolome, J.2    Carreno, V.3    Hepatitis, C.4
  • 81
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis c infection
    • Chen L, Borozan I, Feld J, Sun J, Tannis LL, Coltescu C, Heathcote J, et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C infection. Gastroenterology. 2005;128:1437-44.
    • (2005) Gastroenterology , vol.128 , pp. 1437-1444
    • Chen, L.1    Borozan, I.2    Feld, J.3    Sun, J.4    Tannis, L.L.5    Coltescu, C.6    Heathcote, J.7
  • 83
    • 41149156316 scopus 로고    scopus 로고
    • Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis c
    • Asselah T, Bieche I, Narguet S, Sabbagh A, Laurendeau I, Ripault MP, Boyer N, et al. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C. Gut. 2008;57:516-24.
    • (2008) Gut , vol.57 , pp. 516-524
    • Asselah, T.1    Bieche, I.2    Narguet, S.3    Sabbagh, A.4    Laurendeau, I.5    Ripault, M.P.6    Boyer, N.7
  • 84
    • 41149093018 scopus 로고    scopus 로고
    • Evolutionary struggles between nk cells and viruses
    • Lanier LL. Evolutionary struggles between NK cells and viruses. Nat Rev Immunol. 2008;8:259-68.
    • (2008) Nat Rev Immunol , vol.8 , pp. 259-268
    • Lanier, L.L.1
  • 85
    • 79551666576 scopus 로고    scopus 로고
    • Revisiting human natural killer cell subset function revealed cytolitic cd56(Dim) cd16+ nk cells as rapid producers of abundant ifn-gamma on activation
    • De Maria A, Bozzano F, Cantoni C, Moretta L. Revisiting human natural killer cell subset function revealed cytolitic CD56(dim) CD16+ NK cells as rapid producers of abundant IFN-gamma on activation. Proc Natl Acad Sci U S A. 2011;108(2):728-32.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.2 , pp. 728-732
    • De Maria, A.1    Bozzano, F.2    Cantoni, C.3    Moretta, L.4
  • 86
    • 42449102990 scopus 로고    scopus 로고
    • Up on the tightrope: Natural killer activation and inhibition
    • Lanier LL. Up on the tightrope: natural killer activation and inhibition. Nat Immunol. 2008;9(5):495-502.
    • (2008) Nat Immunol , vol.9 , Issue.5 , pp. 495-502
    • Lanier, L.L.1
  • 87
    • 11144299492 scopus 로고    scopus 로고
    • Nk cell recognition
    • Lanier LL. NK cell recognition. Annu Rev Immunol. 2005;23: 225-74.
    • (2005) Annu Rev Immunol , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 88
    • 49249097006 scopus 로고    scopus 로고
    • Negative signaling by inhibitory receptors: The nk cell paradigm
    • Long EO. Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev. 2008;224:70-84.
    • (2008) Immunol Rev , vol.224 , pp. 70-84
    • Long, E.O.1
  • 90
    • 77957336301 scopus 로고    scopus 로고
    • Increased degranulation of natural killer cells during acute hcv correlates with the magnitude of virus-specific t cell responses
    • Pelletier S, Drouin C, Bedard N, Khakoo SI, Bruneau J, Shoukry NH. Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses. J Hepatol. 2010;53:805-16.
    • (2010) J Hepatol , vol.53 , pp. 805-816
    • Pelletier, S.1    Drouin, C.2    Bedard, N.3    Khakoo, S.I.4    Bruneau, J.5    Shoukry, N.H.6
  • 92
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis c, virus versus innate and adaptative immune responses: A tale of coevolution and coexistence
    • Rehermann B. Hepatitis C, virus versus innate and adaptative immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009;119(7):1745-54.
    • (2009) J Clin Invest , vol.119 , Issue.7 , pp. 1745-1754
    • Rehermann, B.1
  • 94
    • 48249137638 scopus 로고    scopus 로고
    • Altered natural killer cell subset distributions in resolved and persistent hepatitis c virus infection following single source exposure
    • Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, Hegarty JE, O’Farrelly C, et al. Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut. 2008;57: 1121-8.
    • (2008) Gut , vol.57 , pp. 1121-1128
    • Golden-Mason, L.1    Madrigal-Estebas, L.2    Mc Grath, E.3    Conroy, M.J.4    Ryan, E.J.5    Hegarty, J.E.6    O’farrelly, C.7
  • 96
    • 77649184029 scopus 로고    scopus 로고
    • Chronic hepatitis c viral infection reduces nk cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment
    • Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y, Okada S. Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: reversion by anti-viral treatment. Biochem Biophys Res Commun. 2010;393:331-7.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 331-337
    • Dessouki, O.1    Kamiya, Y.2    Nagahama, H.3    Tanaka, M.4    Suzu, S.5    Sasaki, Y.6    Okada, S.7
  • 97
    • 72549104093 scopus 로고    scopus 로고
    • Natural killer cells are polarized toward cytotoxicity in chronic hepatitis c in an interferon-alfa-dependent manner
    • Ahlenstiel G, Titerence RH, Koh C, Edlich B, Feld JJ, Rotman Y, Ghany MG, et al. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology. 2010;138:325-35.e1-2.
    • (2010) Gastroenterology , vol.138
    • Ahlenstiel, G.1    Titerence, R.H.2    Koh, C.3    Edlich, B.4    Feld, J.J.5    Rotman, Y.6    Ghany, M.G.7
  • 98
    • 25144472170 scopus 로고    scopus 로고
    • Shared alterations in nk cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis c virus infections
    • Meier UC, Owen RE, Taylor E, Worth A, Naoumov N, Willberg C, Tang K, et al. Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections. J Virol. 2005;79:12365-74.
    • (2005) J Virol , vol.79 , pp. 12365-12374
    • Meier, U.C.1    Owen, R.E.2    Taylor, E.3    Worth, A.4    Naoumov, N.5    Willberg, C.6    Tang, K.7
  • 99
    • 0037033359 scopus 로고    scopus 로고
    • Inhibition of natural killer cells through engagement of cd81 by the major hepatitis c virus envelope protein
    • Crotta S, Stilla A, Wack A, D’Andrea A, Nuti S, D’Oro U, Mosca M, et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med. 2002;195:35-41.
    • (2002) J Exp Med , vol.195 , pp. 35-41
    • Crotta, S.1    Stilla, A.2    Wack, A.3    D’andrea, A.4    Nuti, S.5    D’oro, U.6    Mosca, M.7
  • 100
    • 75549090719 scopus 로고    scopus 로고
    • Virions subvert natural killer cell activation to generate a cytokine environment permissive for infection
    • Crotta S, Brazzoli M, Piccioli D, Valiante NM, Wack A. Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection. J Hepatol. 2010; 52(2):183-90.
    • (2010) J Hepatol , vol.52 , Issue.2 , pp. 183-190
    • Crotta, S.1    Brazzoli, M.2    Piccioli, D.3    Valiante, N.M.4    Wack, A.5    Hepatitis, C.6
  • 101
    • 33646810822 scopus 로고    scopus 로고
    • Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis c
    • Nattermann J, Feldmann G, Ahlenstiel G, Langhans B, Sauerbruch T, Spengler U. Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut. 2006;55:869-77.
    • (2006) Gut , vol.55 , pp. 869-877
    • Nattermann, J.1    Feldmann, G.2    Ahlenstiel, G.3    Langhans, B.4    Sauerbruch, T.5    Spengler, U.6
  • 102
    • 8444242871 scopus 로고    scopus 로고
    • Negative regulation of nk cell activities by inhibitory receptor cd94/nkg2a leads to altered nk cell-induced modulation of dendritic cell functions in chronic hepatitis c virus infection
    • Jinushi M, Takehara T, Tatsumi T, Kanto T, Miyagi T, Suzuki T, Kanazawa Y, et al. Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. J Immunol. 2004;173:6072-81.
    • (2004) J Immunol , vol.173 , pp. 6072-6081
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Kanto, T.4    Miyagi, T.5    Suzuki, T.6    Kanazawa, Y.7
  • 103
    • 77955848019 scopus 로고    scopus 로고
    • Altered interferon-alpha-signaling in natural killer cells from patients with chronic hepatitis c virus infection
    • Miyagi T, Takehara T, Nishio K, Shimizu S, Kohga K, Li W, Tatsumi T, et al. Altered interferon-alpha-signaling in natural killer cells from patients with chronic hepatitis C virus infection. J Hepatol. 2010;53(3):424-30.
    • (2010) J Hepatol , vol.53 , Issue.3 , pp. 424-430
    • Miyagi, T.1    Takehara, T.2    Nishio, K.3    Shimizu, S.4    Kohga, K.5    Li, W.6    Tatsumi, T.7
  • 104
    • 84155180827 scopus 로고    scopus 로고
    • Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis c patients
    • Edlich B, Ahlenstiel G, Zabaleta Azpiroz A, Stoltzfus J, Noureddin M, Serti E, et al. Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients. Hepatology. 2012;55(1): 39-48.
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 39-48
    • Edlich, B.1    Ahlenstiel, G.2    Zabaleta Azpiroz, A.3    Stoltzfus, J.4    Noureddin, M.5    Serti, E.6
  • 106
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolitic control of viral infections by the innate and adaptative immune response
    • Guidotti LG, Chisari FV. Noncytolitic control of viral infections by the innate and adaptative immune response. Annu Rev Immunol. 2001;19:65-91.
    • (2001) Annu Rev Immunol , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 107
    • 80053593363 scopus 로고    scopus 로고
    • Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis c
    • Ahlenstiel G, Edlich B, Hogdal LJ, Rotman Y, Noureddin M, Feld JJ, Holz LE, et al. Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C. Gastroenterology. 2011;141(4):1231-9.
    • (2011) Gastroenterology , vol.141 , Issue.4 , pp. 1231-1239
    • Ahlenstiel, G.1    Edlich, B.2    Hogdal, L.J.3    Rotman, Y.4    Noureddin, M.5    Feld, J.J.6    Holz, L.E.7
  • 108
    • 0034113629 scopus 로고    scopus 로고
    • Innate and adaptative lymphoid cells in the human liver
    • Doherty DG, O’Farrelly C. Innate and adaptative lymphoid cells in the human liver. Immunol Rev. 2000;174:5-20.
    • (2000) Immunol Rev , vol.174 , pp. 5-20
    • Doherty, D.G.1    O’farrelly, C.2
  • 109
    • 36348973582 scopus 로고    scopus 로고
    • Altered innate immunity in chronic hepatitis c infection: Cause or effect?
    • Szabo G, Chang S, Dolganiuc A. Altered innate immunity in chronic hepatitis C infection: cause or effect? Hepatology. 2007;46:1279-90.
    • (2007) Hepatology , vol.46 , pp. 1279-1290
    • Szabo, G.1    Chang, S.2    Dolganiuc, A.3
  • 110
    • 68049142973 scopus 로고    scopus 로고
    • Fine characterization of intrahepatic nk cells expressing natural killer receptors in chronic hepatitis b and c
    • Bonorino P, Ramzan M, Camous X, Dufeu-Duchesne T, Yhelu MA, Sturm N, Dariz A, et al. Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C. J Hepatol. 2009;51:458-67.
    • (2009) J Hepatol , vol.51 , pp. 458-467
    • Bonorino, P.1    Ramzan, M.2    Camous, X.3    Dufeu-Duchesne, T.4    Yhelu, M.A.5    Sturm, N.6    Dariz, A.7
  • 112
    • 84867218760 scopus 로고    scopus 로고
    • Natural killer p46high expression defines a natural killer cell subset that is potentially involved in control of hepatitis c virus replication and modulation of liver fibrosis
    • Kramer B, Korner C, Kebschull M, Glassner A, Eisenhardt M, Nischalke HD, Alexander M, et al. Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis. Hepatology. 2012;56:1201-13.
    • (2012) Hepatology , vol.56 , pp. 1201-1213
    • Kramer, B.1    Korner, C.2    Kebschull, M.3    Glassner, A.4    Eisenhardt, M.5    Nischalke, H.D.6    Alexander, M.7
  • 113
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis c virus envelope protein e2 to cd81 inhibits natural killer cell functions
    • Tseng CT, Klimpel GR. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med. 2002;195:43-9.
    • (2002) J Exp Med , vol.195 , pp. 43-49
    • Tseng, C.T.1    Klimpel, G.R.2
  • 114
    • 0038108598 scopus 로고    scopus 로고
    • Upregulation of major histocompatibility complex class i on liver cells by hepatitis c virus core protein via p53 and tap1 impairs natural killer cell cytotoxicity
    • Herzer K, Falk CS, Encke J, Eichhorst ST, Ulsenheimer A, Seiger B, Krammer PH. Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity. J Virol. 2003;77:8299-309.
    • (2003) J Virol , vol.77 , pp. 8299-8309
    • Herzer, K.1    Falk, C.S.2    Encke, J.3    Eichhorst, S.T.4    Ulsenheimer, A.5    Seiger, B.6    Krammer, P.H.7
  • 115
    • 13244257273 scopus 로고    scopus 로고
    • The hla-a2 restricted t cell epitope hcv core 35-44 stabilizes hla-e expression and inhibits cytolysis mediated by natural killer cells
    • Nattermann J, Nischalke HD, Hofmeister V, Ahlenstiel G, Zimmermann H, Leifeld L, Weiss EH, et al. The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells. Am J Pathol. 2005;166:443-53.
    • (2005) Am J Pathol , vol.166 , pp. 443-453
    • Nattermann, J.1    Nischalke, H.D.2    Hofmeister, V.3    Ahlenstiel, G.4    Zimmermann, H.5    Leifeld, L.6    Weiss, E.H.7
  • 116
    • 77951909054 scopus 로고    scopus 로고
    • Intrahepatic il-10 maintains nkg2a+ly49- liver nk cells in a functionally hypo -responsive state
    • Lassen MG, Lukens JR, Dolina JS, Brown MG, Hahn YS. Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hypo -responsive state. J Immunol. 2010;184: 2693-701.
    • (2010) J Immunol , vol.184 , pp. 2693-2701
    • Lassen, M.G.1    Lukens, J.R.2    Dolina, J.S.3    Brown, M.G.4    Hahn, Y.S.5
  • 118
    • 33845650186 scopus 로고    scopus 로고
    • Intrahepatic virus-specific il-10-producing cd8 t cells prevent liver damage during chronic hepatitis c virus infection
    • Abel M, Sene D, Pol S, Bourliere M, Poynard T, Charlotte F, Cacoub P, et al. Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology. 2006;44:1607-16.
    • (2006) Hepatology , vol.44 , pp. 1607-1616
    • Abel, M.1    Sene, D.2    Pol, S.3    Bourliere, M.4    Poynard, T.5    Charlotte, F.6    Cacoub, P.7
  • 120
    • 79952753924 scopus 로고    scopus 로고
    • Activation receptor-induced tolerance of mature nk cells in vivo requires signaling through the receptor and is reversible
    • Bolanos FD, Tripathy SK. Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible. J Immunol. 2011;186:2765-71.
    • (2011) J Immunol , vol.186 , pp. 2765-2771
    • Bolanos, F.D.1    Tripathy, S.K.2
  • 121
    • 84877076614 scopus 로고    scopus 로고
    • Natural killer and natural killer t cells in liver fibrosis
    • Gao B, Radaeva S. Natural killer and natural killer T cells in liver fibrosis. Biochim Biophys Acta 2013;1832:1061-9. http://dx.xoi. org/10.1016/j.bbadis.2012.09.008
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1061-1069
    • Gao, B.1    Radaeva, S.2
  • 122
    • 84862993192 scopus 로고    scopus 로고
    • Nk cells from hcv-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a trail-, fasl- and nkg2d- dependent manner
    • Glassner A, Eisenhardt M, Kramer B, Korner C, Coenen M, Sauerbruch T, Spengler U, et al. NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D- dependent manner. Lab Invest. 2012;92:967-77.
    • (2012) Lab Invest , vol.92 , pp. 967-977
    • Glassner, A.1    Eisenhardt, M.2    Kramer, B.3    Korner, C.4    Coenen, M.5    Sauerbruch, T.6    Spengler, U.7
  • 123
    • 84860596931 scopus 로고    scopus 로고
    • Nkp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
    • Gur C, Doron S, Kfir-Erenfeld S, Horwitz E, Abu-Tair L, Safadi R, Mandelboim O. NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut. 2012;61:885-93.
    • (2012) Gut , vol.61 , pp. 885-893
    • Gur, C.1    Doron, S.2    Kfir-Erenfeld, S.3    Horwitz, E.4    Abu-Tair, L.5    Safadi, R.6    Mandelboim, O.7
  • 124
    • 77951861128 scopus 로고    scopus 로고
    • Interferon-alpha-induced trail on natural killer cells is associated with control of hepatitis c virus infection
    • Stegmann KA, Bjorkstrom NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, et al. Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology. 2010;138:1885-97.
    • (2010) Gastroenterology , vol.138 , pp. 1885-1897
    • Stegmann, K.A.1    Bjorkstrom, N.K.2    Veber, H.3    Ciesek, S.4    Riese, P.5    Wiegand, J.6    Hadem, J.7
  • 125
    • 68649104004 scopus 로고    scopus 로고
    • Gammadelta t, cells and the lymphoid stress-surveillance response
    • Hayday AC. Gammadelta T, cells and the lymphoid stress-surveillance response. Immunity. 2009;31:184-96.
    • (2009) Immunity , vol.31 , pp. 184-196
    • Hayday, A.C.1
  • 126
    • 77955689094 scopus 로고    scopus 로고
    • Gammadeltatcr ligands and lineage commitment
    • Kreslavsky T, von Boehmer H. GammadeltaTCR ligands and lineage commitment. Semin Immunol. 2010;22:214-21.
    • (2010) Semin Immunol , vol.22 , pp. 214-221
    • Kreslavsky, T.1    Von Boehmer, H.2
  • 127
    • 30344451987 scopus 로고    scopus 로고
    • Activation of vgamma9vdelta2 t cells by non-peptidic antigens induces the inhibition of subge-nomic hcv replication
    • Agrati C, Alonzi T, De Santis R, Castilletti C, Abbate I, Capobianchi MR, D’Offizi G, et al. Activation of Vgamma9Vdelta2 T cells by non-peptidic antigens induces the inhibition of subge-nomic HCV replication. Int Immunol. 2006;18:11-8.
    • (2006) Int Immunol , vol.18 , pp. 11-18
    • Agrati, C.1    Alonzi, T.2    De Santis, R.3    Castilletti, C.4    Abbate, I.5    Capobianchi, M.R.6    D’offizi, G.7
  • 128
    • 84867410787 scopus 로고    scopus 로고
    • Molecular basis of lipid antigen presentation by cd1d and recognition by natural killer cells
    • Girardi E, Zajonc DM. Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer cells. Immunol Rev. 2012;250:167-79.
    • (2012) Immunol Rev , vol.250 , pp. 167-179
    • Girardi, E.1    Zajonc, D.M.2
  • 129
    • 3242754111 scopus 로고    scopus 로고
    • Hepatic cd1d expression in hepatitis c virus infection and recognition by resident proinflammatory cd1d-reactive t cells
    • Durante-Mangoni E, Wang R, Shaulov A, He Q, Nasser I, Afdal N, Koziel MJ, et al. Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol. 2004;173:2159-66.
    • (2004) J Immunol , vol.173 , pp. 2159-2166
    • Durante-Mangoni, E.1    Wang, R.2    Shaulov, A.3    He, Q.4    Nasser, I.5    Afdal, N.6    Koziel, M.J.7
  • 130
    • 3142687525 scopus 로고    scopus 로고
    • Production of profibrotic cytokines by invariant nkt cells characterizes cirrhosis progression in chronic viral hepatitis
    • De Lalla C, Galli G, Aldrighetti L, Romeo R, Mariani M, Monno A, Nuti S, et al. Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis. J Immunol. 2004;173:1417-25.
    • (2004) J Immunol , vol.173 , pp. 1417-1425
    • De Lalla, C.1    Galli, G.2    Aldrighetti, L.3    Romeo, R.4    Mariani, M.5    Monno, A.6    Nuti, S.7
  • 133
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a singlesource outbreak of hepatitis c
    • Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a singlesource outbreak of hepatitis C. Nat Med. 2000;6:578-82.
    • (2000) Nat Med , vol.6 , pp. 578-582
    • Takaki, A.1    Wiese, M.2    Maertens, G.3    Depla, E.4    Seifert, U.5    Liebetrau, A.6    Miller, J.L.7
  • 134
  • 135
    • 0026550098 scopus 로고
    • The natural history of infection with hepatitis c virus (Hcv) in chimpanzees: Comparison of serologic responses measured with first- and second-generation assays and relationship to hcv viremia
    • Farci P, London WT, Wong DC, Dawson GJ, Vallari DS, Engle R, Purcell RH. The natural history of infection with hepatitis C virus (HCV) in chimpanzees: comparison of serologic responses measured with first- and second-generation assays and relationship to HCV viremia. J Infect Dis. 1992;165:1006-11.
    • (1992) J Infect Dis , vol.165 , pp. 1006-1011
    • Farci, P.1    London, W.T.2    Wong, D.C.3    Dawson, G.J.4    Vallari, D.S.5    Engle, R.6    Purcell, R.H.7
  • 136
    • 18344362819 scopus 로고    scopus 로고
    • Detection of multiple hepatitis c virus genotypes in a cohort of injecting drug users
    • Bowden S, McCaw R, White PA, Crofts N, Aitken CK. Detection of multiple hepatitis C virus genotypes in a cohort of injecting drug users. J Viral Hepat. 2005;12:322-4.
    • (2005) J Viral Hepat , vol.12 , pp. 322-324
    • Bowden, S.1    Mc Caw, R.2    White, P.A.3    Crofts, N.4    Aitken, C.K.5
  • 137
    • 33744494806 scopus 로고    scopus 로고
    • Maintenance of hcv-specific t-cell responses in antibody-deficient patients a decade after early therapy
    • Semmo N, Lucas M, Krashias G, Lauer G, Chapel H, Klenerman P. Maintenance of HCV-specific T-cell responses in antibody-deficient patients a decade after early therapy. Blood. 2006;107:4570-1.
    • (2006) Blood , vol.107 , pp. 4570-4571
    • Semmo, N.1    Lucas, M.2    Krashias, G.3    Lauer, G.4    Chapel, H.5    Klenerman, P.6
  • 140
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis c virus continuously escapes from neutralizing antibody and t-cell responses during chronic infection in vivo
    • von Hahn T, Yoon JC, Alter H, Rice CM, Rehermann B, Balfe P, McKeating JA. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology. 2007;132:667-78.
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • Von Hahn, T.1    Yoon, J.C.2    Alter, H.3    Rice, C.M.4    Rehermann, B.5    Balfe, P.6    Mc Keating, J.A.7
  • 141
    • 77956147218 scopus 로고    scopus 로고
    • Viral entry and escape from antibody-mediated neutralization influence for hepatitis c virus re-infection in liver transplantation
    • Fafi-Kremer S, Fofana I, Soulier E, Carolla P, Meuleman P, Leroux-Roels G, Patel AH, et al. Viral entry and escape from antibody-mediated neutralization influence for hepatitis C virus re-infection in liver transplantation. J Exp Med. 2010; 207:2019-31.
    • (2010) J Exp Med , vol.207 , pp. 2019-2031
    • Fafi-Kremer, S.1    Fofana, I.2    Soulier, E.3    Carolla, P.4    Meuleman, P.5    Leroux-Roels, G.6    Patel, A.H.7
  • 143
    • 84955077577 scopus 로고    scopus 로고
    • In vivo evaluation of the crossgenotype neutralizing activity of polyclonal antibodies against hepatitis c virus
    • Meuleman P, Bukh J, Verhoye L, Farhoudi A, Vanwolleghem T, Wang RY, Desombere I, et al. In vivo evaluation of the crossgenotype neutralizing activity of polyclonal antibodies against hepatitis C virus. Hepatology. 2011;55:364-72.
    • (2011) Hepatology , vol.55 , pp. 364-372
    • Meuleman, P.1    Bukh, J.2    Verhoye, L.3    Farhoudi, A.4    Vanwolleghem, T.5    Wang, R.Y.6    Desombere, I.7
  • 145
    • 29444444292 scopus 로고    scopus 로고
    • Activation of naïve b lymphocytes via cd81, a pathogenetic mechanism for hepatitis c virus-associated b lymphocyte disorders
    • Rosa D, Saletti G, De Gregorio E, Zorat F, Comar C, D’Oro U, Nuti S, et al. Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders. Proc Natl Acad Sci US A. 2005;102: 18544-9.
    • (2005) Proc Natl Acad Sci US A , vol.102 , pp. 18544-18549
    • Rosa, D.1    Saletti, G.2    De Gregorio, E.3    Zorat, F.4    Comar, C.5    D’oro, U.6    Nuti, S.7
  • 146
    • 79958822254 scopus 로고    scopus 로고
    • Enhanced b cell differentiation and reduced proliferative capacity in chronic hepatitis c and chronic hepatitis b virus infections
    • Oliviero B, Cerino A, Varchetta S, Paudice E, Pai S, Ludovisi S, Zaramella M, et al. Enhanced B cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections. J Hepatol. 2011;55:53-60.
    • (2011) J Hepatol , vol.55 , pp. 53-60
    • Oliviero, B.1    Cerino, A.2    Varchetta, S.3    Paudice, E.4    Pai, S.5    Ludovisi, S.6    Zaramella, M.7
  • 147
    • 78049389684 scopus 로고    scopus 로고
    • Cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis c virus infection
    • Sugalski JM, Rodriguez B, Moir S, Anthony DD. Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection. J Immunol. 2010;185:3019-27.
    • (2010) J Immunol , vol.185 , pp. 3019-3027
    • Sugalski, J.M.1    Rodriguez, B.2    Moir, S.3    Anthony, D.D.4    Peripheral Blood, B.5
  • 148
    • 33645796706 scopus 로고    scopus 로고
    • Antibody production and in vitro behavior of cd27-defined b-cell subsets: Persistent hepatitis c virus infection changes the rules
    • Racanelli V, Frassanito MA, Leone P, Galiano M, De Re V, Silvestris F, Dammacco F. Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules. J Virol. 2006;80:3923-34.
    • (2006) J Virol , vol.80 , pp. 3923-3934
    • Racanelli, V.1    Frassanito, M.A.2    Leone, P.3    Galiano, M.4    De Re, V.5    Silvestris, F.6    Dammacco, F.7
  • 149
    • 46049112339 scopus 로고    scopus 로고
    • Evidence for hiv-associated b cell exhaustion in a dysfunctional memory b cell compartment in hiv-infected vire-mic individuals
    • Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, O’Shea MA, Roby G, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected vire-mic individuals. J Exp Med. 2008;205:1797-805.
    • (2008) J Exp Med , vol.205 , pp. 1797-1805
    • Moir, S.1    Ho, J.2    Malaspina, A.3    Wang, W.4    Di Poto, A.C.5    O’shea, M.A.6    Roby, G.7
  • 151
    • 79956259577 scopus 로고    scopus 로고
    • Clonal b cells in patients with hepatitis c virus-associated mixed cryoglobulinemia contain an expanded anergic cd21low b-cell subset
    • Charles ED, Brunetti C, Marukian S, Ritola KD, Talal AK, Marks K, Jacobson IM, et al. Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset. Blood. 2011;117:5425-37.
    • (2011) Blood , vol.117 , pp. 5425-5437
    • Charles, E.D.1    Brunetti, C.2    Marukian, S.3    Ritola, K.D.4    Talal, A.K.5    Marks, K.6    Jacobson, I.M.7
  • 152
    • 84868207639 scopus 로고    scopus 로고
    • B-cell homeostasis in chronic hepatitis c virus-related mixed cryoglobulinemia is maintained through naïve b-cell apoptosis
    • Holz LE, Yoon JC, Rafhuraman S, Moir S, Sneller MC, Rehermann B. B-cell homeostasis in chronic hepatitis C virus-related mixed cryoglobulinemia is maintained through naïve B-cell apoptosis. Hepatology. 2012;56:1602-10.
    • (2012) Hepatology , vol.56 , pp. 1602-1610
    • Holz, L.E.1    Yoon, J.C.2    Rafhuraman, S.3    Moir, S.4    Sneller, M.C.5    Rehermann, B.6
  • 153
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis b virus and hepatitis c virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005;5:215-29.
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 154
    • 0035914925 scopus 로고    scopus 로고
    • Chisari fv determinants of viral clearance and persistence during acute hepatitis c virus infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med. 2001;194:1395-406.
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5
  • 157
    • 21344442371 scopus 로고    scopus 로고
    • Comprehensive analyses of cd8+ t cell responses during longitudinal study of acute human hepatitis c
    • Cox AL, Mosbruger T, Lauer GM, Pardoll D, Thomas DL, Ray SC. Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology. 2005;42:104-12.
    • (2005) Hepatology , vol.42 , pp. 104-112
    • Cox, A.L.1    Mosbruger, T.2    Lauer, G.M.3    Pardoll, D.4    Thomas, D.L.5    Ray, S.C.6
  • 158
    • 33745876557 scopus 로고    scopus 로고
    • Outcome of acute hepatitis c is related to virus-specific cd4 function and maturation of antiviral memory cd8 responses
    • Urbani S, Amadei B, Fisicaro P, Tola D, Orlandini A, Sacchelli L, Mori C, et al. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology. 2006;44:126-39.
    • (2006) Hepatology , vol.44 , pp. 126-139
    • Urbani, S.1    Amadei, B.2    Fisicaro, P.3    Tola, D.4    Orlandini, A.5    Sacchelli, L.6    Mori, C.7
  • 160
    • 1642384546 scopus 로고    scopus 로고
    • Subversion of effector cd8+ t cell differentiation in acute hepatitis c virus infection: Exploring the immunological mechanisms
    • Francavilla V, Accapezzato D, De Salvo M, Rawson P, Cosimi O, Lipp M, Cerino A, et al. Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: exploring the immunological mechanisms. Eur J Immunol. 2004;34:427-37.
    • (2004) Eur J Immunol , vol.34 , pp. 427-437
    • Francavilla, V.1    Accapezzato, D.2    De Salvo, M.3    Rawson, P.4    Cosimi, O.5    Lipp, M.6    Cerino, A.7
  • 161
    • 0035000769 scopus 로고    scopus 로고
    • Sustained dysfunction of antiviral cd8+ t lymphocytes after infection with hepatitis c virus
    • Gruener NH, Lechner F, Jung MC, Diepolder H, Gerlach T, Lauer G, Walker B, et al. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J Virol. 2001;75:5550-8.
    • (2001) J Virol , vol.75 , pp. 5550-5558
    • Gruener, N.H.1    Lechner, F.2    Jung, M.C.3    Diepolder, H.4    Gerlach, T.5    Lauer, G.6    Walker, B.7
  • 162
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of hcv-specific t cells without differential hierarchy demonstrated ex vivo in persistent hcv infection
    • Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology. 2003;38:1437-48.
    • (2003) Hepatology , vol.38 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 163
    • 0036892605 scopus 로고    scopus 로고
    • Virus-specific cd8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis b and c
    • Urbani S, Boni C, Missale G, Elia G, Cavallo C, Massari M, Raimondo G, et al. Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J Virol. 2002;76:12423-34.
    • (2002) J Virol , vol.76 , pp. 12423-12434
    • Urbani, S.1    Boni, C.2    Missale, G.3    Elia, G.4    Cavallo, C.5    Massari, M.6    Raimondo, G.7
  • 164
    • 33847067210 scopus 로고    scopus 로고
    • Discordant role of cd4 t-cell response relative to neutralizing antibody and cd8 t-cell responses in acute hepatitis c
    • Kaplan DE, Sugimoto K, Newton K, et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology. 2007;132:654-66.
    • (2007) Gastroenterology , vol.132 , pp. 654-666
    • Kaplan, D.E.1    Sugimoto, K.2    Newton, K.3
  • 165
    • 7244255737 scopus 로고    scopus 로고
    • Multispecific t cell response and negative hcv rna tests during acute hcv infection are early prognostic factors of spontaneous clearance
    • Spada E, Mele A, Berton A, Ruggeri L, Ferrigno L, Garbuglia AR, Perrone MP, et al. Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut. 2004;53:1673-81.
    • (2004) Gut , vol.53 , pp. 1673-1681
    • Spada, E.1    Mele, A.2    Berton, A.3    Ruggeri, L.4    Ferrigno, L.5    Garbuglia, A.R.6    Perrone, M.P.7
  • 166
    • 33745497485 scopus 로고    scopus 로고
    • Early impairment of hepatitis c virus specific t cell proliferation during acute infection leads to failure of viral clearance
    • Folgori A, Spada E, Pezzanera M, Ruggeri L, Mele A, Garbuglia AR, Perrone MP, et al. Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance. Gut. 2006;55(7):1012-9.
    • (2006) Gut , vol.55 , Issue.7 , pp. 1012-1019
    • Folgori, A.1    Spada, E.2    Pezzanera, M.3    Ruggeri, L.4    Mele, A.5    Garbuglia, A.R.6    Perrone, M.P.7
  • 167
    • 38849095275 scopus 로고    scopus 로고
    • Spontaneous recovery in acute human hepatitis c virus infection: Functional t-cell thresholds and relative importance of cd4 help
    • Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L, Rosen HR. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol. 2008;82:1827-37.
    • (2008) J Virol , vol.82 , pp. 1827-1837
    • Smyk-Pearson, S.1    Tester, I.A.2    Klarquist, J.3    Palmer, B.E.4    Pawlotsky, J.M.5    Golden-Mason, L.6    Rosen, H.R.7
  • 168
    • 33750691709 scopus 로고    scopus 로고
    • Pd-1 expression in acute hepatitis c virus (Hcv) infection is associated with hcv-specific cd8 exhaustion
    • Urbani S, Amadei B, Tola D, Massari M, Schivazappa S, Missale G, Ferrari C. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol. 2006;80:11398-403.
    • (2006) J Virol , vol.80 , pp. 11398-11403
    • Urbani, S.1    Amadei, B.2    Tola, D.3    Massari, M.4    Schivazappa, S.5    Missale, G.6    Ferrari, C.7
  • 169
    • 34548191951 scopus 로고    scopus 로고
    • Upregulation of pd-1 expression on circulating and intrahepatic hepatitis c virus-specific cd8+ t cells associated with reversible immune dysfunction
    • Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007;81:9249-58.
    • (2007) J Virol , vol.81 , pp. 9249-9258
    • Golden-Mason, L.1    Palmer, B.2    Klarquist, J.3    Mengshol, J.A.4    Castelblanco, N.5    Rosen, H.R.6
  • 170
  • 171
    • 84864055607 scopus 로고    scopus 로고
    • Polyfunctional type-1, -2 and -17 cd8+ t cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis c virus infection
    • Franceschini D, Del Porto P, Piconese S, Trella E, Accapezzato D, Paroli M, Morrone S, et al. Polyfunctional type-1, -2 and -17 CD8+ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. PLoS Pathol. 2012;8:e1002759.
    • (2012) Plos Pathol , vol.8
    • Franceschini, D.1    Del Porto, P.2    Piconese, S.3    Trella, E.4    Accapezzato, D.5    Paroli, M.6    Morrone, S.7
  • 172
    • 63049129392 scopus 로고    scopus 로고
    • Th17 cells enhance viral persistence and inhibit t cell cytotoxicity in a model of chronic virus infection
    • Hou W, Kang HS, Kim BS. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J Exp Med. 2009;206:313-28.
    • (2009) J Exp Med , vol.206 , pp. 313-328
    • Hou, W.1    Kang, H.S.2    Kim, B.S.3
  • 173
    • 73449125874 scopus 로고    scopus 로고
    • Interleukin-17-producing cd4(+) t cells increase with severity of liver damage in patients with chronic hepatitis b
    • Zhang JY, Zhang Z, Lin F, Zou ZS, Xu RN, Jin L, Fu JL, et al. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology. 2010;51:81-91.
    • (2010) Hepatology , vol.51 , pp. 81-91
    • Zhang, J.Y.1    Zhang, Z.2    Lin, F.3    Zou, Z.S.4    Xu, R.N.5    Jin, L.6    Fu, J.L.7
  • 174
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis c virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale G, Bertoni R, Lamonaca V, Valli A, Massari M, Mori C, Rumi MG, et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest. 1996;98:706-14.
    • (1996) J Clin Invest , vol.98 , pp. 706-714
    • Missale, G.1    Bertoni, R.2    Lamonaca, V.3    Valli, A.4    Massari, M.5    Mori, C.6    Rumi, M.G.7
  • 175
    • 0029151623 scopus 로고
    • Possible mechanism involving t-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis c virus infection
    • Diepolder HM, Zachoval R, Hoffmann RM, Wierenga EA, Santantonio T, Jung MC, Eichenlaub D, et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet. 1995;346:1006-7.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Wierenga, E.A.4    Santantonio, T.5    Jung, M.C.6    Eichenlaub, D.7
  • 177
    • 84863183220 scopus 로고    scopus 로고
    • Spontaneous clearance of chronic hepatitis c virus infection is associated with appearance of neutralizing antibodies and reversal of t-cell exhaustion
    • Raghuraman S, Park H, Osburn WO, Winkelstein E, Edlin BR, Rehermann B. Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion. J Infect Dis. 2012;205:763-71.
    • (2012) J Infect Dis , vol.205 , pp. 763-771
    • Raghuraman, S.1    Park, H.2    Osburn, W.O.3    Winkelstein, E.4    Edlin, B.R.5    Rehermann, B.6
  • 178
    • 84856846467 scopus 로고    scopus 로고
    • Broadly directed virus-specific cd4+ t cell responses are primed during acute hepatitis c infection, but rapidly disappear from human blood with viral persistence
    • Schulze zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, et al. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med. 2012;209:61-75.
    • (2012) J Exp Med , vol.209 , pp. 61-75
    • Schulze Zur Wiesch, J.1    Ciuffreda, D.2    Lewis-Ximenez, L.3    Kasprowicz, V.4    Nolan, B.E.5    Streeck, H.6    Aneja, J.7
  • 179
    • 13044313467 scopus 로고    scopus 로고
    • Quantitative analysis of hepatitis c virus-specific cd8(+) t cells in peripheral blood and liver using peptide-mhc tetramers
    • He XS, Rehermann B, Lopez-Labrador FX, Boisvert J, Cheung R, Mumm J, Wedemeiyer H, et al. Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci USA. 1999;96:5692-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5692-5697
    • He, X.S.1    Rehermann, B.2    Lopez-Labrador, F.X.3    Boisvert, J.4    Cheung, R.5    Mumm, J.6    Wedemeiyer, H.7
  • 180
    • 0037105567 scopus 로고    scopus 로고
    • Impaired effector function of hepatitis c virus-specific cd8+ t cells in chronic hepatitis c virus infection
    • Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH, Liang TJ, et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol. 2002;169:3447-58.
    • (2002) J Immunol , vol.169 , pp. 3447-3458
    • Wedemeyer, H.1    He, X.S.2    Nascimbeni, M.3    Davis, A.R.4    Greenberg, H.B.5    Hoofnagle, J.H.6    Liang, T.J.7
  • 181
    • 0027443147 scopus 로고
    • Hepatitis c virus (Hcv)-specific cytotoxic t lymphocytes recognize epitopes in the core and envelope proteins of hcv
    • Koziel MJ, Dudley D, Afdhal NH, Choo QL, Houghton M, Ralston R, Walker BD. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol. 1993;67(12):7522-32.
    • (1993) J Virol , vol.67 , Issue.12 , pp. 7522-7532
    • Koziel, M.J.1    Dudley, D.2    Afdhal, N.H.3    Choo, Q.L.4    Houghton, M.5    Ralston, R.6    Walker, B.D.7
  • 182
    • 0031915132 scopus 로고    scopus 로고
    • Liver-derived ctl in hepatitis c virus infection: Breadth and specificity of responses in a cohort of persons with chronic infection
    • Wong DK, Dudley D, Afdhal NH, Dienstag J, Rice CM, Wang L, Houghton M, et al. Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J Immunol. 1998;160:1479-88.
    • (1998) J Immunol , vol.160 , pp. 1479-1488
    • Wong, D.K.1    Dudley, D.2    Afdhal, N.H.3    Dienstag, J.4    Rice, C.M.5    Wang, L.6    Houghton, M.7
  • 183
    • 0034858270 scopus 로고    scopus 로고
    • Direct ex vivo comparison of the breadth and specificity of the t cells in the liver and peripheral blood of patients with chronic hcv infection
    • Grabowska AM, Lechner F, Klenerman P, Tighe PJ, Ryder S, Ball JK, Thomson BJ, et al. Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection. Eur J Immunol. 2001;31:2388-94.
    • (2001) Eur J Immunol , vol.31 , pp. 2388-2394
    • Grabowska, A.M.1    Lechner, F.2    Klenerman, P.3    Tighe, P.J.4    Ryder, S.5    Ball, J.K.6    Thomson, B.J.7
  • 184
    • 33947421722 scopus 로고    scopus 로고
    • Dysfunction and functional restoration of hcv-specific cd8 responses in chronic hepatitis c virus infection
    • Penna A, Pilli M, Zerbini A, Orlandini A, Mezzadri S, Sacchelli L, Missale G, et al. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology. 2007;45:588-601.
    • (2007) Hepatology , vol.45 , pp. 588-601
    • Penna, A.1    Pilli, M.2    Zerbini, A.3    Orlandini, A.4    Mezzadri, S.5    Sacchelli, L.6    Missale, G.7
  • 187
    • 0032783678 scopus 로고    scopus 로고
    • Antibody responses to hepatitis c virus hypervariable region 1: Evidence for cross-reactivity and immune-mediated sequence variation
    • Mondelli MU, Cerino A, Lisa A, Brambilla S, Segagni L, Cividini A, Bissolati M, et al. Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation. Hepatology. 1999;30:537-45.
    • (1999) Hepatology , vol.30 , pp. 537-545
    • Mondelli, M.U.1    Cerino, A.2    Lisa, A.3    Brambilla, S.4    Segagni, L.5    Cividini, A.6    Bissolati, M.7
  • 188
    • 37849039121 scopus 로고    scopus 로고
    • Influence of specific cd4+ t cells and antibodies on evolution of hypervariable region 1 during acute hcv infection
    • Scotta C, Garbuglia AR, Ruggeri L, Spada E, Laurenti L, Perrone MP, Girelli G, et al. Influence of specific CD4+ T cells and antibodies on evolution of hypervariable region 1 during acute HCV infection. J Hepatol. 2008;48:216-28.
    • (2008) J Hepatol , vol.48 , pp. 216-228
    • Scotta, C.1    Garbuglia, A.R.2    Ruggeri, L.3    Spada, E.4    Laurenti, L.5    Perrone, M.P.6    Girelli, G.7
  • 189
    • 28244493685 scopus 로고    scopus 로고
    • The impairment of cd8 responses limits the selection of escape mutations in acute hepatitis c virus infection
    • Urbani S, Amadei B, Cariani E, Fisicaro P, Orlandini A, Missale G, Ferrari C. The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection. J Immunol. 2005;175:7519-29.
    • (2005) J Immunol , vol.175 , pp. 7519-7529
    • Urbani, S.1    Amadei, B.2    Cariani, E.3    Fisicaro, P.4    Orlandini, A.5    Missale, G.6    Ferrari, C.7
  • 193
    • 22344448015 scopus 로고    scopus 로고
    • Mutational escape from cd8+ t cell immunity: Hcv evolution, from chimpanzees to man
    • Bowen DG, Walker CM. Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. J Exp Med. 2005;201:1709-14.
    • (2005) J Exp Med , vol.201 , pp. 1709-1714
    • Bowen, D.G.1    Walker, C.M.2
  • 195
    • 16244377751 scopus 로고    scopus 로고
    • Escape mutations alter proteasome processing of major histocompatibility complex class i-restricted epitopes in persistent hepatitis c virus infection
    • Kimura Y, Gushima T, Rawale S, Kaumaya P, Walker CM. Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection. J Virol. 2005;79:4870-6.
    • (2005) J Virol , vol.79 , pp. 4870-4876
    • Kimura, Y.1    Gushima, T.2    Rawale, S.3    Kaumaya, P.4    Walker, C.M.5
  • 196
    • 75449101959 scopus 로고    scopus 로고
    • Selection-driven immune escape is not a significant factor in the failure of cd4 t cell responses in persistent hepatitis c virus infection
    • Fuller MJ, Shoukry NH, Gushima T, Bowen DG, Callendret B, Campbell KJ, Hasselschwert DL, et al. Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology. 2010;51:378-87.
    • (2010) Hepatology , vol.51 , pp. 378-387
    • Fuller, M.J.1    Shoukry, N.H.2    Gushima, T.3    Bowen, D.G.4    Callendret, B.5    Campbell, K.J.6    Hasselschwert, D.L.7
  • 197
    • 33846090225 scopus 로고    scopus 로고
    • Analysis of cd127 and klrg1 expression on hepatitis c virus-specific cd8+ t cells reveals the existence of different memory t-cell subsets in the peripheral blood and liver
    • Bengsch B, Spangernberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsacker F, Blum HE, et al. Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol. 2007;81:945-53.
    • (2007) J Virol , vol.81 , pp. 945-953
    • Bengsch, B.1    Spangernberg, H.C.2    Kersting, N.3    Neumann-Haefelin, C.4    Panther, E.5    Von Weizsacker, F.6    Blum, H.E.7
  • 198
    • 33947407689 scopus 로고    scopus 로고
    • Liver-infiltrating lymphocytes in chronic human hepatitis c virus infection display an exhausted phenotype with high levels of pd-1 and low levels of cd127 expression
    • Radziewicz H, Ibegbu CC, Fernandez ML, Workowki KA, Obideen K, Wehbi M, Hanson HL, et al. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol. 2007;81:2545-53.
    • (2007) J Virol , vol.81 , pp. 2545-2553
    • Radziewicz, H.1    Ibegbu, C.C.2    Fernandez, M.L.3    Workowki, K.A.4    Obideen, K.5    Wehbi, M.6    Hanson, H.L.7
  • 199
    • 84869880461 scopus 로고    scopus 로고
    • Combined blockade of programmed death-1 and activation of cd137 increase responses of human liver t cells against hbv, but not hcv
    • Fisicaro P, Valdatta C, Massari M, Loggi E, Ravanetti L, Urbani S, Giuberti T, et al. Combined blockade of Programmed Death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV. Gastroenterology. 2012;143:1576-85.
    • (2012) Gastroenterology , vol.143 , pp. 1576-1585
    • Fisicaro, P.1    Valdatta, C.2    Massari, M.3    Loggi, E.4    Ravanetti, L.5    Urbani, S.6    Giuberti, T.7
  • 200
    • 84861579810 scopus 로고    scopus 로고
    • Lack of full cd8 functional restoration after antiviral treatment for acute and chronic hepatitis c virus infection
    • Missale G, Pilli M, Zerbini A, Penna A, Ravanetti L, Barili V, Orlandini A, et al. Lack of full CD8 functional restoration after antiviral treatment for acute and chronic hepatitis C virus infection. Gut. 2012;61:1076-84.
    • (2012) Gut , vol.61 , pp. 1076-1084
    • Missale, G.1    Pilli, M.2    Zerbini, A.3    Penna, A.4    Ravanetti, L.5    Barili, V.6    Orlandini, A.7
  • 201
    • 65649139622 scopus 로고    scopus 로고
    • Pd-l1 negatively regulates cd4+cd25+foxp3+ tregs by limiting stat-5 phosphorylation in patients chronically infected with hcv
    • Franceschini D, Paroli M, Francavilla V, Videtta M, Morrone S, Labbadia G, Cerino A, et al. PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest. 2009;119:551-64.
    • (2009) J Clin Invest , vol.119 , pp. 551-564
    • Franceschini, D.1    Paroli, M.2    Francavilla, V.3    Videtta, M.4    Morrone, S.5    Labbadia, G.6    Cerino, A.7
  • 202
    • 84863630845 scopus 로고    scopus 로고
    • Tim-3 pathway controls regulatory and effector t cell balance during hepatitis c virus infection
    • Moorman JP, Wang JM, Zhang Y, Ji XJ, Ma CJ, Wu XY, Jia ZS, et al. Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection. J Immunol. 2012;189:755-66.
    • (2012) J Immunol , vol.189 , pp. 755-766
    • Moorman, J.P.1    Wang, J.M.2    Zhang, Y.3    Ji, X.J.4    Ma, C.J.5    Wu, X.Y.6    Jia, Z.S.7
  • 204
    • 0033690901 scopus 로고    scopus 로고
    • Interaction between complement receptor gc1qr and hepatitis c virus core protein inhibits t-lymphocyte proliferation
    • Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, Braciale TJ, Hahn YS. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest. 2000;106:1239-49.
    • (2000) J Clin Invest , vol.106 , pp. 1239-1249
    • Kittlesen, D.J.1    Chianese-Bullock, K.A.2    Yao, Z.Q.3    Braciale, T.J.4    Hahn, Y.S.5
  • 205
    • 0033556262 scopus 로고    scopus 로고
    • Suppression of host immune response by the core protein of hepatitis c virus: Possible implications for hepatitis c virus persistence
    • Large MK, Kittlesen DJ, Hahn YS. Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence. J Immunol. 1999;162: 931-8.
    • (1999) J Immunol , vol.162 , pp. 931-938
    • Large, M.K.1    Kittlesen, D.J.2    Hahn, Y.S.3
  • 206
    • 0035132970 scopus 로고    scopus 로고
    • Binding of the hepatitis c virus envelope protein e2 to cd81 provides a co-stimulatory signal for human t cells
    • Wack A, Soldaini E, Tseng C, Nuti S, Klimpel G, Abrignani S. Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cells. Eur J Immunol. 2001;31:166-75.
    • (2001) Eur J Immunol , vol.31 , pp. 166-175
    • Wack, A.1    Soldaini, E.2    Tseng, C.3    Nuti, S.4    Klimpel, G.5    Abrignani, S.6
  • 207
  • 209
    • 84870908918 scopus 로고    scopus 로고
    • Dendritic cells, regulatory t cells and the pathogenesis of chronic hepatitis c
    • Losikoff PT, Self AA, Gregory SH. Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C. Virulence. 2012;3:1-11.
    • (2012) Virulence , vol.3 , pp. 1-11
    • Losikoff, P.T.1    Self, A.A.2    Gregory, S.H.3
  • 210
    • 33750633661 scopus 로고    scopus 로고
    • Hepatitis c virus e2 and cd81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis c
    • Nattermann J, Zimmermann H, Iwan A, von Lillienfeld-Toal M, Leifeld L, Nischalke HD, Langhans B, et al. Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C. Hepatology. 2006;44: 945-54.
    • (2006) Hepatology , vol.44 , pp. 945-954
    • Nattermann, J.1    Zimmermann, H.2    Iwan, A.3    Von Lillienfeld-Toal, M.4    Leifeld, L.5    Nischalke, H.D.6    Langhans, B.7
  • 211
    • 0024408824 scopus 로고
    • Two types of mouse t helper cell. IV. The clones secrete a factor that inhibits cytokine production by th1 clones
    • Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp med. 1989;170:2081-95.
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 212
    • 46349089961 scopus 로고    scopus 로고
    • Systematic review of the treatment of established recurrent hepatitis c with pegylated interferon in combination with ribavirin
    • Berenguer M. Systematic review of the treatment of established recurrent hepatitis C with pegylated interferon in combination with ribavirin. J Hepatol. 2008;49:274-87.
    • (2008) J Hepatol , vol.49 , pp. 274-287
    • Berenguer, M.1
  • 213
    • 38649135757 scopus 로고    scopus 로고
    • Pretransplantation cd56(+) innate lymphocyte populations associated with severity of hepatitis c virus recurrence
    • Rosen HR, Doherty DG, Madrigal-Estebas L, O’Farrelly C, Golden-Mason L. Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Liver Transpl. 2008;14:31-40.
    • (2008) Liver Transpl , vol.14 , pp. 31-40
    • Rosen, H.R.1    Doherty, D.G.2    Madrigal-Estebas, L.3    O’farrelly, C.4    Golden-Mason, L.5
  • 214
    • 58149295512 scopus 로고    scopus 로고
    • Prospective study of natural killer cell phenotype in recurrent hepatitis c virus infection following liver transplantation
    • Varchetta S, Oliviero B, Francesca Donato M, Agnelli F, Rigamonti C, Paudice E, Arosio E, et al. Prospective study of natural killer cell phenotype in recurrent hepatitis C virus infection following liver transplantation. J Hepatol. 2009;50:314-22.
    • (2009) J Hepatol , vol.50 , pp. 314-322
    • Varchetta, S.1    Oliviero, B.2    Francesca Donato, M.3    Agnelli, F.4    Rigamonti, C.5    Paudice, E.6    Arosio, E.7
  • 216
    • 19944389201 scopus 로고    scopus 로고
    • Analysis of a successful hcv-specific cd8+ t cell response in patients with recurrent hcv-infection after orthotopic liver transplantation
    • Gruener NH, Jung MC, Ulsenheimer A, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, et al. Analysis of a successful HCV-specific CD8+ T cell response in patients with recurrent HCV-infection after orthotopic liver transplantation. Liver Transpl. 2004;10:1487-96.
    • (2004) Liver Transpl , vol.10 , pp. 1487-1496
    • Gruener, N.H.1    Jung, M.C.2    Ulsenheimer, A.3    Gerlach, J.T.4    Zachoval, R.5    Diepolder, H.M.6    Baretton, G.7
  • 217
    • 0037418113 scopus 로고    scopus 로고
    • Hepatitis c in the hiv-infected person
    • Sulkowski MS, Thomas DL. Hepatitis C in the HIV-infected person. Ann Intern Med. 2003;138:197-207.
    • (2003) Ann Intern Med , vol.138 , pp. 197-207
    • Sulkowski, M.S.1    Thomas, D.L.2
  • 218
    • 84860306889 scopus 로고    scopus 로고
    • Management of patients coinfected with hcv and hiv: A close look at the role for direct-acting antivirals
    • Naggie S, Sulkowski MS. Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals. Gastroenterology. 2012;142:1324-34.
    • (2012) Gastroenterology , vol.142 , pp. 1324-1334
    • Naggie, S.1    Sulkowski, M.S.2
  • 219
    • 0036188008 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1-hepatitis c virus coinfection: Intraindividual comparison of cellular immune responses against two persistent viruses
    • Lauer GM, Nguyen TN, Day CL, Robbins GK, Flynn T, McGowan K, Rosenberg ES, et al. Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses. J Virol. 2002;76:2817-26.
    • (2002) J Virol , vol.76 , pp. 2817-2826
    • Lauer, G.M.1    Nguyen, T.N.2    Day, C.L.3    Robbins, G.K.4    Flynn, T.5    Mc Gowan, K.6    Rosenberg, E.S.7
  • 220
    • 0029144001 scopus 로고
    • High hepatitis c viremia and impaired antibody response in patients coinfected with hiv
    • Cribier B, Rey D, Schmitt C, Lang JM, Kirn A, Stoll-Keller F. High hepatitis C viremia and impaired antibody response in patients coinfected with HIV. AIDS. 1995;9:1131-6.
    • (1995) AIDS , vol.9 , pp. 1131-1136
    • Cribier, B.1    Rey, D.2    Schmitt, C.3    Lang, J.M.4    Kirn, A.5    Stoll-Keller, F.6
  • 221
    • 19944432793 scopus 로고    scopus 로고
    • The magnitude and breadth of hepatitis c virus-specific cd8+ t cells depend on absolute cd4+ t-cell count in individuals coinfected with hiv-1
    • Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, et al. The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. Blood. 2005;105:1170-8.
    • (2005) Blood , vol.105 , pp. 1170-1178
    • Kim, A.Y.1    Lauer, G.M.2    Ouchi, K.3    Addo, M.M.4    Lucas, M.5    Schulze Zur Wiesch, J.6    Timm, J.7
  • 222
    • 29744444167 scopus 로고    scopus 로고
    • Differences in hcv-specific t cell responses between chronic hcv infection and hiv/hcv co-infection
    • Dutoit V, Ciuffreda D, Comte D, Gonvers JJ, Pantaleo G. Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCV co-infection. Eur J Immunol. 2005;35:3493-504.
    • (2005) Eur J Immunol , vol.35 , pp. 3493-3504
    • Dutoit, V.1    Ciuffreda, D.2    Comte, D.3    Gonvers, J.J.4    Pantaleo, G.5
  • 225
    • 32244435842 scopus 로고    scopus 로고
    • A t-cell hcv vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    • Folgori A, Capone S, Ruggeri L, Meola A, Sporeno E, Ercole BB, Pezzanera M, et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med. 2006;12:190-7.
    • (2006) Nat Med , vol.12 , pp. 190-197
    • Folgori, A.1    Capone, S.2    Ruggeri, L.3    Meola, A.4    Sporeno, E.5    Ercole, B.B.6    Pezzanera, M.7
  • 226
    • 84855372641 scopus 로고    scopus 로고
    • Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species
    • Colloca S, Barnes E, Folgori A, Ammendola V, Capone S, Cirillo A, Siani L, et al. Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med. 2012;4:115ra2.
    • (2012) Sci Transl Med , vol.4
    • Colloca, S.1    Barnes, E.2    Folgori, A.3    Ammendola, V.4    Capone, S.5    Cirillo, A.6    Siani, L.7
  • 227
    • 84866733892 scopus 로고    scopus 로고
    • Successful vaccination induces multifunctional memory t-cell precursors associated with early control of hepatitis c virus
    • Park SH, Shin EC, Capone S, Caggiari L, De Re V, Nicosia A, Folgori A, et al. Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus. Gastroenterology. 2012;143:1048-60.
    • (2012) Gastroenterology , vol.143 , pp. 1048-1060
    • Park, S.H.1    Shin, E.C.2    Capone, S.3    Caggiari, L.4    De Re, V.5    Nicosia, A.6    Folgori, A.7
  • 228
    • 77956168246 scopus 로고    scopus 로고
    • Meta-analysis of hepatitis c virus vaccine efficacy in chimpanzees indicates an importance for structural proteins
    • Dahari H, Feinstone SM, Major ME. Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins. Gastroenterology. 2010;139:965-74.
    • (2010) Gastroenterology , vol.139 , pp. 965-974
    • Dahari, H.1    Feinstone, S.M.2    Major, M.E.3
  • 229
    • 77955661037 scopus 로고    scopus 로고
    • Safety and immunogenicity of hcv e1e2 vaccine adjuvanted with mf59 administered to healthy adults
    • Frey SE, Houghton M, Coates S, Abrignani S, Chien D, Rosa D, Pileri P, et al. Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. Vaccine. 2010;28:6367-73.
    • (2010) Vaccine , vol.28 , pp. 6367-6373
    • Frey, S.E.1    Houghton, M.2    Coates, S.3    Abrignani, S.4    Chien, D.5    Rosa, D.6    Pileri, P.7
  • 230
    • 80051721226 scopus 로고    scopus 로고
    • Immunization of human volunteers with hepatitis c virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains
    • Stamataki Z, Coates S, Abrignani S, Houghton M, McKeating JA. Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains. J Infect Dis. 2011;204:811-3.
    • (2011) J Infect Dis , vol.204 , pp. 811-813
    • Stamataki, Z.1    Coates, S.2    Abrignani, S.3    Houghton, M.4    Mc Keating, J.A.5
  • 231
    • 84955056018 scopus 로고    scopus 로고
    • Recombinant glycoprotein e1/e2 vaccine from a single hcv strain elicit broadly cross-neutralizing antibodies against major hcv genotypes in human
    • Venice, 5-9 Oct. 2012. Oral Presentation O.28. Abstract book
    • Law J, Chen C, Hockman D, Frey S, Beishe R, Wakita T, Bukh J, et al. Recombinant glycoprotein E1/E2 vaccine from a single HCV strain elicit broadly cross-neutralizing antibodies against major HCV genotypes in human. In: 19th International symposium on hepatitis C virus and related viruses, Venice, 5-9 Oct. 2012. Oral Presentation O.28. Abstract book. www.hcv2012.org
    • 19Th International Symposium on Hepatitis C Virus and Related Viruses
    • Law, J.1    Chen, C.2    Hockman, D.3    Frey, S.4    Beishe, R.5    Wakita, T.6    Bukh, J.7
  • 232
    • 84865742652 scopus 로고    scopus 로고
    • Prospects for prophylactic and therapeutic vaccines against hepatitis c virus
    • Feinstone SM, Hu DJ, Major ME. Prospects for prophylactic and therapeutic vaccines against hepatitis C virus. Clin Infect Dis. 2012;55:S25-32.
    • (2012) Clin Infect Dis , vol.55
    • Feinstone, S.M.1    Hu, D.J.2    Major, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.