메뉴 건너뛰기




Volumn 19, Issue SUPPL. 2, 2012, Pages 1-26

A practical guide for the use of boceprevir and telaprevir for the treatment of hepatitis C

Author keywords

boceprevir; hepatitis C virus; telaprevir

Indexed keywords

ANTIHISTAMINIC AGENT; ATAZANAVIR PLUS RITONAVIR; BOCEPREVIR; CALCINEURIN INHIBITOR; CYCLOSPORIN; DARUNAVIR PLUS RITONAVIR; EFAVIRENZ; ERYTHROPOIETIN; FOSAMPRENAVIR PLUS RITONAVIR; INTERLEUKIN 28B; LOPINAVIR PLUS RITONAVIR; PEGINTERFERON; PEGINTERFERON ALPHA2A; PLACEBO; RIBAVIRIN; RITONAVIR; STEROID; TACROLIMUS; TELAPREVIR; TENOFOVIR;

EID: 84858432382     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2012.01590.x     Document Type: Article
Times cited : (72)

References (63)
  • 1
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • Lavanchy D,. The global burden of hepatitis C. Liver Int 2009; 29: 74-81.
    • (2009) Liver Int , vol.29 , pp. 74-81
    • Lavanchy, D.1
  • 2
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • DOI 10.1016/S1473-3099(05)70216-4, PII S1473309905702164
    • Shepard CW, Finelli L, Alter MJ,. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005; 5: 558-567. (Pubitemid 41196755)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.9 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 4
    • 77950611229 scopus 로고    scopus 로고
    • Institute of Medicine recommendations for the prevention and control of hepatitis B and C
    • Mitchell AE, Colvin HM, Palmer Beasley R,. Institute of Medicine recommendations for the prevention and control of hepatitis B and C. Hepatology 2010; 51: 729-733.
    • (2010) Hepatology , vol.51 , pp. 729-733
    • Mitchell, A.E.1    Colvin, H.M.2    Palmer Beasley, R.3
  • 5
    • 33845441692 scopus 로고    scopus 로고
    • Hepatitis C Virus and Liver Transplantation
    • DOI 10.1016/j.cld.2006.08.012, PII S1089326106000286, Hepatitis C Virus Update
    • Verna EC, Brown Jr RS,. Hepatitis C virus and liver transplantation. Clin Liver Dis 2006; 10: 919-940. (Pubitemid 44895436)
    • (2006) Clinics in Liver Disease , vol.10 , Issue.4 , pp. 919-940
    • Verna, E.C.1    Brown Jr., R.S.2
  • 6
    • 79953171086 scopus 로고    scopus 로고
    • Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection
    • Kanwal F, Hoang T, Kramer JR, et al. Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection. Gastroenterology 2011; 140: 1182-1188.
    • (2011) Gastroenterology , vol.140 , pp. 1182-1188
    • Kanwal, F.1    Hoang, T.2    Kramer, J.R.3
  • 7
    • 75149163334 scopus 로고    scopus 로고
    • Aging of hepatitis C virus (HCV)-infected persons in the United States: A multiple cohort model of HCV prevalence and disease progression
    • Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW,. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010; 138: 513-521.
    • (2010) Gastroenterology , vol.138 , pp. 513-521
    • Davis, G.L.1    Alter, M.J.2    El-Serag, H.3    Poynard, T.4    Jennings, L.W.5
  • 9
    • 77956635697 scopus 로고    scopus 로고
    • Outcome of sustained virological responders with histologically advanced chronic hepatitis C
    • Morgan TR, Ghany MG, Kim HY, et al. Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology 2010; 52: 833-844.
    • (2010) Hepatology , vol.52 , pp. 833-844
    • Morgan, T.R.1    Ghany, M.G.2    Kim, H.Y.3
  • 11
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009; 361: 580-593.
    • (2009) N Engl J Med , vol.361 , pp. 580-593
    • McHutchison, J.G.1    Lawitz, E.J.2    Shiffman, M.L.3
  • 12
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • McHutchison JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009; 360: 1827-1838.
    • (2009) N Engl J Med , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1    Everson, G.T.2    Gordon, S.C.3
  • 13
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hezode C, Forestier N, Dusheiko G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009; 360: 1839-1850.
    • (2009) N Engl J Med , vol.360 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 14
    • 77950624760 scopus 로고    scopus 로고
    • The neglected hepatitis C virus genotypes 4, 5 and 6: An international consensus report
    • Antaki N, Craxi A, Kamal S, et al. The neglected hepatitis C virus genotypes 4, 5 and 6: an international consensus report. Liver Int 2010; 30: 342-355.
    • (2010) Liver Int , vol.30 , pp. 342-355
    • Antaki, N.1    Craxi, A.2    Kamal, S.3
  • 15
    • 33645992473 scopus 로고    scopus 로고
    • Extended treatment duration for hepatitis C virus type 1: Comparing 48 versus 72 weeks of peginterferon-alfa-2a plus ribavirin
    • Berg T, von Wagner M, Nasser S, et al. Extended treatment duration for hepatitis C virus type 1: comparing 48 versus 72 weeks of peginterferon-alfa-2a plus ribavirin. Gastroenterology 2006; 130: 1086-1097.
    • (2006) Gastroenterology , vol.130 , pp. 1086-1097
    • Berg, T.1    Von Wagner, M.2    Nasser, S.3
  • 16
    • 37749051824 scopus 로고    scopus 로고
    • Treatment extension to 72 weeks of peginterferon and ribavirin in hepatitis c genotype 1-infected slow responders
    • Pearlman BL, Ehleben C, Saifee S,. Treatment extension to 72 weeks of peginterferon and ribavirin in hepatitis c genotype 1-infected slow responders. Hepatology 2007; 46: 1688-1694.
    • (2007) Hepatology , vol.46 , pp. 1688-1694
    • Pearlman, B.L.1    Ehleben, C.2    Saifee, S.3
  • 18
    • 77957952655 scopus 로고    scopus 로고
    • Randomized trial of peginterferon alfa-2b and ribavirin for 48 or 72 weeks in patients with hepatitis C virus genotype 1 and slow virologic response
    • Buti M, Lurie Y, Zackharova NG, et al. Randomized trial of peginterferon alfa-2b and ribavirin for 48 or 72 weeks in patients with hepatitis C virus genotype 1 and slow virologic response. Hepatology 2010; 52: 1201-1207.
    • (2010) Hepatology , vol.52 , pp. 1201-1207
    • Buti, M.1    Lurie, Y.2    Zackharova, N.G.3
  • 19
    • 67349172961 scopus 로고    scopus 로고
    • Peginterferon alfa-2b and ribavirin: Effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy
    • Poynard T, Colombo M, Bruix J, et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 2009; 136: 1618-1628.
    • (2009) Gastroenterology , vol.136 , pp. 1618-1628
    • Poynard, T.1    Colombo, M.2    Bruix, J.3
  • 20
    • 79952449876 scopus 로고    scopus 로고
    • Retreatment of chronic hepatitis C-genotype 1-infected relapsers to peginterferon/ribavirin with consensus interferon/ribavirin or with extended duration therapy peginterferon/ribavirin
    • Pearlman BL, Ehleben C,. Retreatment of chronic hepatitis C-genotype 1-infected relapsers to peginterferon/ribavirin with consensus interferon/ribavirin or with extended duration therapy peginterferon/ribavirin. Hepatology 2009; 50 (Suppl. 4): 686A.
    • (2009) Hepatology , vol.50 , Issue.SUPPL. 4
    • Pearlman, B.L.1    Ehleben, C.2
  • 21
    • 65349129985 scopus 로고    scopus 로고
    • Re-treatment of patients with chronic hepatitis C who do not respond to peginterferon-alpha2b: A randomized trial
    • Jensen DM, Marcellin P, Freilich B, et al. Re-treatment of patients with chronic hepatitis C who do not respond to peginterferon-alpha2b: a randomized trial. Ann Intern Med 2009; 150: 528-540.
    • (2009) Ann Intern Med , vol.150 , pp. 528-540
    • Jensen, D.M.1    Marcellin, P.2    Freilich, B.3
  • 22
    • 66949176133 scopus 로고    scopus 로고
    • Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results
    • Bacon BR, Shiffman ML, Mendes F, et al. Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results. Hepatology 2009; 49: 1838-1846.
    • (2009) Hepatology , vol.49 , pp. 1838-1846
    • Bacon, B.R.1    Shiffman, M.L.2    Mendes, F.3
  • 23
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1207-1217.
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 24
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011; 364: 2417-2428.
    • (2011) N Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 25
    • 50649112802 scopus 로고    scopus 로고
    • Treatment predictors of a sustained virologic response in hepatitis B and C
    • Kau A, Vermehren J, Sarrazin C,. Treatment predictors of a sustained virologic response in hepatitis B and C. J Hepatol 2008; 49: 634-651.
    • (2008) J Hepatol , vol.49 , pp. 634-651
    • Kau, A.1    Vermehren, J.2    Sarrazin, C.3
  • 27
    • 76449118685 scopus 로고    scopus 로고
    • Efficacy and safety of pegylated interferon combined with ribavirin for the treatment of older patients with chronic hepatitis C
    • Huang CF, Yang JF, Dai CY, et al. Efficacy and safety of pegylated interferon combined with ribavirin for the treatment of older patients with chronic hepatitis C. J Infect Dis 2010; 201: 751-759.
    • (2010) J Infect Dis , vol.201 , pp. 751-759
    • Huang, C.F.1    Yang, J.F.2    Dai, C.Y.3
  • 28
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F, McCone J, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1195-1206.
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3
  • 29
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011; 364: 2405-2416.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 30
    • 78751626981 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon alfa2a and ribavirin for 24 or 48 weeks in treatment-naive genotype 1 HCV patients who achieved an extended rapid viral response: Final results of phase 3 ILLUMINATE Study
    • Sherman KE, Flamm SL, Afdhal NH, et al. Telaprevir in combination with peginterferon alfa2a and ribavirin for 24 or 48 weeks in treatment-naive genotype 1 HCV patients who achieved an extended rapid viral response: final results of phase 3 ILLUMINATE Study. Hepatology 2010; 52 (Suppl. 1): 401A-402A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 31
    • 78650803266 scopus 로고    scopus 로고
    • HCV RESPOND-2 final results: High sustained virologic response among genotype 1 previous non-responders and relapsers to peginterferon/ribavirin when re-treated with boceprevir plus PEGINTRON (peginterferon alfa-2b)/ribavirin
    • Bacon BR, Gordon SC, Lawitz E, et al. HCV RESPOND-2 final results: high sustained virologic response among genotype 1 previous non-responders and relapsers to peginterferon/ribavirin when re-treated with boceprevir plus PEGINTRON (peginterferon alfa-2b)/ribavirin. Hepatology 2010; 52 (Suppl. 1): 430A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 32
    • 84873074147 scopus 로고    scopus 로고
    • Boceprevir. Accessed 3 August 2011
    • FDA Antiviral Drugs Advisory Committee Meeting. Boceprevir. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/ Drugs/AntiviralDrugsAdvisoryCommittee/UCM254079.pdf. Accessed 3 August 2011.
    • FDA Antiviral Drugs Advisory Committee Meeting
  • 33
    • 79956284848 scopus 로고    scopus 로고
    • REALIZE trial final results: Telaprevir-based regimen for genotype 1 hepatitis C virus infection in patients with prior null response, partial response or relapse to peginterferon/ribavirin
    • Zeuzem S, Andreone P, Pol S, et al. REALIZE trial final results: telaprevir-based regimen for genotype 1 hepatitis C virus infection in patients with prior null response, partial response or relapse to peginterferon/ ribavirin. J Hepatol 2011; 54 (Suppl. 1): S3.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 34
    • 79957437679 scopus 로고    scopus 로고
    • Distributive justice and the arrival of direct-acting antivirals: Who should be first in line?
    • Aronsohn A, Jensen D,. Distributive justice and the arrival of direct-acting antivirals: who should be first in line? Hepatology 2011; 53: 1789-1791.
    • (2011) Hepatology , vol.53 , pp. 1789-1791
    • Aronsohn, A.1    Jensen, D.2
  • 35
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009; 41: 1100-1104.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 36
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 41: 1105-1109.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 37
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 38
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson AJ, Muir AJ, Sulkowski MS, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010; 139: 120-129.
    • (2010) Gastroenterology , vol.139 , pp. 120-129
    • Thompson, A.J.1    Muir, A.J.2    Sulkowski, M.S.3
  • 39
    • 79954797695 scopus 로고    scopus 로고
    • IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C
    • Fattovich G, Covolo L, Bibert S, et al. IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C. Ailment Pharmacol Ther 2011; 33: 1162-1172.
    • (2011) Ailment Pharmacol Ther , vol.33 , pp. 1162-1172
    • Fattovich, G.1    Covolo, L.2    Bibert, S.3
  • 40
    • 78650946377 scopus 로고    scopus 로고
    • Chemokine antagonism in chronic hepatitis C virus infection
    • Charles ED, Dustin JB,. Chemokine antagonism in chronic hepatitis C virus infection. J Clin Invest 2011; 121: 25-27.
    • (2011) J Clin Invest , vol.121 , pp. 25-27
    • Charles, E.D.1    Dustin, J.B.2
  • 41
    • 78751492246 scopus 로고    scopus 로고
    • Quantitation of pretreatment serum interferon-Î-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response
    • Darling JM, Aerssens J, Fanning G, et al. Quantitation of pretreatment serum interferon-Î-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. Hepatology 2011; 53: 14-22.
    • (2011) Hepatology , vol.53 , pp. 14-22
    • Darling, J.M.1    Aerssens, J.2    Fanning, G.3
  • 42
    • 80053529403 scopus 로고    scopus 로고
    • Predictors of sustained virologic response among treatment-naive patients with hepatitis C virus genotype 1 when treated with boceprevir (BOC) plus peginterferon alfa-2b/ribavirin (PR)
    • Reddy KR, Bruno S, Rossaro L, et al. Predictors of sustained virologic response among treatment-naive patients with hepatitis C virus genotype 1 when treated with boceprevir (BOC) plus peginterferon alfa-2b/ribavirin (PR). J Hepatol 2011; 54 (Suppl. 1): S190.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Reddy, K.R.1    Bruno, S.2    Rossaro, L.3
  • 43
    • 80053495300 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon alfa-2a and ribavirin: Analyses of pre-defined subpopulations in the phase 3 ADVANCE trial
    • Marcellin P, Jacobson IM, Zeuzem S, et al. Telaprevir in combination with peginterferon alfa-2a and ribavirin: analyses of pre-defined subpopulations in the phase 3 ADVANCE trial. J Hepatol 2011; 54 (Suppl. 1): S183-S184.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Marcellin, P.1    Jacobson, I.M.2    Zeuzem, S.3
  • 44
    • 79957963815 scopus 로고    scopus 로고
    • IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C
    • Chayama K, Hayes CN, Abe H, et al. IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C. J Infect Dis 2011; 204: 84-93.
    • (2011) J Infect Dis , vol.204 , pp. 84-93
    • Chayama, K.1    Hayes, C.N.2    Abe, H.3
  • 45
    • 79960720423 scopus 로고    scopus 로고
    • Telaprevir substantially improved SVR rates across all IL28B genotypes in the ADVANCE trial
    • Jacobson IM, Catlett I, Marcellin P, et al. Telaprevir substantially improved SVR rates across all IL28B genotypes in the ADVANCE trial. J Hepatol 2011; 54 (Suppl. 1): S542-S543.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Jacobson, I.M.1    Catlett, I.2    Marcellin, P.3
  • 46
    • 79960447952 scopus 로고    scopus 로고
    • Similar SVR rates in IL28B CC, CT or TT prior relapser, partial- or null-responder patients treated with telaprevir/peginterferon/ribavirin: Retrospective analysis of the REALIZE study
    • et al.
    • Pol S, Aerssens J, Zeuzem S, et al. Similar SVR rates in IL28B CC, CT or TT prior relapser, partial- or null-responder patients treated with telaprevir/peginterferon/ribavirin: retrospective analysis of the REALIZE study. J Hepatol 2011; 54 (Suppl. 1): S6-S7.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Pol, S.1    Aerssens, J.2    Zeuzem, S.3
  • 47
    • 79960449077 scopus 로고    scopus 로고
    • IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (BOC) combination therapy
    • Poordad F, Bronowicki JP, Gordon SC, et al. IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (BOC) combination therapy. J Hepatol 2011; 54 (Suppl. 1): S6.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Poordad, F.1    Bronowicki, J.P.2    Gordon, S.C.3
  • 49
    • 80053478323 scopus 로고    scopus 로고
    • Predictors of sustained virologic response among genotype 1 previous non-responders and relapsers to peginterferon/ribavirin when re-treated with boceprevir plus peginterferon alfa-2b/ribavirin
    • Zeuzem S, Vierling JM, Esteban R, et al. Predictors of sustained virologic response among genotype 1 previous non-responders and relapsers to peginterferon/ribavirin when re-treated with boceprevir plus peginterferon alfa-2b/ribavirin. J Hepatol 2011; 54 (Suppl. 1): S198-S199.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Zeuzem, S.1    Vierling, J.M.2    Esteban, R.3
  • 50
    • 79960729857 scopus 로고    scopus 로고
    • Subanalyses of the telaprevir lead-in arm in the REALIZE study: Response at week 4 is not a substitute for prior null response categorization
    • Foster GR, Zeuzem S, Andreone P, et al. Subanalyses of the telaprevir lead-in arm in the REALIZE study: response at week 4 is not a substitute for prior null response categorization. J Hepatol 2011; 54 (Suppl. 1): S3-S4.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Foster, G.R.1    Zeuzem, S.2    Andreone, P.3
  • 51
    • 81255140695 scopus 로고    scopus 로고
    • Whitehouse Station, NJ: Merck.
    • Victrelis [package insert]. Whitehouse Station, NJ: Merck, 2011.
    • (2011) Victrelis [Package Insert]
  • 52
    • 84873069149 scopus 로고    scopus 로고
    • European Medicines Agency. Available at:. Accessed 17 August 2011
    • Victrelis [boceprevir]. European Medicines Agency. Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/ 002332/human-med-001464.jsp. Accessed 17 August 2011.
    • Victrelis [Boceprevir]
  • 53
  • 54
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • Pawlotsky JM,. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology 2011; 53: 1742-1751.
    • (2011) Hepatology , vol.53 , pp. 1742-1751
    • Pawlotsky, J.M.1
  • 55
    • 79960735084 scopus 로고    scopus 로고
    • Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials
    • Sullivan JC, De Meyer S, Bartels DJ, et al. Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials. J Hepatol 2011; 54 (Suppl. 1): S4.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Sullivan, J.C.1    De Meyer, S.2    Bartels, D.J.3
  • 56
    • 79955667562 scopus 로고    scopus 로고
    • Frequencies of resistance-associated amino acid variants following combination treatment with boceprevir plus PEGINTRON (peginterferon alfa-2b)/ribavirin in patients with chronic hepatitis C (CHC), genotype 1 (G1)
    • Vierling JM, Kwo PY, Lawitz E, et al. Frequencies of resistance- associated amino acid variants following combination treatment with boceprevir plus PEGINTRON (peginterferon alfa-2b)/ribavirin in patients with chronic hepatitis C (CHC), genotype 1 (G1). Hepatology 2010; 52 (Suppl. 1): 702A-703A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Vierling, J.M.1    Kwo, P.Y.2    Lawitz, E.3
  • 57
    • 82955182885 scopus 로고    scopus 로고
    • Boceprevir resistance-associated variants (RAVS) are observed more frequently in HCV (GT1)-infected patients with poor response to peginterferon alfa-2b/ribavirin
    • Zeuzem S, Barnard RJ, Howe JA, et al. Boceprevir resistance-associated variants (RAVS) are observed more frequently in HCV (GT1)-infected patients with poor response to peginterferon alfa-2b/ribavirin. J Hepatol 2011; 54 (Suppl. 1): S4-S5.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Zeuzem, S.1    Barnard, R.J.2    Howe, J.A.3
  • 58
    • 84858388277 scopus 로고    scopus 로고
    • Anemia during treatment with peginterferon alfa-2B/ribavirin with or without boceprevir is associated with higher SVR Rates: Analysis of previously untreated and previous-treatment-failure patients
    • Sulkowski M, Poordad F, Manns MP, et al. Anemia during treatment with peginterferon alfa-2B/ribavirin with or without boceprevir is associated with higher SVR Rates: analysis of previously untreated and previous-treatment- failure patients. Gastroenterology 2011; 140 (Suppl. 1): S941-S942.
    • (2011) Gastroenterology , vol.140 , Issue.SUPPL. 1
    • Sulkowski, M.1    Poordad, F.2    Manns, M.P.3
  • 59
    • 80053477775 scopus 로고    scopus 로고
    • Anemia during treatment with peginterferon alfa-2b/ribavirin with or without boceprevir is associated with higher SVR rates: Analysis of previously untreated and previous treatment-failure patients
    • Sulkowski MS, Poordad F, Manns MP, et al. Anemia during treatment with peginterferon alfa-2b/ribavirin with or without boceprevir is associated with higher SVR rates: analysis of previously untreated and previous treatment-failure patients. J Hepatol 2011; 54 (Suppl. 1): S194-S195.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Sulkowski, M.S.1    Poordad, F.2    Manns, M.P.3
  • 60
    • 84858417389 scopus 로고    scopus 로고
    • Anemia had no effect on efficacy outcomes in treatment-naive patients who received telaprevir-based regimens in the ADVANCE and ILLUMINATE phase 3 studies
    • Poordad F, Sulkowski MS, Reddy R, et al. Anemia had no effect on efficacy outcomes in treatment-naive patients who received telaprevir-based regimens in the ADVANCE and ILLUMINATE phase 3 studies. Gastroenterology 2011; 140 (Suppl. 1): S898-S899.
    • (2011) Gastroenterology , vol.140 , Issue.SUPPL. 1
    • Poordad, F.1    Sulkowski, M.S.2    Reddy, R.3
  • 61
    • 80054893901 scopus 로고    scopus 로고
    • Interim analysis of a phase 2a double-blind study of TVR in combination with pegIFN-alfa2a and RBV in HIV/HCV co-infected patients
    • 27 February-2 March Boston, MA. Abstract 146LB. Accessed 6 October 2011
    • Sulkowski M, Dieterich D, Sherman K, et al. Interim analysis of a phase 2a double-blind study of TVR in combination with pegIFN-alfa2a and RBV in HIV/HCV co-infected patients. Program and abstracts of the 18th Conference on Retroviruses and Opportunistic Infections; 27 February-2 March, 2011; Boston, MA. Abstract 146LB. Available at: http://www.retroconference.org/2011/Abstracts/ 42467.htm. Accessed 6 October 2011.
    • (2011) Program and Abstracts of the 18th Conference on Retroviruses and Opportunistic Infections
    • Sulkowski, M.1    Dieterich, D.2    Sherman, K.3
  • 62
  • 63
    • 79959549897 scopus 로고    scopus 로고
    • Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents: A potentially lethal cocktail
    • Charlton M,. Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents: a potentially lethal cocktail. Hepatology 2011; 54: 3-5.
    • (2011) Hepatology , vol.54 , pp. 3-5
    • Charlton, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.