Polyfunctional type-1, -2, and -17 CD8+ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection

PLoS Pathogens

Volumn 8, Issue 6, 2012, Pages

  Franceschini, Debora ^a   Del Porto, Paola ^b   Piconese, Silvia ^a   Trella, Emanuele ^a   Accapezzato, Daniele ^a   Paroli, Marino ^a   Morrone, Stefania ^a   Piccolella, Enza ^b   Spada, Enea ^c   Mele, Alfonso ^c   Sidney, John ^d   Sette, Alessandro ^d   Barnaba, Vincenzo ^a,e,f  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^e Pasteur Institute   (Italy)

^f Andrea Cesalpino Foundation   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CASPASE; CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 4; RETINOID RELATED ORPHAN RECEPTOR GAMMA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR T BET;

ADULT; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL SPECIFICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; DISEASE COURSE; EFFECTOR CELL; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; IMMUNOLOGY; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION;

HEPATITIS C VIRUS;

ADULT; APOPTOSIS; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; EPITOPES, T-LYMPHOCYTE; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84864055607     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002759     Document Type: Article

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