Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells

Journal of Immunology

Volumn 173, Issue 3, 2004, Pages 2159-2166

  Durante Mangoni, Emanuele ^a,b   Wang, RuoJie ^a   Shaulov, Angela ^a   He, Qi ^a   Nasser, Imad ^a   Afdhal, Nezam ^a   Koziel, Margaret J ^a   Exley, Mark A ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD161 ANTIGEN; CD1D ANTIGEN; CD56 ANTIGEN; GAMMA INTERFERON; GLYCOLIPID; INTERLEUKIN 13; INTERLEUKIN 4; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CELL LINE; CELL SUBPOPULATION; CHRONICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEPATITIS C; HEPATITIS C VIRUS; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INFLAMMATORY CELL; LIVER FIBROSIS; LIVER INJURY; LYMPHOCYTE COUNT; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS CELL INTERACTION;

EID: 3242754111     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.3.2159     Document Type: Article

References (74)

1. Porcelli, S., and R. Modlin. 1999. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu. Rev. Immunol. 17:297.
2. Bleicher, P., S. Balk, S. Hagen, R. Blumberg, T. Flotte, and C. Terhorst. 1990. Expression of murine CD1 on gastrointestinal epithelium. Science 250:679.
3. Canchis, P., A. Bhan, S. Landau, L. Yang, S. Balk, and R. Blumberg. 1993. Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d. Immunology 80:561.
4. Brossay, L., D. Jullien, S. Cardell, B. C. Sydora, N. Burdin, R. Modlin, and M. Kronenberg. 1997. Mouse CD1 is mainly expressed on hemopoietic-derived cells. J. Immunol. 159:1216.
5. Mandal, M., X. Chen, M. Alegre, N. Chiu, Y. Chen, A. Castano, and C. Wang. 1998. Tissue distribution, regulation and intracellular localization of murine CD1. Mol. Immunol. 35:525.
6. Exley, M., J. Garcia, S. B. Wilson, F. Spada, D. Gerdes, S. M. Tahir, K. T. Patton, R. S. Blumberg, S. Porcelli, A. Chou, and S. P. Balk. 2000. CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes. Immunology 100:37.
7. Tsuneyama, K., M. Yasoshima, K. Harada, K. Hiramatsu, M. Gershwin, and Y. Nakanuma. 1998. Increased CD1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis. Hepatology 28:620.
8. Bendelac, A., M. Rivera, S. Park, and J. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535.
9. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted TCR-mediated activation of Vα14 NKT by glycosylceramides. Science 278:1626.
10. - T cells. J. Exp. Med. 186:109.
11. Burdin, N., and M. Kronenberg. 1999. CD1-mediated immune responses to glycolipids. Curr. Opin. Immunol. 11:326.
12. Taniguchi, M., M. Harada, S. Kojo, T. Nakayama, and H. Wakao. 2003. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483.
13. Vincent, M. S., J. E. Gumperz, and M. B. Brenner. 2003. Understanding the function of CD1-restricted T cells. Nat. Immunol. 4:517.
14. Cui, J., T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, and M. Taniguchi. 1997. Requirement for Vα14 NKT in IL-12-mediated rejection of tumors. Science 278:1623.
15. Exley, M. A., S. Porcelli, M. Furman, J. Garcia, and S. Balk. 1998. CD161 costimulation of CD1d-dependent activation of human T cells expressing invariant Vα24JαQ TCR. J. Exp. Med. 188:867.
16. Metelitsa, L., O. Naidenko, A. Kant, H. Wu, M. Loza, B. Perussia, M. Kronenberg, and R. Seeger. 2001. Human NKT mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. J. Immunol. 167:3114.
17. + T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 182:993.
18. + targets. J. Immunol. 160:3681.
19. Behar, S., T. Podrebarac, C. Roy, C. Wang, and M. Brenner. 1999. Diverse TCRs recognize murine CD1. J. Immunol. 162:161.
20. Chiu, Y., J. Jayawardena, A. Weiss, D. Lee, S. Park, A. Dautry-Varsat, and A. Bendelac. 1999. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J. Exp. Med. 189:103.
21. Eberl, G., R. Lees, S. Smiley, M. Taniguchi, M. Grusby, and H. MacDonald. 1999. Tissue-specific segregation of CD1d-dependent and CD1d-independent NKT cells. J. Immunol. 162:6410.
22. Zeng, D., G. Gazit, S. Dejbakhsh-Jones, S. Balk, S. Snapper, M. Taniguchi, and S. Strober. 1999. Heterogeneity of NKT cells in the bone marrow. J. Immunol. 163:5338.
23. Exley, M. A., S. Tahir, O. Cheng, A. Shaulov, R. Joyce, D. Avigan, R. Sackstein, and S. Balk. 2001. Cutting edge: a major fraction of human bone marrow lymphocytes are Th2-Like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J. Immunol. 167:5531.
24. Exley, M. A., Q. He, O. Cheng, R. J. Wang, C. P. Cheney, S. P. Balk, and M. J. Koziel. 2002. Cutting edge: compartmentalization of Th1-like non-invariant CD1d-reactive T cells in hepatitis C virus-infected liver. J. Immunol. 168:1519.
25. Gumperz, J. E., S. Miyake, T. Yamamura, and M. B. Brenner. 2002. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J. Exp. Med. 195:625.
26. Lanier, L. L. 2001. On guard: activating NK cell receptors. Nat. Immunol 2:23.
27. + NK cells in vitro. J. Immunol. 165:1659.
28. + T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide. Blood 99:1259.
29. Sonoda, K., M. A. Exley, S. Snapper, S. P. Balk, and J. Stein-Streilein. 1999. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190:1215.
30. Wilson, S. B., and T. L. Delovitch. 2003. Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity. Nat. Rev. Immunol. 3:211.
31. Exley, M. A., N. Bigley, O. Cheng, S. Tahir, S. Smiley, Q. Carter, H. Stills, M. Grusby, Y. Koezuka, M. Taniguchi, and S. Balk. 2001. CD1d-reactive T-cell activation leads to amelioration of disease caused by encephalomyocarditis virus. J. Leukocyte Biol. 69:713.
32. Nieuwenhuis, E. E., T. Matsumoto, M. A. Exley, R. A. Schleipman, J. Glickman, D. T. Bailey, N. Corazza, S. P. Colgan, A. B. Onderdonk, and R. S. Blumberg. 2002. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat. Med. 8:588.
33. Grubor-Bauk, B., A. Simmons, G. Mayrhofer, and P. G. Speck. 2003. Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant Vα14-Jα281 TCR. J. Immunol. 170:1430.
34. + T cells and amplification of antiviral immune responses to respiratory syncytial virus. J. Virol. 76:4294.
35. Exley, M. A., N. Bigley, O. Cheng, A. Shaulov, S. Tahir, Q. Carter, J. Garcia, C. Wang, K. Patten, H. Stills, et al. 2003. Innate immune response encephalomyocarditis virus infection mediated by CD1d. Immunology 110:519.
36. Levy, O., J. Orange, P. Hibberd, S. Steinberg, P. LaRussa, A. Weinberg, S. B. Wilson, A. Shaulov, G. Fleisher, R. Geha, et al. 2003. Disseminated Varicella infection due to vaccine (Oka) strain Varicella zoster virus in a patient with a novel deficiency in natural killer T cells. J. Infect. Dis. 188:948.
37. Gillessen, S., Y. N. Naumov, E. E. Nieuwenhuis, M. A. Exley, F. S. Lee, N. Mach, A. D. Luster, R. S. Blumberg, M. Taniguchi, S. P. Balk, et al. 2003. CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion. Proc. Nat1. Acad. Sci. USA 100:8874.
38. Tahir, M., O. Cheng, A. Shaulov, Y. Koezuka, G. Bubley, S. B. Wilson, S. Balk, and M. Exley. 2001. Loss of IFN-γ production by invariant NKT of advanced cancer patients. J. Immunol. 167:4046.
39. Kitamura, H., K. Iwakabe, T. Yahata, S. Nishimura, A. Ohta, Y. Ohmi, M. Sato, K. Takeda, K. Okumura, L. Van Kaer, et al. 1999. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 189:1121.
40. +NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J. Immunol. 163:93.
41. Carnaud, C., D. Lee, O. Donnars, S. H. Park, A. Beavis, Y. Koezuka, and A. Bendelac. 1999. Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:4647.
42. Nishimura, T., H. Kitamura, K. Iwakabe, T. Yahata, A. Ohta, M. Sato, K. Takeda, K. Okumura, L. Van Kaer, T. Kawano, et al. 2000. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int. Immunol. 12:987.
43. Galli, G., S. Nuti, S. Tavarini, L. Galli-Stampino, C. De Lalla, G. Casorati, P. Dellabona, and S. Abrignani. 2003. CD1d-restricted help to B cells by human invariant natural killer T lymphocytes. J. Exp. Med. 197:1051.
44. + Th1 cells. J. Virol. 76:10785.
45. Huber, S., D. Sartini, and M. Exley. 2003. Role of CD1d in coxsackievirus B3-induced myocarditis. J. Immunol. 170:3147.
46. Crispe, I. N. 2003. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 1:51.
47. + T cells for liver injury induced by Salmonella infection in mice. Hepatology 29:1799.
48. Takeda, K., Y. Hayakawa, L. Van Kaer, H. Matsuda, H. Yagita, and K. Okumura. 2000. Critical contribution of liver NKT cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA 97:5498.
49. Osman, Y., T. Kawamura, T. Naito, K. Takeda, L. Van Kaer, K. Okumura, and T. Abo. 2000. Activation of hepatic NKT and subsequent liver injury following administration of α-galactosylceramide. Eur. J. Immunol. 30:1919.
50. Kakimi, K., L. Guidotti, Y. Koezuka, and F. Chisari. 2000. NKT cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192:921.
51. Baron, J. L., L. Gardiner, S. Nishimura, K. Shinkai, R. Locksley, and D. Ganem. 2002. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16:583.
52. + T cells and rapid elimination of effector cells by apoptosis. Eur. J. Immunol. 28:3448.
53. Norris, S., C. Collins, D. G. Doherty, F. Smith, G. McEntee, O. Traynor, N. Nolan, J. Hegarty, and C. O'Farrelly. 1998. Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. J. Hepatol. 28:84.
54. + lymphocytes, and cells that also co-express CD8 by IL-2, IL-12 and anti-CD3 monoclonal antibody. Hum. Immunol. 59:352.
55. + natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J. Immunol. 163:2314.
56. + T cells preferentially accumulate in human liver. Eur. J. Immunol. 29:2406.
57. + T cells and NK cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma. Hepatology 32:962.
58. + natural killer T cells in chronic hepatitis C viral infection. J. Hepatol. 37:101.
59. Kenna, T., L. G. Mason, S. A. Porcelli, Y. Koezuka, J. E. Hegarty, C. O'Farrelly, and D. G. Doherty. 2003. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J. Immunol. 171:1775.
60. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000. In vivo identification of glycolipid antigen-specific T cells using CD1d tetramers. J. Exp. Med. 191:1895.
61. Matsuda, J., O. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of NKT cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192:741.
62. Karadimitris, A., S. Gadola, M. Altamirano, D. Brown, A. Woolfson, P. Klenerman, J. Chen, Y. Koezuka, I. Roberts, D. Price, et al. 2001. Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc. Natl. Acad. Sci. USA 98:3294.
63. Kita, H., O. V. Naidenko, M. Kronenberg, A. A. Ansari, P. Rogers, S. X. He, F. Koning, T. Mikayama, J. Van De Water, R. L. Coppel, M. Kaplan, and M. E. Gershwin. 2002. Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology 123:1031.
64. Koziel, M., D. Dudley, N. Afdhal, Q. Choo, M. Houghton, R. Ralston, and B. Walker. 1993. HCV-specific CTL recognize epitopes in the core and envelope proteins of HCV. J. Virol. 67:7522.
65. + T cells specific for the protein NS4 of HCV in patients with chronic hepatitis C. J. Exp. Med. 178:17.
66. + T cells in peripheral blood and liver using peptide-MHC tetramers. Proc. Natl. Acad. Sci. USA 96:5692.
67. Cerny, A., and F. Chisari. 1999. Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 30:595.
68. Wong D., D. Dudley, N. Afdhal, J. Dienstag, C. M. Rice, L. Wang, M. Houghton, B. D. Walker, and M. J. Koziel. 1998 Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J. Immunol. 160:1479.
69. Sai Y. A. T. Nies, I. M. Arias. 1999. Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells. J. Cell Sci. 112:4535.
70. Chiaramonte, M. G., A. W. Cheever, J. D. Malley, D. D. Donaldson, and T. A. Wynn. 2001. Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34:273.
71. + T-cell and cytokine response. Gastroenterology 121:646.
72. de Lalla, C., G. Galli, L. Aldrighetti, R. Romeo, M. Mariani, A. Monno, S. Nuti, M. Colombo, F. Callea, S. A. Porcelli, et al. 2004. Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis. J. Immunol. In press.
73. Brigl, M., L. Bry, S. C. Kent, J. E. Gumperz, and M. B. Brenner. 2003. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat. Immunol. 4:1230.
74. Godfrey, D. I., H. R. MacDonald, M. Kronenberg, M. J. Smyth, and L. Van Kaer. 2004. NKT cells: what's in a name? Nat. Rev. Immunol. 4:231.