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Volumn 3, Issue 7, 2012, Pages

Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C

Author keywords

Chronic liver disease; Dendritic cells; Hepatitis C; Tolerance

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

EID: 84870908918     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.21823     Document Type: Review
Times cited : (46)

References (139)
  • 1
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • PMID:7679746
    • Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993; 67:1385-95; PMID:7679746
    • (1993) J Virol , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 2
    • 0027068086 scopus 로고
    • The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team
    • PMID:1280771, http://dx.doi.org/10.1056/NEJM199212313272702
    • Alter MJ, Margolis HS, Krawczynski K, Judson FN, Mares A, Alexander WJ, et al. The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N Engl J Med 1992; 327: 1899-905; PMID:1280771; http://dx.doi.org/10. 1056/NEJM199212313272702
    • (1992) N Engl J Med , vol.327 , pp. 1899-1905
    • Alter, M.J.1    Margolis, H.S.2    Krawczynski, K.3    Judson, F.N.4    Mares, A.5    Alexander, W.J.6
  • 3
    • 0036829856 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis C in the United States
    • PMID:12407579, http://dx.doi.org/10.1002/hep.1840360710
    • El-Serag HB. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology 2002; 36(Suppl 1): S74-83; PMID:12407579; http://dx.doi.org/10.1002/hep.1840360710
    • (2002) Hepatology , vol.36 , Issue.SUPPL. 1
    • El-Serag, H.B.1
  • 5
    • 0242456086 scopus 로고    scopus 로고
    • Scope of worldwide hepatitis C problem
    • PMID: 14586889, http://dx.doi.org/10.1053/jlts.2003.50244
    • Brown RS, Jr., Gaglio PJ. Scope of worldwide hepatitis C problem. Liver Transpl 2003; 9:S10-3; PMID: 14586889; http://dx.doi.org/10.1053/jlts.2003.50244
    • (2003) Liver Transpl , vol.9
    • Brown Jr., R.S.1    Gaglio, P.J.2
  • 6
    • 0032547944 scopus 로고    scopus 로고
    • International Hepatitis Interventional Therapy Group. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
    • PMID:9819447, http://dx.doi.org/10.1056/NEJM199811193392102
    • Davis GL, Esteban-Mur R, Rustgi V, Hoefs J, Gordon SC, Trepo C, et al. International Hepatitis Interventional Therapy Group. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. N Engl J Med 1998; 339:1493-9; PMID:9819447; http://dx. doi.org/10.1056/NEJM199811193392102
    • (1998) N Engl J Med , vol.339 , pp. 1493-1499
    • Davis, G.L.1    Esteban-Mur, R.2    Rustgi, V.3    Hoefs, J.4    Gordon, S.C.5    Trepo, C.6
  • 7
    • 84860307792 scopus 로고    scopus 로고
    • Anti-hepatitis C virus drugs in development
    • PMID:22537441, http://dx.doi.org/10.1053/j.gastro.2012.02.015
    • Schaefer EA, Chung RT. Anti-hepatitis C virus drugs in development. Gastroenterology 2012; 142:1340-50, e1; PMID:22537441; http://dx.doi.org/10.1053/j.gastro. 2012.02.015
    • (2012) Gastroenterology , vol.142
    • Schaefer, E.A.1    Chung, R.T.2
  • 8
    • 0033799722 scopus 로고    scopus 로고
    • Estimating future hepatitis C morbidity, mortality, and costs in the United States
    • PMID:11029989, http://dx.doi.org/10.2105/AJPH.90.10.1562
    • Wong JB, McQuillan GM, McHutchison JG, Poynard T. Estimating future hepatitis C morbidity, mortality, and costs in the United States. Am J Public Health 2000; 90:1562-9; PMID:11029989; http://dx. doi.org/10.2105/AJPH.90.10.1562
    • (2000) Am J Public Health , vol.90 , pp. 1562-1569
    • Wong, J.B.1    McQuillan, G.M.2    McHutchison, J.G.3    Poynard, T.4
  • 9
    • 4644229225 scopus 로고    scopus 로고
    • Clearance of hepatitis C virus after newly acquired infection in injection drug users
    • PMID:15346337, http://dx.doi.org/10.1086/423943
    • Jauncey M, Micallef JM, Gilmour S, Amin J, White PA, Rawlinson W, et al. Clearance of hepatitis C virus after newly acquired infection in injection drug users. J Infect Dis 2004; 190:1270-4; PMID:15346337; http://dx.doi.org/10.1086/423943
    • (2004) J Infect Dis , vol.190 , pp. 1270-1274
    • Jauncey, M.1    Micallef, J.M.2    Gilmour, S.3    Amin, J.4    White, P.A.5    Rawlinson, W.6
  • 10
    • 70649084120 scopus 로고    scopus 로고
    • Host genetic determinants of spontaneous hepatitis C clearance
    • PMID:19891557, http://dx.doi.org/10.2217/pgs.09.121
    • Rauch A, Gaudieri S, Thio C, Bochud PY. Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics 2009; 10:1819-37; PMID:19891557; http://dx.doi.org/10.2217/pgs.09. 121
    • (2009) Pharmacogenomics , vol.10 , pp. 1819-1837
    • Rauch, A.1    Gaudieri, S.2    Thio, C.3    Bochud, P.Y.4
  • 11
    • 84857373640 scopus 로고    scopus 로고
    • IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection
    • PMID:22329371, http://dx.doi.org/10.1111/j.1365-2893.2011.01497.x
    • Rao HY, Sun DG, Jiang D, Yang RF, Guo F, Wang JH, et al. IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection. J Viral Hepat 2012; 19:173-81; PMID:22329371; http://dx.doi.org/10.1111/j.1365-2893.2011.01497.x
    • (2012) J Viral Hepat , vol.19 , pp. 173-181
    • Rao, H.Y.1    Sun, D.G.2    Jiang, D.3    Yang, R.F.4    Guo, F.5    Wang, J.H.6
  • 12
    • 0031962298 scopus 로고    scopus 로고
    • Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus
    • PMID:9425943, http://dx.doi.org/10.1002/hep.510270136
    • Kuzushita N, Hayashi N, Moribe T, Katayama K, Kanto T, Nakatani S, et al. Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus. Hepatology 1998; 27: 240-4; PMID:9425943; http://dx.doi.org/10.1002/hep.510270136
    • (1998) Hepatology , vol.27 , pp. 240-244
    • Kuzushita, N.1    Hayashi, N.2    Moribe, T.3    Katayama, K.4    Kanto, T.5    Nakatani, S.6
  • 13
    • 79951483790 scopus 로고    scopus 로고
    • Protective role of HLA-B27 in HIV and hepatitis C virus infection
    • PMID:21302207, http://dx.doi.org/10.1055/s-0031-1272531
    • Neumann-Haefelin C. [Protective role of HLA-B27 in HIV and hepatitis C virus infection]. Dtsch Med Wochenschr 2011; 136:320-4; PMID:21302207; http://dx.doi.org/10.1055/s-0031-1272531
    • (2011) Dtsch Med Wochenschr , vol.136 , pp. 320-324
    • Neumann-Haefelin, C.1
  • 14
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • PMID:10790425, http://dx.doi.org/10.1084/jem.191.9.1499
    • Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000; 191:1499-512; PMID:10790425; http://dx.doi.org/10.1084/jem.191.9.1499
    • (2000) J Exp Med , vol.191 , pp. 1499-1512
    • Lechner, F.1    Wong, D.K.2    Dunbar, P.R.3    Chapman, R.4    Chung, R.T.5    Dohrenwend, P.6
  • 15
    • 84856846467 scopus 로고    scopus 로고
    • Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence
    • PMID:22213804, http://dx.doi.org/10.1084/jem.20100388
    • Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, et al. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med 2012; 209:61-75; PMID:22213804; http://dx.doi.org/10.1084/jem.20100388
    • (2012) J Exp Med , vol.209 , pp. 61-75
    • Schulze Zur Wiesch, J.1    Ciuffreda, D.2    Lewis-Ximenez, L.3    Kasprowicz, V.4    Nolan, B.E.5    Streeck, H.6
  • 16
    • 0036891826 scopus 로고    scopus 로고
    • Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection
    • PMID:12438584, http://dx.doi.org/10.1128/JVI.76.24.12584-12595.2002
    • Day CL, Lauer GM, Robbins GK, McGovern B, Wurcel AG, Gandhi RT, et al. Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection. J Virol 2002; 76:12584-95; PMID:12438584; http://dx.doi.org/10.1128/JVI.76.24.12584-12595.2002
    • (2002) J Virol , vol.76 , pp. 12584-12595
    • Day, C.L.1    Lauer, G.M.2    Robbins, G.K.3    McGovern, B.4    Wurcel, A.G.5    Gandhi, R.T.6
  • 18
    • 75449101959 scopus 로고    scopus 로고
    • Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
    • PMID: 19918975, http://dx.doi.org/10.1002/hep.23319
    • Fuller MJ, Shoukry NH, Gushima T, Bowen DG, Callendret B, Campbell KJ, et al. Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology 2010; 51:378-87; PMID: 19918975; http://dx.doi.org/10.1002/hep.23319
    • (2010) Hepatology , vol.51 , pp. 378-387
    • Fuller, M.J.1    Shoukry, N.H.2    Gushima, T.3    Bowen, D.G.4    Callendret, B.5    Campbell, K.J.6
  • 19
    • 22344440368 scopus 로고    scopus 로고
    • Immune evasion versus recovery after acute hepatitis C virus infection from a shared source
    • PMID: 15939788, http://dx.doi.org/10.1084/jem.20042284
    • Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, et al. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med 2005; 201:1725-31; PMID: 15939788; http://dx.doi.org/10.1084/jem.20042284
    • (2005) J Exp Med , vol.201 , pp. 1725-1731
    • Tester, I.1    Smyk-Pearson, S.2    Wang, P.3    Wertheimer, A.4    Yao, E.5    Lewinsohn, D.M.6
  • 20
    • 0038374730 scopus 로고    scopus 로고
    • Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C
    • PMID:12717401, http://dx.doi.org/10.1053/jhep.2003.50194
    • Ulsenheimer A, Gerlach JT, Gruener NH, Jung MC, Schirren CA, Schraut W, et al. Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C. Hepatology 2003; 37:1189-98; PMID:12717401; http://dx.doi. org/10.1053/jhep.2003.50194
    • (2003) Hepatology , vol.37 , pp. 1189-1198
    • Ulsenheimer, A.1    Gerlach, J.T.2    Gruener, N.H.3    Jung, M.C.4    Schirren, C.A.5    Schraut, W.6
  • 21
    • 0035000769 scopus 로고    scopus 로고
    • Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus
    • PMID: 11356962, http://dx.doi.org/10.1128/JVI.75.12.5550-5558.2001
    • Gruener NH, Lechner F, Jung MC, Diepolder H, Gerlach T, Lauer G, et al. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J Virol 2001; 75:5550-8; PMID: 11356962; http://dx.doi.org/10.1128/JVI.75.12. 5550-5558.2001
    • (2001) J Virol , vol.75 , pp. 5550-5558
    • Gruener, N.H.1    Lechner, F.2    Jung, M.C.3    Diepolder, H.4    Gerlach, T.5    Lauer, G.6
  • 22
    • 0037105567 scopus 로고    scopus 로고
    • Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    • PMID:12218168
    • Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH, et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 2002; 169:3447-58; PMID:12218168
    • (2002) J Immunol , vol.169 , pp. 3447-3458
    • Wedemeyer, H.1    He, X.S.2    Nascimbeni, M.3    Davis, A.R.4    Greenberg, H.B.5    Hoofnagle, J.H.6
  • 23
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • PMID: 15486925, http://dx.doi.org/10.1002/hep.20454
    • Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004; 40:1062-71; PMID: 15486925; http://dx.doi.org/10.1002/hep.20454
    • (2004) Hepatology , vol.40 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6
  • 24
    • 34547604820 scopus 로고    scopus 로고
    • Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection
    • PMID:17475362, http://dx.doi.org/10.1016/j.jhep.2007.03.023
    • Ward SM, Fox BC, Brown PJ, Worthington J, Fox SB, Chapman RW, et al. Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection. J Hepatol 2007; 47:316-24; PMID:17475362; http://dx.doi.org/10.1016/j.jhep.2007.03.023
    • (2007) J Hepatol , vol.47 , pp. 316-324
    • Ward, S.M.1    Fox, B.C.2    Brown, P.J.3    Worthington, J.4    Fox, S.B.5    Chapman, R.W.6
  • 25
    • 77249118149 scopus 로고    scopus 로고
    • Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis
    • PMID:20129690, http://dx.doi.org/10.1016/j.jhep.2009.12.013
    • Claassen MA, de Knegt RJ, Tilanus HW, Janssen HL, Boonstra A. Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis. J Hepatol 2010; 52:315-21; PMID:20129690; http://dx.doi.org/10.1016/j.jhep.2009.12.013
    • (2010) J Hepatol , vol.52 , pp. 315-321
    • Claassen, M.A.1    de Knegt, R.J.2    Tilanus, H.W.3    Janssen, H.L.4    Boonstra, A.5
  • 26
    • 2442712761 scopus 로고    scopus 로고
    • Prospects for dendritic cell vaccination in persistent infection with hepatitis C virus
    • PMID:15163415, http://dx.doi.org/10.1016/j.jcv.2004.03.006
    • Gowans EJ, Jones KL, Bharadwaj M, Jackson DC. Prospects for dendritic cell vaccination in persistent infection with hepatitis C virus. J Clin Virol 2004; 30: 283-90; PMID:15163415; http://dx.doi.org/10.1016/j.jcv.2004.03.006
    • (2004) J Clin Virol , vol.30 , pp. 283-290
    • Gowans, E.J.1    Jones, K.L.2    Bharadwaj, M.3    Jackson, D.C.4
  • 27
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • PMID:9521319, http://dx.doi.org/10.1038/32588
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-52; PMID:9521319; http://dx.doi.org/10.1038/32588
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 28
    • 0028048051 scopus 로고
    • Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
    • PMID:7525461
    • O'Doherty U, Peng M, Gezelter S, Swiggard WJ, Betjes M, Bhardwaj N, et al. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 1994; 82:487-93; PMID:7525461
    • (1994) Immunology , vol.82 , pp. 487-493
    • O'Doherty, U.1    Peng, M.2    Gezelter, S.3    Swiggard, W.J.4    Betjes, M.5    Bhardwaj, N.6
  • 29
    • 0034547923 scopus 로고    scopus 로고
    • BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
    • PMID:11086035
    • Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, et al. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 2000; 165:6037-46; PMID:11086035
    • (2000) J Immunol , vol.165 , pp. 6037-6046
    • Dzionek, A.1    Fuchs, A.2    Schmidt, P.3    Cremer, S.4    Zysk, M.5    Miltenyi, S.6
  • 30
    • 63849217133 scopus 로고    scopus 로고
    • The divergence and interplay between pDC and mDC in humans
    • PMID:19273101, http://dx.doi.org/10.2741/3279
    • Kadowaki N. The divergence and interplay between pDC and mDC in humans. Front Biosci 2009; 14: 808-17; PMID:19273101; http://dx.doi.org/10.2741/3279
    • (2009) Front Biosci , vol.14 , pp. 808-817
    • Kadowaki, N.1
  • 31
    • 36849067521 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells are phenotypically and functionally intact in chronic hepatitis B virus (HBV) infection
    • PMID:18031557, http://dx.doi.org/10.1111/j.1365-2249.2007.03547.x
    • Tavakoli S, Mederacke I, Herzog-Hauff S, Glebe D, Grün S, Strand D, et al. Peripheral blood dendritic cells are phenotypically and functionally intact in chronic hepatitis B virus (HBV) infection. Clin Exp Immunol 2008; 151:61-70; PMID:18031557; http://dx.doi.org/10.1111/j.1365-2249.2007.03547.x
    • (2008) Clin Exp Immunol , vol.151 , pp. 61-70
    • Tavakoli, S.1    Mederacke, I.2    Herzog-Hauff, S.3    Glebe, D.4    Grün, S.5    Strand, D.6
  • 32
    • 0036518287 scopus 로고    scopus 로고
    • Mouse and human dendritic cell subtypes
    • PMID: 11913066, http://dx.doi.org/10.1038/nri746
    • Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2:151-61; PMID: 11913066; http://dx.doi.org/10.1038/nri746
    • (2002) Nat Rev Immunol , vol.2 , pp. 151-161
    • Shortman, K.1    Liu, Y.J.2
  • 33
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • PMID:15771572, http://dx.doi.org/10.1146/annurev.immunol.23.021704.115633
    • Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005; 23:275-306; PMID:15771572; http://dx. doi.org/10.1146/annurev.immunol.23.021704.115633
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 34
    • 22144441229 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells-virus experts of innate immunity
    • PMID:15990333, http://dx.doi.org/10.1016/j.smim.2005.05.008
    • Barchet W, Cella M, Colonna M. Plasmacytoid dendritic cells-virus experts of innate immunity. Semin Immunol 2005; 17:253-61; PMID:15990333; http://dx.doi.org/10.1016/j.smim.2005.05.008
    • (2005) Semin Immunol , vol.17 , pp. 253-261
    • Barchet, W.1    Cella, M.2    Colonna, M.3
  • 35
    • 79953059788 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Recent progress and open questions
    • PMID:21219184, http://dx.doi.org/10.1146/annurev-immunol-031210-101345
    • Reizis B, Bunin A, Ghosh HS, Lewis KL, Sisirak V. Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol 2011; 29:163-83; PMID:21219184; http://dx.doi.org/10.1146/annurev-immunol-031210-101345
    • (2011) Annu Rev Immunol , vol.29 , pp. 163-183
    • Reizis, B.1    Bunin, A.2    Ghosh, H.S.3    Lewis, K.L.4    Sisirak, V.5
  • 36
    • 33947139667 scopus 로고    scopus 로고
    • Differential dysfunction in dendritic cell subsets during chronic HCV infection
    • PMID:17239662, http://dx.doi.org/10.1016/j.clim.2006.12.001
    • Averill L, Lee WM, Karandikar NJ. Differential dysfunction in dendritic cell subsets during chronic HCV infection. Clin Immunol 2007; 123:40-9; PMID:17239662; http://dx.doi.org/10.1016/j.clim. 2006.12.001
    • (2007) Clin Immunol , vol.123 , pp. 40-49
    • Averill, L.1    Lee, W.M.2    Karandikar, N.J.3
  • 37
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • PMID:11561001, http://dx.doi.org/10.1084/jem.194.6.863
    • Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194:863-9; PMID:11561001; http://dx.doi.org/10.1084/jem.194.6.863
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6
  • 38
    • 0032519479 scopus 로고    scopus 로고
    • The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation
    • PMID:9469423
    • de Saint-Vis B, Fugier-Vivier I, Massacrier C, Gaillard C, Vanbervliet B, Aït-Yahia S, et al. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J Immunol 1998; 160:1666-76; PMID:9469423
    • (1998) J Immunol , vol.160 , pp. 1666-1676
    • de Saint-Vis, B.1    Fugier-Vivier, I.2    Massacrier, C.3    Gaillard, C.4    Vanbervliet, B.5    Aït-Yahia, S.6
  • 39
    • 20044384191 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection
    • PMID: 15726647, http://dx.doi.org/10.1002/hep.20592
    • Ulsenheimer A, Gerlach JT, Jung MC, Gruener N, Wächtler M, Backmund M, et al. Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection. Hepatology 2005; 41:643-51; PMID: 15726647; http://dx.doi.org/10.1002/hep.20592
    • (2005) Hepatology , vol.41 , pp. 643-651
    • Ulsenheimer, A.1    Gerlach, J.T.2    Jung, M.C.3    Gruener, N.4    Wächtler, M.5    Backmund, M.6
  • 40
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • PMID:15549123, http://dx.doi.org/10.1038/ni1141
    • Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004; 5: 1219-26; PMID:15549123; http://dx.doi.org/10. 1038/ni1141
    • (2004) Nat Immunol , vol.5 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 41
    • 77952127743 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
    • PMID:20231459, http://dx.doi.org/10.1073/pnas.1002301107
    • Takahashi K, Asabe S, Wieland S, Garaigorta U, Gastaminza P, Isogawa M, et al. Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci U S A 2010; 107:7431-6; PMID:20231459; http://dx.doi.org/10.1073/pnas.1002301107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7431-7436
    • Takahashi, K.1    Asabe, S.2    Wieland, S.3    Garaigorta, U.4    Gastaminza, P.5    Isogawa, M.6
  • 42
    • 67649637825 scopus 로고    scopus 로고
    • Virahep-C Study Group. Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: Associations with antiviral treatment outcomes
    • PMID:19193669, http://dx.doi.org/10.1136/gut.2008.168948
    • Mengshol JA, Golden-Mason L, Castelblanco N, Im KA, Dillon SM, Wilson CC, et al. Virahep-C Study Group. Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes. Gut 2009; 58:964-73; PMID:19193669; http://dx. doi.org/10.1136/gut.2008.168948
    • (2009) Gut , vol.58 , pp. 964-973
    • Mengshol, J.A.1    Golden-Mason, L.2    Castelblanco, N.3    Im, K.A.4    Dillon, S.M.5    Wilson, C.C.6
  • 43
    • 34247246137 scopus 로고    scopus 로고
    • Early activation markers of human peripheral dendritic cells
    • PMID:17462499, http://dx.doi.org/10.1016/j.humimm.2007.01.018
    • Hellman P, Eriksson H. Early activation markers of human peripheral dendritic cells. Hum Immunol 2007; 68:324-33; PMID:17462499; http://dx.doi. org/10.1016/j.humimm.2007.01.018
    • (2007) Hum Immunol , vol.68 , pp. 324-333
    • Hellman, P.1    Eriksson, H.2
  • 44
    • 22644432777 scopus 로고    scopus 로고
    • Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection
    • PMID: 16164031, http://dx.doi.org/10.1016/j.imbio.2005.05.018
    • Szabo G, Dolganiuc A. Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection. Immunobiology 2005; 210:237-47; PMID: 16164031; http://dx.doi.org/10.1016/j.imbio.2005.05.018
    • (2005) Immunobiology , vol.210 , pp. 237-247
    • Szabo, G.1    Dolganiuc, A.2
  • 45
    • 7644226241 scopus 로고    scopus 로고
    • Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    • PMID: 15521019, http://dx.doi.org/10.1053/j.gastro.2004.08.067
    • Dolganiuc A, Oak S, Kodys K, Golenbock DT, Finberg RW, Kurt-Jones E, et al. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 2004; 127:1513-24; PMID: 15521019; http://dx.doi.org/10.1053/j.gastro.2004.08.067
    • (2004) Gastroenterology , vol.127 , pp. 1513-1524
    • Dolganiuc, A.1    Oak, S.2    Kodys, K.3    Golenbock, D.T.4    Finberg, R.W.5    Kurt-Jones, E.6
  • 46
    • 35648991998 scopus 로고    scopus 로고
    • Synergism of Toll-like receptorinduced interleukin-12p70 secretion by monocytederived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses
    • PMID: 17927969, http://dx.doi.org/10.1016/j.cellimm.2007.07.008
    • Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J. Synergism of Toll-like receptorinduced interleukin-12p70 secretion by monocytederived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses. Cell Immunol 2007; 247:72-84; PMID: 17927969; http://dx.doi.org/10.1016/j.cellimm.2007.07.008
    • (2007) Cell Immunol , vol.247 , pp. 72-84
    • Bohnenkamp, H.R.1    Papazisis, K.T.2    Burchell, J.M.3    Taylor-Papadimitriou, J.4
  • 47
    • 79960959972 scopus 로고    scopus 로고
    • The affect of chronic hepatitis C infection on dendritic cell function: A summary of the experimental evidence
    • PMID:21794024, http://dx.doi.org/10.1111/j.1365-2893.2011.01453.x
    • Ryan EJ, O'Farrelly C. The affect of chronic hepatitis C infection on dendritic cell function: a summary of the experimental evidence. J Viral Hepat 2011; 18: 601-7; PMID:21794024; http://dx.doi.org/10.1111/j. 1365-2893.2011.01453.x
    • (2011) J Viral Hepat , vol.18 , pp. 601-607
    • Ryan, E.J.1    O'Farrelly, C.2
  • 48
    • 4043179185 scopus 로고    scopus 로고
    • Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease
    • PMID:15368438, http://dx.doi.org/10.1002/hep.20306
    • Wertheimer AM, Bakke A, Rosen HR. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease. Hepatology 2004; 40:335-45; PMID:15368438; http://dx.doi.org/10.1002/hep.20306
    • (2004) Hepatology , vol.40 , pp. 335-345
    • Wertheimer, A.M.1    Bakke, A.2    Rosen, H.R.3
  • 49
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • PMID: 19587449, http://dx.doi.org/10.1172/JCI39133
    • Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009; 119:1745-54; PMID: 19587449; http://dx.doi.org/10.1172/JCI39133
    • (2009) J Clin Invest , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 50
    • 44649085194 scopus 로고    scopus 로고
    • Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: Role of alpha interferon
    • PMID: 18420803, http://dx.doi.org/10.1099/vir.0.83517-0
    • Cicinnati VR, Kang J, Sotiropoulos GC, Hilgard P, Frilling A, Broelsch CE, et al. Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: role of alpha interferon. J Gen Virol 2008; 89:1243-53; PMID: 18420803; http://dx.doi.org/10.1099/vir.0.83517-0
    • (2008) J Gen Virol , vol.89 , pp. 1243-1253
    • Cicinnati, V.R.1    Kang, J.2    Sotiropoulos, G.C.3    Hilgard, P.4    Frilling, A.5    Broelsch, C.E.6
  • 51
    • 0036623462 scopus 로고    scopus 로고
    • Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases
    • PMID:12044522, http://dx.doi.org/10.1016/S0168-8278(02)00062-4
    • Kunitani H, Shimizu Y, Murata H, Higuchi K, Watanabe A. Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases. J Hepatol 2002; 36:734-41; PMID:12044522; http://dx.doi.org/10.1016/S0168-8278(02)00062-4
    • (2002) J Hepatol , vol.36 , pp. 734-741
    • Kunitani, H.1    Shimizu, Y.2    Murata, H.3    Higuchi, K.4    Watanabe, A.5
  • 52
    • 33750633661 scopus 로고    scopus 로고
    • Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C
    • PMID:17006905, http://dx.doi.org/10.1002/hep.21350
    • Nattermann J, Zimmermann H, Iwan A, von Lilienfeld-Toal M, Leifeld L, Nischalke HD, et al. Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C. Hepatology 2006; 44:945-54; PMID:17006905; http://dx.doi.org/10.1002/hep. 21350
    • (2006) Hepatology , vol.44 , pp. 945-954
    • Nattermann, J.1    Zimmermann, H.2    Iwan, A.3    von Lilienfeld-Toal, M.4    Leifeld, L.5    Nischalke, H.D.6
  • 53
    • 34548850886 scopus 로고    scopus 로고
    • Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics
    • PMID: 17629707, http://dx.doi.org/10.1016/j.cyto.2007.05.013
    • Wald O, Weiss ID, Galun E, Peled A. Chemokines in hepatitis C virus infection: pathogenesis, prognosis and therapeutics. Cytokine 2007; 39:50-62; PMID: 17629707; http://dx.doi.org/10.1016/j.cyto.2007.05. 013
    • (2007) Cytokine , vol.39 , pp. 50-62
    • Wald, O.1    Weiss, I.D.2    Galun, E.3    Peled, A.4
  • 54
    • 0033915422 scopus 로고    scopus 로고
    • Chemokines and dendritic cell traffic
    • PMID:10941822, http://dx.doi.org/10.1023/A:1006659211340
    • Sozzani S, Allavena P, Vecchi A, Mantovani A. Chemokines and dendritic cell traffic. J Clin Immunol 2000; 20:151-60; PMID:10941822; http://dx.doi.org/10.1023/A:1006659211340
    • (2000) J Clin Immunol , vol.20 , pp. 151-160
    • Sozzani, S.1    Allavena, P.2    Vecchi, A.3    Mantovani, A.4
  • 55
    • 0033557170 scopus 로고    scopus 로고
    • Mobilizing dendritic cells for tolerance, priming, and chronic inflammation
    • PMID:9989975, http://dx.doi.org/10.1084/jem.189.4.611
    • Sallusto F, Lanzavecchia A. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J Exp Med 1999; 189:611-4; PMID:9989975; http://dx.doi.org/10.1084/jem.189.4.611
    • (1999) J Exp Med , vol.189 , pp. 611-614
    • Sallusto, F.1    Lanzavecchia, A.2
  • 56
    • 1642581676 scopus 로고    scopus 로고
    • Presence of functional dendritic cells in patients chronically infected with hepatitis C virus
    • PMID:14525790, http://dx.doi.org/10.1182/blood-2003-04-1339
    • Longman RS, Talal AH, Jacobson IM, Albert ML, Rice CM. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 2004; 103:1026-9; PMID:14525790; http://dx. doi.org/10.1182/blood-2003-04-1339
    • (2004) Blood , vol.103 , pp. 1026-1029
    • Longman, R.S.1    Talal, A.H.2    Jacobson, I.M.3    Albert, M.L.4    Rice, C.M.5
  • 57
    • 22544450461 scopus 로고    scopus 로고
    • Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C
    • PMID:15995965, http://dx.doi.org/10.1086/431523
    • Longman RS, Talal AH, Jacobson IM, Rice CM, Albert ML. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J Infect Dis 2005; 192:497-503; PMID:15995965; http://dx.doi.org/10.1086/431523
    • (2005) J Infect Dis , vol.192 , pp. 497-503
    • Longman, R.S.1    Talal, A.H.2    Jacobson, I.M.3    Rice, C.M.4    Albert, M.L.5
  • 58
    • 19944378756 scopus 로고    scopus 로고
    • Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors
    • PMID:15629508, http://dx.doi.org/10.1016/j.jhep.2004.09.014
    • Piccioli D, Tavarini S, Nuti S, Colombatto P, Brunetto M, Bonino F, et al. Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors. J Hepatol 2005; 42:61-7; PMID:15629508; http://dx. doi.org/10.1016/j.jhep.2004.09.014
    • (2005) J Hepatol , vol.42 , pp. 61-67
    • Piccioli, D.1    Tavarini, S.2    Nuti, S.3    Colombatto, P.4    Brunetto, M.5    Bonino, F.6
  • 59
    • 34948911347 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
    • PMID:17893202, http://dx.doi.org/10.1084/jem.20070814
    • Decalf J, Fernandes S, Longman R, Ahloulay M, Audat F, Lefrerre F, et al. Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J Exp Med 2007; 204:2423-37; PMID:17893202; http://dx.doi. org/10.1084/jem.20070814
    • (2007) J Exp Med , vol.204 , pp. 2423-2437
    • Decalf, J.1    Fernandes, S.2    Longman, R.3    Ahloulay, M.4    Audat, F.5    Lefrerre, F.6
  • 60
    • 38449091876 scopus 로고    scopus 로고
    • Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus
    • PMID:18194173, http://dx.doi.org/10.1111/j.1365-2893.2007.00934.x
    • Barnes E, Salio M, Cerundolo V, Francesco L, Pardoll D, Klenerman P, et al. Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus. J Viral Hepat 2008; 15:219-28; PMID:18194173; http://dx. doi.org/10.1111/j.1365-2893.2007.00934.x
    • (2008) J Viral Hepat , vol.15 , pp. 219-228
    • Barnes, E.1    Salio, M.2    Cerundolo, V.3    Francesco, L.4    Pardoll, D.5    Klenerman, P.6
  • 61
    • 79955878456 scopus 로고    scopus 로고
    • Functional impairment of dendritic cells in patients infected with hepatitis C virus genotype 1 who failed peginterferon plus ribavirin therapy
    • PMID:21567425, http://dx.doi.org/10.1002/jmv.22096
    • Liang CC, Liu CH, Lin YL, Liu CJ, Chiang BL, Kao JH. Functional impairment of dendritic cells in patients infected with hepatitis C virus genotype 1 who failed peginterferon plus ribavirin therapy. J Med Virol 2011; 83:1212-20; PMID:21567425; http://dx. doi.org/10.1002/jmv.22096
    • (2011) J Med Virol , vol.83 , pp. 1212-1220
    • Liang, C.C.1    Liu, C.H.2    Lin, Y.L.3    Liu, C.J.4    Chiang, B.L.5    Kao, J.H.6
  • 62
    • 55749109181 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells move down on the list of suspects: In search of the immune pathogenesis of chronic hepatitis C
    • PMID:18929418, http://dx.doi.org/10.1016/j.jhep.2008.09.002
    • Albert ML, Decalf J, Pol S. Plasmacytoid dendritic cells move down on the list of suspects: in search of the immune pathogenesis of chronic hepatitis C. J Hepatol 2008; 49:1069-78; PMID:18929418; http://dx.doi. org/10.1016/j.jhep.2008.09.002
    • (2008) J Hepatol , vol.49 , pp. 1069-1078
    • Albert, M.L.1    Decalf, J.2    Pol, S.3
  • 63
    • 78649964701 scopus 로고    scopus 로고
    • Preserved MHC-II antigen processing and presentation function in chronic HCV infection
    • PMID: 21055734, http://dx.doi.org/10.1016/j.cellimm.2010.10.003
    • Canaday DH, Burant CJ, Jones L, Aung H, Woc-Colburn L, Anthony DD. Preserved MHC-II antigen processing and presentation function in chronic HCV infection. Cell Immunol 2011; 266:187-91; PMID: 21055734; http://dx.doi.org/10.1016/j.cellimm.2010.10.003
    • (2011) Cell Immunol , vol.266 , pp. 187-191
    • Canaday, D.H.1    Burant, C.J.2    Jones, L.3    Aung, H.4    Woc-Colburn, L.5    Anthony, D.D.6
  • 64
    • 0033136306 scopus 로고    scopus 로고
    • Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals
    • PMID:10228041
    • Kanto T, Hayashi N, Takehara T, Tatsumi T, Kuzushita N, Ito A, et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol 1999; 162:5584-91; PMID:10228041
    • (1999) J Immunol , vol.162 , pp. 5584-5591
    • Kanto, T.1    Hayashi, N.2    Takehara, T.3    Tatsumi, T.4    Kuzushita, N.5    Ito, A.6
  • 65
    • 0035121503 scopus 로고    scopus 로고
    • Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection
    • PMID: 11159892, http://dx.doi.org/10.1053/gast.2001.21212
    • Bain C, Fatmi A, Zoulim F, Zarski JP, Trépo C, Inchauspé G. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 2001; 120:512-24; PMID: 11159892; http://dx.doi.org/10.1053/gast.2001. 21212
    • (2001) Gastroenterology , vol.120 , pp. 512-524
    • Bain, C.1    Fatmi, A.2    Zoulim, F.3    Zarski, J.P.4    Trépo, C.5    Inchauspé, G.6
  • 66
    • 0035874506 scopus 로고    scopus 로고
    • Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection
    • PMID:11342445, http://dx.doi.org/10.1182/blood.V97.10.3171
    • Auffermann-Gretzinger S, Keeffe EB, Levy S. Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 2001; 97:3171-6; PMID:11342445; http://dx.doi.org/10. 1182/blood.V97.10.3171
    • (2001) Blood , vol.97 , pp. 3171-3176
    • Auffermann-Gretzinger, S.1    Keeffe, E.B.2    Levy, S.3
  • 67
    • 1842581705 scopus 로고    scopus 로고
    • Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection
    • PMID:15067070
    • Anthony DD, Yonkers NL, Post AB, Asaad R, Heinzel FP, Lederman MM, et al. Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection. J Immunol 2004; 172: 4907-16; PMID:15067070
    • (2004) J Immunol , vol.172 , pp. 4907-4916
    • Anthony, D.D.1    Yonkers, N.L.2    Post, A.B.3    Asaad, R.4    Heinzel, F.P.5    Lederman, M.M.6
  • 68
    • 4344713084 scopus 로고    scopus 로고
    • Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C
    • PMID:15320906, http://dx.doi.org/10.1111/j.1365-2249.2004.02550.x
    • Murakami H, Akbar SM, Matsui H, Horiike N, Onji M. Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C. Clin Exp Immunol 2004; 137:559-65; PMID:15320906; http://dx.doi.org/10.1111/j.1365-2249.2004.02550.x
    • (2004) Clin Exp Immunol , vol.137 , pp. 559-565
    • Murakami, H.1    Akbar, S.M.2    Matsui, H.3    Horiike, N.4    Onji, M.5
  • 69
    • 34247487768 scopus 로고    scopus 로고
    • Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection
    • PMID:17462079, http://dx.doi.org/10.1111/j.1365-2567.2007.02577.x
    • Della Bella S, Crosignani A, Riva A, Presicce P, Benetti A, Longhi R, et al. Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection. Immunology 2007; 121:283-92; PMID:17462079; http://dx.doi.org/10. 1111/j.1365-2567.2007.02577.x
    • (2007) Immunology , vol.121 , pp. 283-292
    • della Bella, S.1    Crosignani, A.2    Riva, A.3    Presicce, P.4    Benetti, A.5    Longhi, R.6
  • 70
    • 33947661034 scopus 로고    scopus 로고
    • TLR liganddependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    • PMID:17372001
    • Yonkers NL, Rodriguez B, Milkovich KA, Asaad R, Lederman MM, Heeger PS, et al. TLR liganddependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection. J Immunol 2007; 178:4436-44; PMID:17372001
    • (2007) J Immunol , vol.178 , pp. 4436-4444
    • Yonkers, N.L.1    Rodriguez, B.2    Milkovich, K.A.3    Asaad, R.4    Lederman, M.M.5    Heeger, P.S.6
  • 71
    • 79959858141 scopus 로고    scopus 로고
    • Dendritic cells in hepatitis C infection: Can they (help) win the battle?
    • PMID:21327958, http://dx.doi.org/10.1007/s00535-011-0377-y
    • Dolganiuc A, Szabo G. Dendritic cells in hepatitis C infection: can they (help) win the battle? J Gastroenterol 2011; 46:432-47; PMID:21327958; http://dx.doi.org/10.1007/s00535-011-0377-y
    • (2011) J Gastroenterol , vol.46 , pp. 432-447
    • Dolganiuc, A.1    Szabo, G.2
  • 72
    • 0037851770 scopus 로고    scopus 로고
    • Hepatitis C virus core and nonstructural protein 3 proteins induce pro-and antiinflammatory cytokines and inhibit dendritic cell differentiation
    • PMID:12759441
    • Dolganiuc A, Kodys K, Kopasz A, Marshall C, Do T, Romics L, Jr., et al. Hepatitis C virus core and nonstructural protein 3 proteins induce pro-and antiinflammatory cytokines and inhibit dendritic cell differentiation. J Immunol 2003; 170:5615-24; PMID:12759441
    • (2003) J Immunol , vol.170 , pp. 5615-5624
    • Dolganiuc, A.1    Kodys, K.2    Kopasz, A.3    Marshall, C.4    Do, T.5    Romics Jr., L.6
  • 73
    • 34547922409 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
    • PMID:17696933, http://dx.doi.org/10.1111/j.1478-3231.2007.01507.x
    • Gelderblom HC, Nijhuis LE, de Jong EC, te Velde AA, Pajkrt D, Reesink HW, et al. Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile. Liver Int 2007; 27:944-53; PMID:17696933; http://dx.doi.org/10.1111/j.1478-3231.2007.01507.x
    • (2007) Liver Int , vol.27 , pp. 944-953
    • Gelderblom, H.C.1    Nijhuis, L.E.2    de Jong, E.C.3    te Velde, A.A.4    Pajkrt, D.5    Reesink, H.W.6
  • 74
    • 34247860688 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells
    • PMID:17362265, http://dx.doi.org/10.1111/j.1365-2249.2007.03367.x
    • MacDonald AJ, Semper AE, Libri NA, Rosenberg WM. Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells. Clin Exp Immunol 2007; 148:494-500; PMID:17362265; http://dx.doi.org/10. 1111/j.1365-2249.2007.03367.x
    • (2007) Clin Exp Immunol , vol.148 , pp. 494-500
    • McDonald, A.J.1    Semper, A.E.2    Libri, N.A.3    Rosenberg, W.M.4
  • 75
    • 9444280924 scopus 로고    scopus 로고
    • Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection
    • PMID:15529255, http://dx.doi.org/10.1086/425425
    • Kanto T, Inoue M, Miyatake H, Sato A, Sakakibara M, Yakushijin T, et al. Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J Infect Dis 2004; 190:1919-26; PMID:15529255; http://dx.doi.org/10.1086/425425
    • (2004) J Infect Dis , vol.190 , pp. 1919-1926
    • Kanto, T.1    Inoue, M.2    Miyatake, H.3    Sato, A.4    Sakakibara, M.5    Yakushijin, T.6
  • 76
    • 41149145956 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production
    • PMID:18216090, http://dx.doi.org/10.1128/JVI.02547-07
    • Saito K, Ait-Goughoulte M, Truscott SM, Meyer K, Blazevic A, Abate G, et al. Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production. J Virol 2008; 82:3320-8; PMID:18216090; http://dx.doi.org/10.1128/JVI.02547-07
    • (2008) J Virol , vol.82 , pp. 3320-3328
    • Saito, K.1    Ait-Goughoulte, M.2    Truscott, S.M.3    Meyer, K.4    Blazevic, A.5    Abate, G.6
  • 77
    • 0347382454 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes
    • PMID: 14635055, http://dx.doi.org/10.1002/eji.200324251
    • Brady MT, MacDonald AJ, Rowan AG, Mills KH. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur J Immunol 2003; 33:3448-57; PMID: 14635055; http://dx.doi.org/10.1002/eji.200324251
    • (2003) Eur J Immunol , vol.33 , pp. 3448-3457
    • Brady, M.T.1    McDonald, A.J.2    Rowan, A.G.3    Mills, K.H.4
  • 78
    • 25144508604 scopus 로고    scopus 로고
    • Minimal T-cellstimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins
    • PMID:16160170, http://dx.doi.org/10.1128/JVI.79.19.12425-12433.2005
    • Gerlach JT, Ulsenheimer A, Grüner NH, Jung MC, Schraut W, Schirren CA, et al. Minimal T-cellstimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins. J Virol 2005; 79:12425-33; PMID:16160170; http://dx.doi.org/10. 1128/JVI.79.19.12425-12433.2005
    • (2005) J Virol , vol.79 , pp. 12425-12433
    • Gerlach, J.T.1    Ulsenheimer, A.2    Grüner, N.H.3    Jung, M.C.4    Schraut, W.5    Schirren, C.A.6
  • 79
    • 57249086246 scopus 로고    scopus 로고
    • Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes
    • PMID: 18835391, http://dx.doi.org/10.1053/j.gastro.2008.07.082
    • Dolganiuc A, Paek E, Kodys K, Thomas J, Szabo G. Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes. Gastroenterology 2008; 135:2119-27; PMID: 18835391; http://dx.doi.org/10.1053/j.gastro.2008.07.082
    • (2008) Gastroenterology , vol.135 , pp. 2119-2127
    • Dolganiuc, A.1    Paek, E.2    Kodys, K.3    Thomas, J.4    Szabo, G.5
  • 80
    • 58149175991 scopus 로고    scopus 로고
    • Decreased interferon-a production and impaired regulatory function of plasmacytoid dendritic cells induced by the hepatitis C virus NS 5 protein
    • PMID: 18822084, http://dx.doi.org/10.1111/j.1348-0421.2008.00067.x
    • Amjad M, Abdel-Haq N, Faisal M, Kamal M, Moudgal V. Decreased interferon-a production and impaired regulatory function of plasmacytoid dendritic cells induced by the hepatitis C virus NS 5 protein. Microbiol Immunol 2008; 52:499-507; PMID: 18822084; http://dx.doi.org/10.1111/j.1348-0421. 2008.00067.x
    • (2008) Microbiol Immunol , vol.52 , pp. 499-507
    • Amjad, M.1    Abdel-Haq, N.2    Faisal, M.3    Kamal, M.4    Moudgal, V.5
  • 81
    • 67349169169 scopus 로고    scopus 로고
    • Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions
    • PMID:19303818, http://dx.doi.org/10.1016/j.clim.2009.02.001
    • Pachiadakis I, Chokshi S, Cooksley H, Farmakiotis D, Sarrazin C, Zeuzem S, et al. Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions. Clin Immunol 2009; 131:415-25; PMID:19303818; http://dx.doi. org/10.1016/j.clim.2009.02.001
    • (2009) Clin Immunol , vol.131 , pp. 415-425
    • Pachiadakis, I.1    Chokshi, S.2    Cooksley, H.3    Farmakiotis, D.4    Sarrazin, C.5    Zeuzem, S.6
  • 82
    • 77954025058 scopus 로고    scopus 로고
    • Immunomodulation by hepatitis C virus-derived proteins: Targeting human dendritic cells by multiple mechanisms
    • PMID: 20410260, http://dx.doi.org/10.1093/intimm/dxq033
    • Krishnadas DK, Ahn JS, Han J, Kumar R, Agrawal B. Immunomodulation by hepatitis C virus-derived proteins: targeting human dendritic cells by multiple mechanisms. Int Immunol 2010; 22:491-502; PMID: 20410260; http://dx.doi.org/10.1093/intimm/dxq033
    • (2010) Int Immunol , vol.22 , pp. 491-502
    • Krishnadas, D.K.1    Ahn, J.S.2    Han, J.3    Kumar, R.4    Agrawal, B.5
  • 83
    • 33750826035 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-a and plasmacytoid dendritic cell loss in chronic HCV infection
    • PMID:17082589
    • Dolganiuc A, Chang S, Kodys K, Mandrekar P, Bakis G, Cormier M, et al. Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-a and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol 2006; 177:6758-68; PMID:17082589
    • (2006) J Immunol , vol.177 , pp. 6758-6768
    • Dolganiuc, A.1    Chang, S.2    Kodys, K.3    Mandrekar, P.4    Bakis, G.5    Cormier, M.6
  • 84
    • 77954508223 scopus 로고    scopus 로고
    • Hepatitis C virus NS4 protein impairs the Th1 polarization of immature dendritic cells
    • PMID: 19804500, http://dx.doi.org/10.1111/j.1365-2893.2009.01213.x
    • Takaki A, Tatsukawa M, Iwasaki Y, Koike K, Noguchi Y, Shiraha H, et al. Hepatitis C virus NS4 protein impairs the Th1 polarization of immature dendritic cells. J Viral Hepat 2010; 17:555-62; PMID: 19804500; http://dx.doi.org/10.1111/j.1365-2893. 2009.01213.x
    • (2010) J Viral Hepat , vol.17 , pp. 555-562
    • Takaki, A.1    Tatsukawa, M.2    Iwasaki, Y.3    Koike, K.4    Noguchi, Y.5    Shiraha, H.6
  • 85
    • 0141566336 scopus 로고    scopus 로고
    • Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses
    • PMID:14512536, http://dx.doi.org/10.1128/JVI.77.20.10862-10871.2003
    • Sarobe P, Lasarte JJ, Zabaleta A, Arribillaga L, Arina A, Melero I, et al. Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses. J Virol 2003; 77:10862-71; PMID:14512536; http://dx.doi.org/10. 1128/JVI.77.20.10862-10871.2003
    • (2003) J Virol , vol.77 , pp. 10862-10871
    • Sarobe, P.1    Lasarte, J.J.2    Zabaleta, A.3    Arribillaga, L.4    Arina, A.5    Melero, I.6
  • 86
    • 46749154594 scopus 로고    scopus 로고
    • Immune responses during acute and chronic infection with hepatitis C virus
    • PMID:18514579, http://dx.doi.org/10.1016/j.clim.2008.03.525
    • Ishii S, Koziel MJ. Immune responses during acute and chronic infection with hepatitis C virus. Clin Immunol 2008; 128:133-47; PMID:18514579; http://dx.doi. org/10.1016/j.clim.2008.03.525
    • (2008) Clin Immunol , vol.128 , pp. 133-147
    • Ishii, S.1    Koziel, M.J.2
  • 87
    • 0031740004 scopus 로고    scopus 로고
    • Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: Enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis
    • PMID:9842887, http://dx.doi.org/10.1002/(SICI)1521-4141(199811)28:11,3448::AID-IMMU3448.3.0.CO;2-5
    • Nuti S, Rosa D, Valiante NM, Saletti G, Caratozzolo M, Dellabona P, et al. Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis. Eur J Immunol 1998; 28:3448-55; PMID:9842887; http://dx. doi.org/10.1002/(SICI)1521-4141(199811)28: 11,3448::AID-IMMU3448.3.0.CO;2-5
    • (1998) Eur J Immunol , vol.28 , pp. 3448-3455
    • Nuti, S.1    Rosa, D.2    Valiante, N.M.3    Saletti, G.4    Caratozzolo, M.5    Dellabona, P.6
  • 88
    • 80052866520 scopus 로고    scopus 로고
    • Human dendritic cells expressing hepatitis C virus core protein display transcriptional and functional changes consistent with maturation
    • PMID:20701679, http://dx.doi.org/10.1111/j.1365-2893.2010.01357.x
    • Landi A, Yu H, Babiuk LA, van Drunen Littel-van den Hurk S. Human dendritic cells expressing hepatitis C virus core protein display transcriptional and functional changes consistent with maturation. J Viral Hepat 2011; 18:700-13; PMID:20701679; http://dx. doi.org/10.1111/j.1365-2893.2010.01357.x
    • (2011) J Viral Hepat , vol.18 , pp. 700-713
    • Landi, A.1    Yu, H.2    Babiuk, L.A.3    van Drunen Littel-van den Hurk, S.4
  • 89
    • 0032538522 scopus 로고    scopus 로고
    • Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    • PMID:9774276, http://dx.doi.org/10.1126/science.282.5388.480
    • Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 1998; 282:480-3; PMID:9774276; http://dx.doi.org/10.1126/science.282.5388.480
    • (1998) Science , vol.282 , pp. 480-483
    • Randolph, G.J.1    Beaulieu, S.2    Lebecque, S.3    Steinman, R.M.4    Muller, W.A.5
  • 90
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in the human immune system
    • PMID: 20559327, http://dx.doi.org/10.1038/nri2785
    • Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10:490-500; PMID: 20559327; http://dx.doi.org/10.1038/nri2785
    • (2010) Nat Rev Immunol , vol.10 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3    Hafler, D.A.4
  • 91
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, Xlinked syndrome (IPEX) is caused by mutations of FOXP3
    • PMID:11137993, http://dx.doi.org/10.1038/83713
    • Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The immune dysregulation, polyendocrinopathy, enteropathy, Xlinked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27:20-1; PMID:11137993; http://dx.doi.org/10.1038/83713
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 92
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • PMID: 12612581, http://dx.doi.org/10.1038/ni909
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4:337-42; PMID: 12612581; http://dx.doi.org/10.1038/ni909
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 93
    • 67649138829 scopus 로고    scopus 로고
    • Regulatory T cells in the control of host-microorganism interactions (*)
    • PMID:19302048, http://dx.doi.org/10.1146/annurev.immunol.021908.132723
    • Belkaid Y, Tarbell K. Regulatory T cells in the control of host-microorganism interactions (*). Annu Rev Immunol 2009; 27:551-89; PMID:19302048; http://dx.doi.org/10.1146/annurev.immunol.021908.132723
    • (2009) Annu Rev Immunol , vol.27 , pp. 551-589
    • Belkaid, Y.1    Tarbell, K.2
  • 94
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: A jack of all trades, master of regulation
    • PMID:18285775, http://dx.doi.org/10.1038/ni1572
    • Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008; 9:239-44; PMID:18285775; http://dx.doi.org/10.1038/ni1572
    • (2008) Nat Immunol , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 95
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
    • PMID:17919943, http://dx.doi.org/10.1016/j.immuni.2007.08.014
    • Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27:635-46; PMID:17919943; http://dx.doi.org/10.1016/j. immuni.2007.08.014
    • (2007) Immunity , vol.27 , pp. 635-646
    • Cao, X.1    Cai, S.F.2    Fehniger, T.A.3    Song, J.4    Collins, L.I.5    Piwnica-Worms, D.R.6
  • 96
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
    • PMID:19464985, http://dx.doi.org/10.1016/j.immuni.2009.05.002
    • Curotto de Lafaille MA, Lafaille JJ. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 2009; 30:626-35; PMID:19464985; http://dx.doi.org/10.1016/j. immuni.2009.05.002
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 97
    • 79952814810 scopus 로고    scopus 로고
    • Human FoxP3(+)CD4(+) regulatory T cells: Their knowns and unknowns
    • PMID: 21301480, http://dx.doi.org/10.1038/icb.2010.137
    • Miyara M, Sakaguchi S. Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns. Immunol Cell Biol 2011; 89:346-51; PMID: 21301480; http://dx.doi.org/10.1038/icb.2010.137
    • (2011) Immunol Cell Biol , vol.89 , pp. 346-351
    • Miyara, M.1    Sakaguchi, S.2
  • 98
    • 84862844377 scopus 로고    scopus 로고
    • The battle against immunopathology: Infectious tolerance mediated by regulatory T cells
    • PMID:22205213, http://dx.doi.org/10.1007/s00018-011-0907-z
    • Gravano DM, Vignali DA. The battle against immunopathology: infectious tolerance mediated by regulatory T cells. Cell Mol Life Sci 2012; 69:1997-2008; PMID:22205213; http://dx.doi.org/10.1007/s00018-011-0907-z
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1997-2008
    • Gravano, D.M.1    Vignali, D.A.2
  • 99
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • PMID:12119350, http://dx.doi.org/10.1084/jem.20020394
    • Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002; 196:255-60; PMID:12119350; http://dx.doi. org/10.1084/jem.20020394
    • (2002) J Exp Med , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 100
    • 33646567156 scopus 로고    scopus 로고
    • Activated CD4+CD25+ T cells selectively kill B lymphocytes
    • PMID: 16418326, http://dx.doi.org/10.1182/blood-2005-11-4502
    • Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 2006; 107:3925-32; PMID: 16418326; http://dx.doi.org/10.1182/blood-2005-11-4502
    • (2006) Blood , vol.107 , pp. 3925-3932
    • Zhao, D.M.1    Thornton, A.M.2    DiPaolo, R.J.3    Shevach, E.M.4
  • 101
    • 33750691006 scopus 로고    scopus 로고
    • The role of regulatory T cells in the control of natural killer cells: Relevance during tumor progression
    • PMID:17100888, http://dx.doi.org/10.1111/j.1600-065X.2006.00445.x
    • Ghiringhelli F, Ménard C, Martin F, Zitvogel L. The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression. Immunol Rev 2006; 214:229-38; PMID:17100888; http://dx. doi.org/10.1111/j.1600-065X.2006.00445.x
    • (2006) Immunol Rev , vol.214 , pp. 229-238
    • Ghiringhelli, F.1    Ménard, C.2    Martin, F.3    Zitvogel, L.4
  • 102
    • 33745486749 scopus 로고    scopus 로고
    • CD4+CD25+ Tregs and NKT cells: Regulators regulating regulators
    • PMID:16735139, http://dx.doi.org/10.1016/j.it.2006.05.003
    • La Cava A, Van Kaer L, Fu-Dong-Shi. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 2006; 27:322-7; PMID:16735139; http://dx.doi.org/10.1016/j.it.2006.05.003
    • (2006) Trends Immunol , vol.27 , pp. 322-327
    • la Cava, A.1    van Kaer, L.2    Fu-Dong-Shi3
  • 103
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cellmediated suppression
    • PMID:19464986, http://dx.doi.org/10.1016/j.immuni.2009.04.010
    • Shevach EM. Mechanisms of foxp3+ T regulatory cellmediated suppression. Immunity 2009; 30:636-45; PMID:19464986; http://dx.doi.org/10.1016/j. immuni.2009.04.010
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 104
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • PMID:12658273, http://dx.doi.org/10.1038/nri1032
    • Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003; 3:253-7; PMID:12658273; http://dx.doi.org/10.1038/nri1032
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 105
    • 33847415066 scopus 로고    scopus 로고
    • Natural regulatory T cells: Mechanisms of suppression
    • PMID:17257897, http://dx.doi.org/10.1016/j.molmed.2007.01.003
    • Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 2007; 13:108-16; PMID:17257897; http://dx.doi.org/10. 1016/j.molmed.2007.01.003
    • (2007) Trends Mol Med , vol.13 , pp. 108-116
    • Miyara, M.1    Sakaguchi, S.2
  • 106
    • 51049101255 scopus 로고    scopus 로고
    • CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-betadependent manner
    • PMID:18710931, http://dx.doi.org/10.1084/jem.20080308
    • Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, et al. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-betadependent manner. J Exp Med 2008; 205:1975-81; PMID:18710931; http://dx.doi.org/10.1084/jem. 20080308
    • (2008) J Exp Med , vol.205 , pp. 1975-1981
    • Andersson, J.1    Tran, D.Q.2    Pesu, M.3    Davidson, T.S.4    Ramsey, H.5    O'Shea, J.J.6
  • 107
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease
    • PMID:1436033, http://dx.doi.org/10.1038/359693a0
    • Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, et al. Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease. Nature 1992; 359:693-9; PMID:1436033; http://dx.doi.org/10.1038/359693a0
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6
  • 108
    • 46249101518 scopus 로고    scopus 로고
    • How regulatory T cells work
    • PMID:18566595, http://dx.doi.org/10.1038/nri2343
    • Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008; 8: 523-32; PMID:18566595; http://dx.doi.org/10.1038/nri2343
    • (2008) Nat Rev Immunol , vol.8 , pp. 523-532
    • Vignali, D.A.1    Collison, L.W.2    Workman, C.J.3
  • 109
    • 82755184094 scopus 로고    scopus 로고
    • Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions
    • PMID:22055883, http://dx.doi.org/10.1016/j.smim.2011.10.002
    • Yamaguchi T, Wing JB, Sakaguchi S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol 2011; 23:424-30; PMID:22055883; http://dx.doi.org/10.1016/j.smim.2011.10.002
    • (2011) Semin Immunol , vol.23 , pp. 424-430
    • Yamaguchi, T.1    Wing, J.B.2    Sakaguchi, S.3
  • 110
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
    • PMID:17449799, http://dx.doi.org/10.1182/blood-2006-12-064527
    • Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007; 110:1225-32; PMID:17449799; http://dx.doi.org/10.1182/blood-2006-12-064527
    • (2007) Blood , vol.110 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    di Mitri, D.3    Sternjak, A.4    Diamantini, A.5    Giometto, R.6
  • 111
    • 67649365966 scopus 로고    scopus 로고
    • Autocrine regulation of T-cell activation by ATP release and P2X7 receptors
    • PMID:19211924, http://dx.doi.org/10.1096/fj.08-126458
    • Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, et al. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J 2009; 23:1685-93; PMID:19211924; http://dx.doi.org/10. 1096/fj.08-126458
    • (2009) FASEB J , vol.23 , pp. 1685-1693
    • Yip, L.1    Woehrle, T.2    Corriden, R.3    Hirsh, M.4    Chen, Y.5    Inoue, Y.6
  • 112
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • PMID:17502665, http://dx.doi.org/10.1084/jem.20062512
    • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257-65; PMID:17502665; http://dx.doi.org/10. 1084/jem.20062512
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3    Friedman, D.4    Usheva, A.5    Erat, A.6
  • 113
    • 36248995916 scopus 로고    scopus 로고
    • Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells
    • PMID: 17762882, http://dx.doi.org/10.1038/sj.cdd.4402220
    • Ren X, Ye F, Jiang Z, Chu Y, Xiong S, Wang Y. Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells. Cell Death Differ 2007; 14:2076-84; PMID: 17762882; http://dx.doi.org/10.1038/sj.cdd.4402220
    • (2007) Cell Death Differ , vol.14 , pp. 2076-2084
    • Ren, X.1    Ye, F.2    Jiang, Z.3    Chu, Y.4    Xiong, S.5    Wang, Y.6
  • 114
    • 33847376532 scopus 로고    scopus 로고
    • Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells
    • PMID:17110462, http://dx.doi.org/10.1182/blood-2006-04-016451
    • Garín MI, Chu CC, Golshayan D, Cernuda-Morollón E, Wait R, Lechler RI. Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007; 109:2058-65; PMID:17110462; http://dx.doi. org/10.1182/blood-2006-04-016451
    • (2007) Blood , vol.109 , pp. 2058-2065
    • Garín, M.I.1    Chu, C.C.2    Golshayan, D.3    Cernuda-Morollón, E.4    Wait, R.5    Lechler, R.I.6
  • 115
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • PMID: 21474713, http://dx.doi.org/10.1126/science.1202947
    • Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011; 332:600-3; PMID: 21474713; http://dx.doi.org/10.1126/science.1202947
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6
  • 116
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • PMID:15485628, http://dx.doi.org/10.1016/j.immuni.2004.08.010
    • Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, et al. Role of LAG-3 in regulatory T cells. Immunity 2004; 21:503-13; PMID:15485628; http://dx.doi.org/10.1016/j.immuni.2004.08.010
    • (2004) Immunity , vol.21 , pp. 503-513
    • Huang, C.T.1    Workman, C.J.2    Flies, D.3    Pan, X.4    Marson, A.L.5    Zhou, G.6
  • 117
    • 44449110691 scopus 로고    scopus 로고
    • Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
    • PMID: 18424711
    • Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L, et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol 2008; 180:5916-26; PMID: 18424711
    • (2008) J Immunol , vol.180 , pp. 5916-5926
    • Liang, B.1    Workman, C.2    Lee, J.3    Chew, C.4    Dale, B.M.5    Colonna, L.6
  • 118
    • 40249108222 scopus 로고    scopus 로고
    • Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
    • PMID: 18328743, http://dx.doi.org/10.1016/j.immuni.2008.01.012
    • Sarris M, Andersen KG, Randow F, Mayr L, Betz AG. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 2008; 28:402-13; PMID: 18328743; http://dx.doi.org/10.1016/j.immuni.2008.01.012
    • (2008) Immunity , vol.28 , pp. 402-413
    • Sarris, M.1    Andersen, K.G.2    Randow, F.3    Mayr, L.4    Betz, A.G.5
  • 119
    • 34247895580 scopus 로고    scopus 로고
    • Defining target antigens for CD25+ FOXP3 + IFN-c-regulatory T cells in chronic hepatitis C virus infection
    • PMID:17199111
    • Li S, Jones KL, Woollard DJ, Dromey J, Paukovics G, Plebanski M, et al. Defining target antigens for CD25+ FOXP3 + IFN-c-regulatory T cells in chronic hepatitis C virus infection. Immunol Cell Biol 2007; 85:197-204; PMID:17199111
    • (2007) Immunol Cell Biol , vol.85 , pp. 197-204
    • Li, S.1    Jones, K.L.2    Woollard, D.J.3    Dromey, J.4    Paukovics, G.5    Plebanski, M.6
  • 120
    • 0037086525 scopus 로고    scopus 로고
    • CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons
    • PMID:11920289, http://dx.doi.org/10.1086/339340
    • MacDonald AJ, Duffy M, Brady MT, McKiernan S, Hall W, Hegarty J, et al. CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. J Infect Dis 2002; 185:720-7; PMID:11920289; http://dx.doi.org/10.1086/339340
    • (2002) J Infect Dis , vol.185 , pp. 720-727
    • McDonald, A.J.1    Duffy, M.2    Brady, M.T.3    McKiernan, S.4    Hall, W.5    Hegarty, J.6
  • 121
    • 39349117113 scopus 로고    scopus 로고
    • Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection
    • PMID:18171284, http://dx.doi.org/10.1086/523651
    • Smyk-Pearson S, Golden-Mason L, Klarquist J, Burton JR, Jr., Tester IA, Wang CC, et al. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis 2008; 197:46-57; PMID:18171284; http://dx.doi. org/10.1086/523651
    • (2008) J Infect Dis , vol.197 , pp. 46-57
    • Smyk-Pearson, S.1    Golden-Mason, L.2    Klarquist, J.3    Burton Jr., J.R.4    Tester, I.A.5    Wang, C.C.6
  • 122
    • 19944370822 scopus 로고    scopus 로고
    • T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection
    • PMID:15919940, http://dx.doi.org/10.1128/JVI.79.12.7860-7867.2005
    • Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005; 79: 7860-7; PMID:15919940; http://dx.doi.org/10.1128/JVI.79.12.7860-7867.2005
    • (2005) J Virol , vol.79 , pp. 7860-7867
    • Boettler, T.1    Spangenberg, H.C.2    Neumann-Haefelin, C.3    Panther, E.4    Urbani, S.5    Ferrari, C.6
  • 123
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • PMID:14647055
    • Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003; 38:1437-48; PMID:14647055
    • (2003) Hepatology , vol.38 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 124
    • 43249107955 scopus 로고    scopus 로고
    • Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection
    • PMID:18337568, http://dx.doi.org/10.1128/JVI.01548-07
    • Ebinuma H, Nakamoto N, Li Y, Price DA, Gostick E, Levine BL, et al. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J Virol 2008; 82:5043-53; PMID:18337568; http://dx.doi.org/10. 1128/JVI.01548-07
    • (2008) J Virol , vol.82 , pp. 5043-5053
    • Ebinuma, H.1    Nakamoto, N.2    Li, Y.3    Price, D.A.4    Gostick, E.5    Levine, B.L.6
  • 125
    • 74549199294 scopus 로고    scopus 로고
    • Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection
    • PMID:20041222, http://dx.doi.org/10.1371/journal.ppat.1000707
    • Li S, Floess S, Hamann A, Gaudieri S, Lucas A, Hellard M, et al. Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. PLoS Pathog 2009; 5:e1000707; PMID:20041222; http://dx.doi.org/10. 1371/journal.ppat.1000707
    • (2009) PLoS Pathog , vol.5
    • Li, S.1    Floess, S.2    Hamann, A.3    Gaudieri, S.4    Lucas, A.5    Hellard, M.6
  • 126
    • 77954895261 scopus 로고    scopus 로고
    • Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C
    • PMID:20222873, http://dx.doi.org/10.1042/CS20090661
    • Langhans B, Braunschweiger I, Arndt S, Schulte W, Satoguina J, Layland LE, et al. Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C. Clin Sci (Lond) 2010; 119:97-109; PMID:20222873; http://dx.doi.org/10.1042/CS20090661
    • (2010) Clin Sci (Lond) , vol.119 , pp. 97-109
    • Langhans, B.1    Braunschweiger, I.2    Arndt, S.3    Schulte, W.4    Satoguina, J.5    Layland, L.E.6
  • 127
    • 79251564716 scopus 로고    scopus 로고
    • Hepatitis C virus induces regulatory T cells by naturally occurring viral variants to suppress T cell responses
    • PMID: 21197453, http://dx.doi.org/10.1155/2011/806061
    • Cusick MF, Schiller JJ, Gill JC, Eckels DD. Hepatitis C virus induces regulatory T cells by naturally occurring viral variants to suppress T cell responses. Clin Dev Immunol 2011; 2011:806061; PMID: 21197453; http://dx.doi.org/10.1155/2011/806061
    • (2011) Clin Dev Immunol , vol.2011 , pp. 806061
    • Cusick, M.F.1    Schiller, J.J.2    Gill, J.C.3    Eckels, D.D.4
  • 128
    • 0026052537 scopus 로고
    • An autoantibody cross-reactive to hepatitis C virus core and a host nuclear antigen
    • PMID:1723001, http://dx.doi.org/10.3109/08916939109001900
    • Mishiro S, Takeda K, Hoshi Y, Yoshikawa A, Gotanda T, Itoh Y. An autoantibody cross-reactive to hepatitis C virus core and a host nuclear antigen. Autoimmunity 1991; 10:269-73; PMID:1723001; http://dx.doi.org/10.3109/08916939109001900
    • (1991) Autoimmunity , vol.10 , pp. 269-273
    • Mishiro, S.1    Takeda, K.2    Hoshi, Y.3    Yoshikawa, A.4    Gotanda, T.5    Itoh, Y.6
  • 129
    • 19944366276 scopus 로고    scopus 로고
    • Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection
    • PMID:15919939, http://dx.doi.org/10.1128/JVI.79.12.7852-7859.2005
    • Rushbrook SM, Ward SM, Unitt E, Vowler SL, Lucas M, Klenerman P, et al. Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 2005; 79: 7852-9; PMID:15919939; http://dx.doi.org/10.1128/JVI.79.12.7852-7859.2005
    • (2005) J Virol , vol.79 , pp. 7852-7859
    • Rushbrook, S.M.1    Ward, S.M.2    Unitt, E.3    Vowler, S.L.4    Lucas, M.5    Klenerman, P.6
  • 130
    • 70349429634 scopus 로고    scopus 로고
    • FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C
    • PMID:19596013, http://dx.doi.org/10.1053/j.gastro.2009.06.059
    • Heeg MH, Ulsenheimer A, Grüner NH, Zachoval R, Jung MC, Gerlach JT, et al. FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C. Gastroenterology 2009; 137:1280-8, e1-6; PMID:19596013; http://dx.doi.org/10.1053/j.gastro. 2009.06.059
    • (2009) Gastroenterology , vol.137
    • Heeg, M.H.1    Ulsenheimer, A.2    Grüner, N.H.3    Zachoval, R.4    Jung, M.C.5    Gerlach, J.T.6
  • 131
    • 22244462678 scopus 로고    scopus 로고
    • Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons
    • PMID: 15962220, http://dx.doi.org/10.1086/430949
    • Blackard JT, Smeaton L, Hiasa Y, Horiike N, Onji M, Jamieson DJ, et al. Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons. J Infect Dis 2005; 192:258-65; PMID: 15962220; http://dx.doi.org/10.1086/430949
    • (2005) J Infect Dis , vol.192 , pp. 258-265
    • Blackard, J.T.1    Smeaton, L.2    Hiasa, Y.3    Horiike, N.4    Onji, M.5    Jamieson, D.J.6
  • 132
    • 34047261821 scopus 로고    scopus 로고
    • Hepatitis C virus infects T cells and affects interferongamma signaling in T cell lines
    • PMID:17175001, http://dx.doi.org/10.1016/j.virol.2006.11.009
    • Kondo Y, Sung VM, Machida K, Liu M, Lai MM. Hepatitis C virus infects T cells and affects interferongamma signaling in T cell lines. Virology 2007; 361: 161-73; PMID:17175001; http://dx.doi.org/10.1016/j.virol.2006.11.009
    • (2007) Virology , vol.361 , pp. 161-173
    • Kondo, Y.1    Sung, V.M.2    McHida, K.3    Liu, M.4    Lai, M.M.5
  • 133
    • 3042788418 scopus 로고    scopus 로고
    • Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation
    • PMID: 15254204, http://dx.doi.org/10.1128/JVI.78.15.8322-8332.2004
    • Ludwig IS, Lekkerkerker AN, Depla E, Bosman F, Musters RJ, Depraetere S, et al. Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. J Virol 2004; 78:8322-32; PMID: 15254204; http://dx.doi.org/10.1128/JVI.78.15. 8322-8332.2004
    • (2004) J Virol , vol.78 , pp. 8322-8332
    • Ludwig, I.S.1    Lekkerkerker, A.N.2    Depla, E.3    Bosman, F.4    Musters, R.J.5    Depraetere, S.6
  • 134
    • 84860227446 scopus 로고    scopus 로고
    • Up-regulation of FOXP3 and induction of suppressive function in CD4+ Jurkat T-cells expressing hepatitis C virus core protein
    • PMID:22214248, http://dx.doi.org/10.1042/CS20110631
    • Dominguez-Villar M, Fernandez-Ponce C, Munoz-Suano A, Gomez E, Rodríguez-Iglesias M, Garcia-Cozar F. Up-regulation of FOXP3 and induction of suppressive function in CD4+ Jurkat T-cells expressing hepatitis C virus core protein. Clin Sci (Lond) 2012; 123:15-27; PMID:22214248; http://dx.doi.org/10. 1042/CS20110631
    • (2012) Clin Sci (Lond) , vol.123 , pp. 15-27
    • Dominguez-Villar, M.1    Fernandez-Ponce, C.2    Munoz-Suano, A.3    Gomez, E.4    Rodríguez-Iglesias, M.5    Garcia-Cozar, F.6
  • 135
    • 0042971652 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells
    • PMID:12615891, http://dx.doi.org/10.1146/annurev.immunol.21.120601.141040
    • Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21:685-711; PMID:12615891; http://dx.doi. org/10.1146/annurev.immunol.21.120601.141040
    • (2003) Annu Rev Immunol , vol.21 , pp. 685-711
    • Steinman, R.M.1    Hawiger, D.2    Nussenzweig, M.C.3
  • 136
    • 78149277909 scopus 로고    scopus 로고
    • How tolerogenic dendritic cells induce regulatory T cells
    • PMID:21056730, http://dx.doi.org/10.1016/B978-0-12-380995-7.00004-5
    • Maldonado RA, von Andrian UH. How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol 2010; 108:111-65; PMID:21056730; http://dx.doi. org/10.1016/B978-0-12-380995-7.00004-5
    • (2010) Adv Immunol , vol.108 , pp. 111-165
    • Maldonado, R.A.1    von Andrian, U.H.2
  • 137
    • 75149196666 scopus 로고    scopus 로고
    • Immune tolerance: What is unique about the liver
    • PMID:19717280, http://dx.doi.org/10.1016/j.jaut.2009.08.008
    • Tiegs G, Lohse AW. Immune tolerance: what is unique about the liver. J Autoimmun 2010; 34:1-6; PMID:19717280; http://dx.doi.org/10.1016/j.jaut. 2009.08.008
    • (2010) J Autoimmun , vol.34 , pp. 1-6
    • Tiegs, G.1    Lohse, A.W.2
  • 138
    • 61449193205 scopus 로고    scopus 로고
    • Human liver dendritic cells promote T cell hyporesponsiveness
    • PMID:19201843, http://dx.doi.org/10.4049/jimmunol.0803404
    • Bamboat ZM, Stableford JA, Plitas G, Burt BM, Nguyen HM, Welles AP, et al. Human liver dendritic cells promote T cell hyporesponsiveness. J Immunol 2009; 182:1901-11; PMID:19201843; http://dx.doi. org/10.4049/jimmunol.0803404
    • (2009) J Immunol , vol.182 , pp. 1901-1911
    • Bamboat, Z.M.1    Stableford, J.A.2    Plitas, G.3    Burt, B.M.4    Nguyen, H.M.5    Welles, A.P.6
  • 139
    • 77953730386 scopus 로고    scopus 로고
    • Connecting the mechanisms of T-cell regulation: Dendritic cells as the missing link
    • PMID:20636819, http://dx.doi.org/10.1111/j.1600-065X.2010.00913.x
    • Cobbold SP, Adams E, Nolan KF, Regateiro FS, Waldmann H. Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link. Immunol Rev 2010; 236:203-18; PMID:20636819; http://dx. doi.org/10.1111/j.1600-065X.2010.00913.x
    • (2010) Immunol Rev , vol.236 , pp. 203-218
    • Cobbold, S.P.1    Adams, E.2    Nolan, K.F.3    Regateiro, F.S.4    Waldmann, H.5


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