Human immunodeficiency virus type 1-hepatitis C virus coinfection: Intraindividual comparison of cellular immune responses against two persistent viruses

Journal of Virology

Volumn 76, Issue 6, 2002, Pages 2817-2826

  Lauer, Georg M ^a   Nguyen, Tam N ^a   Day, Cheryl L ^a   Robbins, Gregory K ^a   Flynn, Theresa ^a   McGowan, Katherine ^a   Rosenberg, Eric S ^a   Lucas, Michaela ^a   Klenerman, Paul ^a   Chung, Raymond T ^a   Walker, Bruce D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; VIRUS PROTEIN;

ADULT; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; SUPERINFECTION; T LYMPHOCYTE; VIREMIA; VIRUS INFECTION; VIRUS LOAD;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HEPACIVIRUS; HEPATITIS C; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; RNA, VIRAL; VIRAL LOAD;

EID: 0036188008     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.6.2817-2826.2002     Document Type: Article

References (61)

1. The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxie T lymphocytes derived from HIV-1-infected individuals
2. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
3. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif
4. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
5. Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival
6. Death by neglect as a deletional mechanism of peripheral tolerance
7. Proliferative responses to human immunodeficiency virus type 1 (HIV-1) antigens in HIV-1-infected patients with immune reconstitution
8. Hepatitis C in patients with human immunodeficiency virus infection: Diagnosis, natural history, meta-analysis of sexual and vertical transmission, and therapeutic issues
9. T-lymphocyte response to hepatitis C virus in different clinical courses of infection
10. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease
11. HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage
12. Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection
13. Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
14. Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs
15. + responses in HIV type 1-infected patients: Comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy
16. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections
17. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
18. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
19. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C
20. Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection
21. Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis
22. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: The Swiss HIV Cohort Study
23. + T lymphocytes after infection with hepatitis C virus
24. Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection
25. Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers
26. Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection
27. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
28. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
29. A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection. A report from the Multicenter AIDS Cohort Study
30. Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: Different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma
31. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release
32. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis
33. Haemophilic patients with hepatitis C have higher viral load compared to other well-defined patient groups
34. CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity
35. A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals
36. CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained
37. Analysis of successful immune responses in persons infected with hepatitis C virus
38. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
39. HLA class II favors clearance of HCV infection and progression of the chronic liver damage
40. + cytotoxic T-cell responses during chronic viral infection
41. Compartmentalization of T lymphocytes to the site of disease: Intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
42. Frequency of HLA allele-specific peptide motifs in HIV-1 proteins correlates with the allele's association with relative rates of disease progression after HIV-1 infection
43. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
44. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes
45. Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CDS+ T cells upon acute versus persistent viral infection
46. Functional T cell reconstitution and human immunodeficiency virus-1-specific cell-mediated immunity during highly active antiretroviral therapy
47. Impact of human immunodeficiency virus infection on progression to end-stage liver disease in individuals with hemophilia and hepatitis C virus infection
48. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
49. Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens
50. Immune control of HIV-1 after early treatment of acute infection
51. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia
52. Liverderived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma
53. Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis
54. Support for patients with hepatitis C: An exploratory qualitative study of medical specialists' perceptions
55. Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease
56. Infection with GB virus C and reduced mortality among HIV-infected patients
57. HAART in HIV-infected patients: Restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia
58. Liver-derived CTL in hepatitis C virus infection: Breadth and specificity of responses in a cohort of persons with chronic infection
59. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV
60. Effect of coinfection with GB virus C on survival among patients with HIV infection
61. Viral immune evasion due to persistence of activated T cells without effector function