Influence of specific CD4+ T cells and antibodies on evolution of hypervariable region 1 during acute HCV infection

Journal of Hepatology

Volumn 48, Issue 2, 2008, Pages 216-228

  Scottà, Cristiano ^a   Garbuglia, Anna Rosa ^b   Ruggeri, Lionello ^c   Spada, Enea ^d   Laurenti, Luca ^a   Perrone, Maria Paola ^a   Girelli, Gabriella ^a   Mele, Alfonso ^d   Capobianchi, Maria Rosaria ^b   Folgori, Antonella ^c   Nicosia, Alfredo ^c   Del Porto, Paola ^a   Piccolella, Enza ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^c IRBM   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cellular immune response; Genetic diversity; HCV acute infection; Humoral immune response; Hypervariable region 1

Indexed keywords

GAMMA INTERFERON;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL SPECIFICITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; HEPATITIS C; HUMAN; HUMORAL IMMUNITY; IMMUNOGLOBULIN VARIABLE REGION; INFECTION RISK; MALE; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS IMMUNITY;

ACUTE DISEASE; ADULT; AMINO ACID SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; EVOLUTION, MOLECULAR; FEMALE; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; VARIATION (GENETICS); VIRAL PROTEINS;

EID: 37849039121     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.09.011     Document Type: Article

References (39)

1. Bowen D.G., and Walker C.M. The origin of quasispecies: cause or consequence of chronic hepatitis C viral infection?. J Hepatol 42 (2005) 408-417
2. Weiner A.J., Brauer M.J., Rosenblatt J., Richman K.H., Tung J., Crawford K., et al. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 180 (1991) 842-848
3. Farci P., Shimoda A., Coiana A., Diaz G., Peddis G., Melpolder J.C., et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 288 (2000) 339-344
4. Farci P., Alter H.J., Wong D.C., Miller R.H., Govindarajan S., Engle R., et al. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci USA 91 (1994) 7792-7796
5. Shimizu Y.K., Hijikata M., Iwamoto A., Alter H.J., Purcell R.H., and Yoshikura H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol 68 (1994) 1494-1500
6. Del Porto P., Puntoriero G., Scotta C., Nicosia A., and Piccolella E. High prevalence of hypervariable region 1-specific and -cross-reactive CD4(+) T cells in HCV-infected individuals responsive to IFN-alpha treatment. Virology 269 (2000) 313-324
7. Tsai S.L., Chen Y.M., Chen M.H., Huang C.Y., Sheen I.S., Yeh C.T., et al. Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity. Gastroenterology 115 (1998) 954-965
8. Frasca L., Del Porto P., Tuosto L., Marinari B., Scotta C., Carbonari M., et al. Hypervariable region 1 variants act as TCR antagonists for hepatitis C virus-specific CD4+ T cells. J Immunol 163 (1999) 650-658
9. Frasca L., Scotta C., Del Porto P., Nicosia A., Pasquazzi C., Versace I., et al. Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes. Hepatology 38 (2003) 653-663
10. Grakoui A., Shoukry N.H., Woollard D.J., Han J.H., Hanson H.L., Ghrayeb J., et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 302 (2003) 659-662
11. Manzin A., Solforosi L., Petrelli E., Macarri G., Tosone G., Piazza M., et al. Evolution of hypervariable region 1 of hepatitis C virus in primary infection. J Virol 72 (1998) 6271-6276
12. Ray S.C., Wang Y.M., Laeyendecker O., Ticehurst J.R., Villano S.A., and Thomas D.L. Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoy. J Virol 73 (1999) 2938-2946
13. Spada E., Mele A., Berton A., Ruggeri L., Ferrigno L., Garbuglia A.R., et al. Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut 53 (2004) 1673-1681
14. Guglietta S., Garbuglia A.R., Pacciani V., Scotta C., Perrone M.P., Laurenti L., et al. Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection. Eur J Immunol 35 (2005) 2627-2637
15. Enomoto N., Kurosaki M., Tanaka Y., Marumo F., and Sato C. Fluctuation of hepatitis C virus quasispecies in persistent infection andinterferon treatment revealed by single-strand conformation polymorphismanalysis. J Gen Virol 75 (1994) 1361-1369
16. Sandres K., Dubois M., Pasqiuer C., Payen J.L., Alric L., Duffaut M., et al. Genetic heterogeneity of hypervariable region 1 of the hepatitis C virus (HCV) genome and sensitivity of HCV to alpha interferon theraphy. J Virol 74 (2000) 661-668
17. Gerotto M., Sullivan D.G., Polyak S.J., Chemello L., Cavalletto L., Pontisso P., et al. Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C. J Virol 73 (1999) 7241-7247
18. Torres-Puente M., Bracho M.A., Jiménez N., Garcia-Robles I., Moya A., and Gonzalez-Candelas F. Sampling and repeatibility in the evaluation of hepatitis C virus genetic variability. J Gen Virol 84 (2003) 2343-2350
19. Shannon C.E. A mathematical theory of communication (1949), University Illinois Press
20. Thompson J.D., Higgins D.G., and Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignement through sequence weighting, position-specific gap penalties, and weight matrix choice. Nucleic Acids Res 22 (1994) 4373-4680
21. Hamming R.W. Coding and information theory. 2nd ed. (1986), Prentice-Hall, Englewood Cliffs, NJ
22. Nei M., and Gojobori T. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3 (1986) 418-426
23. Hughes A.L., and Nei M. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 335 (1988) 167-170
24. Del Porto P., D'Amato M., Fiorillo M.T., Tuosto L., Piccolella E., and Sorrentino R. Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone. J Immunol 153 (1994) 3093-3100
25. Shirai M., Arichi T., Chen M., Masaki T., Nishioka M., Ikeda K., et al. T cell recognition of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region. J Immunol 162 (1999) 568-576
26. Allain J.P., Dong Y., Vandamme A.M., Moulton V., and Salemi M. Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: studies of infected donor-recipient clusters. J Virol 74 (2000) 2541-2549
27. Kumar U., Monjardino J., and Thomas H.C. Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient. Gastroenterology 106 (1994) 1072-1075
28. Kaplan D.E., Sugimoto K., Newton K., Valiga M.E., Ikeda F., Aytaman A., et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132 (2007) 654-666
29. Logvinoff C., Major M.E., Oldach D., Heyward S., Talal A., Balfe P., et al. Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proc Natl Acad Sci USA 101 (2004) 10149-10154
30. Lavillette D., Morice Y., Germanidis G., Donot P., Soulier A., Pagkalos E., et al. Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J Virol 79 (2005) 6023-6034
31. Diepolder H.M., Zachoval R., Hoffmann R.M., Wierenga E.A., Santantonio T., and Jung M.C. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346 (1995) 1006-1007
32. Urbani S., Amadei B., Fisicaro P., Tola D., Orlandini A., Sacchelli L., et al. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology 44 (2006) 126-139
33. Lechner F., Wong D.K., Dunbar P.R., Chapman R., Chung R.T., Dohrenwend P., et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 191 (2000) 1499-1512
34. Thimme R., Oldach D., Chang K.M., Steiger C., Ray S.C., and Chisari F.V. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194 (2001) 1395-1406
35. Folgori A., Spada E., Pezzanera M., Ruggeri L., Mele A., Garbuglia A.R., et al. Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance. Gut 55 (2006) 1012-1019
36. Chen M., Sällberg M., Sönnerborg A., Weiland O., Mattsson L., Jin L., et al. Limited humoral immunity in hepatitis C virus infection. Gastroenterology 116 (1999) 135-143
37. Mondelli M.U., Cerino A., Lisa A., Brambilla S., Segagni L., Cividini A., et al. Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation. Hepatology 30 (1999) 537-545
38. Zibert A., Kraas W., Meisel H., Jung G., and Roggendorf M. Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus. J Virol 71 (1997) 4123-4127
39. Penin F., Combet C., Germanidis G., Frainais P.O., Deléage G., and Pawlotsky J.M. Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment. J Virol 75 (2001) 5703-5710