Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation

Journal of Clinical Investigation

Volumn 106, Issue 10, 2000, Pages 1239-1249

  Kittlesen, David J ^a   Chianese Bullock, Kimberly A ^a   Yao, Zhi Qiang ^a   Braciale, Thomas J ^a   Hahn, Young S ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR GC1QR; CORE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LYMPHOCYTE PROLIFERATION; METABOLIC INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; T LYMPHOCYTE;

EID: 0033690901     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10323     Document Type: Article

References (52)

1. Epidemiology of hepatitis C
2. Non-A, non-B hepatitis viruses
3. Hepatitis C virus: Pathogenesis and immune regulation
4. Association between high serum alanine amino-transferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis
5. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
6. Association between hepatitis C virus and mixed cryoglobulinemia
7. Membranoproliferative glomerulonephritis associated with hepatitis C virus infection
8. Hepatitis C
9. Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease
10. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
11. Expression and identification of hepatitis C virus polyprotein cleavage products
12. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
13. Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS-5 regions
14. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins
15. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycopotein variants: Potential role in chronic HCV infections
16. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA-A2.1 binding motif
17. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV
18. The histological features of chronic hepatitis C and autoimmune chronic hepatitis: A comparative analysis
19. Immunoelectron microscopic observations on the inflammatoy infiltates and HLA antigens in hepatitis B and non-A, non-B
20. + T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
21. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis
22. Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatitis C virus persistence
23. Buoyant density of hepatitis C virus recovered from infected hosts: Two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation
24. Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates
25. T-lymphocyte response to hepatitis C virus in different clinical courses of infection
26. The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest
27. Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprorein that binds to the globular 'heads' of Clq
28. Human T cells express specific binding sites for Clq. Role in T cell activation and proliferation
29. Interaction of Clq with its receptor on cultured cell lines induces an anti-proliferative response
30. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-β receptor
31. Identification of functional domains on gClQ-R, a cell surface protein that binds to the globular 'heads' of ClQ, using monoclonal antibodies and synthetic peprides
32. Evidence that the two Clq binding membrane proteins, gClq-R and cClq-R, associate to form a complex
33. Structure and function of gClq-R: A multiligand binding cellular protein
34. Detection of hepatitis C virus core protein circulating within different virus particle populations
35. The multiligand-binding protein gClqR, putative Clq receptor, is a mitochondrial protein
36. Intracellular localization of the human receptor for the globular domains of Clq
37. T cell-dependent immune response in Clq-deficient mice: Defective interferon γ production by antigen-specific T cells
38. Homozygous Clq deficiency causes glomerulonephritis associated with multiple apoptotic bodies
39. Clq-binding proteins and Clq receptors
40. Clq receptors: Regulating specific functions of phagocytic cells
41. The binding protein for globular heads of complement Clq, gClqR. Functional expression and characterization as a novel vitronectin binding factor
42. Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein
43. Functional expression of cloned human splicing factor SF2: Homology to RNA-binding proteins, U1 70K, and drosophila splicing regulators
44. Non-A, non-B hepatitis viruses
45. Membrane receptors for soluble defense collagens
46. Mechanism of suppression of cell-mediated immunity by measles virus
47. Biosynthesis and biochemical properties of the hepatitis C virus core protein
48. Differential subcellular localization of hepatitis C virus core gene products
49. Immunopathology of Hepatitis C
50. Characteristics of the intrahepatic cytotoxic T lymphocyte responses in chronic hepatitis C virus infection
51. Differential cyrotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
52. + T cells in peripheral blood and liver using peptide-MHC teames