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Volumn 9, Issue 5, 2008, Pages 495-502

Up on the tightrope: Natural killer cell activation and inhibition

Author keywords

[No Author keywords available]

Indexed keywords

CD244 ANTIGEN; CD94 ANTIGEN; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE RECEPTOR; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN TYROSINE PHOSPHATASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 42449102990     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1581     Document Type: Review
Times cited : (1321)

References (78)
  • 1
    • 0022616253 scopus 로고
    • Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy
    • Kärre, K., Ljunggren, H.G., Piontek, G. & Kiessling, R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature 319, 675-678 (1986).
    • (1986) Nature , vol.319 , pp. 675-678
    • Kärre, K.1    Ljunggren, H.G.2    Piontek, G.3    Kiessling, R.4
  • 2
    • 0034613151 scopus 로고    scopus 로고
    • Immune inhibitory receptors
    • Ravetch, J.V. & Lanier, L.L. Immune inhibitory receptors. Science 290, 84-89 (2000).
    • (2000) Science , vol.290 , pp. 84-89
    • Ravetch, J.V.1    Lanier, L.L.2
  • 3
    • 34047163529 scopus 로고    scopus 로고
    • KLRG1 binds cadherins and preferentially associates with SHIP-1
    • Tessmer, M.S. et al. KLRG1 binds cadherins and preferentially associates with SHIP-1. Int. Immunol. 19, 391-400 (2007).
    • (2007) Int. Immunol , vol.19 , pp. 391-400
    • Tessmer, M.S.1
  • 4
    • 0041534399 scopus 로고    scopus 로고
    • Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
    • Stebbins, C.C. et al. Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol. Cell. Biol. 23, 6291-6299 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 6291-6299
    • Stebbins, C.C.1
  • 5
    • 38449117450 scopus 로고    scopus 로고
    • Protein kinase C regulates expressiog and function of inhibitory killer cell Ig-like receptors in NK cells
    • Alvarez-Arias, D.A. & Campbell, K.S. Protein kinase C regulates expressiog and function of inhibitory killer cell Ig-like receptors in NK cells. J. Immunol. 179, 5281-5290 (2007).
    • (2007) J. Immunol , vol.179 , pp. 5281-5290
    • Alvarez-Arias, D.A.1    Campbell, K.S.2
  • 6
    • 30144443832 scopus 로고    scopus 로고
    • Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
    • Bryceson, Y.T., March, M.E., Ljunggren, H.G. & Long, E.O. Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 107, 159-166 (2005).
    • (2005) Blood , vol.107 , pp. 159-166
    • Bryceson, Y.T.1    March, M.E.2    Ljunggren, H.G.3    Long, E.O.4
  • 7
    • 17444427074 scopus 로고    scopus 로고
    • Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors
    • Feng, J., Garrity, D., Call, M.E., Moffett, H. & Wucherpfennig, K.W. Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity 22, 427-438 (2005).
    • (2005) Immunity , vol.22 , pp. 427-438
    • Feng, J.1    Garrity, D.2    Call, M.E.3    Moffett, H.4    Wucherpfennig, K.W.5
  • 8
    • 0024822508 scopus 로고
    • Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells
    • Lanier, L.L., Yu, G. & Phillips, J.H. Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells. Nature 342, 803-805 (1989).
    • (1989) Nature , vol.342 , pp. 803-805
    • Lanier, L.L.1    Yu, G.2    Phillips, J.H.3
  • 9
    • 0026082601 scopus 로고
    • Analysis of FcγRIII (CD16) membrane expression and association with CD3ζ and FcεRI- by site-directed mutation
    • Lanier, L.L., Yu, G. & Phillips, J.H. Analysis of FcγRIII (CD16) membrane expression and association with CD3ζ and FcεRI- by site-directed mutation. J. Immunol. 146, 1571-1576 (1991).
    • (1991) J. Immunol , vol.146 , pp. 1571-1576
    • Lanier, L.L.1    Yu, G.2    Phillips, J.H.3
  • 10
    • 14444279642 scopus 로고    scopus 로고
    • DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase
    • McVicar, D.W. et al. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J. Biol. Chem. 273, 32934-32942 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 32934-32942
    • McVicar, D.W.1
  • 11
    • 0036194976 scopus 로고    scopus 로고
    • Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
    • Colucci, F. et al. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat. Immunol. 3, 288-294 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 288-294
    • Colucci, F.1
  • 12
    • 33644751667 scopus 로고    scopus 로고
    • Multiplicity and plasticity of natural killer cell signaling pathways
    • Chiesa, S. et al. Multiplicity and plasticity of natural killer cell signaling pathways. Blood 107, 2364-2372 (2006).
    • (2006) Blood , vol.107 , pp. 2364-2372
    • Chiesa, S.1
  • 13
    • 33646491409 scopus 로고    scopus 로고
    • Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
    • Hesslein, D.G., Takaki, R., Hermiston, M.L., Weiss, A. & Lanier, L.L. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc. Natl. Acad. Sci. USA 103, 7012-7017 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 7012-7017
    • Hesslein, D.G.1    Takaki, R.2    Hermiston, M.L.3    Weiss, A.4    Lanier, L.L.5
  • 14
    • 33646875354 scopus 로고    scopus 로고
    • Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45
    • Mason, L.H., Willette-Brown, J., Taylor, L.S. & McVicar, D.W. Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45. J. Immunol. 176, 6615-6623 (2006).
    • (2006) J. Immunol , vol.176 , pp. 6615-6623
    • Mason, L.H.1    Willette-Brown, J.2    Taylor, L.S.3    McVicar, D.W.4
  • 15
    • 18644385629 scopus 로고    scopus 로고
    • A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary NK cells
    • Huntington, N.D., Xu, Y., Nutt, S.L. & Tarlinton, D,.M. A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary NK cells. J. Exp. Med. 201, 1421-1433 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 1421-1433
    • Huntington, N.D.1    Xu, Y.2    Nutt, S.L.3    Tarlinton, D.M.4
  • 16
    • 23244455179 scopus 로고    scopus 로고
    • Phospholipase Cγ2 Is a critical signaling mediator for murine NK cell activating receptors
    • Tassi, I. et al. Phospholipase Cγ2 Is a critical signaling mediator for murine NK cell activating receptors. J. Immunol. 175, 749-754 (2005).
    • (2005) J. Immunol , vol.175 , pp. 749-754
    • Tassi, I.1
  • 17
    • 4644359297 scopus 로고    scopus 로고
    • Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity
    • Cella, M. et al. Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J. Exp. Med. 200 817-823 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 817-823
    • Cella, M.1
  • 18
    • 0026451188 scopus 로고
    • Fcγ receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-γl and PLC-γ2 in natural killer cells
    • Ting, A.T., Karnitz, L.M., Schoon, R.A., Abraham, R.T. & Leibson, P.J. Fcγ receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-γl and PLC-γ2 in natural killer cells. J. Exp. Med. 176, 1751-1755 (1992).
    • (1992) J. Exp. Med , vol.176 , pp. 1751-1755
    • Ting, A.T.1    Karnitz, L.M.2    Schoon, R.A.3    Abraham, R.T.4    Leibson, P.J.5
  • 19
    • 0032479968 scopus 로고    scopus 로고
    • The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing
    • Billadeau, D.D. et al. The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J. Exp. Med. 188, 549-559 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 549-559
    • Billadeau, D.D.1
  • 20
    • 0035859914 scopus 로고    scopus 로고
    • Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement
    • Paolini, R., Molfetta, R., Piccoli, M., Frati, L. & Santoni, A. Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement. Proc. Natl. Acad. Sci. USA 98, 9611-9616 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9611-9616
    • Paolini, R.1    Molfetta, R.2    Piccoli, M.3    Frati, L.4    Santoni, A.5
  • 21
    • 0037114633 scopus 로고    scopus 로고
    • SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells
    • Galandrini, R. et al. SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells. Blood 100, 4581-4589 (2002).
    • (2002) Blood , vol.100 , pp. 4581-4589
    • Galandrini, R.1
  • 22
    • 0025754310 scopus 로고
    • DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
    • Houchins, J.P., Yabe, T., McSherry, C. & Bach, F.H. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173, 1017-1020 (1991).
    • (1991) J. Exp. Med , vol.173 , pp. 1017-1020
    • Houchins, J.P.1    Yabe, T.2    McSherry, C.3    Bach, F.H.4
  • 23
    • 0033618504 scopus 로고    scopus 로고
    • Activation of natural killer cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • Bauer, S. et al. Activation of natural killer cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727-730 (1999).
    • (1999) Science , vol.285 , pp. 727-730
    • Bauer, S.1
  • 24
    • 0036333884 scopus 로고    scopus 로고
    • The role of the NKG2D immunoreceptor in immune cell activation and natural killing
    • Jamieson, A.M. et al. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17, 19-29 (2002).
    • (2002) Immunity , vol.17 , pp. 19-29
    • Jamieson, A.M.1
  • 25
    • 0033618624 scopus 로고    scopus 로고
    • An activating receptor complex on natural killer and T cells formed by NKG2D and DAP10
    • Wu, J. et al. An activating receptor complex on natural killer and T cells formed by NKG2D and DAP10. Science 285, 730-732 (1999).
    • (1999) Science , vol.285 , pp. 730-732
    • Wu, J.1
  • 26
    • 0036915968 scopus 로고    scopus 로고
    • Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    • Diefenbach, A. et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3, 1142-1149 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 1142-1149
    • Diefenbach, A.1
  • 27
    • 0036910991 scopus 로고    scopus 로고
    • NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    • Gilfillan, S., Ho, E.L., Cella, M., Yokoyama, W.M. & Colonna, M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 3, 1150-1155 (2002).
    • (2002) Nat Immunol , vol.3 , pp. 1150-1155
    • Gilfillan, S.1    Ho, E.L.2    Cella, M.3    Yokoyama, W.M.4    Colonna, M.5
  • 28
    • 4043128155 scopus 로고    scopus 로고
    • A structural basis for the association of DAP12 with mouse, but not human, NRG2D
    • Rosen, U.B. et al. A structural basis for the association of DAP12 with mouse, but not human, NRG2D. J. Immunol. 173, 2470-2478 (2004).
    • (2004) J. Immunol , vol.173 , pp. 2470-2478
    • Rosen, U.B.1
  • 29
    • 3843057067 scopus 로고    scopus 로고
    • Comparative analysis of human NK cell activation induced by NIKG2D and natural cytotoxicity receptors
    • Andre, P. et al. Comparative analysis of human NK cell activation induced by NIKG2D and natural cytotoxicity receptors. Eur. J. Immunol. 34, 961-971 (2004).
    • (2004) Eur. J. Immunol , vol.34 , pp. 961-971
    • Andre, P.1
  • 30
    • 19644365065 scopus 로고    scopus 로고
    • The activating NKG2D receptor assembles in the membrane with two signaling dinners into a hexameric structure
    • Garrity, D., Call, M.E., Feng, J. & Wucherpfennig, K.W. The activating NKG2D receptor assembles in the membrane with two signaling dinners into a hexameric structure. Proc. Natl. Acad. Sci. USA 102, 7641-7646 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 7641-7646
    • Garrity, D.1    Call, M.E.2    Feng, J.3    Wucherpfennig, K.W.4
  • 31
    • 0034596890 scopus 로고    scopus 로고
    • DAP10 a6d DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells
    • Wu, J., Cherwinski, H., Spies, T., Phillips, J.H. & Lanier, L.L. DAP10 a6d DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J. Exp. Med. 192, 1059-1068 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 1059-1068
    • Wu, J.1    Cherwinski, H.2    Spies, T.3    Phillips, J.H.4    Lanier, L.L.5
  • 32
    • 33645976783 scopus 로고    scopus 로고
    • NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells
    • Upshaw, J.L. et al. NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat. Immunol. 7, 524-532 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 524-532
    • Upshaw, J.L.1
  • 33
    • 0037600740 scopus 로고    scopus 로고
    • NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway
    • Billadeau, D.D, Upshaw, J.L., Schoon, R.A., Dick, C.J. & Leibson, P.J. NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat. Immunol. 4, 557-564 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 557-564
    • Billadeau, D.D.1    Upshaw, J.L.2    Schoon, R.A.3    Dick, C.J.4    Leibson, P.J.5
  • 34
    • 33746901647 scopus 로고    scopus 로고
    • Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    • Graham, D.B. et al. Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J. Immunol. 177, 2349-2355 (2006).
    • (2006) J. Immunol , vol.177 , pp. 2349-2355
    • Graham, D.B.1
  • 35
    • 37549019661 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse
    • Giurisato, E. et al. Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse. Mol. Cell. Biol. 27, 8583-8599 (2007).
    • (2007) Mol. Cell. Biol , vol.27 , pp. 8583-8599
    • Giurisato, E.1
  • 36
    • 0038276047 scopus 로고    scopus 로고
    • NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
    • Zompi, S. et al. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat. Immunol. 4, 565-572 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 565-572
    • Zompi, S.1
  • 37
    • 36248957695 scopus 로고    scopus 로고
    • NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
    • Horng, T., Bezbradica, J.S. & Medzhitov, R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat. Immunol. 8, 1345-1352 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 1345-1352
    • Horng, T.1    Bezbradica, J.S.2    Medzhitov, R.3
  • 38
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    • Meresse, B. et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21, 357-366 (2004).
    • (2004) Immunity , vol.21 , pp. 357-366
    • Meresse, B.1
  • 39
    • 0037080348 scopus 로고    scopus 로고
    • UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK calls
    • Sutherland, C.L. et al. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK calls. J. Immunol. 168, 671-679 (2002).
    • (2002) J. Immunol , vol.168 , pp. 671-679
    • Sutherland, C.L.1
  • 40
    • 0034998410 scopus 로고    scopus 로고
    • ULBP1, 2, 3: Novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells
    • Kubin, M. et al. ULBP1, 2, 3: Novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 31, 1428-1437 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 1428-1437
    • Kubin, M.1
  • 43
    • 34247892632 scopus 로고    scopus 로고
    • Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
    • Ma, C.S., Nichols, K.E. & Tangye, S.G. Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu. Rev Immunol. 25, 337-379 (2007).
    • (2007) Annu. Rev Immunol , vol.25 , pp. 337-379
    • Ma, C.S.1    Nichols, K.E.2    Tangye, S.G.3
  • 44
    • 33750727672 scopus 로고    scopus 로고
    • NK cell regulation by SLAM family receptors and SAP-related adapteis
    • Veillette, A. NK cell regulation by SLAM family receptors and SAP-related adapteis. Immunol. Rev. 214, 22-34 (2006).
    • (2006) Immunol. Rev , vol.214 , pp. 22-34
    • Veillette, A.1
  • 45
    • 36049042916 scopus 로고    scopus 로고
    • Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    • Veillette, A., Dong, Z. & Latour, S. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity 27, 698-710 (2007).
    • (2007) Immunity , vol.27 , pp. 698-710
    • Veillette, A.1    Dong, Z.2    Latour, S.3
  • 46
    • 0027220087 scopus 로고
    • Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
    • Valiante, N.M. & Trinchieri, G. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J. Exp. Med. 178, 1397-1406 (1993).
    • (1993) J. Exp. Med , vol.178 , pp. 1397-1406
    • Valiante, N.M.1    Trinchieri, G.2
  • 47
    • 0033564638 scopus 로고    scopus 로고
    • Cutting edge: Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
    • Tangye, S.G. et al. Cutting edge: Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J. Immunol. 162, 6981-6985 (1999).
    • (1999) J. Immunol , vol.162 , pp. 6981-6985
    • Tangye, S.G.1
  • 48
    • 0035817326 scopus 로고    scopus 로고
    • NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease
    • Bottino, C. et al. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 194, 235-246 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 235-246
    • Bottino, C.1
  • 49
    • 0035890037 scopus 로고    scopus 로고
    • Cutting edge: Activation of NK cell-mediated cytotoxicity by a SAP- independent receptor of the CD2 family
    • Bouchon, A., Cella, M., Grierson, H.L., Cohen, J.I. & Colonna, M. Cutting edge: Activation of NK cell-mediated cytotoxicity by a SAP- independent receptor of the CD2 family. J. Immunol. 167, 5517-5521 (2001).
    • (2001) J. Immunol , vol.167 , pp. 5517-5521
    • Bouchon, A.1    Cella, M.2    Grierson, H.L.3    Cohen, J.I.4    Colonna, M.5
  • 50
    • 0027383871 scopus 로고
    • Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells
    • Mathew, P.A. et al. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151 5328-5337 (1993).
    • (1993) J. Immunol , vol.151 , pp. 5328-5337
    • Mathew, P.A.1
  • 51
    • 0027244760 scopus 로고
    • A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
    • Garni-Wagner, B.A., Purohit, A., Mathew, P.A., Bennett, M. & Kumar, K. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J. Immunol. 151, 60-70 (1993).
    • (1993) J. Immunol , vol.151 , pp. 60-70
    • Garni-Wagner, B.A.1    Purohit, A.2    Mathew, P.A.3    Bennett, M.4    Kumar, K.5
  • 52
    • 0033616820 scopus 로고    scopus 로고
    • Characterizatíon of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4
    • Schatzle, J.D. et al. Characterizatíon of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4. Proc. Natl. Acad. Sci. USA 96, 3870-3875 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3870-3875
    • Schatzle, J.D.1
  • 53
    • 33746568382 scopus 로고    scopus 로고
    • Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor
    • Chen, R., Latour, S., Shi, X. & Veillette, A. Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor. Mol. Cell. Biol. 26, 5559-5568 (2006).
    • (2006) Mol. Cell. Biol , vol.26 , pp. 5559-5568
    • Chen, R.1    Latour, S.2    Shi, X.3    Veillette, A.4
  • 54
    • 27144508418 scopus 로고    scopus 로고
    • Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
    • Roncagalli, R. et al. Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat. Immunol. 6, 1002-1010 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1002-1010
    • Roncagalli, R.1
  • 55
    • 33644871161 scopus 로고    scopus 로고
    • Identification and charecterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters
    • Calpe, S. et al. Identification and charecterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics 58, 15-25 (2006).
    • (2006) Immunogenetics , vol.58 , pp. 15-25
    • Calpe, S.1
  • 56
    • 34548512477 scopus 로고    scopus 로고
    • Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase
    • Clarkson, N.G., Simmonds, S.J., Puklavec, M.J. & Brown, M.H. Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase, J. Biol. Chem. 282, 25385-25394 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 25385-25394
    • Clarkson, N.G.1    Simmonds, S.J.2    Puklavec, M.J.3    Brown, M.H.4
  • 57
    • 0034664724 scopus 로고    scopus 로고
    • Cutting edge: Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
    • Tangye, S.G., Phillips, J.H., Lanier, L.L. & Nichols, K.E. Cutting edge: functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J. Immunol. 165, 2932-2936 (2000).
    • (2000) J. Immunol , vol.165 , pp. 2932-2936
    • Tangye, S.G.1    Phillips, J.H.2    Lanier, L.L.3    Nichols, K.E.4
  • 58
    • 0033729573 scopus 로고    scopus 로고
    • Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
    • Nakajima, H. et al. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Eur. J. Immunol. 30, 3309-3318 (2000).
    • (2000) Eur. J. Immunol , vol.30 , pp. 3309-3318
    • Nakajima, H.1
  • 59
    • 0034618065 scopus 로고    scopus 로고
    • X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    • Parolini, S. et al. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J. Exp. Med. 192, 337-346 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 337-346
    • Parolini, S.1
  • 60
    • 22344436371 scopus 로고    scopus 로고
    • Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
    • Bloch-Queyrat, C. et al. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J. Exp. Med. 202 181-192 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 181-192
    • Bloch-Queyrat, C.1
  • 61
    • 2442428477 scopus 로고    scopus 로고
    • 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells
    • Lee, K.M. et al. 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J. Exp. Med. 199. 1245-1254 (2004).
    • (2004) J. Exp. Med , vol.199 , pp. 1245-1254
    • Lee, K.M.1
  • 62
    • 11844292050 scopus 로고    scopus 로고
    • Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells
    • Vaidya, S.V. et al. Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J. Immunol. 174, 800-807 (2005).
    • (2005) J. Immunol , vol.174 , pp. 800-807
    • Vaidya, S.V.1
  • 63
    • 34548821222 scopus 로고    scopus 로고
    • 2B4 inhibits NK cell fratricide
    • Taniguchi, R.T., Guzior, D. & Kumar, V. 2B4 inhibits NK cell fratricide. Blood 110, 2020-2023 (2007).
    • (2007) Blood , vol.110 , pp. 2020-2023
    • Taniguchi, R.T.1    Guzior, D.2    Kumar, V.3
  • 64
    • 33645748974 scopus 로고    scopus 로고
    • Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions
    • Lee, K.M. et al. Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood 107, 3181-3188 (2006).
    • (2006) Blood , vol.107 , pp. 3181-3188
    • Lee, K.M.1
  • 66
    • 20444389785 scopus 로고    scopus 로고
    • Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)
    • Eissmann, P. et al. Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood 105, 4722-4729 (2005).
    • (2005) Blood , vol.105 , pp. 4722-4729
    • Eissmann, P.1
  • 67
    • 2442445760 scopus 로고    scopus 로고
    • Molecular dissection of 2B4 signaling: Implications for signal transduction by SLAM-related receptors
    • Chen, R. et al. Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. Mol. Cell. Biol. 24, 5144-5156 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 5144-5156
    • Chen, R.1
  • 68
    • 0034292341 scopus 로고    scopus 로고
    • NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)
    • Watzl, C., Stebbins, C.C. & Long, E.O. NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244). J. Immunol. 165, 3545-3548 (2000).
    • (2000) J. Immunol , vol.165 , pp. 3545-3548
    • Watzl, C.1    Stebbins, C.C.2    Long, E.O.3
  • 69
    • 25444439255 scopus 로고    scopus 로고
    • The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing
    • Saborit-Villarroya, I. et al. The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing. J. Immunol. 175, 4226-4235 (2005).
    • (2005) J. Immunol , vol.175 , pp. 4226-4235
    • Saborit-Villarroya, I.1
  • 70
    • 17044373652 scopus 로고    scopus 로고
    • Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease
    • Aoukaty, A. & Tan, R. Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease. J. Immunol. 174, 4551-4558 (2005).
    • (2005) J. Immunol , vol.174 , pp. 4551-4558
    • Aoukaty, A.1    Tan, R.2
  • 71
    • 0035575998 scopus 로고    scopus 로고
    • 2B4 (CD244)-mediated activation of cytotoxicity and IFN-γ release in human NK cells involves distinct pathways
    • Chuang, S.S., Kumaresan, P.R. & Mathew, P.A. 2B4 (CD244)-mediated activation of cytotoxicity and IFN-γ release in human NK cells involves distinct pathways. J. Immunol. 167, 6210-6216 (2001).
    • (2001) J. Immunol , vol.167 , pp. 6210-6216
    • Chuang, S.S.1    Kumaresan, P.R.2    Mathew, P.A.3
  • 72
    • 0037066785 scopus 로고    scopus 로고
    • Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase
    • Aoukaty, A. & Tan, R. Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase. J. Biol. Chem. 277, 13331-13337 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 13331-13337
    • Aoukaty, A.1    Tan, R.2
  • 73
    • 0036644060 scopus 로고    scopus 로고
    • 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-emriched microdomains: Properties required for 2B4 lytic function
    • Klem, J., Verrett, P.C., Kumar, V. & Schatzle, J.D. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-emriched microdomains: Properties required for 2B4 lytic function. J. Immunol. 169, 55-62 (2002).
    • (2002) J. Immunol , vol.169 , pp. 55-62
    • Klem, J.1    Verrett, P.C.2    Kumar, V.3    Schatzle, J.D.4
  • 74
    • 0034528476 scopus 로고    scopus 로고
    • Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: Evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells
    • Bottino, C. et al. Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: Evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells. Eur. J. Immunol. 30, 3718-3722 (2000).
    • (2000) Eur. J. Immunol , vol.30 , pp. 3718-3722
    • Bottino, C.1
  • 75
    • 0037244127 scopus 로고    scopus 로고
    • Natural killer cell inhibitory receptors block actin cytoskeletal-dependent recruitment of 2B4 (CD244) to lipid rafts
    • Watzl, C. & Long, E.O. Natural killer cell inhibitory receptors block actin cytoskeletal-dependent recruitment of 2B4 (CD244) to lipid rafts. J. Exp. Med. 197, 77-85 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 77-85
    • Watzl, C.1    Long, E.O.2
  • 76
    • 33744911367 scopus 로고    scopus 로고
    • Cutting edge: Dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets
    • Wahle, J.A. et al. Cutting edge: Dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets. J. Immunol. 176, 7165-7169 (2006).
    • (2006) J. Immunol , vol.176 , pp. 7165-7169
    • Wahle, J.A.1
  • 77
    • 40049084080 scopus 로고    scopus 로고
    • Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell
    • Wahle, J.A. et al. Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell. J. Immunol. 179, 8009-8015 (2007).
    • (2007) J. Immunol , vol.179 , pp. 8009-8015
    • Wahle, J.A.1
  • 78
    • 48549099675 scopus 로고    scopus 로고
    • Serial killing of tumor cells by human natural killer cells enhancement by therapeutic antibodies
    • Bhat, R. & Watzl, C. Serial killing of tumor cells by human natural killer cells enhancement by therapeutic antibodies. PLoS ONE 2 e326 (2007).
    • (2007) PLoS ONE , vol.2
    • Bhat, R.1    Watzl, C.2


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