Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression

Journal of Virology

Volumn 81, Issue 6, 2007, Pages 2545-2553

  Radziewicz, Henry ^a   Ibegbu, Chris C ^a   Fernandez, Marina L ^a   Workowski, Kimberly A ^a   Obideen, Kamil ^a   Wehbi, Mohammad ^a   Hanson, Holly L ^a   Steinberg, James P ^a   Masopust, David ^a   Wherry, E John ^b   Altman, John D ^a   Rouse, Barry T ^c   Freeman, Gordon J ^d   Ahmed, Rafi ^a   Grakoui, Arash ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WISTAR INSTITUTE   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 7 RECEPTOR; PROTEIN PD 1; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; VIRUS REPLICATION;

ADULT; AGED; ANTIGENS, CD; APOPTOSIS REGULATORY PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LIVER; MALE; MIDDLE AGED; VIRAL LOAD;

HEPATITIS C VIRUS; MURINAE;

EID: 33947407689     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02021-06     Document Type: Article

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