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Volumn 1832, Issue 7, 2013, Pages 1061-1069

Natural killer and natural killer T cells in liver fibrosis

Author keywords

Alcoholic liver disease; IFN gamma; NAFLD; NKG2D; Viral hepatitis

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; OSTEOPONTIN; SONIC HEDGEHOG PROTEIN;

EID: 84877076614     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.09.008     Document Type: Review
Times cited : (121)

References (93)
  • 1
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134:1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 3
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    • Friedman S.L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 2008, 88:125-172.
    • (2008) Physiol. Rev. , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 9
    • 70149090633 scopus 로고    scopus 로고
    • Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
    • Gao B., Radaeva S., Park O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J. Leukoc. Biol. 2009, 86:513-528.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 513-528
    • Gao, B.1    Radaeva, S.2    Park, O.3
  • 10
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier L.L. NK cell recognition. Annu. Rev. Immunol. 2005, 23:225-274.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 11
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • Raulet D.H. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 2003, 3:781-790.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 12
    • 10644244482 scopus 로고    scopus 로고
    • Mouse Ly49 NK receptors: balancing activation and inhibition
    • Ortaldo J.R., Young H.A. Mouse Ly49 NK receptors: balancing activation and inhibition. Mol. Immunol. 2005, 42:445-450.
    • (2005) Mol. Immunol. , vol.42 , pp. 445-450
    • Ortaldo, J.R.1    Young, H.A.2
  • 14
    • 0036486763 scopus 로고    scopus 로고
    • Role of chemokines in the biology of natural killer cells
    • Robertson M.J. Role of chemokines in the biology of natural killer cells. J. Leukoc. Biol. 2002, 71:173-183.
    • (2002) J. Leukoc. Biol. , vol.71 , pp. 173-183
    • Robertson, M.J.1
  • 15
    • 17144374753 scopus 로고    scopus 로고
    • Toward an understanding of NKT cell biology: progress and paradoxes
    • Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol. 2005, 23:877-900.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 877-900
    • Kronenberg, M.1
  • 17
    • 0029860153 scopus 로고    scopus 로고
    • The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver
    • Luo D., Vanderkerken K., Bouwens L., Kuppen P.J., Baekeland M., Seynaeve C., Wisse E. The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver. Hepatology 1996, 24:1475-1480.
    • (1996) Hepatology , vol.24 , pp. 1475-1480
    • Luo, D.1    Vanderkerken, K.2    Bouwens, L.3    Kuppen, P.J.4    Baekeland, M.5    Seynaeve, C.6    Wisse, E.7
  • 18
    • 0027504912 scopus 로고
    • Definition and functions of natural killer cells
    • Lotzova E. Definition and functions of natural killer cells. Nat. Immun. 1993, 12:169-176.
    • (1993) Nat. Immun. , vol.12 , pp. 169-176
    • Lotzova, E.1
  • 19
    • 33644517272 scopus 로고    scopus 로고
    • Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans
    • Ishiyama K., Ohdan H., Ohira M., Mitsuta H., Arihiro K., Asahara T. Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans. Hepatology 2006, 43:362-372.
    • (2006) Hepatology , vol.43 , pp. 362-372
    • Ishiyama, K.1    Ohdan, H.2    Ohira, M.3    Mitsuta, H.4    Arihiro, K.5    Asahara, T.6
  • 20
    • 0036826745 scopus 로고    scopus 로고
    • Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway
    • Vermijlen D., Luo D., Froelich C.J., Medema J.P., Kummer J.A., Willems E., Braet F., Wisse E. Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J. Leukoc. Biol. 2002, 72:668-676.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 668-676
    • Vermijlen, D.1    Luo, D.2    Froelich, C.J.3    Medema, J.P.4    Kummer, J.A.5    Willems, E.6    Braet, F.7    Wisse, E.8
  • 21
    • 32044443617 scopus 로고    scopus 로고
    • Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
    • Radaeva S., Sun R., Jaruga B., Nguyen V.T., Tian Z., Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 2006, 130:435-452.
    • (2006) Gastroenterology , vol.130 , pp. 435-452
    • Radaeva, S.1    Sun, R.2    Jaruga, B.3    Nguyen, V.T.4    Tian, Z.5    Gao, B.6
  • 23
    • 33845644601 scopus 로고    scopus 로고
    • STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity
    • Jeong W.I., Park O., Radaeva S., Gao B. STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology 2006, 44:1441-1451.
    • (2006) Hepatology , vol.44 , pp. 1441-1451
    • Jeong, W.I.1    Park, O.2    Radaeva, S.3    Gao, B.4
  • 24
    • 35349017872 scopus 로고    scopus 로고
    • Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1
    • Radaeva S., Wang L., Radaev S., Jeong W.I., Park O., Gao B. Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293:G809-G816.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.293
    • Radaeva, S.1    Wang, L.2    Radaev, S.3    Jeong, W.I.4    Park, O.5    Gao, B.6
  • 26
    • 37349108815 scopus 로고    scopus 로고
    • Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
    • Jeong W.I., Park O., Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 2008, 134:248-258.
    • (2008) Gastroenterology , vol.134 , pp. 248-258
    • Jeong, W.I.1    Park, O.2    Gao, B.3
  • 27
    • 77958154113 scopus 로고    scopus 로고
    • CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation
    • Hintermann E., Bayer M., Pfeilschifter J.M., Luster A.D., Christen U. CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J. Autoimmun. 2010, 35:424-435.
    • (2010) J. Autoimmun. , vol.35 , pp. 424-435
    • Hintermann, E.1    Bayer, M.2    Pfeilschifter, J.M.3    Luster, A.D.4    Christen, U.5
  • 29
  • 30
    • 84856573261 scopus 로고    scopus 로고
    • Negative regulation of Schistosoma japonicum egg-induced liver fibrosis by natural killer cells
    • Hou X., Yu F., Man S., Huang D., Zhang Y., Liu M., Ren C., Shen J. Negative regulation of Schistosoma japonicum egg-induced liver fibrosis by natural killer cells. PLoS Negl. Trop. Dis. 2012, 6:e1456.
    • (2012) PLoS Negl. Trop. Dis. , vol.6
    • Hou, X.1    Yu, F.2    Man, S.3    Huang, D.4    Zhang, Y.5    Liu, M.6    Ren, C.7    Shen, J.8
  • 31
    • 84860596931 scopus 로고    scopus 로고
    • NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
    • Gur C., Doron S., Kfir-Erenfeld S., Horwitz E., Abu-Tair L., Safadi R., Mandelboim O. NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut 2012, 61:885-893.
    • (2012) Gut , vol.61 , pp. 885-893
    • Gur, C.1    Doron, S.2    Kfir-Erenfeld, S.3    Horwitz, E.4    Abu-Tair, L.5    Safadi, R.6    Mandelboim, O.7
  • 32
    • 84876134219 scopus 로고    scopus 로고
    • Granule exocytosis mediates immune surveillance of senescent cells, Oncogene (in press)
    • A. Sagiv, M. Yon, J. Simon, S.W. Lowe, V. Krizhanovsky, Granule exocytosis mediates immune surveillance of senescent cells, Oncogene (in press), http://dx.doi.org/10.1038/onc.2012.206.
    • Sagiv, A.1    Yon, M.2    Simon, J.3    Lowe, S.W.4    Krizhanovsky, V.5
  • 34
    • 84862993192 scopus 로고    scopus 로고
    • NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner
    • Glassner A., Eisenhardt M., Kramer B., Korner C., Coenen M., Sauerbruch T., Spengler U., Nattermann J. NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. Lab. Invest. 2012, 92:967-977.
    • (2012) Lab. Invest. , vol.92 , pp. 967-977
    • Glassner, A.1    Eisenhardt, M.2    Kramer, B.3    Korner, C.4    Coenen, M.5    Sauerbruch, T.6    Spengler, U.7    Nattermann, J.8
  • 35
    • 84867218760 scopus 로고    scopus 로고
    • NKp46(High) expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis, Hepatology (in press)
    • K.C. Krämer, B. Kebschull, M. Glässner, A. Eisenhardt, M. Nischalke, H.D. Alexander, M. Sauerbruch, T. Spengler, U. Nattermann J., NKp46(High) expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis, Hepatology (in press), http://dx.doi.org/10.1002/hep.25804.
    • Krämer, K.C.1    Kebschull, B.2    Glässner, M.3    Eisenhardt, A.4    Nischalke, M.5    Alexander, H.D.6    Sauerbruch M.Spengler, T.7    Nattermann, U.J.8
  • 37
    • 0037219276 scopus 로고    scopus 로고
    • Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
    • Taimr P., Higuchi H., Kocova E., Rippe R.A., Friedman S., Gores G.J. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 2003, 37:87-95.
    • (2003) Hepatology , vol.37 , pp. 87-95
    • Taimr, P.1    Higuchi, H.2    Kocova, E.3    Rippe, R.A.4    Friedman, S.5    Gores, G.J.6
  • 39
    • 0037370003 scopus 로고    scopus 로고
    • Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype
    • Schnabl B., Purbeck C.A., Choi Y.H., Hagedorn C.H., Brenner D. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology 2003, 37:653-664.
    • (2003) Hepatology , vol.37 , pp. 653-664
    • Schnabl, B.1    Purbeck, C.A.2    Choi, Y.H.3    Hagedorn, C.H.4    Brenner, D.5
  • 40
    • 0026782189 scopus 로고
    • Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma
    • Rockey D.C., Maher J.J., Jarnagin W.R., Gabbiani G., Friedman S.L. Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma. Hepatology 1992, 16:776-784.
    • (1992) Hepatology , vol.16 , pp. 776-784
    • Rockey, D.C.1    Maher, J.J.2    Jarnagin, W.R.3    Gabbiani, G.4    Friedman, S.L.5
  • 41
    • 33749983749 scopus 로고    scopus 로고
    • Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
    • Wolk K., Sabat R. Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev. 2006, 17:367-380.
    • (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 367-380
    • Wolk, K.1    Sabat, R.2
  • 42
    • 84865564349 scopus 로고    scopus 로고
    • Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis, Hepatology
    • F.D. Kong X, Wang H, Hong F, Bertola A, Wang FS, Gao B., Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis, Hepatology 56 (2012) 1150-1159.
    • (2012) , vol.56 , pp. 1150-1159
    • Kong, X.1    Wang, H.2    Hong, F.3    Bertola, A.4    Wang, F.S.5    Gao, B.6
  • 44
    • 80053281871 scopus 로고    scopus 로고
    • Role of NKT cells in autoimmune liver disease
    • Santodomingo-Garzon T., Swain M.G. Role of NKT cells in autoimmune liver disease. Autoimmun. Rev. 2011, 10:793-800.
    • (2011) Autoimmun. Rev. , vol.10 , pp. 793-800
    • Santodomingo-Garzon, T.1    Swain, M.G.2
  • 45
    • 57149093788 scopus 로고    scopus 로고
    • NK and NKT cells in liver injury and fibrosis
    • Notas G., Kisseleva T., Brenner D. NK and NKT cells in liver injury and fibrosis. Clin. Immunol. 2009, 130:16-26.
    • (2009) Clin. Immunol. , vol.130 , pp. 16-26
    • Notas, G.1    Kisseleva, T.2    Brenner, D.3
  • 47
    • 0032169234 scopus 로고    scopus 로고
    • Rapid death and regeneration of NKT cells in anti-CD3epsilon- or IL-12-treated mice: a major role for bone marrow in NKT cell homeostasis
    • Eberl G., MacDonald H.R. Rapid death and regeneration of NKT cells in anti-CD3epsilon- or IL-12-treated mice: a major role for bone marrow in NKT cell homeostasis. Immunity 1998, 9:345-353.
    • (1998) Immunity , vol.9 , pp. 345-353
    • Eberl, G.1    MacDonald, H.R.2
  • 48
    • 77649231838 scopus 로고    scopus 로고
    • Lipid and glycolipid antigens of CD1d-restricted natural killer T cells
    • Venkataswamy M.M., Porcelli S.A. Lipid and glycolipid antigens of CD1d-restricted natural killer T cells. Semin. Immunol. 2010, 22:68-78.
    • (2010) Semin. Immunol. , vol.22 , pp. 68-78
    • Venkataswamy, M.M.1    Porcelli, S.A.2
  • 49
    • 84868220062 scopus 로고    scopus 로고
    • The protective role of VSIG4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and NKT-cells
    • Jung K., Park C., Choi Y.H., Jeon Y., Park S.H., Seo S.K., Jin D., Choi I. The protective role of VSIG4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and NKT-cells. Hepatology 2012, 10.1002/hep.25906.
    • (2012) Hepatology
    • Jung, K.1    Park, C.2    Choi, Y.H.3    Jeon, Y.4    Park, S.H.5    Seo, S.K.6    Jin, D.7    Choi, I.8
  • 50
    • 22544445833 scopus 로고    scopus 로고
    • Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells
    • Biburger M., Tiegs G. Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells. J. Immunol. 2005, 175:1540-1550.
    • (2005) J. Immunol. , vol.175 , pp. 1540-1550
    • Biburger, M.1    Tiegs, G.2
  • 53
    • 66149098871 scopus 로고    scopus 로고
    • Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
    • Park O., Jeong W.I., Wang L., Wang H., Lian Z.X., Gershwin M.E., Gao B. Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 2009, 49:1683-1694.
    • (2009) Hepatology , vol.49 , pp. 1683-1694
    • Park, O.1    Jeong, W.I.2    Wang, L.3    Wang, H.4    Lian, Z.X.5    Gershwin, M.E.6    Gao, B.7
  • 54
    • 79956079647 scopus 로고    scopus 로고
    • CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice
    • Ishikawa S., Ikejima K., Yamagata H., Aoyama T., Kon K., Arai K., Takeda K., Watanabe S. CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice. J. Hepatol. 2011, 54:1195-1204.
    • (2011) J. Hepatol. , vol.54 , pp. 1195-1204
    • Ishikawa, S.1    Ikejima, K.2    Yamagata, H.3    Aoyama, T.4    Kon, K.5    Arai, K.6    Takeda, K.7    Watanabe, S.8
  • 55
    • 84859997837 scopus 로고    scopus 로고
    • Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity
    • Ji Y., Sun S., Xu A., Bhargava P., Yang L., Lam K.S., Gao B., Lee C.H., Kersten S., Qi L. Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J. Biol. Chem. 2012, 287:13561-13571.
    • (2012) J. Biol. Chem. , vol.287 , pp. 13561-13571
    • Ji, Y.1    Sun, S.2    Xu, A.3    Bhargava, P.4    Yang, L.5    Lam, K.S.6    Gao, B.7    Lee, C.H.8    Kersten, S.9    Qi, L.10
  • 56
    • 79958022995 scopus 로고    scopus 로고
    • Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity
    • Mantell B.S., Stefanovic-Racic M., Yang X., Dedousis N., Sipula I.J., O'Doherty R.M. Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity. PLoS One 2011, 6:e19831.
    • (2011) PLoS One , vol.6
    • Mantell, B.S.1    Stefanovic-Racic, M.2    Yang, X.3    Dedousis, N.4    Sipula, I.J.5    O'Doherty, R.M.6
  • 58
    • 84873181067 scopus 로고    scopus 로고
    • Role of NKT cells in the pathogenesis of NAFLD
    • Tajiri K., Shimizu Y. Role of NKT cells in the pathogenesis of NAFLD. Int. J. Hepatol. 2012, 2012:850836.
    • (2012) Int. J. Hepatol. , vol.2012 , pp. 850836
    • Tajiri, K.1    Shimizu, Y.2
  • 60
    • 25844437136 scopus 로고    scopus 로고
    • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    • Li Z., Soloski M.J., Diehl A.M. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 2005, 42:880-885.
    • (2005) Hepatology , vol.42 , pp. 880-885
    • Li, Z.1    Soloski, M.J.2    Diehl, A.M.3
  • 61
    • 4043140819 scopus 로고    scopus 로고
    • Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis
    • Li Z., Oben J.A., Yang S., Lin H., Stafford E.A., Soloski M.J., Thomas S.A., Diehl A.M. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology 2004, 40:434-441.
    • (2004) Hepatology , vol.40 , pp. 434-441
    • Li, Z.1    Oben, J.A.2    Yang, S.3    Lin, H.4    Stafford, E.A.5    Soloski, M.J.6    Thomas, S.A.7    Diehl, A.M.8
  • 64
    • 67649669912 scopus 로고    scopus 로고
    • Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease
    • Tajiri K., Shimizu Y., Tsuneyama K., Sugiyama T. Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease. Eur. J. Gastroenterol. Hepatol. 2009, 21:673-680.
    • (2009) Eur. J. Gastroenterol. Hepatol. , vol.21 , pp. 673-680
    • Tajiri, K.1    Shimizu, Y.2    Tsuneyama, K.3    Sugiyama, T.4
  • 68
    • 78751537869 scopus 로고    scopus 로고
    • Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells
    • Jin Z., Sun R., Wei H., Gao X., Chen Y., Tian Z. Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. Hepatology 2011, 53:219-229.
    • (2011) Hepatology , vol.53 , pp. 219-229
    • Jin, Z.1    Sun, R.2    Wei, H.3    Gao, X.4    Chen, Y.5    Tian, Z.6
  • 72
    • 84867183026 scopus 로고    scopus 로고
    • Race- and gender-related variation in NKp46 expression associated with differential anti-HCV immunity
    • Golden-Mason L., Bambha K.M., Cheng L., Rosen H.R. Race- and gender-related variation in NKp46 expression associated with differential anti-HCV immunity. Hepatology 2012, 10.1002/hep.25771.
    • (2012) Hepatology
    • Golden-Mason, L.1    Bambha, K.M.2    Cheng, L.3    Rosen, H.R.4
  • 73
    • 78049514314 scopus 로고    scopus 로고
    • Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro
    • Golden-Mason L., Cox A.L., Randall J.A., Cheng L., Rosen H.R. Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology 2010, 52:1581-1589.
    • (2010) Hepatology , vol.52 , pp. 1581-1589
    • Golden-Mason, L.1    Cox, A.L.2    Randall, J.A.3    Cheng, L.4    Rosen, H.R.5
  • 79
    • 77957336301 scopus 로고    scopus 로고
    • Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses
    • Pelletier S., Drouin C., Bedard N., Khakoo S.I., Bruneau J., Shoukry N.H. Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses. J. Hepatol. 2010, 53:805-816.
    • (2010) J. Hepatol. , vol.53 , pp. 805-816
    • Pelletier, S.1    Drouin, C.2    Bedard, N.3    Khakoo, S.I.4    Bruneau, J.5    Shoukry, N.H.6
  • 81
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: pathogenesis and new therapeutic targets
    • Gao B., Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011, 141:1572-1585.
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 82
    • 32044458248 scopus 로고    scopus 로고
    • Alcohol and hepatitis virus interactions in liver pathology
    • Gao B. Alcohol and hepatitis virus interactions in liver pathology. Comprehensive Handbook of Alcohol related Pathology 2005, 2:819-832.
    • (2005) Comprehensive Handbook of Alcohol related Pathology , vol.2 , pp. 819-832
    • Gao, B.1
  • 84
    • 0042123683 scopus 로고    scopus 로고
    • NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells
    • Kenna T., Mason L.G., Porcelli S.A., Koezuka Y., Hegarty J.E., O'Farrelly C., Doherty D.G. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J. Immunol. 2003, 171:1775-1779.
    • (2003) J. Immunol. , vol.171 , pp. 1775-1779
    • Kenna, T.1    Mason, L.G.2    Porcelli, S.A.3    Koezuka, Y.4    Hegarty, J.E.5    O'Farrelly, C.6    Doherty, D.G.7
  • 88
    • 40749156951 scopus 로고    scopus 로고
    • Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis
    • Gao B., Radaeva S., Jeong W.I. Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis. Expert Rev. Gastroenterol. Hepatol. 2007, 1:173-180.
    • (2007) Expert Rev. Gastroenterol. Hepatol. , vol.1 , pp. 173-180
    • Gao, B.1    Radaeva, S.2    Jeong, W.I.3
  • 90
    • 0033050596 scopus 로고    scopus 로고
    • Long-term administration of interferon-alpha in non-responder patients with chronic hepatitis C: follow-up of liver fibrosis over 5 years
    • Guerret S., Desmouliere A., Chossegros P., Costa A.M., Badid C., Trepo C., Grimaud J.A., Chevallier M. Long-term administration of interferon-alpha in non-responder patients with chronic hepatitis C: follow-up of liver fibrosis over 5 years. J. Viral Hepat. 1999, 6:125-133.
    • (1999) J. Viral Hepat. , vol.6 , pp. 125-133
    • Guerret, S.1    Desmouliere, A.2    Chossegros, P.3    Costa, A.M.4    Badid, C.5    Trepo, C.6    Grimaud, J.A.7    Chevallier, M.8
  • 92
    • 80054758173 scopus 로고    scopus 로고
    • Current status of novel antifibrotic therapies in patients with chronic liver disease
    • Cohen-Naftaly M., Friedman S.L. Current status of novel antifibrotic therapies in patients with chronic liver disease. Therap. Adv. Gastroenterol. 2011, 4:391-417.
    • (2011) Therap. Adv. Gastroenterol. , vol.4 , pp. 391-417
    • Cohen-Naftaly, M.1    Friedman, S.L.2
  • 93
    • 0041313958 scopus 로고    scopus 로고
    • Interleukin-12 and -18 induce severe liver injury in mice recovered from peritonitis after sublethal endotoxin challenge
    • Ono S., Ueno C., Seki S., Matsumoto A., Mochizuki H. Interleukin-12 and -18 induce severe liver injury in mice recovered from peritonitis after sublethal endotoxin challenge. Surgery 2003, 134:92-100.
    • (2003) Surgery , vol.134 , pp. 92-100
    • Ono, S.1    Ueno, C.2    Seki, S.3    Matsumoto, A.4    Mochizuki, H.5


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