NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL-and NKG2D-dependent manner

Laboratory Investigation

Volumn 92, Issue 7, 2012, Pages 967-977

  Glässner, Andreas ^a   Eisenhardt, Marianne ^a   Krämer, Benjamin ^a   Körner, Christian ^a   Coenen, Martin ^a   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a   Nattermann, Jacob ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

apoptosis; hepatic stellate cells; hepatitis C virus; natural killer cell; NKG2D; TRAIL

Indexed keywords

ANTIBODY; CASPASE 3; FAS LIGAND; GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NATURAL KILLER CELL RECEPTOR NKG2D; PEGINTERFERON ALPHA; RECOMBINANT ALPHA INTERFERON; RIBAVIRIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADULT; AGED; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; ENZYME ACTIVITY; FEMALE; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; STELLATE CELL; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; APOPTOSIS; CASE-CONTROL STUDIES; FAS LIGAND PROTEIN; FEMALE; HEPATIC STELLATE CELLS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862993192     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.54     Document Type: Article

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