Target Family-Directed Masterkeys in Chemogenomics

Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective

Volumn , Issue , 2005, Pages 5-41

  Müller, Gerhard ^a  

^a Axxima Pharmaceuticals AG   (Germany)

Author keywords

Chemogenomics; Medicinal chemistry; Privileged structures; Target families

Indexed keywords

CHEMOGENOMICS; MEDICINAL CHEMISTRY; PRIVILEGED STRUCTURES;

EID: 84954212772     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/3527603948.ch1     Document Type: Chapter

References (101)

1. B.R. Stockwell, Nat. Rev. Genet. 2000, 1, 116-125.
2. G. McBeath, Genome Biol. 2001, 2, 1-6.
3. G. Müller, Drug Discov. Today 2003, 8, 681-691.
4. S. Class, Chem. Eng. News 2002, 80, 39-49.
5. G.M. Mine, Annu. Rep. Med. Chem. 2003, 38, 383-396.
6. J.A. DiMasi, R.W. Hansen, H.G. Grabowski, J. Health Econ. 2003, 22, 151-185.
7. Pharmaceutical Research and Manufacturers of America (PhRMA), Pharmaceutical Industry Profile 2002 (Washington, DC, PhRMA 2002).
8. F.S. Smith, Nat. Rev. Drug Disc. 2003, 2, 95-96.
9. Pharmaceutical Research and Manufacturers of America (PhRMA), Pharmaceutical Industry Profile 2002 (Washington, DC, PhRMA 2003), see also: http://www.phrma.org/publications/publications/profile02/index.cfm.
10. J. Drews, Science 2000, 287, 1960-1963.
11. J. Drews, Drug Discov. Today 2000, 5, 2-4.
12. J. Drews, Drug Discov. Today 2003, 8, 411-420.
13. D. Hunter, J. Cell. Biochem. 2001, Suppl. 37, 22-27.
14. E.J. Martin, J.M. Blaney, M.A. Sinai, D.C. Spellmeyer, A.K. Wong, W.H. Moss, J. Med. Chem. 1995, 38, 1431-1436.
15. W.P. Walters, Drug Discov. Today 1998, 3, 160-178.
16. C.A. Lipinski, J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
17. R.A. Goodnow, J. Cell. Biochem. 2001, Suppl. 37, 13-21.
18. A.L. Hopkins, C.R. Groom, Nat. Rev. Drug Discov. 2002, 1, 727-730.
19. S. Fox, H. Wang, L. Sopchak, S. Farr-Jones, J. Biomol. Screening 2002, 7, 313-316.
20. L. Weber, Curr. Opin. Chem. Biol. 2000, 4, 295-302.
21. D.F. Veber, F.H. Drake, M. Gowen, Curr. Opin. Chem. Biol. 1997, 1, 151-156.
22. G. Dorman, P. Krajcs, F. Darvas, Curr. Drug Disc. 2001, 21-24.
23. M. Namchuk, Targets 2002, 1, 125-129.
24. E. Martin, A. Wong, J. Chem. Inf. Comput. Sci. 2000, 40, 215-220.
25. R.E. Dolle, J. Comb. Chem. 2003, 5, 693-753.
26. C.K. Atterwill, M.G. Wing, Altern. Lab. Anim. 2000, 28, 857-867.
27. H. van de Waterbeemd, E. Gifford, Nat. Rev. Drug Discov. 2003, 2, 192-204.
28. P.W. Erhardt, Pure Appl. Chem. 2002, 74, 703-785.
29. K.H. Bleicher, H.-J. Böhm, K. Müller, A.I. Alanine, Nat. Rev. Drug Discov. 2003, 2, 369-378.
30. J. Drews, Nature Biotech. 1996, 14, 1516-1518.
31. J. Drews, S. Ryser, Drug Inf. J. 1996, 30, 97-108.
32. P. Tollman, P. Guy, J. Altshuler, A. Flanagan, M. Steiner, Boston Consulting Group Report: A Revolution in R&D. http://www.bcg.com/publications/files/eng_genomicsgenetics_rep_11_01.pdf, 2001.
33. M. Mort, Modern Drug Discov. 2000, 3, 28-29.
34. Lehman Brothers and McKinsey & Co: The Fruits of Genomics (Lehman Brothers, New York, Jan. 2001).
35. D.E. Szymkowski, Drug Discov. Today 2001, 6, 398-399.
36. Intelligent Drug Design, Nature 1996, 384, Suppl. to Issue No. 6604, 5.
37. S.P. Davies, H. Reddy, M. Caivano, P. Cohen, Biochem. J. 2000, 351, 95-105.
38. J. Bain, H. McLauchlan, M. Elliott, P. Cohen, Biochem. J. 2003, 371, 199-204.
39. M. Vieth, R.E. Higgs, D.H. Robertson, M. Shapiro, E.A. Gragg, H. Hemmerle, Biochim. Biophys. Acta 2004, 1697, 243-257.
40. C.A. Lipinski, F. Lombardo, B.W. Dolminy, P.J. Feeney, Adv. Drug Deliv. Rev. 1997, 23, 3-26.
41. B.E. Evans, K.E. Rittle, M.G. Bock, R.M. DiPardo, R.M. Freidinger, W.L. Whitter, G.F. Lundell, D.F. Veber, P.S. Anderson, R.S.L. Chang, V.J. Lotti, D.J. Cerino, T.B. Chen, P.J. Kling, K.A. Kunkel, J.P. Springer, J. Hirshfield, J. Med. Chem. 1988, 31, 2235-2246.
42. A.A. Patchett, R.P. Nargund, Annu. Rep. Med. Chem. 2000, 35, 289-298.
43. R.S. Chang, V.J. Lotti, T.B. Chen, M.E. Keegan, Neurosci. Lett. 1986, 72, 211-214.
44. D. Roemer, H.H. Buscher, R.C. Hill, R. Maurer, T.J. Petcher, H. Zeugner, W. Benson, E. Finner, W. Milkowski, P.W. Thies, Nature 1982, 298, 759-760.
45. I.C. Choong, J.A. Ellman, Annu. Rep. Med. Chem. 1996, 31, 309-318.
46. O. Roche, P. Schneider, J. Zuegge, W. Guba, M. Kansy, A. Alanine, K. Bleicher, F. Danel, E.M. Gutknecht, M. Rogers-Evans, W. Neidhart, H. Stalder, M. Dillon, E. Sjogren, N. Fotouhi, P. Gillespie, R. Goodnow, W. Harris, P. Jones, M. Taniguchi, S. Tsujii, W. von Der Saal, G. Zimmermann, G. Schneider, J. Med. Chem. 2002, 45, 137-142.
47. S.L. McGovern, E. Caselli, N. Grigorieff, B.K. Shoichet, J. Med. Chem. 2002, 45, 1712-1722.
48. S.L. McGovern, B.K. Shoichet, J. Med. Chem. 2003, 46, 1478-1483.
49. J. Seidler, S.L. McGovern, T.M. Doman, B.K. Shoichet, J. Med. Chem. 2003, 46, 4477-4486.
50. S.L. McGovern, B.T. Hefland, B. Feng, B.K. Shoichet, J. Med. Chem. 2003, 46, 4265-4272.
51. A.J. Ryan, N.M. Gray, P.N. Lowe, C.-W. Chung, J. Med. Chem. 2003, 46, 3448-3451.
52. G.W. Bemis, M.A. Murcko, J. Med. Chem. 1996, 39, 2887-2893.
53. G.W. Bemis, M.A. Murcko, J. Med. Chem. 1999, 42, 5095-5099.
54. X.Q. Lewell, D.B. Judd, S.P. Watson, M.M. Hann, J. Chem. Inf. Comput. Sci. 1998, 38, 511-522.
55. X.Q. Lewell, A.C. Jones, C.L. Bruce, G. Harper, M.J. Jones, I.M. Mclay, J. Bradshaw, J. Med. Chem. 2003, 46, 3257-3274.
56. R.P. Sheridan, J. Chem. Inf. Comput. Sci. 2003, 43, 1037-1050.
57. P.J. Hajduk, M. Bures, J. Praestgaard, S.W. Fesik, J. Med. Chem. 2000, 43, 3443-3447.
58. J.A. Ellman, Acc. Chem. Res. 1996, 29, 132-143.
59. S.H. DeWitt, A.W. Czarnik, Acc. Chem. Res. 1996, 29, 114-122.
60. R.A. Wiley, D.H. Rich, Med. Res. Rev. 1993, 13, 327-384.
61. C.J. Burns, R.D. Groneberg, J.M. Salvino, G. McGeehan, S.M. Condon, R. Morris, M. Morrissette, R. Mathew, S. Darnbrough, K. Neuenschwander, A. Scotese, S.W. Djuric, J. Ullrich, R. Labaudiniere, Angew. Chem. Int. Ed. Engl. 1998, 37, 2848-2850.
62. R.D. Groneberg, C.J. Burns, M.M. Morrissette, J.W. Ullrich, R.L. Morris, S. Darnbrough, S.W. Djuric, S.M. Condon, G.M. McGeehan, R. Labaudiniere, K. Neuenschwander, A.C. Scotese, J.A. Kline, J. Med. Chem. 1999, 42, 541-544.
63. D. Hoyer, M.M.A. Awad, J.M. Salvino, P.R. Seoane, R.E. Dolle, W.T. Houck, D.G. Sawutz, Bioorg. Med. Chem. Lett. 1995, 5, 367-370.
64. Y. Abe, H. Kayakiri, S. Satoh, T. Inoue, Y. Sawada, K. Imai, N. Inamura, M. Asano, C. Hatori, A. Katayama, T. Oku, H. Tanaka, J. Med. Chem. 1998, 41, 564-578.
65. Y. Abe, H. Kayakiri, S. Satoh, T. Inoue, Y. Sawada, N. Inamura, M. Asano, I. Aramori, C. Hatori, H. Sawai, T. Oku, H. Tanaka, J. Med. Chem. 1998, 41, 4062-4079.
66. Y. Abe, H. Kayakiri, S. Satoh, T. Inoue, Y. Sawada, N. Inamura, M. Asano, C. Hatori, H. Sawai, T. Oku, H. Tanaka, J. Med. Chem. 1998, 41, 4053-4061.
67. J.I. Armstrong, A.R. Portley, Y.-T. Chang, D.M. Nierengarten, B.N. Cook, K.G. Bowman, A. Bishop, N.S. Gray, K.M. Shokat, P.G. Schultz, C.R. Bertozzi, Angew. Chem. Int. Ed. Engl. 2000, 39, 1303-1306.
68. D.E. Verdugo, M.T. Cancilla, X. Ge, N.S. Gray, Y.-T. Chang, P.G. Schultz, M. Negishi, J.A. Leary, C.R. Bertozzi, J. Med. Chem. 2001, 44, 2683-2686.
69. Y. Kakuta, L.G. Pedersen, C.W. Carter, M. Negishi, L.C. Pedersen, Nat. Struct. Biol. 1997, 4, 904-908.
70. Y. Kakuta, T. Sueyoshi, M. Negishi, L.C. Pedersen, J. Biol. Chem. 1999, 274, 10673-10676.
71. C.-H. Lin, G.-J. Shen, E. Garcia-Junceda, C.-H. Wong, J. Am. Chem. Soc. 1995, 117, 8031-8032.
72. Y.T. Chang, N.S. Gray, G.R. Rosania, D.P. Sutherlin, S. Kwon, T.C. Norman, R. Sorahia, M. Leost, L. Meijer, P.G. Schultz, Chem. Biol. 1999, 6, 361-375.
73. A.J. Souers, A.A. Virgilio, S.A. Rosenquist, W. Fenuik, J.A. Ellman, J. Am. Chem. Soc. 1999, 121, 1817-1825.
74. A.J. Souers, A.A. Virgilio, S.S. Schurer, J.A. Ellman, T.P. Kogan, H.E. West, W. Ankener, P. Vanderslice, Bioorg. Med. Chem. Lett. 1998, 8, 2297-2302.
75. M. Gurrath, G. Müller, H. Kessler, M. Aumailley, R. Timpl, Eur. J. Biochem. 1992, 210, 911-921.
76. S.P. Rohrer, E.T. Birzin, R.T. Mosley, S.C. Berk, S.M. Hutchins, D.M. Shen, Y. Xiong, E.C. Hayes, R.M. Parmar, F. Foor, S.W. Mitra, S.J. Degrado, M. Shu, J.M. Klopp, S.J. Cai, A. Blake, W.W.S. Chan, A. Pasternak, L. Yang, A.A. Patchett, R.G. Smith, K. Champman, J.M. Schaeffer, Science 1998, 282, 737-740.
77. G. Müller, Topics in Current Chemistry 2000, 211, 17-59.
78. D. Leung, G. Abbenante, D.P. Fairlie, J. Med. Chem. 2000, 43, 305-341.
79. C. Southan, Drug Discov. Today 2001, 6, 681-688.
80. M.P. Weir, S.S. Bethell, A. Cleasby, C.J. Campbell, R.J. Dennis, C.J. Dix, H. Finch, H. Jhoti, C.J. Mooney, S. Patel, C.M. Tang, M. Ward, A.J. Wonacott, C.W. Wharton, Biochem. 1998, 37, 6645-6657.
81. M.J. O'Neill, J.A. Lewis, H.M. Noble, S. Holland, C. Mansat, J.E. Farthing, G. Foster, D. Nobel, S.J. Lane, P.J. Sidebottom, S.M. Lynn, M.V. Hayes, C.J. Dix, J. Nat. Prod. 1998, 61, 1328-1331.
82. S.J.F. MacDonald, M.D. Dowle, L.A. Harrison, G.D. Clarke, G.G. Inglis, M.R. Johnson, P. Shah, R.A. Smith, A. Amour, G. Fleetwood, D.C. Humphreys, C.R. Molloy, M. Dixon, R.E. Godward, A.J. Wonacott, O.M. Singh, S.T. Hodgson, G.W. Hardy, J. Med. Chem. 2001, 45, 3878-3890.
83. S.J.F. MacDonald, M.D. Dowle, L.A. Harrison, P. Shah, M.R. Johnson, G.G. Inglis, G.D. Clarke, R.A. Smith, D. Humphreys, C.R. Molloy, A. Amour, M. Dixon, G. Murkitt, R.E. Godward, T. Padfield, T. Skarzynski, O.M. Singh, K.A. Kumar, G. Fleetwood, S.T. Hodgson, G.W. Hardy, H. Finch, Bioorg. Med. Chem. Lett. 2001, 11, 895-898.
84. A.D. Borthwick, S.J. Angier, A.J. Crame, A.M. Exall, T.M. Haley, G.J. Hart, A.M. Mason, A.M. Pennell, G.G. Weingarten, J. Med. Chem. 2000, 43, 4452-4464.
85. A.D. Borthwick, A.J. Crame, P.F. Ertl, A.M. Exall, T.M. Haley, G.J. Hart, A.M. Mason, A.M. Pennell, O.M. Singh, G.G. Weingarten, J.M. Woolven, J. Med. Chem. 2002, 45, 1-18.
86. D.M. Andrews, S.J. Carey, H. Chaignot, B.A. Coomber, N.M. Gray, S.L. Hind, P.S. Jones, G. Mills, J.E. Robinson, M.J. Slater, Organic Lett. 2002, 4, 4475-4478.
87. D.M. Andrews, H. Chaignot, B.A. Coomber, A.C. Good, S.L. Hind, M.R. Johnson, P.S. Jones, G. Mills J.E. Robinson, T. Skarzynski, M.J. Slater, D.O. Somers, Organic Lett. 2002, 4, 4479-4482.
88. D.F. Veber, S.K. Thompson, Curr. Opin. Drug Discov. Dev. 2000, 3, 362-369.
89. H.-H. Otto, T. Schirmeister, Chem. Rev. 1997, 97, 133-171.
90. I. Schechter, A. Berger, Biochem. Biophys. Res. Com. 1967, 27, 157-162.
91. A.M.M. Mjalli, K.T. Chapman, M. MacCoss, N.A. Thornberry, E.P. Peterson, Bioorg. Med. Chem.Lett. 1994, 4, 1965-1968.
92. D.S. Yamashita, W.W. Smith, B. Zhao, C.A. Janson, T.A. Tomaszek, M.J. Bossard, M.A. Levy, H.-J. Oh, T.J. Carr, S.K. Thompson, C.F. Ijames, S.A. Carr, M. McQueney, K.J.D. Alessio, B.Y. Amagadzie, C.R. Hanning, S. Abdel-Meguid, R.L. DesJarlais, J.G. Gleason, D.F. Veber, J. Am. Chem. Soc. 1997, 119, 11351-11352.
93. R.W. Marquis, D.S. Yamashita, Y. Ru, S.M. LoCastro, H.-J. Oh, K.F. Erhard, R.L. DesJarlais, M.S. Head, W.W. Smith, B. Zhao, C.A. Janson, S.S. Abdel-Meguid, T.A. Tomaszek, M.A. Levy, D.F. Veber, J. Med. Chem. 1998, 41, 3563-3567.
94. D.S. Yamashita, X. Dong, H.-J. Oh, C.S. Brook, T.A. Tomaszek, L. Szewczuk, D.G. Tew, D.F. Veber, J. Comb. Chem. 1999, 1, 207-215.
95. A. Lee, L. Huang, J.A. Ellman, J. Am. Chem. Soc. 1999, 121, 9907-9914.
96. P. Abato, J.L. Conroy, C.T. Seto, J. Med. Chem. 1999, 42, 4001-4009.
97. T.C. Sanders, C.T. Seto, J. Med. Chem. 1999, 42, 2969-2976.
98. J.L. Conroy, C.T. Seto, J. Org. Chem. 1998, 63, 2367-2370.
99. E. Vieira, A. Binggeli, V. Breu, D. Bur, W. Fischli, R. Güller, G. Hirth, H.P. Märki, M. Müller, C. Oefner, M. Scalone, H. Stadler, M. Wilhelm, W. Wostl, Bioorg. Med. Chem. Lett. 1999, 9, 1397-1402.
100. R. Güller, A. Binggeli, V. Breu, W. Fischli, G. Hirth, C. Jenny, M. Kansy, F. Montavon, M. Müller, C. Oefner,H. Stadler, E. Vieira, M. Wilhelm, W. Wostl, H.P. Märki, Bioorg. Med. Chem. Lett. 1999, 9, 1403-1408.
101. A. Schoop, C. Kallus, G. Müller, unpublished results.