The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 7, 2001, Pages 895-898

  Macdonald, Simon J F ^a   Dowle, Michael D ^a   Harrison, Lee A ^a   Shah, Pritom ^a   Johnson, Martin R ^a   Inglis, Graham G A ^a   Clarke, Geoffrey D E ^a   Smith, Robin A ^a   Humphreys, Davina ^a   Molloy, Christopher R ^a   Amour, Augustin ^a   Dixon, Mary ^a   Murkitt, Graham ^a   Godward, Rosalind E ^a   Padfield, Tony ^a   Skarzynski, Tadeusz ^a   Singh, Onkar M P ^a   Abhhilash Kumar, K ^a   Fleetwood, Gill ^a   Hodgson, Simon T ^a   Hardy, George W ^a   Finch, Harry ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GW 311616 A; LEUKOCYTE ELASTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HAMSTER; HUMAN; NONHUMAN; PHARMACODYNAMICS; RAT;

ADMINISTRATION, ORAL; ANIMALS; BACTERIA; BACTERIAL INFECTIONS; BIOLOGICAL AVAILABILITY; CRICETINAE; CRYSTALLIZATION; DOGS; DRUG STABILITY; LACTAMS; LEUKOCYTE ELASTASE; METABOLIC CLEARANCE RATE; PANCREATIC ELASTASE; PIPERIDINES; RATS; SERINE ENDOPEPTIDASES; SERPINS;

EID: 0035832099     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00078-6     Document Type: Article

References (13)

1. Orally active, intracellular inhibitors of Human Leukocyte Elastase (HLE)