Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The α-methyl-trans-lactam template

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4452-4464

  Borthwick, A D ^a   Angier, S J ^a   Crame, A J ^a   Exall, A M ^a   Haley, T M ^a   Hart, G J ^a   Mason, A M ^a   Pennell, A M K ^a   Weingarten, G G ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 2 OXOHEXAHYDROPYRROLO[3,2 B]PYRROLE 1,4 DICARBOXYLIC ACID 4 BENZYL ESTER 1 VINYL ESTER; 4 ACETOXYACETYL 6 METHYL 5 OXOHEXAHYDROPYRROLO[3,2 B]PYRROLE 1 CARBOXYLIC ACID BENZYL ESTER; ACICLOVIR; BRINASE; FOSCARNET; GANCICLOVIR; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CYTOMEGALOVIRUS; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; NONHUMAN; STEREOCHEMISTRY;

CYTOMEGALOVIRUS; DRUG DESIGN; HUMANS; LACTAMS; PYRROLES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034676308     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000078q     Document Type: Article

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