Pyrrolidine-5,5-trans-lactams. 2. The Use of X-ray Crystal Structure Data in the Optimization of P3 and P4 Substituents

Organic Letters

Volumn 4, Issue 25, 2002, Pages 4479-4482

  Andrews, David M ^a   Chaignot, Helene ^a   Coomber, Barry A ^a   Good, Andrew C ^a,b   Hind, S Lucy ^a   Johnson, Martin R ^a   Jones, Paul S ^a   Mills, Gail ^a   Robinson, J Ed ^a   Skarzynski, Tadeusz ^a   Slater, Martin J ^a   Somers, Donald O'N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LACTAM; NS3 PROTEIN, HEPATITIS C VIRUS; PYRROLIDINE DERIVATIVE; VIRUS PROTEIN;

ARTICLE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; HEPATITIS C VIRUS; IC 50; METABOLISM; PROTEIN CONFORMATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; LACTAMS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PYRROLIDINES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 18744381560     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol027014p     Document Type: Article

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