A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 1. Construction of the basic framework

Journal of Medicinal Chemistry

Volumn 41, Issue 4, 1998, Pages 564-578

  Abe, Yoshito ^a,b   Kayakiri, Hiroshi ^a,b   Satoh, Shigeki ^a,b   Inoue, Takayuki ^a,b   Sawada, Yuki ^a,b   Imai, Keisuke ^a,b   Inamura, Noriaki ^a   Asano, Masayuki ^a,b   Hatori, Chie ^a,b   Katayama, Akira ^a,b   Oku, Teruo ^a,b   Tanaka, Hirokazu ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b Department of Medicinal Chemistry ^*

Author keywords

[No Author keywords available]

Indexed keywords

3 BROMO 8 [[2,6 DICHLORO 3 [N [(N' ETHYLUREIDO)ACETYL] N METHYLAMINO]BENZYL]OXY] 2 METHYLIMIDAZO[1,2 A]PYRIDINE; BRADYKININ; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; ILEUM; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANGIOTENSIN II; ANIMALS; BIOLOGICAL AVAILABILITY; BRADYKININ; BRONCHODILATOR AGENTS; DRUG DESIGN; GUINEA PIGS; ILEUM; IMIDAZOLES; INDICATORS AND REAGENTS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCLE, SMOOTH; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTION;

EID: 15444356141     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970591c     Document Type: Article

References (29)

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