Conformationally constrained 1,3-diamino ketones: A series of potent inhibitors of the cysteine protease cathepsin K [3]

Journal of Medicinal Chemistry

Volumn 41, Issue 19, 1998, Pages 3563-3567

  Marquis, R W ^a   Yamashita, D S ^a   Ru, Y ^a   LoCastro, S M ^a   Oh, H J ^a   Erhard, K F ^a   DesJarlais, R L ^a   Head, M S ^a   Smith, W W ^a   Zhao, B ^a   Janson, C A ^a   Abdel Meguid, S S ^a   Tomaszek, T A ^a   Levy, M A ^a   Veber, D F ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIAMINOKETONE DERIVATIVE; CATHEPSIN K; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; KETONE DERIVATIVE; UNCLASSIFIED DRUG;

DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; INHIBITION KINETICS; LETTER;

BINDING SITES; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; DIAMINES; KETONES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032505149     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980295f     Document Type: Letter

References (19)