Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

Science

Volumn 282, Issue 5389, 1998, Pages 737-740

  Rohrer, Susan P ^a   Birzin, Elizabeth T ^a   Mosley, Ralph T ^a   Berk, Scott C ^a   Hutchins, Steven M ^a   Shen, Dong Ming ^a   Xiong, Yusheng ^a   Hayes, Edward C ^a   Parmar, Rupa M ^a   Foor, Forrest ^a   Mitra, Sudha W ^a   Degrado, Sylvia J ^a   Shu, Min ^a   Klopp, John M ^a   Cai, Sheng Jian ^a   Blake, Allan ^a   Chan, Wanda W S ^a   Pasternak, Alex ^a   Yang, Lihu ^a   Patchett, Arthur A ^a   Smith, Roy G ^a   Chapman, Kevin T ^a   Schaeffer, James M ^a   more..

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GLUCAGON; GROWTH HORMONE; HORMONE RECEPTOR STIMULATING AGENT; INSULIN; L 264930; L 363377; L 779976; L 796778; L 797591; L 803087; L 817818; RECEPTOR SUBTYPE; SOMATOSTATIN 14; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; AGONIST; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMISTRY; CHO CELL; DRUG RECEPTOR BINDING; GLUCAGON RELEASE; GROWTH HORMONE RELEASE; INSULIN RELEASE; MOLECULAR MODEL; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

AMIDES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELLS, CULTURED; CRICETINAE; DRUG DESIGN; GLUCAGON; GROWTH HORMONE; INSULIN; ISLETS OF LANGERHANS; LIGANDS; MEMBRANE PROTEINS; MICE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PITUITARY GLAND, ANTERIOR; RATS; RECEPTORS, SOMATOSTATIN;

ANIMALIA;

EID: 0032561511     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5389.737     Document Type: Article

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35. We thank K. Cheng, L.-Y. Pai, and T.-J. Wu for growth hormone secretion assays.