Novel natural product 5,5-trans-lactone inhibitors of human α-thrombin: Mechanism of action and structural studies

Biochemistry

Volumn 37, Issue 19, 1998, Pages 6645-6657

  Weir, Malcolm P ^a   Bethell, Susanne S ^a   Cleasby, Anne ^a   Campbell, Callum J ^a   Dennis, Richard J ^a   Dix, Clive J ^a   Finch, Harry ^a   Jhoti, Harren ^a   Mooney, Christopher J ^a   Patel, Shila ^a   Tang, Chi Man ^a   Ward, Malcolm ^a   Wonacott, Alan J ^a   Wharton, Christopher W ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LACTONE; THROMBIN;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; COVALENT BOND; CRYSTAL STRUCTURE; DEACYLATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ACYLATION; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOMERISM; KINETICS; LACTONES; MASS SPECTROMETRY; MODELS, MOLECULAR; SERINE PROTEINASE INHIBITORS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRITERPENES;

LANTANA CAMARA;

EID: 0032510807     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972499o     Document Type: Article

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