Piperidine-renin inhibitors compounds with improved physicochemical properties

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 10, 1999, Pages 1403-1408

  Güller, Rolf ^b   Binggeli, Alfred ^a   Breu, Volker ^a   Bur, Daniel ^a   Fischli, Walter ^c   Hirth, Georges ^a   Jenny, Christian ^a   Kansy, Manfred ^a   Montavon, François ^a   Müller, Marcel ^a   Oefner, Christian ^a   Stadler, Heinz ^a   Vieira, Eric ^a   Wilhelm, Maurice ^a   Wostl, Wolfgang ^a   Märki, Hans Peter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Chemspeed Ltd   (Switzerland)

^c ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PIPERIDINE DERIVATIVE; QUINOLINE DERIVATIVE; RENIN INHIBITOR; TETRAHYDROQUINOLINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; LIPOPHILICITY; MARMOSET; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; RACEMIC MIXTURE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM DEPLETION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CALLITHRIX; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PIPERIDINES; RECOMBINANT PROTEINS; RENIN;

EID: 0003694381     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00196-1     Document Type: Article

References (19)

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