A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 2. Overcoming the species difference between guinea pig and man

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 4053-4061

  Abe, Yoshito ^a   Kayakiri, Hiroshi ^a   Satoh, Shigeki ^a   Inoue, Takayuki ^a   Sawada, Yuki ^a   Inamura, Noriaki ^a   Asano, Masayuki ^a   Hatori, Chie ^a   Sawai, Hiroe ^a   Oku, Teruo ^a   Tanaka, Hirokazu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 BROMO 8 [2,6 DICHLORO 3 [N [4 (N,N DIMETHYLCARBAMOYL)CINNAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYLIMIDAZO[1,2 A]PYRIDINE; 3 BROMO 8 [[2,6 DICHLORO 3 [N [4 (N,N DIMETHYLCARBAMOYL)CINNAMAMIDOACETYL] N METHYLAMINO]BENZYL]OXY] 2 METHYLIMIDAZOL[1,2 A]PYRIDINE; 8 [[3 (N ACYLGLYCL N METHYLAMINO) 2,6 DICHLOROBENZYL]OXY] 3 HALO 2 METHYLIMIDAZO[1,2 A]PYRIDINE; BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GUINEA PIG; HUMAN; HUMAN CELL; ILEUM; INFLAMMATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOCONSTRICTION; CELL LINE; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HUMANS; ILEUM; MALE; PYRIDINES; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15644374841     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980214f     Document Type: Article

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