Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality

Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2002, Pages 1-18

  Borthwick, A D ^a   Crame, A J ^a   Ertl, P F ^a   Exall, A M ^a   Haley, T M ^a   Hart, G J ^a   Mason, A M ^a   Pennell, A M K ^a   Singh, O M P ^a   Weingarten, G G ^a   Woolven, J M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 OXOHEXAHYDROPYRROLO[3,2 B]PYRROLE DERIVATIVE; ACETYLCHOLINESTERASE; ELASTASE; PROTEINASE; PROTEINASE INHIBITOR; PYRROLIDINE 5,5 LACTAM DERIVATIVE; THROMBIN; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HUMAN CYTOMEGALOVIRUS; MOLECULAR DYNAMICS; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOMEGALOVIRUS; LACTAMS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEASE INHIBITORS; PYRROLES; SERINE ENDOPEPTIDASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037011893     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102203     Document Type: Article

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