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Volumn 1, Issue 2, 1997, Pages 151-156

The new partnership of genomics and chemistry for accelerated drug development

Author keywords

[No Author keywords available]

Indexed keywords

CHEMISTRY; GENE LIBRARY; HUMAN; PHARMACEUTICS; REVIEW;

EID: 0031197032     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(97)80003-8     Document Type: Article
Times cited : (32)

References (37)
  • 1
    • 36849159719 scopus 로고
    • Retroviral protease-like sequence in the yeast transposon Ty 1
    • Toh H, Ono M, Saigo K, Miyata T: Retroviral protease-like sequence in the yeast transposon Ty 1. Nature 1985, 315:691.
    • (1985) Nature , vol.315 , pp. 691
    • Toh, H.1    Ono, M.2    Saigo, K.3    Miyata, T.4
  • 2
    • 0023189868 scopus 로고
    • A structural model for the retroviral proteases
    • Pearl L, Taylor W: A structural model for the retroviral proteases. Nature 1987, 329:351-354.
    • (1987) Nature , vol.329 , pp. 351-354
    • Pearl, L.1    Taylor, W.2
  • 8
    • 0030953242 scopus 로고    scopus 로고
    • Microbial pathogenesis: Genomics and beyond
    • Strauss EJ, Falkow S: Microbial pathogenesis: genomics and beyond. Science 1997, 276:707-712.
    • (1997) Science , vol.276 , pp. 707-712
    • Strauss, E.J.1    Falkow, S.2
  • 11
    • 0031093489 scopus 로고    scopus 로고
    • Discovering genes for new medicines
    • Haseltine WA: Discovering genes for new medicines. Sci Am 1997, 92-97.
    • (1997) Sci Am , pp. 92-97
    • Haseltine, W.A.1
  • 12
    • 15844422855 scopus 로고    scopus 로고
    • Cathepsin K but not cathepsin B, L or S is abundantly expressed in human osteoclasts
    • Drake FH, Dodds R, James I, Connor J, Debouck C, Richardson S, Lee-Rykaczewski E, Rieman D, Barthlow R, Hastings G, Gowen M: Cathepsin K but not cathepsin B, L or S is abundantly expressed in human osteoclasts. J Biol Chem 1996, 271:12511-12516. The authors analyzed the contents of a cDNA library generated from human osteoclast cells. Cathepsin K, a putative cysteine protease, was isolated and was subsequently shown [19] to be involved in bone resorption in vivo. Without a cDNA library, it is unlikely that this protein would have been isolated. Research efforts are focusing on developing inhibitors of this protease for treatment of osteoporosis.
    • (1996) J Biol Chem , vol.271 , pp. 12511-12516
    • Drake, F.H.1    Dodds, R.2    James, I.3    Connor, J.4    Debouck, C.5    Richardson, S.6    Lee-Rykaczewski, E.7    Rieman, D.8    Barthlow, R.9    Hastings, G.10    Gowen, M.11
  • 13
    • 0028840683 scopus 로고
    • Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway
    • Price LA, Kajkowski EM, Hadcock JR, Ozenberger BA, Pausch MH: Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. Mol Cell Biol 1995, 15:6188-6195.
    • (1995) Mol Cell Biol , vol.15 , pp. 6188-6195
    • Price, L.A.1    Kajkowski, E.M.2    Hadcock, J.R.3    Ozenberger, B.A.4    Pausch, M.H.5
  • 15
    • 0031159620 scopus 로고    scopus 로고
    • A new dimension for the human genome project: Towards comprehensive expression maps
    • Stracher T, Abitbol M, Davidson D, Beckmann JS: A new dimension for the human genome project: towards comprehensive expression maps. Nat Genet 1997, 16:126-132. The authors present an update on methods used to analyze the tissue specific expression of genes identified in the human genome project.
    • (1997) Nat Genet , vol.16 , pp. 126-132
    • Stracher, T.1    Abitbol, M.2    Davidson, D.3    Beckmann, J.S.4
  • 17
    • 0025812496 scopus 로고
    • The production and characterization of osteoclast-selective monoclonal antibodies which distinguish between multinucleated cells derived from different human tissues
    • James IE, Walsh S, Dodds RA, Gowen M: The production and characterization of osteoclast-selective monoclonal antibodies which distinguish between multinucleated cells derived from different human tissues. J Histochem Cytochem 1991, 39:905-914.
    • (1991) J Histochem Cytochem , vol.39 , pp. 905-914
    • James, I.E.1    Walsh, S.2    Dodds, R.A.3    Gowen, M.4
  • 22
    • 0031569846 scopus 로고    scopus 로고
    • Genomic organization and chromosome localization of the human cathepsin K gene
    • Rood J, Van Horn S, Drake FH, Gowen M, Debouck C: Genomic organization and chromosome localization of the human cathepsin K gene. Genomics 1997, 41:169-176.
    • (1997) Genomics , vol.41 , pp. 169-176
    • Rood, J.1    Van Horn, S.2    Drake, F.H.3    Gowen, M.4    Debouck, C.5
  • 24
    • 0029809357 scopus 로고    scopus 로고
    • Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
    • Gelb BD, Shi G-P, Chapman HA, Desnic RJ: Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 1996, 273:1236-1238.
    • (1996) Science , vol.273 , pp. 1236-1238
    • Gelb, B.D.1    Shi, G.-P.2    Chapman, H.A.3    Desnic, R.J.4
  • 25
    • 15844426346 scopus 로고    scopus 로고
    • A cDNA encoding the calcitonin gene-related peptide type 1 receptor
    • Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y: A cDNA encoding the calcitonin gene-related peptide type 1 receptor. J Biol Chem 1996, 271:11325-11329. The authors report the isolation of the cDNA for CGRP (calcitonin gene-related peptide), a G-protein-coupled receptor.
    • (1996) J Biol Chem , vol.271 , pp. 11325-11329
    • Aiyar, N.1    Rand, K.2    Elshourbagy, N.A.3    Zeng, Z.4    Adamou, J.E.5    Bergsma, D.J.6    Li, Y.7
  • 29
    • 9444236174 scopus 로고    scopus 로고
    • Small peptides as potent mimetics of the protein hormone erythropoietin
    • Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, Mulcahy LS, Johnson DL, Barrett RW, Jolliffe LK, Dower WJ: Small peptides as potent mimetics of the protein hormone erythropoietin. Science 1996, 273:458-463. The authors report the isolation of a small (20-residue peptide) agonist at the erythropoietin (EPO) receptor by screening a combinatorial phage display library. Natural ligands of EPO are large folded proteins, and searches for smaller ligands have been unfruitful until now.
    • (1996) Science , vol.273 , pp. 458-463
    • Wrighton, N.C.1    Farrell, F.X.2    Chang, R.3    Kashyap, A.K.4    Barbone, F.P.5    Mulcahy, L.S.6    Johnson, D.L.7    Barrett, R.W.8    Jolliffe, L.K.9    Dower, W.J.10
  • 31
    • 0017578611 scopus 로고
    • Design of specific inhibitors of angiotensin-converting enzyme: New class of orally active antihypertensive agents
    • Wilson WA, Clark MT, Pellmar TC: Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 1977, 196:441-444.
    • (1977) Science , vol.196 , pp. 441-444
    • Wilson, W.A.1    Clark, M.T.2    Pellmar, T.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.