-
1
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
ICGC Breast Cancer Consortium ICGC MMML-Seq Consortium ICGC PedBrain
-
L.B. Alexandrov, S. Nik-Zainal, D.C. Wedge, S.A. Aparicio, S. Behjati, A.V. Biankin, G.R. Bignell, N. Bolli, A. Borg, A.L. Børresen-Dale, et al. Australian Pancreatic Cancer Genome Initiative ICGC Breast Cancer Consortium ICGC MMML-Seq Consortium ICGC PedBrain Signatures of mutational processes in human cancer Nature 500 2013 415 421
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.4
Behjati, S.5
Biankin, A.V.6
Bignell, G.R.7
Bolli, N.8
Borg, A.9
Børresen-Dale, A.L.10
-
2
-
-
58049218983
-
Tissue damage-induced intestinal stem cell division in Drosophila
-
A. Amcheslavsky, J. Jiang, and Y.T. Ip Tissue damage-induced intestinal stem cell division in Drosophila Cell Stem Cell 4 2009 49 61
-
(2009)
Cell Stem Cell
, vol.4
, pp. 49-61
-
-
Amcheslavsky, A.1
Jiang, J.2
Ip, Y.T.3
-
3
-
-
84965187257
-
The age distribution of cancer and a multi-stage theory of carcinogenesis
-
P. Armitage, and R. Doll The age distribution of cancer and a multi-stage theory of carcinogenesis Br. J. Cancer 8 1954 1 12
-
(1954)
Br. J. Cancer
, vol.8
, pp. 1-12
-
-
Armitage, P.1
Doll, R.2
-
4
-
-
3042761646
-
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
-
D.J. Baker, K.B. Jeganathan, J.D. Cameron, M. Thompson, S. Juneja, A. Kopecka, R. Kumar, R.B. Jenkins, P.C. de Groen, P. Roche, and J.M. van Deursen BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice Nat. Genet. 36 2004 744 749
-
(2004)
Nat. Genet.
, vol.36
, pp. 744-749
-
-
Baker, D.J.1
Jeganathan, K.B.2
Cameron, J.D.3
Thompson, M.4
Juneja, S.5
Kopecka, A.6
Kumar, R.7
Jenkins, R.B.8
De Groen, P.C.9
Roche, P.10
Van Deursen, J.M.11
-
5
-
-
84871717211
-
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
-
D.J. Baker, M.M. Dawlaty, T. Wijshake, K.B. Jeganathan, L. Malureanu, J.H. van Ree, R. Crespo-Diaz, S. Reyes, L. Seaburg, V. Shapiro, and et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan Nat. Cell Biol. 15 2013 96 102
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 96-102
-
-
Baker, D.J.1
Dawlaty, M.M.2
Wijshake, T.3
Jeganathan, K.B.4
Malureanu, L.5
Van Ree, J.H.6
Crespo-Diaz, R.7
Reyes, S.8
Seaburg, L.9
Shapiro, V.10
-
6
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
N. Barker, J.H. van Es, J. Kuipers, P. Kujala, M. van den Born, M. Cozijnsen, A. Haegebarth, J. Korving, H. Begthel, P.J. Peters, and H. Clevers Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 2007 1003 1007
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
Van Es, J.H.2
Kuipers, J.3
Kujala, P.4
Van Den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
7
-
-
84875965163
-
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
-
I. Beerman, C. Bock, B.S. Garrison, Z.D. Smith, H. Gu, A. Meissner, and D.J. Rossi Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging Cell Stem Cell 12 2013 413 425
-
(2013)
Cell Stem Cell
, vol.12
, pp. 413-425
-
-
Beerman, I.1
Bock, C.2
Garrison, B.S.3
Smith, Z.D.4
Gu, H.5
Meissner, A.6
Rossi, D.J.7
-
8
-
-
84904043095
-
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
-
I. Beerman, J. Seita, M.A. Inlay, I.L. Weissman, and D.J. Rossi Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle Cell Stem Cell 15 2014 37 50
-
(2014)
Cell Stem Cell
, vol.15
, pp. 37-50
-
-
Beerman, I.1
Seita, J.2
Inlay, M.A.3
Weissman, I.L.4
Rossi, D.J.5
-
9
-
-
70349559751
-
P53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
-
Y. Begus-Nahrmann, A. Lechel, A.C. Obenauf, K. Nalapareddy, E. Peit, E. Hoffmann, F. Schlaudraff, B. Liss, P. Schirmacher, H. Kestler, and et al. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice Nat. Genet. 41 2009 1138 1143
-
(2009)
Nat. Genet.
, vol.41
, pp. 1138-1143
-
-
Begus-Nahrmann, Y.1
Lechel, A.2
Obenauf, A.C.3
Nalapareddy, K.4
Peit, E.5
Hoffmann, E.6
Schlaudraff, F.7
Liss, B.8
Schirmacher, P.9
Kestler, H.10
-
11
-
-
84858316884
-
Hot topics in epigenetic mechanisms of aging: 2011
-
M. Berdasco, and M. Esteller Hot topics in epigenetic mechanisms of aging: 2011 Aging Cell 11 2012 181 186
-
(2012)
Aging Cell
, vol.11
, pp. 181-186
-
-
Berdasco, M.1
Esteller, M.2
-
12
-
-
29144473036
-
Impaired DNA replication within progenitor cell pools promotes leukemogenesis
-
G. Bilousova, A. Marusyk, C.C. Porter, R.D. Cardiff, and J. DeGregori Impaired DNA replication within progenitor cell pools promotes leukemogenesis PLoS Biol. 3 2005 e401
-
(2005)
PLoS Biol.
, vol.3
, pp. e401
-
-
Bilousova, G.1
Marusyk, A.2
Porter, C.C.3
Cardiff, R.D.4
DeGregori, J.5
-
13
-
-
52949093944
-
JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
-
B. Biteau, C.E. Hochmuth, and H. Jasper JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut Cell Stem Cell 3 2008 442 455
-
(2008)
Cell Stem Cell
, vol.3
, pp. 442-455
-
-
Biteau, B.1
Hochmuth, C.E.2
Jasper, H.3
-
14
-
-
78449240115
-
Lifespan extension by preserving proliferative homeostasis in Drosophila
-
B. Biteau, J. Karpac, S. Supoyo, M. Degennaro, R. Lehmann, and H. Jasper Lifespan extension by preserving proliferative homeostasis in Drosophila PLoS Genet. 6 2010 e1001159
-
(2010)
PLoS Genet.
, vol.6
, pp. e1001159
-
-
Biteau, B.1
Karpac, J.2
Supoyo, S.3
Degennaro, M.4
Lehmann, R.5
Jasper, H.6
-
15
-
-
80755174406
-
Maintaining tissue homeostasis: Dynamic control of somatic stem cell activity
-
B. Biteau, C.E. Hochmuth, and H. Jasper Maintaining tissue homeostasis: dynamic control of somatic stem cell activity Cell Stem Cell 9 2011 402 411
-
(2011)
Cell Stem Cell
, vol.9
, pp. 402-411
-
-
Biteau, B.1
Hochmuth, C.E.2
Jasper, H.3
-
16
-
-
84874591240
-
The role of mitochondria in aging
-
A. Bratic, and N.G. Larsson The role of mitochondria in aging J. Clin. Invest. 123 2013 951 957
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 951-957
-
-
Bratic, A.1
Larsson, N.G.2
-
17
-
-
70349617469
-
Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
-
N. Buchon, N.A. Broderick, S. Chakrabarti, and B. Lemaitre Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila Genes Dev. 23 2009 2333 2344
-
(2009)
Genes Dev.
, vol.23
, pp. 2333-2344
-
-
Buchon, N.1
Broderick, N.A.2
Chakrabarti, S.3
Lemaitre, B.4
-
18
-
-
84874362586
-
Replication stress links structural and numerical cancer chromosomal instability
-
R.A. Burrell, S.E. McClelland, D. Endesfelder, P. Groth, M.C. Weller, N. Shaikh, E. Domingo, N. Kanu, S.M. Dewhurst, E. Gronroos, and et al. Replication stress links structural and numerical cancer chromosomal instability Nature 494 2013 492 496
-
(2013)
Nature
, vol.494
, pp. 492-496
-
-
Burrell, R.A.1
McClelland, S.E.2
Endesfelder, D.3
Groth, P.4
Weller, M.C.5
Shaikh, N.6
Domingo, E.7
Kanu, N.8
Dewhurst, S.M.9
Gronroos, E.10
-
19
-
-
84924038121
-
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
-
K. Busch, K. Klapproth, M. Barile, M. Flossdorf, T. Holland-Letz, S.M. Schlenner, M. Reth, T. Höfer, and H.R. Rodewald Fundamental properties of unperturbed haematopoiesis from stem cells in vivo Nature 518 2015 542 546
-
(2015)
Nature
, vol.518
, pp. 542-546
-
-
Busch, K.1
Klapproth, K.2
Barile, M.3
Flossdorf, M.4
Holland-Letz, T.5
Schlenner, S.M.6
Reth, M.7
Höfer, T.8
Rodewald, H.R.9
-
20
-
-
84868208186
-
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
-
L. Busque, J.P. Patel, M.E. Figueroa, A. Vasanthakumar, S. Provost, Z. Hamilou, L. Mollica, J. Li, A. Viale, A. Heguy, and et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis Nat. Genet. 44 2012 1179 1181
-
(2012)
Nat. Genet.
, vol.44
, pp. 1179-1181
-
-
Busque, L.1
Patel, J.P.2
Figueroa, M.E.3
Vasanthakumar, A.4
Provost, S.5
Hamilou, Z.6
Mollica, L.7
Li, J.8
Viale, A.9
Heguy, A.10
-
22
-
-
84860614281
-
Short-term calorie restriction enhances skeletal muscle stem cell function
-
M. Cerletti, Y.C. Jang, L.W. Finley, M.C. Haigis, and A.J. Wagers Short-term calorie restriction enhances skeletal muscle stem cell function Cell Stem Cell 10 2012 515 519
-
(2012)
Cell Stem Cell
, vol.10
, pp. 515-519
-
-
Cerletti, M.1
Jang, Y.C.2
Finley, L.W.3
Haigis, M.C.4
Wagers, A.J.5
-
23
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
G.A. Challen, D. Sun, M. Jeong, M. Luo, J. Jelinek, J.S. Berg, C. Bock, A. Vasanthakumar, H. Gu, Y. Xi, and et al. Dnmt3a is essential for hematopoietic stem cell differentiation Nat. Genet. 44 2012 23 31
-
(2012)
Nat. Genet.
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
Luo, M.4
Jelinek, J.5
Berg, J.S.6
Bock, C.7
Vasanthakumar, A.8
Gu, H.9
Xi, Y.10
-
24
-
-
84925116257
-
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells
-
G.A. Challen, D. Sun, A. Mayle, M. Jeong, M. Luo, B. Rodriguez, C. Mallaney, H. Celik, L. Yang, Z. Xia, and et al. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells Cell Stem Cell 15 2014 350 364
-
(2014)
Cell Stem Cell
, vol.15
, pp. 350-364
-
-
Challen, G.A.1
Sun, D.2
Mayle, A.3
Jeong, M.4
Luo, M.5
Rodriguez, B.6
Mallaney, C.7
Celik, H.8
Yang, L.9
Xia, Z.10
-
25
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
T. Cheng, N. Rodrigues, H. Shen, Y. Yang, D. Dombkowski, M. Sykes, and D.T. Scadden Hematopoietic stem cell quiescence maintained by p21cip1/waf1 Science 287 2000 1804 1808
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
Scadden, D.T.7
-
26
-
-
84902185782
-
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression
-
C.W. Cheng, G.B. Adams, L. Perin, M. Wei, X. Zhou, B.S. Lam, S. Da Sacco, M. Mirisola, D.I. Quinn, T.B. Dorff, and et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression Cell Stem Cell 14 2014 810 823
-
(2014)
Cell Stem Cell
, vol.14
, pp. 810-823
-
-
Cheng, C.W.1
Adams, G.B.2
Perin, L.3
Wei, M.4
Zhou, X.5
Lam, B.S.6
Da Sacco, S.7
Mirisola, M.8
Quinn, D.I.9
Dorff, T.B.10
-
27
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
A.R. Choudhury, Z. Ju, M.W. Djojosubroto, A. Schienke, A. Lechel, S. Schaetzlein, H. Jiang, A. Stepczynska, C. Wang, J. Buer, and et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation Nat. Genet. 39 2007 99 105
-
(2007)
Nat. Genet.
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
Schienke, A.4
Lechel, A.5
Schaetzlein, S.6
Jiang, H.7
Stepczynska, A.8
Wang, C.9
Buer, J.10
-
28
-
-
84880548336
-
The intestinal crypt, a prototype stem cell compartment
-
H. Clevers The intestinal crypt, a prototype stem cell compartment Cell 154 2013 274 284
-
(2013)
Cell
, vol.154
, pp. 274-284
-
-
Clevers, H.1
-
29
-
-
84929222950
-
Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome
-
S. Colla, D.S. Ong, Y. Ogoti, M. Marchesini, N.A. Mistry, K. Clise-Dwyer, S.A. Ang, P. Storti, A. Viale, N. Giuliani, and et al. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome Cancer Cell 27 2015 644 657
-
(2015)
Cancer Cell
, vol.27
, pp. 644-657
-
-
Colla, S.1
Ong, D.S.2
Ogoti, Y.3
Marchesini, M.4
Mistry, N.A.5
Clise-Dwyer, K.6
Ang, S.A.7
Storti, P.8
Viale, A.9
Giuliani, N.10
-
30
-
-
84894304555
-
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
-
M.R. Corces-Zimmerman, W.J. Hong, I.L. Weissman, B.C. Medeiros, and R. Majeti Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission Proc. Natl. Acad. Sci. USA 111 2014 2548 2553
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 2548-2553
-
-
Corces-Zimmerman, M.R.1
Hong, W.J.2
Weissman, I.L.3
Medeiros, B.C.4
Majeti, R.5
-
31
-
-
84893397675
-
Senescent cells harbour features of the cancer epigenome
-
H.A. Cruickshanks, T. McBryan, D.M. Nelson, N.D. Vanderkraats, P.P. Shah, J. van Tuyn, T. Singh Rai, C. Brock, G. Donahue, D.S. Dunican, and et al. Senescent cells harbour features of the cancer epigenome Nat. Cell Biol. 15 2013 1495 1506
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 1495-1506
-
-
Cruickshanks, H.A.1
McBryan, T.2
Nelson, D.M.3
Vanderkraats, N.D.4
Shah, P.P.5
Van Tuyn, J.6
Singh Rai, T.7
Brock, C.8
Donahue, G.9
Dunican, D.S.10
-
32
-
-
67149099680
-
Histone H4 lysine 16 acetylation regulates cellular lifespan
-
W. Dang, K.K. Steffen, R. Perry, J.A. Dorsey, F.B. Johnson, A. Shilatifard, M. Kaeberlein, B.K. Kennedy, and S.L. Berger Histone H4 lysine 16 acetylation regulates cellular lifespan Nature 459 2009 802 807
-
(2009)
Nature
, vol.459
, pp. 802-807
-
-
Dang, W.1
Steffen, K.K.2
Perry, R.3
Dorsey, J.A.4
Johnson, F.B.5
Shilatifard, A.6
Kaeberlein, M.7
Kennedy, B.K.8
Berger, S.L.9
-
33
-
-
84861902129
-
Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells
-
J. de Navascués, C.N. Perdigoto, Y. Bian, M.H. Schneider, A.J. Bardin, A. Martínez-Arias, and B.D. Simons Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells EMBO J. 31 2012 2473 2485
-
(2012)
EMBO J.
, vol.31
, pp. 2473-2485
-
-
De Navascués, J.1
Perdigoto, C.N.2
Bian, Y.3
Schneider, M.H.4
Bardin, A.J.5
Martínez-Arias, A.6
Simons, B.D.7
-
34
-
-
65249121864
-
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
-
S. Dhawan, S.I. Tschen, and A. Bhushan Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation Genes Dev. 23 2009 906 911
-
(2009)
Genes Dev.
, vol.23
, pp. 906-911
-
-
Dhawan, S.1
Tschen, S.I.2
Bhushan, A.3
-
35
-
-
84884417141
-
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
-
J.R. Dörr, Y. Yu, M. Milanovic, G. Beuster, C. Zasada, J.H. Däbritz, J. Lisec, D. Lenze, A. Gerhardt, K. Schleicher, and et al. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy Nature 501 2013 421 425
-
(2013)
Nature
, vol.501
, pp. 421-425
-
-
Dörr, J.R.1
Yu, Y.2
Milanovic, M.3
Beuster, G.4
Zasada, C.5
Däbritz, J.H.6
Lisec, J.7
Lenze, D.8
Gerhardt, A.9
Schleicher, K.10
-
36
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
37
-
-
84925491509
-
MTORC1-mediated translational elongation limits intestinal tumour initiation and growth
-
W.J. Faller, T.J. Jackson, J.R. Knight, R.A. Ridgway, T. Jamieson, S.A. Karim, C. Jones, S. Radulescu, D.J. Huels, K.B. Myant, and et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth Nature 517 2015 497 500
-
(2015)
Nature
, vol.517
, pp. 497-500
-
-
Faller, W.J.1
Jackson, T.J.2
Knight, J.R.3
Ridgway, R.A.4
Jamieson, T.5
Karim, S.A.6
Jones, C.7
Radulescu, S.8
Huels, D.J.9
Myant, K.B.10
-
38
-
-
35548929551
-
Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
-
Z. Feng, W. Hu, A.K. Teresky, E. Hernando, C. Cordon-Cardo, and A.J. Levine Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations Proc. Natl. Acad. Sci. USA 104 2007 16633 16638
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 16633-16638
-
-
Feng, Z.1
Hu, W.2
Teresky, A.K.3
Hernando, E.4
Cordon-Cardo, C.5
Levine, A.J.6
-
39
-
-
84907969138
-
Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4
-
P. Fernandez, P. Scaffidi, E. Markert, J.H. Lee, S. Rane, and T. Misteli Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4 Cell Rep. 9 2014 248 260
-
(2014)
Cell Rep.
, vol.9
, pp. 248-260
-
-
Fernandez, P.1
Scaffidi, P.2
Markert, E.3
Lee, J.H.4
Rane, S.5
Misteli, T.6
-
40
-
-
84906254220
-
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
-
J. Flach, S.T. Bakker, M. Mohrin, P.C. Conroy, E.M. Pietras, D. Reynaud, S. Alvarez, M.E. Diolaiti, F. Ugarte, E.C. Forsberg, and et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature 512 2014 198 202
-
(2014)
Nature
, vol.512
, pp. 198-202
-
-
Flach, J.1
Bakker, S.T.2
Mohrin, M.3
Conroy, P.C.4
Pietras, E.M.5
Reynaud, D.6
Alvarez, S.7
Diolaiti, M.E.8
Ugarte, F.9
Forsberg, E.C.10
-
41
-
-
62449083712
-
Association of FOXO3A variation with human longevity confirmed in German centenarians
-
F. Flachsbart, A. Caliebe, R. Kleindorp, H. Blanché, H. von Eller-Eberstein, S. Nikolaus, S. Schreiber, and A. Nebel Association of FOXO3A variation with human longevity confirmed in German centenarians Proc. Natl. Acad. Sci. USA 106 2009 2700 2705
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2700-2705
-
-
Flachsbart, F.1
Caliebe, A.2
Kleindorp, R.3
Blanché, H.4
Von Eller-Eberstein, H.5
Nikolaus, S.6
Schreiber, S.7
Nebel, A.8
-
42
-
-
84857050624
-
Age-related somatic structural changes in the nuclear genome of human blood cells
-
L.A. Forsberg, C. Rasi, H.R. Razzaghian, G. Pakalapati, L. Waite, K.S. Thilbeault, A. Ronowicz, N.E. Wineinger, H.K. Tiwari, D. Boomsma, and et al. Age-related somatic structural changes in the nuclear genome of human blood cells Am. J. Hum. Genet. 90 2012 217 228
-
(2012)
Am. J. Hum. Genet.
, vol.90
, pp. 217-228
-
-
Forsberg, L.A.1
Rasi, C.2
Razzaghian, H.R.3
Pakalapati, G.4
Waite, L.5
Thilbeault, K.S.6
Ronowicz, A.7
Wineinger, N.E.8
Tiwari, H.K.9
Boomsma, D.10
-
43
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
G. Genovese, A.K. Kähler, R.E. Handsaker, J. Lindberg, S.A. Rose, S.F. Bakhoum, K. Chambert, E. Mick, B.M. Neale, M. Fromer, and et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence N. Engl. J. Med. 371 2014 2477 2487
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2477-2487
-
-
Genovese, G.1
Kähler, A.K.2
Handsaker, R.E.3
Lindberg, J.4
Rose, S.A.5
Bakhoum, S.F.6
Chambert, K.7
Mick, E.8
Neale, B.M.9
Fromer, M.10
-
44
-
-
84856922362
-
Paternal age effect mutations and selfish spermatogonial selection: Causes and consequences for human disease
-
A. Goriely, and A.O. Wilkie Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease Am. J. Hum. Genet. 90 2012 175 200
-
(2012)
Am. J. Hum. Genet.
, vol.90
, pp. 175-200
-
-
Goriely, A.1
Wilkie, A.O.2
-
45
-
-
31444433936
-
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
-
L.C. Greaves, S.L. Preston, P.J. Tadrous, R.W. Taylor, M.J. Barron, D. Oukrif, S.J. Leedham, M. Deheragoda, P. Sasieni, M.R. Novelli, and et al. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission Proc. Natl. Acad. Sci. USA 103 2006 714 719
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 714-719
-
-
Greaves, L.C.1
Preston, S.L.2
Tadrous, P.J.3
Taylor, R.W.4
Barron, M.J.5
Oukrif, D.6
Leedham, S.J.7
Deheragoda, M.8
Sasieni, P.9
Novelli, M.R.10
-
46
-
-
77954660029
-
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. Elegans
-
E.L. Greer, T.J. Maures, A.G. Hauswirth, E.M. Green, D.S. Leeman, G.S. Maro, S. Han, M.R. Banko, O. Gozani, and A. Brunet Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans Nature 466 2010 383 387
-
(2010)
Nature
, vol.466
, pp. 383-387
-
-
Greer, E.L.1
Maures, T.J.2
Hauswirth, A.G.3
Green, E.M.4
Leeman, D.S.5
Maro, G.S.6
Han, S.7
Banko, M.R.8
Gozani, O.9
Brunet, A.10
-
47
-
-
84892714390
-
PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan
-
L. Guo, J. Karpac, S.L. Tran, and H. Jasper PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan Cell 156 2014 109 122
-
(2014)
Cell
, vol.156
, pp. 109-122
-
-
Guo, L.1
Karpac, J.2
Tran, S.L.3
Jasper, H.4
-
48
-
-
0242721689
-
End resection initiates genomic instability in the absence of telomerase
-
J.A. Hackett, and C.W. Greider End resection initiates genomic instability in the absence of telomerase Mol. Cell Biol. 23 2003 8450 8461
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 8450-8461
-
-
Hackett, J.A.1
Greider, C.W.2
-
49
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
W.C. Hahn, C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, and R.A. Weinberg Creation of human tumour cells with defined genetic elements Nature 400 1999 464 468
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
50
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
51
-
-
84872806231
-
Genome-wide methylation profiles reveal quantitative views of human aging rates
-
G. Hannum, J. Guinney, L. Zhao, L. Zhang, G. Hughes, S. Sadda, B. Klotzle, M. Bibikova, J.B. Fan, Y. Gao, and et al. Genome-wide methylation profiles reveal quantitative views of human aging rates Mol. Cell 49 2013 359 367
-
(2013)
Mol. Cell
, vol.49
, pp. 359-367
-
-
Hannum, G.1
Guinney, J.2
Zhao, L.3
Zhang, L.4
Hughes, G.5
Sadda, S.6
Klotzle, B.7
Bibikova, M.8
Fan, J.B.9
Gao, Y.10
-
52
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, N.L. Nadon, J.E. Wilkinson, K. Frenkel, C.S. Carter, and et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
53
-
-
78650744017
-
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis
-
C.J. Henry, A. Marusyk, V. Zaberezhnyy, B. Adane, and J. DeGregori Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis Proc. Natl. Acad. Sci. USA 107 2010 21713 21718
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 21713-21718
-
-
Henry, C.J.1
Marusyk, A.2
Zaberezhnyy, V.3
Adane, B.4
DeGregori, J.5
-
54
-
-
0029829887
-
Telomerase activity in human intestine
-
E. Hiyama, N. Tatsumoto, T. Kodama, K. Hiyama, J. Shay, and T. Yokoyama Telomerase activity in human intestine Int. J. Oncol. 9 1996 453 458
-
(1996)
Int. J. Oncol.
, vol.9
, pp. 453-458
-
-
Hiyama, E.1
Tatsumoto, N.2
Kodama, T.3
Hiyama, K.4
Shay, J.5
Yokoyama, T.6
-
55
-
-
84900443034
-
Cell biology of disease: Telomeropathies: An emerging spectrum disorder
-
B. Holohan, W.E. Wright, and J.W. Shay Cell biology of disease: Telomeropathies: an emerging spectrum disorder J. Cell Biol. 205 2014 289 299
-
(2014)
J. Cell Biol.
, vol.205
, pp. 289-299
-
-
Holohan, B.1
Wright, W.E.2
Shay, J.W.3
-
56
-
-
84886111619
-
DNA methylation age of human tissues and cell types
-
S. Horvath DNA methylation age of human tissues and cell types Genome Biol. 14 2013 R115
-
(2013)
Genome Biol.
, vol.14
, pp. R115
-
-
Horvath, S.1
-
57
-
-
84878896680
-
Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts
-
J.C. Hsieh, D. Van Den Berg, H. Kang, C.L. Hsieh, and M.R. Lieber Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts Aging Cell 12 2013 269 279
-
(2013)
Aging Cell
, vol.12
, pp. 269-279
-
-
Hsieh, J.C.1
Van Den Berg, D.2
Kang, H.3
Hsieh, C.L.4
Lieber, M.R.5
-
58
-
-
84861628224
-
Detectable clonal mosaicism and its relationship to aging and cancer
-
K.B. Jacobs, M. Yeager, W. Zhou, S. Wacholder, Z. Wang, B. Rodriguez-Santiago, A. Hutchinson, X. Deng, C. Liu, M.J. Horner, and et al. Detectable clonal mosaicism and its relationship to aging and cancer Nat. Genet. 44 2012 651 658
-
(2012)
Nat. Genet.
, vol.44
, pp. 651-658
-
-
Jacobs, K.B.1
Yeager, M.2
Zhou, W.3
Wacholder, S.4
Wang, Z.5
Rodriguez-Santiago, B.6
Hutchinson, A.7
Deng, X.8
Liu, C.9
Horner, M.J.10
-
59
-
-
84920053873
-
Age-related clonal hematopoiesis associated with adverse outcomes
-
S. Jaiswal, P. Fontanillas, J. Flannick, A. Manning, P.V. Grauman, B.G. Mar, R.C. Lindsley, C.H. Mermel, N. Burtt, A. Chavez, and et al. Age-related clonal hematopoiesis associated with adverse outcomes N. Engl. J. Med. 371 2014 2488 2498
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2488-2498
-
-
Jaiswal, S.1
Fontanillas, P.2
Flannick, J.3
Manning, A.4
Grauman, P.V.5
Mar, B.G.6
Lindsley, R.C.7
Mermel, C.H.8
Burtt, N.9
Chavez, A.10
-
60
-
-
84865827060
-
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
-
M. Jan, T.M. Snyder, M.R. Corces-Zimmerman, P. Vyas, I.L. Weissman, S.R. Quake, and R. Majeti Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia Sci. Transl. Med. 4 2012 149ra118
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 149ra118
-
-
Jan, M.1
Snyder, T.M.2
Corces-Zimmerman, M.R.3
Vyas, P.4
Weissman, I.L.5
Quake, S.R.6
Majeti, R.7
-
61
-
-
34250017413
-
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
-
Z. Ju, H. Jiang, M. Jaworski, C. Rathinam, A. Gompf, C. Klein, A. Trumpp, and K.L. Rudolph Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment Nat. Med. 13 2007 742 747
-
(2007)
Nat. Med.
, vol.13
, pp. 742-747
-
-
Ju, Z.1
Jiang, H.2
Jaworski, M.3
Rathinam, C.4
Gompf, A.5
Klein, C.6
Trumpp, A.7
Rudolph, K.L.8
-
62
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
T.W. Kang, T. Yevsa, N. Woller, L. Hoenicke, T. Wuestefeld, D. Dauch, A. Hohmeyer, M. Gereke, R. Rudalska, A. Potapova, and et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development Nature 479 2011 547 551
-
(2011)
Nature
, vol.479
, pp. 547-551
-
-
Kang, T.W.1
Yevsa, T.2
Woller, N.3
Hoenicke, L.4
Wuestefeld, T.5
Dauch, D.6
Hohmeyer, A.7
Gereke, M.8
Rudalska, R.9
Potapova, A.10
-
63
-
-
84878679199
-
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
-
J. Kaplon, L. Zheng, K. Meissl, B. Chaneton, V.A. Selivanov, G. Mackay, S.H. van der Burg, E.M. Verdegaal, M. Cascante, T. Shlomi, and et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence Nature 498 2013 109 112
-
(2013)
Nature
, vol.498
, pp. 109-112
-
-
Kaplon, J.1
Zheng, L.2
Meissl, K.3
Chaneton, B.4
Selivanov, V.A.5
Mackay, G.6
Van Der Burg, S.H.7
Verdegaal, E.M.8
Cascante, M.9
Shlomi, T.10
-
64
-
-
84870700189
-
Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage
-
S. Kapuria, J. Karpac, B. Biteau, D. Hwangbo, and H. Jasper Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage PLoS Genet. 8 2012 e1003045
-
(2012)
PLoS Genet.
, vol.8
, pp. e1003045
-
-
Kapuria, S.1
Karpac, J.2
Biteau, B.3
Hwangbo, D.4
Jasper, H.5
-
65
-
-
0027771804
-
A C. Elegans mutant that lives twice as long as wild type
-
C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. elegans mutant that lives twice as long as wild type Nature 366 1993 461 464
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
66
-
-
77950200010
-
The genetics of ageing
-
C.J. Kenyon The genetics of ageing Nature 464 2010 504 512
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
67
-
-
0037068376
-
Methylation reveals a niche: Stem cell succession in human colon crypts
-
K.M. Kim, and D. Shibata Methylation reveals a niche: stem cell succession in human colon crypts Oncogene 21 2002 5441 5449
-
(2002)
Oncogene
, vol.21
, pp. 5441-5449
-
-
Kim, K.M.1
Shibata, D.2
-
68
-
-
27544433550
-
Age-related human small intestine methylation: Evidence for stem cell niches
-
J.Y. Kim, K.D. Siegmund, S. Tavaré, and D. Shibata Age-related human small intestine methylation: evidence for stem cell niches BMC Med. 3 2005 10
-
(2005)
BMC Med.
, vol.3
, pp. 10
-
-
Kim, J.Y.1
Siegmund, K.D.2
Tavaré, S.3
Shibata, D.4
-
69
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
K.D. Kimura, H.A. Tissenbaum, Y. Liu, and G. Ruvkun daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans Science 277 1997 942 946
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
70
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
K.W. Kinzler, and B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
71
-
-
15444377643
-
P21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
-
T.E. Kippin, D.J. Martens, and D. van der Kooy p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity Genes Dev. 19 2005 756 767
-
(2005)
Genes Dev.
, vol.19
, pp. 756-767
-
-
Kippin, T.E.1
Martens, D.J.2
Van Der Kooy, D.3
-
72
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
A.G. Knudson Jr. Mutation and cancer: statistical study of retinoblastoma Proc. Natl. Acad. Sci. USA 68 1971 820 823
-
(1971)
Proc. Natl. Acad. Sci. USA
, vol.68
, pp. 820-823
-
-
Knudson, A.G.1
-
73
-
-
85027924783
-
Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas
-
S. Kozar, E. Morrissey, A.M. Nicholson, M. van der Heijden, H.I. Zecchini, R. Kemp, S. Tavaré, L. Vermeulen, and D.J. Winton Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas Cell Stem Cell 13 2013 626 633
-
(2013)
Cell Stem Cell
, vol.13
, pp. 626-633
-
-
Kozar, S.1
Morrissey, E.2
Nicholson, A.M.3
Van Der Heijden, M.4
Zecchini, H.I.5
Kemp, R.6
Tavaré, S.7
Vermeulen, L.8
Winton, D.J.9
-
74
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
G.C. Kujoth, A. Hiona, T.D. Pugh, S. Someya, K. Panzer, S.E. Wohlgemuth, T. Hofer, A.Y. Seo, R. Sullivan, W.A. Jobling, and et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging Science 309 2005 481 484
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
-
75
-
-
0020520516
-
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
-
H. Land, L.F. Parada, and R.A. Weinberg Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes Nature 304 1983 596 602
-
(1983)
Nature
, vol.304
, pp. 596-602
-
-
Land, H.1
Parada, L.F.2
Weinberg, R.A.3
-
76
-
-
84861591789
-
Detectable clonal mosaicism from birth to old age and its relationship to cancer
-
C.C. Laurie, C.A. Laurie, K. Rice, K.F. Doheny, L.R. Zelnick, C.P. McHugh, H. Ling, K.N. Hetrick, E.W. Pugh, C. Amos, and et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer Nat. Genet. 44 2012 642 650
-
(2012)
Nat. Genet.
, vol.44
, pp. 642-650
-
-
Laurie, C.C.1
Laurie, C.A.2
Rice, K.3
Doheny, K.F.4
Zelnick, L.R.5
McHugh, C.P.6
Ling, H.7
Hetrick, K.N.8
Pugh, E.W.9
Amos, C.10
-
77
-
-
80052298366
-
Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage
-
W.H. Lien, X. Guo, L. Polak, L.N. Lawton, R.A. Young, D. Zheng, and E. Fuchs Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage Cell Stem Cell 9 2011 219 232
-
(2011)
Cell Stem Cell
, vol.9
, pp. 219-232
-
-
Lien, W.H.1
Guo, X.2
Polak, L.3
Lawton, L.N.4
Young, R.A.5
Zheng, D.6
Fuchs, E.7
-
78
-
-
84892440367
-
Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging
-
L. Liu, T.H. Cheung, G.W. Charville, B.M. Hurgo, T. Leavitt, J. Shih, A. Brunet, and T.A. Rando Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging Cell Rep. 4 2013 189 204
-
(2013)
Cell Rep.
, vol.4
, pp. 189-204
-
-
Liu, L.1
Cheung, T.H.2
Charville, G.W.3
Hurgo, B.M.4
Leavitt, T.5
Shih, J.6
Brunet, A.7
Rando, T.A.8
-
79
-
-
77958485383
-
Intestinal stem cell replacement follows a pattern of neutral drift
-
C. Lopez-Garcia, A.M. Klein, B.D. Simons, and D.J. Winton Intestinal stem cell replacement follows a pattern of neutral drift Science 330 2010 822 825
-
(2010)
Science
, vol.330
, pp. 822-825
-
-
Lopez-Garcia, C.1
Klein, A.M.2
Simons, B.D.3
Winton, D.J.4
-
81
-
-
84898746948
-
Age-related epigenetic drift in the pathogenesis of MDS and AML
-
S. Maegawa, S.M. Gough, N. Watanabe-Okochi, Y. Lu, N. Zhang, R.J. Castoro, M.R. Estecio, J. Jelinek, S. Liang, T. Kitamura, and et al. Age-related epigenetic drift in the pathogenesis of MDS and AML Genome Res. 24 2014 580 591
-
(2014)
Genome Res.
, vol.24
, pp. 580-591
-
-
Maegawa, S.1
Gough, S.M.2
Watanabe-Okochi, N.3
Lu, Y.4
Zhang, N.5
Castoro, R.J.6
Estecio, M.R.7
Jelinek, J.8
Liang, S.9
Kitamura, T.10
-
82
-
-
84899077299
-
Cellular evidence for selfish spermatogonial selection in aged human testes
-
G.J. Maher, A. Goriely, and A.O. Wilkie Cellular evidence for selfish spermatogonial selection in aged human testes Andrology 2 2014 304 314
-
(2014)
Andrology
, vol.2
, pp. 304-314
-
-
Maher, G.J.1
Goriely, A.2
Wilkie, A.O.3
-
83
-
-
77957981121
-
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
-
G. Mariño, A.P. Ugalde, A.F. Fernández, F.G. Osorio, A. Fueyo, J.M. Freije, and C. López-Otín Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function Proc. Natl. Acad. Sci. USA 107 2010 16268 16273
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16268-16273
-
-
Mariño, G.1
Ugalde, A.P.2
Fernández, A.F.3
Osorio, F.G.4
Fueyo, A.5
Freije, J.M.6
López-Otín, C.7
-
84
-
-
84926674860
-
DNA methylation age of blood predicts all-cause mortality in later life
-
R.E. Marioni, S. Shah, A.F. McRae, B.H. Chen, E. Colicino, S.E. Harris, J. Gibson, A.K. Henders, P. Redmond, S.R. Cox, and et al. DNA methylation age of blood predicts all-cause mortality in later life Genome Biol. 16 2015 25
-
(2015)
Genome Biol.
, vol.16
, pp. 25
-
-
Marioni, R.E.1
Shah, S.2
McRae, A.F.3
Chen, B.H.4
Colicino, E.5
Harris, S.E.6
Gibson, J.7
Henders, A.K.8
Redmond, P.9
Cox, S.R.10
-
85
-
-
84860528235
-
The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells
-
M. Maryanovich, G. Oberkovitz, H. Niv, L. Vorobiyov, Y. Zaltsman, O. Brenner, T. Lapidot, S. Jung, and A. Gross The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells Nat. Cell Biol. 14 2012 535 541
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 535-541
-
-
Maryanovich, M.1
Oberkovitz, G.2
Niv, H.3
Vorobiyov, L.4
Zaltsman, Y.5
Brenner, O.6
Lapidot, T.7
Jung, S.8
Gross, A.9
-
86
-
-
54149091257
-
Metabolism and regulation of canonical histone mRNAs: Life without a poly(A) tail
-
W.F. Marzluff, E.J. Wagner, and R.J. Duronio Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail Nat. Rev. Genet. 9 2008 843 854
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 843-854
-
-
Marzluff, W.F.1
Wagner, E.J.2
Duronio, R.J.3
-
87
-
-
84921468426
-
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
-
A. Mayle, L. Yang, B. Rodriguez, T. Zhou, E. Chang, C.V. Curry, G.A. Challen, W. Li, D. Wheeler, V.I. Rebel, and M.A. Goodell Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation Blood 125 2015 629 638
-
(2015)
Blood
, vol.125
, pp. 629-638
-
-
Mayle, A.1
Yang, L.2
Rodriguez, B.3
Zhou, T.4
Chang, E.5
Curry, C.V.6
Challen, G.A.7
Li, W.8
Wheeler, D.9
Rebel, V.I.10
Goodell, M.A.11
-
88
-
-
84924620531
-
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
-
T. McKerrell, N. Park, T. Moreno, C.S. Grove, H. Ponstingl, J. Stephens, C. Crawley, J. Craig, M.A. Scott, C. Hodkinson, et al. Understanding Society Scientific Group Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis Cell Rep. 10 2015 1239 1245
-
(2015)
Cell Rep.
, vol.10
, pp. 1239-1245
-
-
McKerrell, T.1
Park, N.2
Moreno, T.3
Grove, C.S.4
Ponstingl, H.5
Stephens, J.6
Crawley, C.7
Craig, J.8
Scott, M.A.9
Hodkinson, C.10
-
89
-
-
84929155888
-
Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion
-
J.K. Meena, A. Cerutti, C. Beichler, Y. Morita, C. Bruhn, M. Kumar, J.M. Kraus, M.R. Speicher, Z.Q. Wang, H.A. Kestler, and et al. Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion EMBO J. 34 2015 1371 1384
-
(2015)
EMBO J.
, vol.34
, pp. 1371-1384
-
-
Meena, J.K.1
Cerutti, A.2
Beichler, C.3
Morita, Y.4
Bruhn, C.5
Kumar, M.6
Kraus, J.M.7
Speicher, M.R.8
Wang, Z.Q.9
Kestler, H.A.10
-
90
-
-
84923361911
-
Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
-
P. Missios, Y. Zhou, L.M. Guachalla, G. von Figura, A. Wegner, S.R. Chakkarappan, T. Binz, A. Gompf, G. Hartleben, M.D. Burkhalter, and et al. Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice Nat. Commun. 5 2014 4924
-
(2014)
Nat. Commun.
, vol.5
, pp. 4924
-
-
Missios, P.1
Zhou, Y.2
Guachalla, L.M.3
Von Figura, G.4
Wegner, A.5
Chakkarappan, S.R.6
Binz, T.7
Gompf, A.8
Hartleben, G.9
Burkhalter, M.D.10
-
91
-
-
77956251480
-
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
-
M. Mohrin, E. Bourke, D. Alexander, M.R. Warr, K. Barry-Holson, M.M. Le Beau, C.G. Morrison, and E. Passegué Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis Cell Stem Cell 7 2010 174 185
-
(2010)
Cell Stem Cell
, vol.7
, pp. 174-185
-
-
Mohrin, M.1
Bourke, E.2
Alexander, D.3
Warr, M.R.4
Barry-Holson, K.5
Le Beau, M.M.6
Morrison, C.G.7
Passegué, E.8
-
92
-
-
84961288162
-
Chromatin signatures of cancer
-
M.A. Morgan, and A. Shilatifard Chromatin signatures of cancer Genes Dev. 29 2015 238 249
-
(2015)
Genes Dev.
, vol.29
, pp. 238-249
-
-
Morgan, M.A.1
Shilatifard, A.2
-
93
-
-
79955698235
-
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
-
G.L. Norddahl, C.J. Pronk, M. Wahlestedt, G. Sten, J.M. Nygren, A. Ugale, M. Sigvardsson, and D. Bryder Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging Cell Stem Cell 8 2011 499 510
-
(2011)
Cell Stem Cell
, vol.8
, pp. 499-510
-
-
Norddahl, G.L.1
Pronk, C.J.2
Wahlestedt, M.3
Sten, G.4
Nygren, J.M.5
Ugale, A.6
Sigvardsson, M.7
Bryder, D.8
-
94
-
-
84903744004
-
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
-
B.J. North, M.A. Rosenberg, K.B. Jeganathan, A.V. Hafner, S. Michan, J. Dai, D.J. Baker, Y. Cen, L.E. Wu, A.A. Sauve, and et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan EMBO J. 33 2014 1438 1453
-
(2014)
EMBO J.
, vol.33
, pp. 1438-1453
-
-
North, B.J.1
Rosenberg, M.A.2
Jeganathan, K.B.3
Hafner, A.V.4
Michan, S.5
Dai, J.6
Baker, D.J.7
Cen, Y.8
Wu, L.E.9
Sauve, A.A.10
-
95
-
-
80155123827
-
Altered modes of stem cell division drive adaptive intestinal growth
-
L.E. O'Brien, S.S. Soliman, X. Li, and D. Bilder Altered modes of stem cell division drive adaptive intestinal growth Cell 147 2011 603 614
-
(2011)
Cell
, vol.147
, pp. 603-614
-
-
O'Brien, L.E.1
Soliman, S.S.2
Li, X.3
Bilder, D.4
-
96
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
-
J.E. Ohm, K.M. McGarvey, X. Yu, L. Cheng, K.E. Schuebel, L. Cope, H.P. Mohammad, W. Chen, V.C. Daniel, W. Yu, and et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing Nat. Genet. 39 2007 237 242
-
(2007)
Nat. Genet.
, vol.39
, pp. 237-242
-
-
Ohm, J.E.1
McGarvey, K.M.2
Yu, X.3
Cheng, L.4
Schuebel, K.E.5
Cope, L.6
Mohammad, H.P.7
Chen, W.8
Daniel, V.C.9
Yu, W.10
-
97
-
-
28544436371
-
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
-
E. Passegué, A.J. Wagers, S. Giuriato, W.C. Anderson, and I.L. Weissman Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates J. Exp. Med. 202 2005 1599 1611
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1599-1611
-
-
Passegué, E.1
Wagers, A.J.2
Giuriato, S.3
Anderson, W.C.4
Weissman, I.L.5
-
98
-
-
77149164811
-
Feedback between p21 and reactive oxygen production is necessary for cell senescence
-
J.F. Passos, G. Nelson, C. Wang, T. Richter, C. Simillion, C.J. Proctor, S. Miwa, S. Olijslagers, J. Hallinan, A. Wipat, and et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence Mol. Syst. Biol. 6 2010 347
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 347
-
-
Passos, J.F.1
Nelson, G.2
Wang, C.3
Richter, T.4
Simillion, C.5
Proctor, C.J.6
Miwa, S.7
Olijslagers, S.8
Hallinan, J.9
Wipat, A.10
-
99
-
-
40649108843
-
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
-
K.J. Pearson, K.N. Lewis, N.L. Price, J.W. Chang, E. Perez, M.V. Cascajo, K.L. Tamashiro, S. Poosala, A. Csiszar, Z. Ungvari, and et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction Proc. Natl. Acad. Sci. USA 105 2008 2325 2330
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 2325-2330
-
-
Pearson, K.J.1
Lewis, K.N.2
Price, N.L.3
Chang, J.W.4
Perez, E.5
Cascajo, M.V.6
Tamashiro, K.L.7
Poosala, S.8
Csiszar, A.9
Ungvari, Z.10
-
100
-
-
84918515620
-
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
-
T.S. Rai, J.J. Cole, D.M. Nelson, D. Dikovskaya, W.J. Faller, M.G. Vizioli, R.N. Hewitt, O. Anannya, T. McBryan, I. Manoharan, and et al. HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia Genes Dev. 28 2014 2712 2725
-
(2014)
Genes Dev.
, vol.28
, pp. 2712-2725
-
-
Rai, T.S.1
Cole, J.J.2
Nelson, D.M.3
Dikovskaya, D.4
Faller, W.J.5
Vizioli, M.G.6
Hewitt, R.N.7
Anannya, O.8
McBryan, T.9
Manoharan, I.10
-
101
-
-
77950657253
-
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
-
V.K. Rakyan, T.A. Down, S. Maslau, T. Andrew, T.P. Yang, H. Beyan, P. Whittaker, O.T. McCann, S. Finer, A.M. Valdes, and et al. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains Genome Res. 20 2010 434 439
-
(2010)
Genome Res.
, vol.20
, pp. 434-439
-
-
Rakyan, V.K.1
Down, T.A.2
Maslau, S.3
Andrew, T.4
Yang, T.P.5
Beyan, H.6
Whittaker, P.7
McCann, O.T.8
Finer, S.9
Valdes, A.M.10
-
102
-
-
33745614062
-
Stem cells, ageing and the quest for immortality
-
T.A. Rando Stem cells, ageing and the quest for immortality Nature 441 2006 1080 1086
-
(2006)
Nature
, vol.441
, pp. 1080-1086
-
-
Rando, T.A.1
-
103
-
-
80455143200
-
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
-
M. Rera, S. Bahadorani, J. Cho, C.L. Koehler, M. Ulgherait, J.H. Hur, W.S. Ansari, T. Lo Jr., D.L. Jones, and D.W. Walker Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog Cell Metab. 14 2011 623 634
-
(2011)
Cell Metab.
, vol.14
, pp. 623-634
-
-
Rera, M.1
Bahadorani, S.2
Cho, J.3
Koehler, C.L.4
Ulgherait, M.5
Hur, J.H.6
Ansari, W.S.7
Lo, T.8
Jones, D.L.9
Walker, D.W.10
-
104
-
-
49849083943
-
Whole chromosome instability and cancer: A complex relationship
-
R.M. Ricke, J.H. van Ree, and J.M. van Deursen Whole chromosome instability and cancer: a complex relationship Trends Genet. 24 2008 457 466
-
(2008)
Trends Genet.
, vol.24
, pp. 457-466
-
-
Ricke, R.M.1
Van Ree, J.H.2
Van Deursen, J.M.3
-
105
-
-
48549086606
-
Ulcerative colitis is a disease of accelerated colon aging: Evidence from telomere attrition and DNA damage
-
R.A. Risques, L.A. Lai, T.A. Brentnall, L. Li, Z. Feng, J. Gallaher, M.T. Mandelson, J.D. Potter, M.P. Bronner, and P.S. Rabinovitch Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage Gastroenterology 135 2008 410 418
-
(2008)
Gastroenterology
, vol.135
, pp. 410-418
-
-
Risques, R.A.1
Lai, L.A.2
Brentnall, T.A.3
Li, L.4
Feng, Z.5
Gallaher, J.6
Mandelson, M.T.7
Potter, J.D.8
Bronner, M.P.9
Rabinovitch, P.S.10
-
106
-
-
84897022044
-
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging
-
L. Ritsma, S.I. Ellenbroek, A. Zomer, H.J. Snippert, F.J. de Sauvage, B.D. Simons, H. Clevers, and J. van Rheenen Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging Nature 507 2014 362 365
-
(2014)
Nature
, vol.507
, pp. 362-365
-
-
Ritsma, L.1
Ellenbroek, S.I.2
Zomer, A.3
Snippert, H.J.4
De Sauvage, F.J.5
Simons, B.D.6
Clevers, H.7
Van Rheenen, J.8
-
107
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
D.J. Rossi, D. Bryder, J. Seita, A. Nussenzweig, J. Hoeijmakers, and I.L. Weissman Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age Nature 447 2007 725 729
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
108
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
K.L. Rudolph, S. Chang, H.W. Lee, M. Blasco, G.J. Gottlieb, C. Greider, and R.A. DePinho Longevity, stress response, and cancer in aging telomerase-deficient mice Cell 96 1999 701 712
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
DePinho, R.A.7
-
109
-
-
0034978564
-
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
-
K.L. Rudolph, M. Millard, M.W. Bosenberg, and R.A. DePinho Telomere dysfunction and evolution of intestinal carcinoma in mice and humans Nat. Genet. 28 2001 155 159
-
(2001)
Nat. Genet.
, vol.28
, pp. 155-159
-
-
Rudolph, K.L.1
Millard, M.2
Bosenberg, M.W.3
DePinho, R.A.4
-
110
-
-
84861461464
-
Axis of ageing: Telomeres, p53 and mitochondria
-
E. Sahin, and R.A. DePinho Axis of ageing: telomeres, p53 and mitochondria Nat. Rev. Mol. Cell Biol. 13 2012 397 404
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 397-404
-
-
Sahin, E.1
DePinho, R.A.2
-
111
-
-
33846649587
-
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
-
Y. Schlesinger, R. Straussman, I. Keshet, S. Farkash, M. Hecht, J. Zimmerman, E. Eden, Z. Yakhini, E. Ben-Shushan, B.E. Reubinoff, and et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer Nat. Genet. 39 2007 232 236
-
(2007)
Nat. Genet.
, vol.39
, pp. 232-236
-
-
Schlesinger, Y.1
Straussman, R.2
Keshet, I.3
Farkash, S.4
Hecht, M.5
Zimmerman, J.6
Eden, E.7
Yakhini, Z.8
Ben-Shushan, E.9
Reubinoff, B.E.10
-
112
-
-
2442704201
-
DNA end joining becomes less efficient and more error-prone during cellular senescence
-
A. Seluanov, D. Mittelman, O.M. Pereira-Smith, J.H. Wilson, and V. Gorbunova DNA end joining becomes less efficient and more error-prone during cellular senescence Proc. Natl. Acad. Sci. USA 101 2004 7624 7629
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7624-7629
-
-
Seluanov, A.1
Mittelman, D.2
Pereira-Smith, O.M.3
Wilson, J.H.4
Gorbunova, V.5
-
113
-
-
34548179310
-
Cancer and ageing: Convergent and divergent mechanisms
-
M. Serrano, and M.A. Blasco Cancer and ageing: convergent and divergent mechanisms Nat. Rev. Mol. Cell Biol. 8 2007 715 722
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 715-722
-
-
Serrano, M.1
Blasco, M.A.2
-
114
-
-
0029612230
-
Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea
-
P.M. Shaver-Walker, C. Urlando, K.S. Tao, X.B. Zhang, and J.A. Heddle Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea Proc. Natl. Acad. Sci. USA 92 1995 11470 11474
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11470-11474
-
-
Shaver-Walker, P.M.1
Urlando, C.2
Tao, K.S.3
Zhang, X.B.4
Heddle, J.A.5
-
115
-
-
84866378702
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
A.H. Shih, O. Abdel-Wahab, J.P. Patel, and R.L. Levine The role of mutations in epigenetic regulators in myeloid malignancies Nat. Rev. Cancer 12 2012 599 612
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 599-612
-
-
Shih, A.H.1
Abdel-Wahab, O.2
Patel, J.P.3
Levine, R.L.4
-
116
-
-
84894245627
-
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
-
L.I. Shlush, S. Zandi, A. Mitchell, W.C. Chen, J.M. Brandwein, V. Gupta, J.A. Kennedy, A.D. Schimmer, A.C. Schuh, K.W. Yee, et al. HALT Pan-Leukemia Gene Panel Consortium Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia Nature 506 2014 328 333
-
(2014)
Nature
, vol.506
, pp. 328-333
-
-
Shlush, L.I.1
Zandi, S.2
Mitchell, A.3
Chen, W.C.4
Brandwein, J.M.5
Gupta, V.6
Kennedy, J.A.7
Schimmer, A.D.8
Schuh, A.C.9
Yee, K.W.10
-
117
-
-
78649880379
-
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
-
O. Sirin, G.L. Lukov, R. Mao, O.M. Conneely, and M.A. Goodell The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells Nat. Cell Biol. 12 2010 1213 1219
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1213-1219
-
-
Sirin, O.1
Lukov, G.L.2
Mao, R.3
Conneely, O.M.4
Goodell, M.A.5
-
118
-
-
67649993396
-
Future of cancer incidence in the United States: Burdens upon an aging, changing nation
-
B.D. Smith, G.L. Smith, A. Hurria, G.N. Hortobagyi, and T.A. Buchholz Future of cancer incidence in the United States: burdens upon an aging, changing nation J. Clin. Oncol. 27 2009 2758 2765
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2758-2765
-
-
Smith, B.D.1
Smith, G.L.2
Hurria, A.3
Hortobagyi, G.N.4
Buchholz, T.A.5
-
119
-
-
77957223906
-
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
-
H.J. Snippert, L.G. van der Flier, T. Sato, J.H. van Es, M. van den Born, C. Kroon-Veenboer, N. Barker, A.M. Klein, J. van Rheenen, B.D. Simons, and H. Clevers Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells Cell 143 2010 134 144
-
(2010)
Cell
, vol.143
, pp. 134-144
-
-
Snippert, H.J.1
Van Der Flier, L.G.2
Sato, T.3
Van Es, J.H.4
Van Den Born, M.5
Kroon-Veenboer, C.6
Barker, N.7
Klein, A.M.8
Van Rheenen, J.9
Simons, B.D.10
Clevers, H.11
-
120
-
-
84894232184
-
Geriatric muscle stem cells switch reversible quiescence into senescence
-
P. Sousa-Victor, S. Gutarra, L. García-Prat, J. Rodriguez-Ubreva, L. Ortet, V. Ruiz-Bonilla, M. Jardí, E. Ballestar, S. González, A.L. Serrano, and et al. Geriatric muscle stem cells switch reversible quiescence into senescence Nature 506 2014 316 321
-
(2014)
Nature
, vol.506
, pp. 316-321
-
-
Sousa-Victor, P.1
Gutarra, S.2
García-Prat, L.3
Rodriguez-Ubreva, J.4
Ortet, L.5
Ruiz-Bonilla, V.6
Jardí, M.7
Ballestar, E.8
González, S.9
Serrano, A.L.10
-
121
-
-
84899768899
-
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal
-
D. Sun, M. Luo, M. Jeong, B. Rodriguez, Z. Xia, R. Hannah, H. Wang, T. Le, K.F. Faull, R. Chen, and et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal Cell Stem Cell 14 2014 673 688
-
(2014)
Cell Stem Cell
, vol.14
, pp. 673-688
-
-
Sun, D.1
Luo, M.2
Jeong, M.3
Rodriguez, B.4
Xia, Z.5
Hannah, R.6
Wang, H.7
Le, T.8
Faull, K.F.9
Chen, R.10
-
122
-
-
84908125658
-
Clonal dynamics of native haematopoiesis
-
J. Sun, A. Ramos, B. Chapman, J.B. Johnnidis, L. Le, Y.J. Ho, A. Klein, O. Hofmann, and F.D. Camargo Clonal dynamics of native haematopoiesis Nature 514 2014 322 327
-
(2014)
Nature
, vol.514
, pp. 322-327
-
-
Sun, J.1
Ramos, A.2
Chapman, B.3
Johnnidis, J.B.4
Le, L.5
Ho, Y.J.6
Klein, A.7
Hofmann, O.8
Camargo, F.D.9
-
123
-
-
54049113081
-
Hematopoiesis is not clonal in healthy elderly women
-
S.I. Swierczek, N. Agarwal, R.H. Nussenzveig, G. Rothstein, A. Wilson, A. Artz, and J.T. Prchal Hematopoiesis is not clonal in healthy elderly women Blood 112 2008 3186 3193
-
(2008)
Blood
, vol.112
, pp. 3186-3193
-
-
Swierczek, S.I.1
Agarwal, N.2
Nussenzveig, R.H.3
Rothstein, G.4
Wilson, A.5
Artz, A.6
Prchal, J.T.7
-
124
-
-
0027421332
-
Comparison of somatic mutation in a transgenic versus host locus
-
K.S. Tao, C. Urlando, and J.A. Heddle Comparison of somatic mutation in a transgenic versus host locus Proc. Natl. Acad. Sci. USA 90 1993 10681 10685
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10681-10685
-
-
Tao, K.S.1
Urlando, C.2
Heddle, J.A.3
-
125
-
-
84924087352
-
Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
-
S. Tao, D. Tang, Y. Morita, T. Sperka, O. Omrani, A. Lechel, V. Sakk, J. Kraus, H.A. Kestler, M. Kühl, and K.L. Rudolph Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage EMBO J. 34 2015 624 640
-
(2015)
EMBO J.
, vol.34
, pp. 624-640
-
-
Tao, S.1
Tang, D.2
Morita, Y.3
Sperka, T.4
Omrani, O.5
Lechel, A.6
Sakk, V.7
Kraus, J.8
Kestler, H.A.9
Kühl, M.10
Rudolph, K.L.11
-
126
-
-
77950650405
-
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
-
A.E. Teschendorff, U. Menon, A. Gentry-Maharaj, S.J. Ramus, D.J. Weisenberger, H. Shen, M. Campan, H. Noushmehr, C.G. Bell, A.P. Maxwell, and et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer Genome Res. 20 2010 440 446
-
(2010)
Genome Res.
, vol.20
, pp. 440-446
-
-
Teschendorff, A.E.1
Menon, U.2
Gentry-Maharaj, A.3
Ramus, S.J.4
Weisenberger, D.J.5
Shen, H.6
Campan, M.7
Noushmehr, H.8
Bell, C.G.9
Maxwell, A.P.10
-
127
-
-
84921288028
-
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions
-
C. Tomasetti, and B. Vogelstein Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions Science 347 2015 78 81
-
(2015)
Science
, vol.347
, pp. 78-81
-
-
Tomasetti, C.1
Vogelstein, B.2
-
128
-
-
84908587479
-
Bone marrow failure and the telomeropathies
-
D.M. Townsley, B. Dumitriu, and N.S. Young Bone marrow failure and the telomeropathies Blood 124 2014 2775 2783
-
(2014)
Blood
, vol.124
, pp. 2775-2783
-
-
Townsley, D.M.1
Dumitriu, B.2
Young, N.S.3
-
129
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
A. Trifunovic, A. Wredenberg, M. Falkenberg, J.N. Spelbrink, A.T. Rovio, C.E. Bruder, M. Bohlooly-Y, S. Gidlöf, A. Oldfors, R. Wibom, and et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase Nature 429 2004 417 423
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly-Y, M.7
Gidlöf, S.8
Oldfors, A.9
Wibom, R.10
-
130
-
-
84874655208
-
Nrf2 regulates haematopoietic stem cell function
-
J.J. Tsai, J.A. Dudakov, K. Takahashi, J.H. Shieh, E. Velardi, A.M. Holland, N.V. Singer, M.L. West, O.M. Smith, L.F. Young, and et al. Nrf2 regulates haematopoietic stem cell function Nat. Cell Biol. 15 2013 309 316
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 309-316
-
-
Tsai, J.J.1
Dudakov, J.A.2
Takahashi, K.3
Shieh, J.H.4
Velardi, E.5
Holland, A.M.6
Singer, N.V.7
West, M.L.8
Smith, O.M.9
Young, L.F.10
-
131
-
-
84864648787
-
Aging of the microenvironment influences clonality in hematopoiesis
-
V. Vas, K. Senger, K. Dörr, A. Niebel, and H. Geiger Aging of the microenvironment influences clonality in hematopoiesis PLoS ONE 7 2012 e42080
-
(2012)
PLoS ONE
, vol.7
, pp. e42080
-
-
Vas, V.1
Senger, K.2
Dörr, K.3
Niebel, A.4
Geiger, H.5
-
132
-
-
0028077099
-
Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
-
H. Vaziri, W. Dragowska, R.C. Allsopp, T.E. Thomas, C.B. Harley, and P.M. Lansdorp Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age Proc. Natl. Acad. Sci. USA 91 1994 9857 9860
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9857-9860
-
-
Vaziri, H.1
Dragowska, W.2
Allsopp, R.C.3
Thomas, T.E.4
Harley, C.B.5
Lansdorp, P.M.6
-
133
-
-
84906218639
-
Senescent cells and their secretory phenotype as targets for cancer therapy
-
M.C. Velarde, M. Demaria, and J. Campisi Senescent cells and their secretory phenotype as targets for cancer therapy Interdiscip. Top. Gerontol. 38 2013 17 27
-
(2013)
Interdiscip. Top. Gerontol.
, vol.38
, pp. 17-27
-
-
Velarde, M.C.1
Demaria, M.2
Campisi, J.3
-
134
-
-
84888019491
-
Defining stem cell dynamics in models of intestinal tumor initiation
-
L. Vermeulen, E. Morrissey, M. van der Heijden, A.M. Nicholson, A. Sottoriva, S. Buczacki, R. Kemp, S. Tavaré, and D.J. Winton Defining stem cell dynamics in models of intestinal tumor initiation Science 342 2013 995 998
-
(2013)
Science
, vol.342
, pp. 995-998
-
-
Vermeulen, L.1
Morrissey, E.2
Van Der Heijden, M.3
Nicholson, A.M.4
Sottoriva, A.5
Buczacki, S.6
Kemp, R.7
Tavaré, S.8
Winton, D.J.9
-
135
-
-
13944282126
-
Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells
-
C.R. Walkley, M.L. Fero, W.M. Chien, L.E. Purton, and G.A. McArthur Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells Nat. Cell Biol. 7 2005 172 178
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 172-178
-
-
Walkley, C.R.1
Fero, M.L.2
Chien, W.M.3
Purton, L.E.4
McArthur, G.A.5
-
136
-
-
84928569602
-
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
-
D. Walter, A. Lier, A. Geiselhart, F.B. Thalheimer, S. Huntscha, M.C. Sobotta, B. Moehrle, D. Brocks, I. Bayindir, P. Kaschutnig, and et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells Nature 520 2015 549 552
-
(2015)
Nature
, vol.520
, pp. 549-552
-
-
Walter, D.1
Lier, A.2
Geiselhart, A.3
Thalheimer, F.B.4
Huntscha, S.5
Sobotta, M.C.6
Moehrle, B.7
Brocks, D.8
Bayindir, I.9
Kaschutnig, P.10
-
137
-
-
84863229585
-
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
-
J. Wang, Q. Sun, Y. Morita, H. Jiang, A. Gross, A. Lechel, K. Hildner, L.M. Guachalla, A. Gompf, D. Hartmann, and et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage Cell 148 2012 1001 1014
-
(2012)
Cell
, vol.148
, pp. 1001-1014
-
-
Wang, J.1
Sun, Q.2
Morita, Y.3
Jiang, H.4
Gross, A.5
Lechel, A.6
Hildner, K.7
Guachalla, L.M.8
Gompf, A.9
Hartmann, D.10
-
138
-
-
84911397097
-
Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres
-
J. Wang, X. Lu, V. Sakk, C.A. Klein, and K.L. Rudolph Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres Blood 124 2014 3237 3240
-
(2014)
Blood
, vol.124
, pp. 3237-3240
-
-
Wang, J.1
Lu, X.2
Sakk, V.3
Klein, C.A.4
Rudolph, K.L.5
-
139
-
-
84874192375
-
FOXO3A directs a protective autophagy program in haematopoietic stem cells
-
M.R. Warr, M. Binnewies, J. Flach, D. Reynaud, T. Garg, R. Malhotra, J. Debnath, and E. Passegué FOXO3A directs a protective autophagy program in haematopoietic stem cells Nature 494 2013 323 327
-
(2013)
Nature
, vol.494
, pp. 323-327
-
-
Warr, M.R.1
Binnewies, M.2
Flach, J.3
Reynaud, D.4
Garg, T.5
Malhotra, R.6
Debnath, J.7
Passegué, E.8
-
140
-
-
84896718645
-
Aging of blood can be tracked by DNA methylation changes at just three CpG sites
-
C.I. Weidner, Q. Lin, C.M. Koch, L. Eisele, F. Beier, P. Ziegler, D.O. Bauerschlag, K.H. Jöckel, R. Erbel, T.W. Mühleisen, and et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites Genome Biol. 15 2014 R24
-
(2014)
Genome Biol.
, vol.15
, pp. R24
-
-
Weidner, C.I.1
Lin, Q.2
Koch, C.M.3
Eisele, L.4
Beier, F.5
Ziegler, P.6
Bauerschlag, D.O.7
Jöckel, K.H.8
Erbel, R.9
Mühleisen, T.W.10
-
141
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
M. Widschwendter, H. Fiegl, D. Egle, E. Mueller-Holzner, G. Spizzo, C. Marth, D.J. Weisenberger, M. Campan, J. Young, I. Jacobs, and P.W. Laird Epigenetic stem cell signature in cancer Nat. Genet. 39 2007 157 158
-
(2007)
Nat. Genet.
, vol.39
, pp. 157-158
-
-
Widschwendter, M.1
Fiegl, H.2
Egle, D.3
Mueller-Holzner, E.4
Spizzo, G.5
Marth, C.6
Weisenberger, D.J.7
Campan, M.8
Young, J.9
Jacobs, I.10
Laird, P.W.11
-
142
-
-
52949122885
-
FOXO3A genotype is strongly associated with human longevity
-
B.J. Willcox, T.A. Donlon, Q. He, R. Chen, J.S. Grove, K. Yano, K.H. Masaki, D.C. Willcox, B. Rodriguez, and J.D. Curb FOXO3A genotype is strongly associated with human longevity Proc. Natl. Acad. Sci. USA 105 2008 13987 13992
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13987-13992
-
-
Willcox, B.J.1
Donlon, T.A.2
He, Q.3
Chen, R.4
Grove, J.S.5
Yano, K.6
Masaki, K.H.7
Willcox, D.C.8
Rodriguez, B.9
Curb, J.D.10
-
143
-
-
0000055057
-
Pleiotropy, natural selection and the evolution of senescence
-
G.C. Williams Pleiotropy, natural selection and the evolution of senescence Evolution 11 1957 398 411
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
144
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
A. Wilson, E. Laurenti, G. Oser, R.C. van der Wath, W. Blanco-Bose, M. Jaworski, S. Offner, C.F. Dunant, L. Eshkind, E. Bockamp, and et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Cell 135 2008 1118 1129
-
(2008)
Cell
, vol.135
, pp. 1118-1129
-
-
Wilson, A.1
Laurenti, E.2
Oser, G.3
Van Der Wath, R.C.4
Blanco-Bose, W.5
Jaworski, M.6
Offner, S.7
Dunant, C.F.8
Eshkind, L.9
Bockamp, E.10
-
145
-
-
0023894101
-
A clonal marker induced by mutation in mouse intestinal epithelium
-
D.J. Winton, M.A. Blount, and B.A. Ponder A clonal marker induced by mutation in mouse intestinal epithelium Nature 333 1988 463 466
-
(1988)
Nature
, vol.333
, pp. 463-466
-
-
Winton, D.J.1
Blount, M.A.2
Ponder, B.A.3
-
146
-
-
84930003179
-
Age-related mutations associated with clonal hematopoietic expansion and malignancies
-
M. Xie, C. Lu, J. Wang, M.D. McLellan, K.J. Johnson, M.C. Wendl, J.F. McMichael, H.K. Schmidt, V. Yellapantula, C.A. Miller, and et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies Nat. Med. 20 2014 1472 1478
-
(2014)
Nat. Med.
, vol.20
, pp. 1472-1478
-
-
Xie, M.1
Lu, C.2
Wang, J.3
McLellan, M.D.4
Johnson, K.J.5
Wendl, M.C.6
McMichael, J.F.7
Schmidt, H.K.8
Yellapantula, V.9
Miller, C.A.10
-
147
-
-
30744467177
-
Population aging and cancer: A cross-national concern
-
R. Yancik Population aging and cancer: a cross-national concern Cancer J. 11 2005 437 441
-
(2005)
Cancer J.
, vol.11
, pp. 437-441
-
-
Yancik, R.1
-
148
-
-
84876482887
-
C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence
-
M. Ye, H. Zhang, G. Amabile, H. Yang, P.B. Staber, P. Zhang, E. Levantini, M. Alberich-Jordà, J. Zhang, A. Kawasaki, and D.G. Tenen C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence Nat. Cell Biol. 15 2013 385 394
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 385-394
-
-
Ye, M.1
Zhang, H.2
Amabile, G.3
Yang, H.4
Staber, P.B.5
Zhang, P.6
Levantini, E.7
Alberich-Jordà, M.8
Zhang, J.9
Kawasaki, A.10
Tenen, D.G.11
-
149
-
-
84862994618
-
MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
-
O.H. Yilmaz, P. Katajisto, D.W. Lamming, Y. Gültekin, K.E. Bauer-Rowe, S. Sengupta, K. Birsoy, A. Dursun, V.O. Yilmaz, M. Selig, and et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake Nature 486 2012 490 495
-
(2012)
Nature
, vol.486
, pp. 490-495
-
-
Yilmaz, O.H.1
Katajisto, P.2
Lamming, D.W.3
Gültekin, Y.4
Bauer-Rowe, K.E.5
Sengupta, S.6
Birsoy, K.7
Dursun, A.8
Yilmaz, V.O.9
Selig, M.10
|