Intestinal stem cell replacement follows a pattern of neutral drift

Science

Volumn 330, Issue 6005, 2010, Pages 822-825

  Lopez Garcia, Carlos ^a   Klein, Allon M ^b,c   Simons, Benjamin D ^c   Winton, Douglas J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; GENETIC ANALYSIS; GENETIC ENGINEERING; REGENERATION;

ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL RENEWAL; CLONING; CONTROLLED STUDY; GENETIC DRIFT; HOMEOSTASIS; INTESTINE EPITHELIUM; PHYSICS; POPULATION DYNAMICS; PRIORITY JOURNAL; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; CLONE CELLS; COLON; HOMEOSTASIS; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE; STEM CELLS;

EID: 77958485383     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1196236     Document Type: Article

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24. We thank H. Zecchini and R. Kemp at Cancer Research UK, Cambridge Research Institute (CRI), and the CRI Biological Resource Unit and Histopathology Core. This work was supported by Cancer Research UK (D.J.W.), Seneca Foundation (Region de Murcia, Spain) (C.L.-G.), the Engineering and Physical Sciences Research Council fellowship EP/F043325/1 (A.M.K.), and the Engineering and Physical Sciences Research Council Programme grant EP/F032773/1 (B.D.S.). A patent application on drug and toxicity testing has been submitted.