-
1
-
-
48449087282
-
The contributions of Paul Ehrlich to pharmacology: A tribute on the occasion of the centenary of his Nobel Prize
-
F. Bosch, and L. Rosich The contributions of Paul Ehrlich to pharmacology: a tribute on the occasion of the centenary of his Nobel Prize Pharmacology 82 2008 171 179
-
(2008)
Pharmacology
, vol.82
, pp. 171-179
-
-
Bosch, F.1
Rosich, L.2
-
2
-
-
2942564021
-
Pursuing the leadlikeness concept in pharmaceutical research
-
M.M. Hann, and T.I. Oprea Pursuing the leadlikeness concept in pharmaceutical research Curr. Opin. Chem. Biol. 8 2004 255 263
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 255-263
-
-
Hann, M.M.1
Oprea, T.I.2
-
3
-
-
79951967029
-
Principles of early drug discovery
-
J.P. Hughes, and et al. Principles of early drug discovery Br. J. Pharmacol. 162 2011 1239 1249
-
(2011)
Br. J. Pharmacol.
, vol.162
, pp. 1239-1249
-
-
Hughes, J.P.1
-
4
-
-
77952536073
-
Recent pa-tent applications in high-throughput drug screening
-
N.A. Listed Recent pa-tent applications in high-throughput drug screening Nat. Biotechnol. 28 2010 329
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 329
-
-
Listed, N.A.1
-
5
-
-
61849148824
-
Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?
-
H.F. Ji, and et al. Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep. 10 2009 194 200
-
(2009)
EMBO Rep.
, vol.10
, pp. 194-200
-
-
Ji, H.F.1
-
6
-
-
0018847617
-
Classics in infectious diseases: On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. Influenzae by Alexander Fleming, Reprinted from the British Journal of Experimental Pathology 10:226-236, 1929
-
A. Fleming Classics in infectious diseases: on the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae by Alexander Fleming, Reprinted from the British Journal of Experimental Pathology 10:226-236, 1929 Rev. Infect. Dis. 2 1980 129 139
-
(1980)
Rev. Infect. Dis.
, vol.2
, pp. 129-139
-
-
Fleming, A.1
-
7
-
-
69249217897
-
Polyphenols in the prevention and treatment of sepsis syndromes: Rationale and pre-clinical evidence
-
H. Shapiro, and et al. Polyphenols in the prevention and treatment of sepsis syndromes: rationale and pre-clinical evidence Nutrition 25 2009 981 997
-
(2009)
Nutrition
, vol.25
, pp. 981-997
-
-
Shapiro, H.1
-
8
-
-
78049438719
-
Fruit polyphenols, immunity and inflammation
-
J. Gonzalez-Gallego, and et al. Fruit polyphenols, immunity and inflammation Br. J. Nutr. 104 Suppl. 3 2010 S15 S27
-
(2010)
Br. J. Nutr.
, vol.104
, pp. S15-S27
-
-
Gonzalez-Gallego, J.1
-
9
-
-
84879922413
-
Modulation of immune function by polyphenols: Possible contribution of epigenetic factors
-
A. Cuevas, and et al. Modulation of immune function by polyphenols: possible contribution of epigenetic factors Nutrients 5 2013 2314 2332
-
(2013)
Nutrients
, vol.5
, pp. 2314-2332
-
-
Cuevas, A.1
-
10
-
-
19944390217
-
Xenobiotics and the evolution of multicellular animals: Emergence and diversification of ligand-activated transcription factors
-
M.E. Baker Xenobiotics and the evolution of multicellular animals: emergence and diversification of ligand-activated transcription factors Integr. Comp. Biol. 45 2005 172 178
-
(2005)
Integr. Comp. Biol.
, vol.45
, pp. 172-178
-
-
Baker, M.E.1
-
11
-
-
0016265996
-
Variability in response to drugs
-
M.D. Rawlins Variability in response to drugs Br. Med. J. 4 1974 91 94
-
(1974)
Br. Med. J.
, vol.4
, pp. 91-94
-
-
Rawlins, M.D.1
-
12
-
-
79955768389
-
Pharmacogenetics, pharmacogenomics, and individualized medicine
-
Q. Ma, and A.Y. Lu Pharmacogenetics, pharmacogenomics, and individualized medicine Pharmacol. Rev. 63 2011 437 459
-
(2011)
Pharmacol. Rev.
, vol.63
, pp. 437-459
-
-
Ma, Q.1
Lu, A.Y.2
-
13
-
-
33744528341
-
Pharmacovigilance in a genomic era
-
P. Farahani, and M. Levine Pharmacovigilance in a genomic era Pharmacogenomics J. 6 2006 158 161
-
(2006)
Pharmacogenomics J.
, vol.6
, pp. 158-161
-
-
Farahani, P.1
Levine, M.2
-
14
-
-
4544321119
-
Cutting the cost of drug development?
-
M.D. Rawlins Cutting the cost of drug development? Nat. Rev. Drug Discov. 3 2004 360 364
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 360-364
-
-
Rawlins, M.D.1
-
15
-
-
53249132632
-
Balancing early market access to new drugs with the need for benefit/risk data: A mounting dilemma
-
H.G. Eichler, and et al. Balancing early market access to new drugs with the need for benefit/risk data: a mounting dilemma Nat. Rev. Drug Discov. 7 2008 818 826
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 818-826
-
-
Eichler, H.G.1
-
16
-
-
38349090575
-
The state of innovation in drug development
-
I. Kola The state of innovation in drug development Clin. Pharmacol. Ther. 83 2008 227 230
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 227-230
-
-
Kola, I.1
-
17
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
M.J. Keiser, and et al. Predicting new molecular targets for known drugs Nature 462 2009 175 181
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
-
18
-
-
0027172047
-
Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer
-
V.C. Jordan Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer Br. J. Pharmacol. 110 1993 507 517
-
(1993)
Br. J. Pharmacol.
, vol.110
, pp. 507-517
-
-
Jordan, V.C.1
-
19
-
-
84893926524
-
Tamoxifen use for the management of mania: A review of current preclinical evidence
-
F. Armani, and et al. Tamoxifen use for the management of mania: a review of current preclinical evidence Psychopharmacology 231 2014 639 649
-
(2014)
Psychopharmacology
, vol.231
, pp. 639-649
-
-
Armani, F.1
-
20
-
-
84863085673
-
Multi-target drugs: The trend of drug research and development
-
J.J. Lu, and et al. Multi-target drugs: the trend of drug research and development PLoS ONE 7 2012 e40262
-
(2012)
PLoS ONE
, vol.7
, pp. e40262
-
-
Lu, J.J.1
-
21
-
-
41549108420
-
From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage
-
A. Petrelli, and S. Giordano From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage Curr. Med. Chem. 15 2008 422 432
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 422-432
-
-
Petrelli, A.1
Giordano, S.2
-
22
-
-
84893494195
-
From single target to multitarget/network therapeutics in Alzheimer's therapy
-
H. Zheng, and et al. From single target to multitarget/network therapeutics in Alzheimer's therapy Pharmaceuticals (Basel) 7 2014 113 135
-
(2014)
Pharmaceuticals (Basel)
, vol.7
, pp. 113-135
-
-
Zheng, H.1
-
23
-
-
33845762340
-
Multi-target therapeutics: When the whole is greater than the sum of the parts
-
G.R. Zimmermann, and et al. Multi-target therapeutics: when the whole is greater than the sum of the parts Drug Discov. Today 12 2007 34 42
-
(2007)
Drug Discov. Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
-
24
-
-
15044349115
-
The efficiency of multi-target drugs: The network approach might help drug design
-
P. Csermely, and et al. The efficiency of multi-target drugs: the network approach might help drug design Trends Pharmacol. Sci. 26 2005 178 182
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, pp. 178-182
-
-
Csermely, P.1
-
25
-
-
84938683124
-
Clinical trial success rates of anti-obesity agents: The importance of combination therapies
-
H.T. Hussain, and et al. Clinical trial success rates of anti-obesity agents: the importance of combination therapies Obes. Rev. 16 2015 707 714
-
(2015)
Obes. Rev.
, vol.16
, pp. 707-714
-
-
Hussain, H.T.1
-
26
-
-
84982995031
-
Aace/Ace comprehensive diabetes management algorithm 2015
-
A.J. Garber, and et al. Aace/Ace comprehensive diabetes management algorithm 2015 Endocr. Pract. 21 2015 438 447
-
(2015)
Endocr. Pract.
, vol.21
, pp. 438-447
-
-
Garber, A.J.1
-
27
-
-
0037898667
-
Treatment of hypertension in adults with diabetes
-
C. Arauz-Pacheco, and et al. Treatment of hypertension in adults with diabetes Diabetes Care 26 Suppl. 1 2003 S80 S82
-
(2003)
Diabetes Care
, vol.26
, pp. S80-S82
-
-
Arauz-Pacheco, C.1
-
28
-
-
66749130805
-
Managing diabetic dyslipidemia: Aggressive approach
-
K.A. Spratt Managing diabetic dyslipidemia: aggressive approach J. Am. Osteopath. Assoc. 109 2009 S2 S7
-
(2009)
J. Am. Osteopath. Assoc.
, vol.109
, pp. S2-S7
-
-
Spratt, K.A.1
-
29
-
-
84858785688
-
Antibody therapy of cancer
-
A.M. Scott, and et al. Antibody therapy of cancer Nat. Rev. Cancer 12 2012 278 287
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 278-287
-
-
Scott, A.M.1
-
30
-
-
84858760109
-
Combining immunotherapy and targeted therapies in cancer treatment
-
M. Vanneman, and G. Dranoff Combining immunotherapy and targeted therapies in cancer treatment Nat. Rev. Cancer 12 2012 237 251
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 237-251
-
-
Vanneman, M.1
Dranoff, G.2
-
32
-
-
84884595281
-
The background, discovery and clinical development of BCR-ABL inhibitors
-
G.K. Lambert, and et al. The background, discovery and clinical development of BCR-ABL inhibitors Drug Discov. Today 18 2013 992 1000
-
(2013)
Drug Discov. Today
, vol.18
, pp. 992-1000
-
-
Lambert, G.K.1
-
33
-
-
84906085263
-
Editorial: Signalling pathways in anti-cancer drug resistance
-
C. Chen, and et al. Editorial: Signalling pathways in anti-cancer drug resistance Curr. Med. Chem. 21 2014 3007 3008
-
(2014)
Curr. Med. Chem.
, vol.21
, pp. 3007-3008
-
-
Chen, C.1
-
34
-
-
4644271084
-
Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
-
B.L. Roth, and et al. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia Nat. Rev. Drug Discov. 3 2004 353 359
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 353-359
-
-
Roth, B.L.1
-
35
-
-
84893266738
-
Combination therapy: The propitious rationale for drug development
-
N. Phougat, and et al. Combination therapy: the propitious rationale for drug development Comb. Chem. High Throughput Screen. 17 2014 53 67
-
(2014)
Comb. Chem. High Throughput Screen.
, vol.17
, pp. 53-67
-
-
Phougat, N.1
-
36
-
-
84886412875
-
Intellectual property rights: An overview and implications in pharmaceutical industry
-
C.N. Saha, and S. Bhattacharya Intellectual property rights: an overview and implications in pharmaceutical industry J. Adv. Pharm. Technol. Res. 2 2011 88 93
-
(2011)
J. Adv. Pharm. Technol. Res.
, vol.2
, pp. 88-93
-
-
Saha, C.N.1
Bhattacharya, S.2
-
37
-
-
80051954603
-
Opportunities and challenges in the development of experimental drug combinations for cancer
-
R.W. Humphrey, and et al. Opportunities and challenges in the development of experimental drug combinations for cancer J. Natl. Cancer Inst. 103 2011 1222 1226
-
(2011)
J. Natl. Cancer Inst.
, vol.103
, pp. 1222-1226
-
-
Humphrey, R.W.1
-
38
-
-
84891517325
-
Longer exclusivity sought for fixed-dose drug combinations
-
E. Dolgin Longer exclusivity sought for fixed-dose drug combinations Nat. Med. 19 2013 1075
-
(2013)
Nat. Med.
, vol.19
, pp. 1075
-
-
Dolgin, E.1
-
39
-
-
79952779822
-
Development of novel combination therapies
-
J. Woodcock, and et al. Development of novel combination therapies N. Engl. J. Med. 364 2011 985 987
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 985-987
-
-
Woodcock, J.1
-
41
-
-
37549040575
-
The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
-
G.L. Verdine, and L.D. Walensky The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members Clin. Cancer Res. 13 2007 7264 7270
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7264-7270
-
-
Verdine, G.L.1
Walensky, L.D.2
-
42
-
-
84897463745
-
Spatio-temporal simulation of first pass drug perfusion in the liver
-
L.O. Schwen, and et al. Spatio-temporal simulation of first pass drug perfusion in the liver PLoS Comput. Biol. 10 2014 e1003499
-
(2014)
PLoS Comput. Biol.
, vol.10
, pp. e1003499
-
-
Schwen, L.O.1
-
43
-
-
80052841941
-
A systems approach for tumor pharmacokinetics
-
G.M. Thurber, and R. Weissleder A systems approach for tumor pharmacokinetics PLoS ONE 6 2011 e24696
-
(2011)
PLoS ONE
, vol.6
, pp. e24696
-
-
Thurber, G.M.1
Weissleder, R.2
-
44
-
-
36348946976
-
Functional selectivity through protean and biased agonism: Who steers the ship?
-
T. Kenakin Functional selectivity through protean and biased agonism: who steers the ship? Mol. Pharmacol. 72 2007 1393 1401
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 1393-1401
-
-
Kenakin, T.1
-
45
-
-
78751498756
-
Functional selectivity and biased receptor signaling
-
T. Kenakin Functional selectivity and biased receptor signaling J. Pharmacol. Exp. Ther. 336 2011 296 302
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.336
, pp. 296-302
-
-
Kenakin, T.1
-
46
-
-
84860163107
-
Anti-obesity drugs: A review about their effects and their safety
-
G. Derosa, and P. Maffioli Anti-obesity drugs: a review about their effects and their safety Expert Opin. Drug Saf. 11 2012 459 471
-
(2012)
Expert Opin. Drug Saf.
, vol.11
, pp. 459-471
-
-
Derosa, G.1
Maffioli, P.2
-
47
-
-
12744258029
-
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
-
R.G. Pertwee Inverse agonism and neutral antagonism at cannabinoid CB1 receptors Life Sci. 76 2005 1307 1324
-
(2005)
Life Sci.
, vol.76
, pp. 1307-1324
-
-
Pertwee, R.G.1
-
48
-
-
47549095647
-
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis
-
M.A. Steiner, and C.T. Wotjak Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis Prog. Brain Res. 170 2008 397 432
-
(2008)
Prog. Brain Res.
, vol.170
, pp. 397-432
-
-
Steiner, M.A.1
Wotjak, C.T.2
-
49
-
-
84922741113
-
Stress regulates endocannabinoid-CB1 receptor signaling
-
C.J. Hillard Stress regulates endocannabinoid-CB1 receptor signaling Semin. Immunol. 26 2014 380 388
-
(2014)
Semin. Immunol.
, vol.26
, pp. 380-388
-
-
Hillard, C.J.1
-
50
-
-
84881368891
-
Peripherally restricted CB1 receptor blockers
-
R.J. Chorvat Peripherally restricted CB1 receptor blockers Bioorg. Med. Chem. Lett. 23 2013 4751 4760
-
(2013)
Bioorg. Med. Chem. Lett.
, vol.23
, pp. 4751-4760
-
-
Chorvat, R.J.1
-
51
-
-
65649122618
-
Cannabinoid receptor antagonists: Pharmacological opportunities, clinical experience, and translational prognosis
-
D.R. Janero, and A. Makriyannis Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis Expert Opin. Emerg. Drugs 14 2009 43 65
-
(2009)
Expert Opin. Emerg. Drugs
, vol.14
, pp. 43-65
-
-
Janero, D.R.1
Makriyannis, A.2
-
52
-
-
1642283136
-
Dopamine partial agonists: A new class of antipsychotic
-
J.A. Lieberman Dopamine partial agonists: a new class of antipsychotic CNS Drugs 18 2004 251 267
-
(2004)
CNS Drugs
, vol.18
, pp. 251-267
-
-
Lieberman, J.A.1
-
53
-
-
84898008848
-
The therapeutic promise of positive allosteric modulation of nicotinic receptors
-
V.V. Uteshev The therapeutic promise of positive allosteric modulation of nicotinic receptors Eur. J. Pharmacol. 727 2014 181 185
-
(2014)
Eur. J. Pharmacol.
, vol.727
, pp. 181-185
-
-
Uteshev, V.V.1
-
54
-
-
84879514548
-
Discovery of positive allosteric modulators and silent allosteric modulators of the mu-opioid receptor
-
N.T. Burford, and et al. Discovery of positive allosteric modulators and silent allosteric modulators of the mu-opioid receptor Proc. Natl. Acad. Sci. U.S.A. 110 2013 10830 10835
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 10830-10835
-
-
Burford, N.T.1
-
55
-
-
2642632786
-
Arrhythmia, heart rate variability, and antiepileptic drugs
-
T. Tomson, and G. Kenneback Arrhythmia, heart rate variability, and antiepileptic drugs Epilepsia 38 1997 S48 S51
-
(1997)
Epilepsia
, vol.38
, pp. S48-S51
-
-
Tomson, T.1
Kenneback, G.2
-
56
-
-
84867491632
-
Clinical pharmacology of non-steroidal anti-inflammatory drugs: A review
-
S. Bacchi, and et al. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review Antiinflamm. Antiallergy Agents Med. Chem. 11 2012 52 64
-
(2012)
Antiinflamm. Antiallergy Agents Med. Chem.
, vol.11
, pp. 52-64
-
-
Bacchi, S.1
-
57
-
-
0037364161
-
The development of COX2 inhibitors
-
R.J. Flower The development of COX2 inhibitors Nat. Rev. Drug Discov. 2 2003 179 191
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 179-191
-
-
Flower, R.J.1
-
58
-
-
77953506537
-
Progress in COX-2 inhibitors: A journey so far
-
A.K. Chakraborti, and et al. Progress in COX-2 inhibitors: a journey so far Curr. Med. Chem. 17 2010 1563 1593
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 1563-1593
-
-
Chakraborti, A.K.1
-
59
-
-
0034952428
-
Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: Randomized placebo-controlled, double blind clinical trial
-
B. Schmid, and et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial Phytother. Res. 15 2001 344 350
-
(2001)
Phytother. Res.
, vol.15
, pp. 344-350
-
-
Schmid, B.1
-
60
-
-
79953826032
-
® (tetrahydrocannabinol + cannabidiol), an endocannabinoid system modulator: Basic features and main clinical data
-
® (tetrahydrocannabinol + cannabidiol), an endocannabinoid system modulator: basic features and main clinical data Expert Rev. Neurother. 11 2011 15 19
-
(2011)
Expert Rev. Neurother.
, vol.11
, pp. 15-19
-
-
Vermersch, P.1
-
61
-
-
33645786113
-
Human studies of cannabinoids and medicinal cannabis
-
R. Pertwee, Springer
-
P. Robson Human studies of cannabinoids and medicinal cannabis R. Pertwee, Cannabinoids 2005 Springer 719 756
-
(2005)
Cannabinoids
, pp. 719-756
-
-
Robson, P.1
-
62
-
-
84872256489
-
Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?
-
J. Fernandez-Ruiz, and et al. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Br. J. Clin. Pharmacol. 75 2013 323 333
-
(2013)
Br. J. Clin. Pharmacol.
, vol.75
, pp. 323-333
-
-
Fernandez-Ruiz, J.1
-
63
-
-
0015817954
-
Pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol
-
I.G. Karniol, and E.A. Carlini Pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol Psychopharmacologia 33 1973 53 70
-
(1973)
Psychopharmacologia
, vol.33
, pp. 53-70
-
-
Karniol, I.G.1
Carlini, E.A.2
-
64
-
-
0016210392
-
Cannabidiol interferes with the effects of delta 9-tetrahydrocannabinol in man
-
I.G. Karniol, and et al. Cannabidiol interferes with the effects of delta 9-tetrahydrocannabinol in man Eur. J. Pharmacol. 28 1974 172 177
-
(1974)
Eur. J. Pharmacol.
, vol.28
, pp. 172-177
-
-
Karniol, I.G.1
-
65
-
-
84857791339
-
The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis
-
D. Baker, and et al. The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis Mult. Scler. Relat. Disord. 1 2012 64 75
-
(2012)
Mult. Scler. Relat. Disord.
, vol.1
, pp. 64-75
-
-
Baker, D.1
-
66
-
-
84865780020
-
Spasticity mechanisms - For the clinician
-
A. Mukherjee, and A. Chakravarty Spasticity mechanisms - for the clinician Front. Neurol. 1 2010 149
-
(2010)
Front. Neurol.
, vol.1
, pp. 149
-
-
Mukherjee, A.1
Chakravarty, A.2
-
67
-
-
77953200017
-
Clinical assessment and management of spasticity: A review
-
T. Rekand Clinical assessment and management of spasticity: a review Acta Neurol. Scand. 122 Suppl. 190 2010 62 66
-
(2010)
Acta Neurol. Scand.
, vol.122
, pp. 62-66
-
-
Rekand, T.1
-
68
-
-
78650641401
-
Endocannabinoid signaling in the brain: Biosynthetic mechanisms in the limelight
-
V. Di Marzo Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight Nat. Neurosci. 14 2011 9 15
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 9-15
-
-
Di Marzo, V.1
-
69
-
-
0034594905
-
Cannabinoids control spasticity and tremor in a multiple sclerosis model
-
D. Baker, and et al. Cannabinoids control spasticity and tremor in a multiple sclerosis model Nature 404 2000 84 87
-
(2000)
Nature
, vol.404
, pp. 84-87
-
-
Baker, D.1
-
70
-
-
1642505613
-
In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake
-
E. de Lago, and et al. In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake Eur. J. Pharmacol. 484 2004 249 257
-
(2004)
Eur. J. Pharmacol.
, vol.484
, pp. 249-257
-
-
De Lago, E.1
-
71
-
-
30344432108
-
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
-
A. Ligresti, and et al. New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis Br. J. Pharmacol. 147 2006 83 91
-
(2006)
Br. J. Pharmacol.
, vol.147
, pp. 83-91
-
-
Ligresti, A.1
-
72
-
-
84888622971
-
Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors
-
G. Pryce, and et al. Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors Mult. Scler. 19 2013 1896 1904
-
(2013)
Mult. Scler.
, vol.19
, pp. 1896-1904
-
-
Pryce, G.1
-
73
-
-
0035256557
-
Endocannabinoids control spasticity in a multiple sclerosis model
-
D. Baker, and et al. Endocannabinoids control spasticity in a multiple sclerosis model FASEB J. 15 2001 300 302
-
(2001)
FASEB J.
, vol.15
, pp. 300-302
-
-
Baker, D.1
-
74
-
-
0034751335
-
Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
-
T. Bisogno, and et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide Br. J. Pharmacol. 134 2001 845 852
-
(2001)
Br. J. Pharmacol.
, vol.134
, pp. 845-852
-
-
Bisogno, T.1
-
75
-
-
59549106886
-
The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
-
J. Ahrens, and et al. The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function Pharmacology 83 2009 217 222
-
(2009)
Pharmacology
, vol.83
, pp. 217-222
-
-
Ahrens, J.1
-
76
-
-
1642313742
-
Anandamide enhances extracellular levels of adenosine and induces sleep: An in vivo microdialysis study
-
E. Murillo-Rodriguez, and et al. Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study Sleep 26 2003 943 947
-
(2003)
Sleep
, vol.26
, pp. 943-947
-
-
Murillo-Rodriguez, E.1
-
77
-
-
84912567630
-
Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: Potential for the treatment of neuronal hyperexcitability
-
F.A. Iannotti, and et al. Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability ACS Chem. Neurosci. 5 2014 1131 1141
-
(2014)
ACS Chem. Neurosci.
, vol.5
, pp. 1131-1141
-
-
Iannotti, F.A.1
-
78
-
-
38649131504
-
Why endocannabinoids are not all alike
-
V. Di Marzo, and L. Cristino Why endocannabinoids are not all alike Nat. Neurosci. 11 2008 124 126
-
(2008)
Nat. Neurosci.
, vol.11
, pp. 124-126
-
-
Di Marzo, V.1
Cristino, L.2
-
79
-
-
84892488774
-
Evaluation of the effects of Sativex (THC BDS: CBD BDS) on inhibition of spasticity in a chronic relapsing experimental allergic autoimmune encephalomyelitis: A model of multiple sclerosis
-
A. Hilliard, and et al. Evaluation of the effects of Sativex (THC BDS: CBD BDS) on inhibition of spasticity in a chronic relapsing experimental allergic autoimmune encephalomyelitis: a model of multiple sclerosis ISRN Neurol. 2012 2012 802649
-
(2012)
ISRN Neurol.
, vol.2012
, pp. 802649
-
-
Hilliard, A.1
-
80
-
-
84937141345
-
Sativex in the management of multiple sclerosis-related spasticity: Role of the corticospinal modulation
-
M. Russo, and et al. Sativex in the management of multiple sclerosis-related spasticity: role of the corticospinal modulation Neural Plast. 2015 2015 656582
-
(2015)
Neural Plast.
, vol.2015
, pp. 656582
-
-
Russo, M.1
-
81
-
-
84876488583
-
A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis
-
R.M. Langford, and et al. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis J. Neurol. 260 2013 984 997
-
(2013)
J. Neurol.
, vol.260
, pp. 984-997
-
-
Langford, R.M.1
-
82
-
-
36849070991
-
Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial
-
D.J. Rog, and et al. Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial Clin. Ther. 29 2007 2068 2079
-
(2007)
Clin. Ther.
, vol.29
, pp. 2068-2079
-
-
Rog, D.J.1
-
83
-
-
84860660570
-
Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: A randomized, placebo-controlled, graded-dose trial
-
R.K. Portenoy, and et al. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial J. Pain 13 2012 438 449
-
(2012)
J. Pain
, vol.13
, pp. 438-449
-
-
Portenoy, R.K.1
-
84
-
-
75949093107
-
Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
-
J.R. Johnson, and et al. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain J. Pain Symptom Manage. 39 2010 167 179
-
(2010)
J. Pain Symptom Manage.
, vol.39
, pp. 167-179
-
-
Johnson, J.R.1
-
85
-
-
84882452814
-
An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics
-
J.R. Johnson, and et al. An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics J. Pain Symptom Manage. 46 2013 207 218
-
(2013)
J. Pain Symptom Manage.
, vol.46
, pp. 207-218
-
-
Johnson, J.R.1
-
86
-
-
77957688293
-
Moving towards supraspinal TRPV1 receptors for chronic pain relief
-
E. Palazzo, and et al. Moving towards supraspinal TRPV1 receptors for chronic pain relief Mol. Pain 6 2010 66
-
(2010)
Mol. Pain
, vol.6
, pp. 66
-
-
Palazzo, E.1
-
87
-
-
84857237101
-
TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception
-
C. Giordano, and et al. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception Cereb. Cortex 22 2012 2495 2518
-
(2012)
Cereb. Cortex
, vol.22
, pp. 2495-2518
-
-
Giordano, C.1
-
88
-
-
3843109109
-
Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee
-
A. Kornbluth, and D.B. Sachar Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee Am. J. Gastroenterol. 99 2004 1371 1385
-
(2004)
Am. J. Gastroenterol.
, vol.99
, pp. 1371-1385
-
-
Kornbluth, A.1
Sachar, D.B.2
-
89
-
-
84914104629
-
Ulcerative colitis: Epidemiology, diagnosis, and management
-
J.D. Feuerstein, and A.S. Cheifetz Ulcerative colitis: epidemiology, diagnosis, and management Mayo Clin. Proc. 89 2014 1553 1563
-
(2014)
Mayo Clin. Proc.
, vol.89
, pp. 1553-1563
-
-
Feuerstein, J.D.1
Cheifetz, A.S.2
-
90
-
-
0034903792
-
The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study
-
W.A. Faubion Jr, and et al. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study Gastroenterology 121 2001 255 260
-
(2001)
Gastroenterology
, vol.121
, pp. 255-260
-
-
Faubion, W.A.1
-
91
-
-
0031989183
-
The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease
-
R.P. MacDermott, and et al. The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease Inflamm. Bowel Dis. 4 1998 54 67
-
(1998)
Inflamm. Bowel Dis.
, vol.4
, pp. 54-67
-
-
MacDermott, R.P.1
-
92
-
-
84860557456
-
New therapies for inflammatory bowel disease: From the bench to the bedside
-
S. Danese New therapies for inflammatory bowel disease: from the bench to the bedside Gut 61 2012 918 932
-
(2012)
Gut
, vol.61
, pp. 918-932
-
-
Danese, S.1
-
93
-
-
84949524385
-
P414 Cannabidiol for symptomatic treatment of ulcerative colitis: Results from a randomised, double-blind, placebo-controlled, parallel group, multi-centred pilot study
-
ECCO
-
P. Irving, and et al. P414 Cannabidiol for symptomatic treatment of ulcerative colitis: results from a randomised, double-blind, placebo-controlled, parallel group, multi-centred pilot study 10th Congress of the European Crohn's and Colitis Organisation (ECCO) ECCO 2015
-
(2015)
10th Congress of the European Crohn's and Colitis Organisation (ECCO)
-
-
Irving, P.1
-
94
-
-
84856532346
-
A national profile of childhood epilepsy and seizure disorder
-
S. Russ, and et al. A national profile of childhood epilepsy and seizure disorder Pediatrics 129 2012 256 264
-
(2012)
Pediatrics
, vol.129
, pp. 256-264
-
-
Russ, S.1
-
95
-
-
0034598762
-
Early identification of refractory epilepsy
-
P. Kwan, and M.J. Brodie Early identification of refractory epilepsy N. Engl. J. Med. 342 2000 314 319
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 314-319
-
-
Kwan, P.1
Brodie, M.J.2
-
96
-
-
79953726784
-
The core Dravet syndrome phenotype
-
C. Dravet The core Dravet syndrome phenotype Epilepsia 52 Suppl. 2 2011 3 9
-
(2011)
Epilepsia
, vol.52
, pp. 3-9
-
-
Dravet, C.1
-
98
-
-
76749110725
-
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
-
N.A. Jones, and et al. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo J. Pharmacol. Exp. Ther. 332 2010 569 577
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.332
, pp. 569-577
-
-
Jones, N.A.1
-
99
-
-
84860685529
-
Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
-
N.A. Jones, and et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures Seizure 21 2012 344 352
-
(2012)
Seizure
, vol.21
, pp. 344-352
-
-
Jones, N.A.1
-
100
-
-
84887809109
-
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
-
B.E. Porter, and C. Jacobson Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy Epilepsy Behav. 29 2013 574 577
-
(2013)
Epilepsy Behav.
, vol.29
, pp. 574-577
-
-
Porter, B.E.1
Jacobson, C.2
-
101
-
-
70350173587
-
Parental SCN1A mutation mosaicism in familial Dravet syndrome
-
K.K. Selmer, and et al. Parental SCN1A mutation mosaicism in familial Dravet syndrome Clin. Genet. 76 2009 398 403
-
(2009)
Clin. Genet.
, vol.76
, pp. 398-403
-
-
Selmer, K.K.1
-
102
-
-
79955014000
-
Molecular genetics of Dravet syndrome
-
P. De Jonghe Molecular genetics of Dravet syndrome Dev. Med. Child Neurol. 53 Suppl. 2 2011 7 10
-
(2011)
Dev. Med. Child Neurol.
, vol.53
, pp. 7-10
-
-
De Jonghe, P.1
-
104
-
-
0036402177
-
Basic pharmacology of valproate: A review after 35 years of clinical use for the treatment of epilepsy
-
W. Loscher Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy CNS Drugs 16 2002 669 694
-
(2002)
CNS Drugs
, vol.16
, pp. 669-694
-
-
Loscher, W.1
-
105
-
-
3042748137
-
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
-
B.A. Lynch, and et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam Proc. Natl. Acad. Sci. U.S.A. 101 2004 9861 9866
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 9861-9866
-
-
Lynch, B.A.1
-
106
-
-
79960115996
-
Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
-
A. Shrivastava, and et al. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy Mol. Cancer Ther. 10 2011 1161 1172
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1161-1172
-
-
Shrivastava, A.1
-
107
-
-
84881474333
-
Role of the mTOR signaling pathway in epilepsy
-
X.F. Meng, and et al. Role of the mTOR signaling pathway in epilepsy J. Neurol. Sci. 332 2013 4 15
-
(2013)
J. Neurol. Sci.
, vol.332
, pp. 4-15
-
-
Meng, X.F.1
-
108
-
-
84897860455
-
Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se
-
A.J. Hill, and et al. Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se Neurosci. Lett. 566 2014 269 274
-
(2014)
Neurosci. Lett.
, vol.566
, pp. 269-274
-
-
Hill, A.J.1
-
109
-
-
79960328574
-
Effects of cannabinoids and cannabinoid-enriched cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
-
L. De Petrocellis, and et al. Effects of cannabinoids and cannabinoid-enriched cannabis extracts on TRP channels and endocannabinoid metabolic enzymes Br. J. Pharmacol. 163 2011 1479 1494
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 1479-1494
-
-
De Petrocellis, L.1
-
110
-
-
84887007718
-
TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo
-
L.E. Gonzalez-Reyes, and et al. TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo Exp. Neurol. 250 2013 321 332
-
(2013)
Exp. Neurol.
, vol.250
, pp. 321-332
-
-
Gonzalez-Reyes, L.E.1
-
111
-
-
84872004645
-
Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy
-
F.J. Sun, and et al. Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy J. Mol. Neurosci. 49 2013 182 193
-
(2013)
J. Mol. Neurosci.
, vol.49
, pp. 182-193
-
-
Sun, F.J.1
-
112
-
-
84873747457
-
Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb
-
H.F. Shu, and et al. Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb Brain Dev. 35 2013 252 260
-
(2013)
Brain Dev.
, vol.35
, pp. 252-260
-
-
Shu, H.F.1
-
113
-
-
38349158960
-
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
-
R.G. Pertwee The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin Br. J. Pharmacol. 153 2008 199 215
-
(2008)
Br. J. Pharmacol.
, vol.153
, pp. 199-215
-
-
Pertwee, R.G.1
-
114
-
-
50249101147
-
Inhibition of endocannabinoid metabolism attenuates enhanced hippocampal neuronal activity induced by kainic acid
-
B. Coomber, and et al. Inhibition of endocannabinoid metabolism attenuates enhanced hippocampal neuronal activity induced by kainic acid Synapse 62 2008 746 755
-
(2008)
Synapse
, vol.62
, pp. 746-755
-
-
Coomber, B.1
-
115
-
-
0141593557
-
Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide y receptors
-
J.O. Malva, and et al. Presynaptic modulation controlling neuronal excitability and epileptogenesis: role of kainate, adenosine and neuropeptide Y receptors Neurochem. Res. 28 2003 1501 1515
-
(2003)
Neurochem. Res.
, vol.28
, pp. 1501-1515
-
-
Malva, J.O.1
-
116
-
-
77951037192
-
The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes
-
K.H. Yang, and et al. The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes J. Pharmacol. Exp. Ther. 333 2010 547 554
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.333
, pp. 547-554
-
-
Yang, K.H.1
-
117
-
-
46649094780
-
Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
-
A.C. Campos, and F.S. Guimaraes Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats Psychopharmacology 199 2008 223 230
-
(2008)
Psychopharmacology
, vol.199
, pp. 223-230
-
-
Campos, A.C.1
Guimaraes, F.S.2
-
118
-
-
84855464578
-
Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy
-
W.H. Theodore, and et al. Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy Epilepsia 53 2012 129 133
-
(2012)
Epilepsia
, vol.53
, pp. 129-133
-
-
Theodore, W.H.1
-
119
-
-
82655189157
-
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
-
G. Esposito, and et al. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement PLoS ONE 6 2011 e28668
-
(2011)
PLoS ONE
, vol.6
, pp. e28668
-
-
Esposito, G.1
-
120
-
-
0037442829
-
Nonpsychotropic cannabinoid receptors regulate microglial cell migration
-
L. Walter, and et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration J. Neurosci. 23 2003 1398 1405
-
(2003)
J. Neurosci.
, vol.23
, pp. 1398-1405
-
-
Walter, L.1
-
121
-
-
84861610134
-
A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data
-
H. Yu, and et al. A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data PLoS ONE 7 2012 e37608
-
(2012)
PLoS ONE
, vol.7
, pp. e37608
-
-
Yu, H.1
-
122
-
-
33749011163
-
The NCI60 human tumour cell line anticancer drug screen
-
R.H. Shoemaker The NCI60 human tumour cell line anticancer drug screen Nat. Rev. Cancer 6 2006 813 823
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 813-823
-
-
Shoemaker, R.H.1
-
123
-
-
33845876254
-
The Connectivity Map: A new tool for biomedical research
-
J. Lamb The Connectivity Map: a new tool for biomedical research Nat. Rev. Cancer 7 2007 54 60
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 54-60
-
-
Lamb, J.1
-
124
-
-
38549111882
-
Informatics and computational strategies for the study of lipids
-
L. Yetukuri, and et al. Informatics and computational strategies for the study of lipids Mol. Biosyst. 4 2008 121 127
-
(2008)
Mol. Biosyst.
, vol.4
, pp. 121-127
-
-
Yetukuri, L.1
-
125
-
-
66349098682
-
Update of the LIPID MAPS comprehensive classification system for lipids
-
E. Fahy, and et al. Update of the LIPID MAPS comprehensive classification system for lipids J. Lipid Res. 50 Suppl. 2009 S9 S14
-
(2009)
J. Lipid Res.
, vol.50
, pp. S9-S14
-
-
Fahy, E.1
-
126
-
-
84896802719
-
Predicting cooperative drug effects through the quantitative cellular profiling of response to individual drugs
-
J. Zhao, and et al. Predicting cooperative drug effects through the quantitative cellular profiling of response to individual drugs CPT Pharmacometrics Syst. Pharmacol. 3 2014 e102
-
(2014)
CPT Pharmacometrics Syst. Pharmacol.
, vol.3
, pp. e102
-
-
Zhao, J.1
-
127
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
A.A. Borisy, and et al. Systematic discovery of multicomponent therapeutics Proc. Natl. Acad. Sci. U.S.A. 100 2003 7977 7982
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 7977-7982
-
-
Borisy, A.A.1
-
128
-
-
42449099889
-
Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm
-
P.K. Wong, and et al. Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm Proc. Natl. Acad. Sci. U.S.A. 105 2008 5105 5110
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 5105-5110
-
-
Wong, P.K.1
-
129
-
-
76549129820
-
Drug combination studies and their synergy quantification using the Chou-Talalay method
-
T.C. Chou Drug combination studies and their synergy quantification using the Chou-Talalay method Cancer Res. 70 2010 440 446
-
(2010)
Cancer Res.
, vol.70
, pp. 440-446
-
-
Chou, T.C.1
-
130
-
-
51049119630
-
A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores
-
J.C. Boik, and R.A. Newman A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores BMC Pharmacol. 8 2008 13
-
(2008)
BMC Pharmacol.
, vol.8
, pp. 13
-
-
Boik, J.C.1
Newman, R.A.2
-
131
-
-
84875160515
-
Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: Preclinical, clinical and beyond
-
H.A. Barton, and et al. Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond Expert Opin. Drug Metab. Toxicol. 9 2013 459 472
-
(2013)
Expert Opin. Drug Metab. Toxicol.
, vol.9
, pp. 459-472
-
-
Barton, H.A.1
-
132
-
-
84872179153
-
Defining principles of combination drug mechanisms of action
-
J.R. Pritchard, and et al. Defining principles of combination drug mechanisms of action Proc. Natl. Acad. Sci. U.S.A. 110 2013 E170 E179
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. E170-E179
-
-
Pritchard, J.R.1
-
133
-
-
79955953533
-
Use of secondary structure element information in drug design: Polypharmacology and conserved motifs in protein-ligand binding and protein-protein interfaces
-
O. Koch Use of secondary structure element information in drug design: polypharmacology and conserved motifs in protein-ligand binding and protein-protein interfaces Future Med. Chem. 3 2011 699 708
-
(2011)
Future Med. Chem.
, vol.3
, pp. 699-708
-
-
Koch, O.1
-
134
-
-
77956836440
-
A systems biology approach to identify effective cocktail drugs
-
Z. Wu, and et al. A systems biology approach to identify effective cocktail drugs BMC Syst. Biol. 4 Suppl. 2 2010 S7
-
(2010)
BMC Syst. Biol.
, vol.4
, pp. S7
-
-
Wu, Z.1
-
135
-
-
84855272311
-
Prediction of drug combinations by integrating molecular and pharmacological data
-
X.M. Zhao, and et al. Prediction of drug combinations by integrating molecular and pharmacological data PLoS Comput. Biol. 7 2011 e1002323
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. e1002323
-
-
Zhao, X.M.1
-
136
-
-
84893526598
-
An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae
-
S. Li, and et al. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae PLoS ONE 8 2013 e78902
-
(2013)
PLoS ONE
, vol.8
, pp. e78902
-
-
Li, S.1
-
139
-
-
16444373665
-
-
U.S. Department of Health and Human Services, Food and Drug Administration
-
Center for Drug Evaluation and Research Guidance for Industry: Botanical Drug Products 2004 U.S. Department of Health and Human Services, Food and Drug Administration
-
(2004)
Guidance for Industry: Botanical Drug Products
-
-
-
140
-
-
0037278017
-
The inheritance of chemical phenotype in Cannabis sativa L
-
E.P. de Meijer, and et al. The inheritance of chemical phenotype in Cannabis sativa L Genetics 163 2003 335 346
-
(2003)
Genetics
, vol.163
, pp. 335-346
-
-
De Meijer, E.P.1
-
141
-
-
27444441102
-
The inheritance of chemical phenotype in Cannabis sativa L. (II): Cannabigerol predominant plants
-
E.P.M. de Meijer, and K.M. Hammond The inheritance of chemical phenotype in Cannabis sativa L. (II): cannabigerol predominant plants Euphytica 145 2005 189 198
-
(2005)
Euphytica
, vol.145
, pp. 189-198
-
-
De Meijer, E.P.M.1
Hammond, K.M.2
-
142
-
-
56649095906
-
The inheritance of chemical phenotype in Cannabis sativa L. (III): Variation in cannabichromene proportion
-
E.P.M. de Meijer, and et al. The inheritance of chemical phenotype in Cannabis sativa L. (III): variation in cannabichromene proportion Euphytica 165 2009 293 311
-
(2009)
Euphytica
, vol.165
, pp. 293-311
-
-
De Meijer, E.P.M.1
-
143
-
-
67349141443
-
The inheritance of chemical phenotype in Cannabis sativa L. (IV): Cannabinoid-free plants
-
E.P.M. de Meijer, and et al. The inheritance of chemical phenotype in Cannabis sativa L. (IV): cannabinoid-free plants Euphytica 168 2009 95 112
-
(2009)
Euphytica
, vol.168
, pp. 95-112
-
-
De Meijer, E.P.M.1
-
144
-
-
3343009510
-
A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae)
-
K.W. Hillig, and P.G. Mahlberg A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae) Am. J. Bot. 91 2004 966 975
-
(2004)
Am. J. Bot.
, vol.91
, pp. 966-975
-
-
Hillig, K.W.1
Mahlberg, P.G.2
-
145
-
-
70349189518
-
Non-psychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb
-
A.A. Izzo, and et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb Trends Pharmacol. Sci. 30 2009 515 527
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 515-527
-
-
Izzo, A.A.1
-
147
-
-
4544275181
-
The endocannabinoid system and its therapeutic exploitation
-
V. Di Marzo, and et al. The endocannabinoid system and its therapeutic exploitation Nat. Rev. Drug Discov. 3 2004 771 784
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 771-784
-
-
Di Marzo, V.1
-
148
-
-
84920829439
-
Are cannabidiol and Delta(9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system?. A systematic review
-
J.M. McPartland, and et al. Are cannabidiol and Delta(9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system?. A systematic review Br. J. Pharmacol. 172 2015 737 753
-
(2015)
Br. J. Pharmacol.
, vol.172
, pp. 737-753
-
-
McPartland, J.M.1
-
150
-
-
84922693089
-
What we know and do not know about the cannabinoid receptor 2 (CB2)
-
A.M. Malfitano, and et al. What we know and do not know about the cannabinoid receptor 2 (CB2) Semin. Immunol. 26 2014 369 379
-
(2014)
Semin. Immunol.
, vol.26
, pp. 369-379
-
-
Malfitano, A.M.1
-
151
-
-
84874337167
-
Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling
-
M.H. Jantti, and et al. Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling Mol. Pharmacol. 83 2013 621 632
-
(2013)
Mol. Pharmacol.
, vol.83
, pp. 621-632
-
-
Jantti, M.H.1
-
152
-
-
38649114788
-
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
-
W.I. Jeong, and et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver Cell Metab. 7 2008 227 235
-
(2008)
Cell Metab.
, vol.7
, pp. 227-235
-
-
Jeong, W.I.1
-
153
-
-
81155125290
-
The endocannabinoid system: Role in energy regulation
-
T.F. Gamage, and A.H. Lichtman The endocannabinoid system: role in energy regulation Pediatr. Blood Cancer 58 2012 144 148
-
(2012)
Pediatr. Blood Cancer
, vol.58
, pp. 144-148
-
-
Gamage, T.F.1
Lichtman, A.H.2
-
154
-
-
79960336157
-
The endocannabinoid system and cancer: Therapeutic implication
-
J. Guindon, and A.G. Hohmann The endocannabinoid system and cancer: therapeutic implication Br. J. Pharmacol. 163 2011 1447 1463
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 1447-1463
-
-
Guindon, J.1
Hohmann, A.G.2
-
155
-
-
84872156419
-
The endocannabinoid system and the brain
-
R. Mechoulam, and L.A. Parker The endocannabinoid system and the brain Annu. Rev. Psychol. 64 2013 21 47
-
(2013)
Annu. Rev. Psychol.
, vol.64
, pp. 21-47
-
-
Mechoulam, R.1
Parker, L.A.2
-
156
-
-
78650120798
-
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB(1) and CB(2)
-
R.G. Pertwee, and et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB(1) and CB(2) Pharmacol. Rev. 62 2010 588 631
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 588-631
-
-
Pertwee, R.G.1
-
157
-
-
33645102523
-
Localization of equilibrative nucleoside transporters in the rat brain
-
L. Alanko, and et al. Localization of equilibrative nucleoside transporters in the rat brain J. Chem. Neuroanat. 31 2006 162 168
-
(2006)
J. Chem. Neuroanat.
, vol.31
, pp. 162-168
-
-
Alanko, L.1
-
158
-
-
84875726038
-
Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
-
F. Borrelli, and et al. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease Biochem. Pharmacol. 85 2013 1306 1316
-
(2013)
Biochem. Pharmacol.
, vol.85
, pp. 1306-1316
-
-
Borrelli, F.1
|