Peripherally restricted CB1 receptor blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 17, 2013, Pages 4751-4760

  Chorvat, Robert J ^a  

^a Jenrin Discovery   (United States)

Author keywords

AM6545; Cannabinoid receptor blocker; CB1 antagonist; Diabetes; Inverse agonist; JD5037; Liver diseases; Metabolic disorders; Obesity; Peripherally restricted; Rimonabant; Silent antagonist

Indexed keywords

BRAIN RECEPTOR; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; ENDOCANNABINOID; LIPOPROTEIN LIPASE; PLACEBO; RIMONABANT; TARANABANT; TM 38837; UNCLASSIFIED DRUG;

ANXIETY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; CATALEPSY; DEPRESSION; DIABETIC NEPHROPATHY; DRUG EFFICACY; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TRANSIT; GENE ACTIVATION; HUMAN; IN VITRO STUDY; INSULIN RESISTANCE; LIVER DISEASE; METABOLIC DISORDER; NONHUMAN; OBESITY; PHYSICAL CHEMISTRY; RECEPTOR OCCUPANCY; SIDE EFFECT; TISSUE DISTRIBUTION; WEIGHT GAIN;

AM6545; CANNABINOID RECEPTOR BLOCKER; CB1-ANTAGONIST; DIABETES; INVERSE AGONIST; JD5037; LIVER DISEASES; METABOLIC DISORDERS; OBESITY; PERIPHERALLY RESTRICTED; RIMONABANT; SILENT ANTAGONIST;

ANIMALS; BRAIN; COCAINE; DRUG DISCOVERY; HUMANS; LIVER DISEASES; METABOLIC DISEASES; MORPHOLINES; OBESITY; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; SULFONAMIDES;

EID: 84881368891     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.066     Document Type: Review

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