The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease

Inflammatory Bowel Diseases

Volumn 4, Issue 1, 1998, Pages 54-67

  MacDermott, Richard P ^a,b   Sanderson, Ian R ^b   Reinecker, Hans Christian ^b  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chemokines; Crohn's disease; Cytokines; Ulcerative colitis

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR;

CROHN DISEASE; EPITHELIUM CELL; HUMAN; IMMUNOLOGY; LEUKOCYTE; METABOLISM; REVIEW; ULCERATIVE COLITIS;

CHEMOKINES; COLITIS, ULCERATIVE; CROHN DISEASE; EPITHELIAL CELLS; HUMANS; LEUKOCYTES; RECEPTORS, CHEMOKINE;

EID: 0031989183     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/00054725-199802000-00009     Document Type: Review

References (136)

1. MacDermott RP, Stenson WF. Alterations in the mucosal immune system in ulcerative colitis and Crohn's disease. Adv Immunol 1988;42:285-323.
2. MacDermott RP. Alterations in the mucosal immune system in ulcerative colitis and Crohn's disease. Med Clin North Am 1994; 78:1207-31.
3. MacDermott RP. The role of the mucosal immune system in inflammatory bowel disease. In: Kagnoff MF, Kiyono H, eds. Essentials of mucosal immunology. San Diego: Academic Press, 1996:321-39.
4. Saverymuttu SH, Peters AM, Lavender JP, Chadwick VS, Hodgson HJ. In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease. Gut 1985;26:378-83.
5. Scholmerich J, Schmidt E, Schumichen C, Billmann P, Schmidt H, Gerok W. Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m hexamethyl propylene amine oxide as leukocyte label. Gastroenterology 1988;95:1287-93.
6. Pullman WE, Sullivan PJ, Barrett PJ, Lising J, Booth JA, Doe WF. Assessment of inflammatory bowel disease activity by technetium 99m phagocyte scanning. Gastroenterology 1988;95:989-96.
7. Sharon P, Stenson F. Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 1984;86:453-60.
8. Halstensen TS, Mollnes TE, Brandtzaeg P. Persistent complement activation in submucosal blood vessels of active inflammatory bowel disease: immunohistochemical evidence. Gastroenterology 1989;97:10-9.
9. Ahrenstedt O, Knutson L, Nilssoh B, Nilsson-Ekdahl K, Odlind B, Hallgren R. Enhanced local production of complement components in the small intestines of patients with Crohn's disease. N Engl J Med 1990;322:1345-9.
10. Baggiolini M, Dewald B, Moser B. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv Immunol 1994;55:97-179.
11. Taub DD, Oppenheim JJ. Chemokines, inflammation and the immune system. Ther Immunol 1994;1:229-46.
12. Taub DD. Chemokine-leukocyte interactions. The voodoo that they do so well. Cytokine Growth Factor Rev 1996;7:355-76.
13. Adams DH, Lloyd AR. Chemokines: leucocyte recruitment and activation cytokines. Lancet 1997;349:490-5.
14. Baggiolini M, Dewald B, Moser B. Human chemokines: an up-date. Annn Rev Immunol 1997;15:675-705.
15. Oppenheim JJ, Zachariae CO, Mukaida N, Matsushima K. Properties of the novel proinflammatory supergene intercrine cytokine family. Annu Rev Immunol 1991;9:617-48.
16. Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ, et al. Lymphotactin: a cytokine that represents a new class of chemokine. Science 1994;266:1395-9.
17. Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J 1990;4:2868-80.
18. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991;67:1033-6.
19. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-14.
20. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994;8:504-12.
21. Shattil SJ, Ginsberg MH. Integrin signaling in vascular biology. J Clin Invest 1997;100:1-5.
22. Lasky LA. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 1992;258:964-9.
23. Bevilacqua M, Nelson RM. Selectins. J Clin Invest 1993;91:379-87.
24. Nieto M, Frade JMR, Sancho D, Mellado M, Martinez-A C, Sanchez-Madrid F. Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. J Exp Med 1997; 186:153-8.
25. Baggiolini M, Boulay F, Badwey JA, Curnette JT. Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst. FASEB J 1993;7:1004-10.
26. Tobler A, Meier R, Seitz M, Dewald B, Baggiolini M, Fey MF. Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts. Blood 1992;79:45-51.
27. Kelvin DJ, Michiel DF, Johnston JA, Lloyd AR, Sprenger H, Oppenheim JJ, Wang JM. Chemokines and serpentines: the molecular biology of chemokine receptors. J Leukoc Biol 1993;54: 604-12.
28. Grob PM, David E, Warren TC, DeLeon RP, Farina PR, Homon CA. Characterization of a receptor for human monocyte-derived neutrophil chemotactic factor/interleukin-8. J Biol Chem 1990; 265:8311-6.
29. Samanta AK, Oppenheim JJ, Matsushima K. Interleukin-8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils. J Biol Chem 1990;265:183-9.
30. Holmes WE, Lee J, Kuang WJ, Rice GC, Wood WI. Structure and functional expression of a human interleukin-8 receptor. Science 1991;253:1278-80.
31. Murphy PM, Tiffany HL. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 1991; 253:1280-3.
32. Yoshimura T, Leonard EJ. Identification of high affinity receptors for human monocyte chemoattractant protein-1 on human monocytes. J Immunol 1990;145:292-7.
33. Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 1994;12:593-633.
34. Wells TNC, Power CA, Narasimhan M, Hoogewerf AJ, Cooke R, Chung C, Peitsch MC, Proudfoot AEI. Selectivity and antagonism of chemokine receptors. J Leukoc Biol 1996;59:53-60.
35. Raport CJ, Schweickart VL, Chantry D, Eddy RL, Shows TB, Godiska R, Gray PW. New members of the chemokine receptor gene family. J Leukoc Biol 1996;59:18-23.
36. Clark-Lewis I, Kim KS, Rajarathnam K, Gong JH, Dewald B, Moser B, Baggiolini M, Sykes BD. Structure-activity relationships of chemokines. J Leukoc Biol 1995;57:703-11.
37. Murphy PM. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev 1996;7:47-64.
38. Simon MI, Strathmann MP, Gautham N. Diversity of G proteins in signal transduction. Science 1991;252:802-8.
39. Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI. Characterization of two high affinity human interleukin-8 receptors. J Biol Chem 1992;267:16283-7.
40. Horuk R. The interleukin-8 receptor family: from chemokines to malaria. Immunol Today 1994;15:169-73.
41. Gayle RB, Sleath PR, Srinivason S, Birks CW, Weerawarna KS, Cerretti KP, Kozlosky CJ, Nelson N, Vanden TB, Beckmann MP. Importance of the amino acid terminus of the interleukin-8 receptor in ligand interactions. J Biol Chem 1993;268:7283-9.
42. Horuk R. Molecular properties of the chemokine receptor family. TIPS 1994;15:159-65.
43. Wang JM, Sherry B, Fivash MJ, Kelvin DJ, Oppenheim JJ. Human recombinant macrophage inflammatory protein-1 alpha and -beta and monocyte chemotactic and activating factor utilize common and unique receptors on human monocytes. J Immunol 1993; 150:3022-9.
44. Wang JM, McVicar DW, Oppenheim JJ, Kelvin DJ. Identification of RANTES receptors on human monocytic cells: competition for binding and desensitization by homologous chemotactic cytokines. J Exp Med 1993;177:699-705.
45. Horuk R, ed. Chemoattractant ligands and their receptors. Boca Raton: CRC Press, 1996.
46. Horuk R, ed. Chemokines: methods in enzymology, vol 287. San Diego: Academic Press, 1997.
47. Horuk R, ed. Chemokine receptors: methods in enzymology, vol 288. San Diego: Academic Press, 1997.
48. Vaddi K, Keller M, Newton RC. The chemokine facts book. San Diego: Academic Press, 1997,
49. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995;270:1811-5.
50. Cocchi F, DeVico AL, Garzino-Demo A, Cara A, Gallo RC, Lusso P. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nature Med 1996;2:1244-7.
51. Feng Y, Broker C, Kennedy PE, Berger EA. HIV-1 entry cofactor: function cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 1996;272:872-7.
52. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996;381:667-73.
53. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Marzio PD, Marmon S, Sutton RE, Hill CM, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996;381:661-6.
54. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996;272:1955-8.
55. Bates P. Chemokine receptors and HIV-1: an attractive pair? Cell 1996;86:1-3.
56. D'Souza MP, Harden VA. Chemokines and HIV-1 second receptors: confluence to two fields generates optimism in AIDS research. Nature Med 1996;2:1293-300.
57. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996;85:1135-48.
58. Dimitrov DS. Fusin - a place for HIV-1 and T4 cells to meet. Nature Med 1996;2:640-1.
59. Rucker J, Samson M, Doranz BJ, Libert F, Berson JF, Yi Y, Smyth RJ, Collman RG, Broder CC, Vassart G, et al. Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 1996;87:437-46.
60. Liu R, Paxton WA, Choe S, Ceradini D, Mretin SR, Horuk R, MacDonald ME, Stuhlmann H, Koup RA, Landau NR. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 86:367-77.
61. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996;382:722-5.
62. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SD, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-62.
63. Fauci AS. Resistance to HIV-1 infection: it's in the genes. A genetic defect in the HIV-1 co-receptor provides resistance to infection. Nature Med 1996;2:966-7.
64. O'Brien SJ, Dean M. In search of the AIDS-resistance genes. Sci Am 1997;277:44-51.
65. Cohen OJ, Caccarezza M, Lam GK, Baird BF, Wildt K, Murphy PM, Zimmerman PA, Nutman TB, Fox CH, Hoover S, et al. Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors. J Clin Invest 1997;100:1581-9.
66. Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobson LP, Kaslow R, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Science 1997;277:959-65.
67. Michael NL, Louie LG, Rohrbaugh AL, Schultz KA, Dayhoff DE, Wang CE, Sheppard HW. The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Nature Med 1997;3:1160-2.
68. Chen JD, Bai X, Yang AG, Cong Y, Chen SY. Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy. Nature Med 1997;3:1110-6.
69. Endres MJ, Clapham PR, Marsh M, Ahuja M, Turner JD, McKnight A, Thomas JF, Stoebenau-Haggarty B, Choe S, Vance PJ, et al. CD4-independent infection by HIV-2 is mediated by fusin/ CXCR4. Cell 1996;87:745-56.
70. Ben-Baruch A, Michiel DF, Oppenheim JJ. Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 1995; 270:11703-6.
71. Sanderson IR, Walker WA. Mucosal barrier. In: Ogra R, Mestecky J, McGhee J, Bienenstock J, Lamm M, Strober W, eds. Mucosal immunology. San Diego: Academic Press, 1994:41-51.
72. Mason DW, Dallman M, Barclay AN. Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium. Nature 1981;293:150-1.
73. Mayer L, Shlien R. Evidence for function of Ia molecules on gut epithelial cells in man. J Exp Med 1987;166:1471-83.
74. Eckmann L, Jung HC, Shurer-Maly C, Panja A, Morzycka-Wroblewska E, Kagnoff MF. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology 1993;105:1689-97.
75. Stadnyk AW. Cytokine production by epithelial cells. FASEB J 1994;8:1041-7.
76. Sanderson IR. Nutrition and gene regulation. In: Walker WA, Watkins J, eds. Nutrition in pediatrics - basic science and clinical aspects, 2nd ed. Hamilton: BC Decker, 1996:213-32.
77. Isaacs PET, Kim YS. Blind loop syndrome and small bowel bacterial contamination. Clin Gastroenterol 1983;12:395-414.
78. Vanderhoof JA. Short bowel syndrome in children. Curr Opin Pediatr 1995;7:560-8.
79. Sanderson IR, Udeen S, Davies PSW, Savage MO, Walker-Smith JA. Remission induced by an elemental diet in small bowel Crohn's disease. Arch Dis Child 1987;62:123-7.
80. Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor BR. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 1996;98:945-53.
81. Eckmann L, Kagnoff MF, Fierer J. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun 1993;61:4569-74.
82. Jung HC, Eckmann L, Yang SK, Panja A, Fierer J, Morzycka-Wroblewska E, Kagnoff MF. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 1995;95:55-65.
83. McCormick BA, Miller SI, Carnes D, Madara JL. Transepithelial signaling to neutrophils by Salmonellae: a novel virulence mechanism for gastroenteritis. Infect Immun 1995;63:2302-9.
84. Sheth R, Anderson J, Sato T, Oh B, Hempson SJ, Rollo E, Mackow ER, Shaw RD. Rotavirus stimulates IL-8 secretion from cultured epithelial cells. Virology 1996;221:251-9.
85. Standiford TJ, Kunkel SL, Basha MA, Chensue SW, Lynch JP, Toews GP, Westwick J, Strieter RM. Interleukin-8 gene expression by a pulmonary epithelial cell line: A model for cytokine networks in the lung. J Clin Invest 1990;86:1945-53.
86. Paine R, Rolfe MW, Standiford TJ, Burdick MD, Rollins BJ, Stricter RM. MCP-1 expression by rat type II alveolar epithelial cells in primary culture. J Immunol 1993;150:4561-70.
87. Kagnoff MF, Eckmann L. Epithelial cells as sensors for microbial infection. J Clin Invest 1997;100:6-10.
88. Yang SK, Eckmann L, Panja A, Kagnoff MF. Differential and regulated expression of CXC, CC, and C-chemokines by human colon epithelial cells. Gastroenterology 1997;113:1214-23.
89. Bry L, Falk PG, Midtvdet T, Gordon JI. A model of host-microbial interactions in an open mammalian ecosystem. Science 1996;273:1380-3.
90. Ohno Y, Lee J, Fusunyan RD, MacDermott RP, Sanderson IR. Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. Proc Natl Acad Sci USA 1997; 94:10279-84.
91. Fusunyan RD, Quinn JJ, Ohno Y, MacDermott RP, Sanderson IR. Butyrate enhances interleukin-8 secretion by intestinal epithelial cells in response to interleukin-1b and lipopolysaccharide. Pediatr Res 1998;43:84-90.
92. Sanderson IR, Ezzell RM, Kedinger M, Erlanger M, Xu Z, Pringault E, Leon-Robine S, Walker WA. Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix. Proc Natl Acad Sci USA 1996;93:7717-22.
93. Quinn JJ, Fusunyan RD, MacDermott RP, Sanderson IR. Butyrate switches the patter of chemokine secretion by intestinal epithelial cells [Abstract]. Gastroenterology 1996;110:A833.
94. Cummings JH, Pomare EW, Branch WJ, Naylor CPE, MacFarlane GT. Short chain fatty acids in human large intestine, portal, hepatic, and venous blood. Gut 1987;28:1221-7.
95. Lloyd DR, Brown JD, Brown GA, Booth IW. Elevated short chain fatty acid concentrations in anaerobic small bowel contamination. Acta Paediatr 1992;81:51-6.
96. Nasmyth DG, Godwin PGR, Dixon MF, Williams NS, Johnston D. Ileal ecology after pouch-anal anastomosis or ileostomy: a study of mucosal morphology, fecal bacteriology, fecal volatile fatty acids, and their interrelationships. Gastroenterology 1989; 96:817-24.
97. Marteau P, Pochart P, Bouhnik Y, Rambaud JC. The fate and effects of transiting, non-pathogenic microorganisms in the human intestine. In: Simopoulous AO, Corring T, Rerat A, eds. Intestinal flora, immunity, nutrition and health. Basel: Karger, 1993:1-21.
98. Cominelli F, Nast CC, Clark BD, Schindler R, Lierena R, Eysselein VE, Thompson RC, Dinarello CA. Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J Clin Invest 1990; 86:972-80.
99. Youngman KR, Simon PL, West GA, Cominelli F, Rachmilewitz D, Klein JS, Fiocchi C. Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 1993;104:749-58.
100. Breur RI, Soergel KH, Lashner BA, Christ ML, Hanauer SB, Vanagunas A, Harig JM, Keshavarzian A, Robinson M, Sellin JH, Weinberg D, Vidican DE, Flemal KL, Rademaker AW. Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo-controlled trial. Gut 1997;40:485-91.
101. Harig JM, Soergal KH, Komorowski RA, Wood CM. Treatment of diversion colitis with short-chain-fatty acid irrigation. N Engl J Med 1989;320:23-8.
102. Vernia P, Cittadini M, Caprilli R, Torsoli A. Topical treatment of refractory distal ulcerative colitis with 5-ASA and sodium butyrate. Dig Dis Sci 1995;40:305-7.
103. Schroder JM. Generation of NAP-1 and related peptides in psoriasis and other inflammatory skin diseases. Cytokines 1992;4: 54-76.
104. Seitz M, Dewald B, Gerber N, Baggiolini M. Enhanced production of neutrophil-activating peptide/interleukin-8 in rheumatoid arthritis. J Clin Invest 1991;87:463-9.
105. Rampart M, Herman AG, Grillet B, Opdenakker G, Damme JV. Development and application of a radioimmunoassay for interleukin-8: detection of interleukin-8 in synovial fluids from patients with inflammatory joint disease. Lab Invest 1992;66:512-8.
106. Koch AE, Kunkel SL, Harlow LA, Johnson B, Evanhoff HL, Haines GK, Burdick MD, Pope RM, Streiter RM. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J Clin Invest 1992;90:772-9.
107. Carre PC, Mortenson RL, King TE Jr, Noble PW, Sable CL, Riches DW. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis: a potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest 1991;88:1802-10.
108. Strieter RM, Standiford T, Huffnagle GB, Coletti LM, Lukacs NW, Kunkel SL. The good, the bad, and the ugly: the role of chemokines in models of human disease. J Immunol 1996;150: 3583-6.
109. Kunkel SL, Lukacs N, Strieter RM. Chemokines and their role in human disease. Agent Actions Supplement 1995;46:11-22.
110. Gura T. Chemokines take center stage in inflammatory ills. Science 1996;272:954-6.
111. Kunkel SL, Lukacs N, Kasama T, Strieter RM. The role of chemokines in inflammatory joint disease. J Leukoc Biol 1996;59: 6-12.
112. Lukacs NW, Strieter RM, Chensue SW, Kunkel SL. Activation and regulation of chemokines in allergic airway inflammation. J Leukoc Biol 1996;59:13-7.
113. Ransohoff RM, Glabinski A, Tani M. Chemokines in immune-mediated inflammation of the central nervous system. Cytokine Growth Factor Rev 1996;7:35-46.
114. Czaja MJ, Geerts A, Xu J, Schmiedeberg P, Ju Y. Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease. J Leukoc Biol 1994;55: 120-6.
115. Brown Z, Robson RL, Westwick J. Regulation and expression of chemokines: potential role in glomerulonephritis. J Leukoc Biol 1996;59:75-80.
116. Smith RE, Strieter RM, Zhang K, Phan SH, Standiford TJ, Lukacs NW, Kunkel SL. A role of C-C chemokines in fibrotic lung disease. J Leukoc Biol 1995;57:782-7.
117. Car BD, Meloni F, Luisetti M, Semenzato F, Gialdroni-Grassi G, Walz A. Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med 1994;149:655-9.
118. Koch AE, Kunkel SL, Harlow LA, Mazarakis DD, Haines GK, Burdick MD, Pope RM, Walz A, Strieter RM. Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. J Clin Invest 1994;94:1012-8.
119. Standiford TJ, Kunkel SL, Strieter RM. Interleukin-8: a major mediator of acute pulmonary inflammation. Reg Immunol 1993; 5:134-41.
120. Antoniades HN, Neville-Golden J, Galanopoulos T, Dradin RL, Valente AJ, Graves DT. Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis. Proc Natl Acad Sci USA 1992;89:5371-5.
121. Mahida YR, Ceska M, Effenberger F, Kurlak L, Lindley I, Hawkey CJ. Enhanced synthesis of neutrophil activating peptide-1/interleukin-8 in active ulcerative colitis. Clin Sci 1992;82: 273-5.
122. Izzo RS, Witkon K, Chen AI, Hadjiyane C, Weinstein MI, Pellecchia C. Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis. Am J Gastroenterol 1992;87:1447-52.
123. Izzo RS, Witkon K, Chen AI, Hadjiyane C, Weinstein MI, Pellecchia C. Neutrophil-activating peptide (interleukin-8) in colonic mucosa from patients with Crohn's disease. Scand J Gastroenterol 1993;28:296-300.
124. Raab Y, Gerdin B, Ahlstedt S, Hallgren R. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. Gut 1993;34:1203-6.
125. Kesharvarzian A, Fusunyan RD, D'Astice M, Eiznhamer D, Sanderson IR, MacDermott RP. Rectal dialysates from active ulcerative colitis patients contained increased IL-8: a possible objective measurement of colonic mucosal inflammation and disease activity [Abstract]. Gastroenterology 1995;108:A848.
126. Ina K, Kusugami K, Yamaguchi T, Imada A, Hosokawa T, Ohsuga M, Shinoda M, Ando T, Ito K, Yokoyama Y. Mucosal interleukin-8 is involved in neutrophil migration and binding to extracellular matrix in inflammatory bowel disease. Am J Gastroenterol 1997;92:1342-6.
127. Mitsuyama K, Toyonaga A, Sasaki E, Watanabe K, Tateishi H, Nishiyama T, Saiki T, Ikeda H, Tsuruta O, Tanikawa K. IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease. Clin Exp Immunol 1994;96:432-6.
128. Daig R, Andus T, Aschenbrenner E, Falk W, Scholmerich J, Gross V. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996;38:216-22.
129. Mazzucchelli L, Hauser C, Z'graggen K, Wagner J, Hess M, Laissue JA, Mueller C. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 1994;144:997-1007.
130. Izutani R, Ohyanagi H, MacDermott RP. Quantitative PCR for detection of femtogram quantities of interleukin-8 mRNA expression. Microbiol Immunol 1994;38:233-7.
131. Izutani R, Loh EY, Reinecker HC, Ohno Y, Fusunyan RD, Lichtenstein GR, Rombeau JL, MacDermott RP. Increased expression of interleukin-8 mRNA in ulcerative colitis and Crohn's disease mucosa and epithelial cells. Inflammatory Bowel Diseases 1995; 1:37-47.
132. Grimm MC, Elsbury SKO, Pavli P, Doe WF. Interleukin 8: cells of origin in inflammatory bowel disease. Gut 1996;39:90-8.
133. Reinecker HC, Loh EY, Ringler DJ, Mehta A, Rombeau JL, MacDermott RP. Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 1995;108:40-50.
134. Grimm MS, Elsbury SKO, Pavli P, Doe WF. Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. J Leukoc Biol 1996;56:804-12.
135. Mazzucchelli L, Hauser C, Z'graggen K, Wagner HE, Heiss MW, Laissue JA, Mueller C. Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J Pathol 1996;178:201-6.
136. Z'Graggen, Walz A, Mazzucchelli L, Streiter RM, Mueller C. The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Gastroenterology 1997;113:808-16.