Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

PLoS Computational Biology

Volumn 10, Issue 3, 2014, Pages

  Schwen, Lars Ole ^a   Krauss, Markus ^b,c   Niederalt, Christoph ^b   Gremse, Felix ^c   Kiessling, Fabian ^c   Schenk, Andrea ^a   Preusser, Tobias ^a,d   Kuepfer, Lars ^b,c  

^a FRAUNHOFER MEVIS   (Germany)

^b BAYER AG   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BLOOD; COMPUTERIZED TOMOGRAPHY; DETOXIFICATION; MASS TRANSFER; PHARMACOKINETICS; PHYSIOLOGICAL MODELS;

DRUG INJECTION; HEPATIC TISSUE; LIVER TISSUE; MECHANISTICS; METABOLIZATION; PHARMACOKINETIC MODELING; QUASI EQUILIBRIUM; SPATIALLY RESOLVED; SPATIO-TEMPORAL SIMULATION; SPATIOTEMPORAL DISTRIBUTIONS;

TISSUE;

CARBON TETRACHLORIDE; MIDAZOLAM; SPIRAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; FATTY LIVER; FIRST PASS EFFECT; LIVER CLEARANCE; LIVER METABOLISM; LIVER NECROSIS; LIVER PERFUSION; LIVER WEIGHT; METABOLIC CAPACITY; MOUSE; NONHUMAN; SIMULATION; SPATIOTEMPORAL ANALYSIS;

ALGORITHMS; ANIMALS; COMPUTER SIMULATION; CONTRAST MEDIA; FLUORESCEINS; LIVER; METABOLIC DETOXICATION, DRUG; MICE; MIDAZOLAM; PERFUSION; PERMEABILITY; SPATIO-TEMPORAL ANALYSIS; SPIRAMYCIN; SUCCINIMIDES; X-RAY MICROTOMOGRAPHY; XENOBIOTICS;

EID: 84897463745     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003499     Document Type: Article

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