The synaptic vesicle is the protein SV2A is the binding site for the antiepileptic drug levetiracetam

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 26, 2004, Pages 9861-9866

  Lynch, Berkley A ^a   Lambeng, Nathalie ^a   Nocka, Karl ^a   Kensel Hammes, Patricia ^b   Bajjalieh, Sandra M ^b   Matagne, Alain ^a   Fuks, Bruno ^a  

^a UCB PHARMA   (Belgium)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; BRAIN PROTEIN; ETIRACETAM; ISOPROTEIN; PROTEIN SV2A; PROTEIN SV2B; PROTEIN SV2C; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; BINDING SITE; BRAIN MEMBRANE; BRAIN PROTECTION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; EPILEPSY; EXOCYTOSIS; FIBROBLAST; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEIZURE; SYNAPSE VESICLE;

ANIMALS; ANTICONVULSANTS; BINDING SITES; BRAIN; FIBROBLASTS; GENE DELETION; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR MEMBRANES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR WEIGHT; NERVE TISSUE PROTEINS; PHOTOAFFINITY LABELS; PIRACETAM; PRECIPITIN TESTS; PROTEIN BINDING; RATS; SEIZURES; SYNAPTIC VESICLES;

ANIMALIA;

EID: 3042748137     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308208101     Document Type: Article

References (28)

1. Scheuer, M. L. & Pedley, T. A. (1990) N. Engl. J. Med. 323, 1468-1474.
2. Hovinga, C. A. (2001) Pharmacotherapy 21, 1375-1388.
3. Nash, E. M. & Sangha, K. S. (2001) Am. J. Health Syst. Pharm. 58, 1195-1199.
4. Klitgaard, H. (2001) Epilepsia 42, Suppl. 4, 13-18.
5. Klitgaard, H., Matagne, A., Gobert, J. & Wulfert, E. (1998) Eur. J. Pharmacol. 353, 191-206.
6. Margineanu, D. G. & Klitgaard, H. (2000) Pharmacol. Res. 42, 281-285.
7. Niespodziany, I., Klitgaard, H. & Margineanu, D. G. (2003) NeuroReport 14, 1273-1276.
8. Löscher, W., Hönack, D. & Rundfeldt, C. (1998) J. Pharmacol. Exp. Ther. 284, 474-479.
9. Margineanu, D. G. & Klitgaard, H. (2002) in Antiepileptic Drugs, eds. Levy, R. H., Mattson, R. H., Meldrum, B. S. & Perucca, E. (Lippincott Williams & Wilkins, Philadelphia), 5th Ed., pp. 419-427.
10. Rigo, J. M., Hans, G., Nguyen, L., Rocher, V., Belachew, S., Malgrange, B., Leprince, P., Moonen, G., Selak, I., Matagne, A. & Klitgaard, H. (2002) Br. J. Pharmacol. 136, 659-672.
11. Noyer, M., Gillard, M., Matagne, A., Hénichart, J.-P. & Wülfert, E. (1995) Eur. J. Pharmacol. 286, 137-146.
12. Fuks, B., Gillard, M., Michel, P., Lynch, B. A., Vertongen, P., Leprince, P., Klitgaard, H. & Chatelain, P. (2003) Eur. J. Pharmacol. 478, 11-19.
13. Buckley, K. & Kelly, R. B. (1985) J. Cell Biol. 100, 1284-1294.
14. Bajjalieh, S. M., Frantz, G. D., Weimann, J. M., McConnell, S. K. & Scheller, R. H. (1994) J. Neurosci. 14, 5223-5235.
15. Gillard, M., Fuks, B., Michel, P., Vertongen, P., Massingham, R. & Chatelain, P. (2003) Eur. J. Pharmacol. 478, 1-9.
16. Crowder, K. M., Gunther, J. M., Jones, T. A., Hale, B. D., Zhang, H. Z., Peterson, M. R., Scheller, R. H., Chavkin, C. & Bajjalieh, S. M. (1999) Proc. Natl. Acad. Sci. USA 96, 15268-15273.
17. Janz, R., Goda, Y., Geppert, M., Missler, M. & Sudhof, T. C. (1999) Neuron 24, 1003-1016.
18. Huttner, W. B., Schiebler, W., Greengard, P. & De Camilli, P. (1983) J. Cell Biol. 96, 1374-1388.
19. Pyle, R. A., Schivell, A. E., Hidaka, H. & Bajjalieh, S. M. (2000) J. Biol. Chem. 275, 17195-17200.
20. Chapman, A. G., Croucher, M. J. & Meldrum, B. S. (1984) Arzneimittelforschung 34, 1261-1264.
21. Feany, M. B., Lee, S., Edwards, R. H. & Buckley, K. M. (1992) Cell 70, 861-867.
22. Xu, T. & Bajjalieh, S. M. (2001) Nat. Cell Biol. 3, 691-698.
23. Bajjalieh, S. M., Peterson, K., Shinghal, R. & Scheller, R. H. (1992) Science 257, 1271-1273.
24. Schivell, A. E., Batchelor, R. H. & Bajjalieh, S. M. (1996) J. Biol. Chem. 271, 27770-27775.
25. Reigada, D., Diez-Perez, I., Gorostiza, P., Verdaguer, A., Gomez de Aranda, I., Pineda, O., Vilarrasa, J., Marsal, J., Blasi, J., Aleu, J. & Solsona, C. (2003) Proc. Natl. Acad. Sci. USA 100, 3485-3490.
26. Jeffery, C. J. (2003) Trends Genet. 19, 415-417.
27. Birnstiel, S., Wulfert, E. & Beck, S. G. (1997) Naunyn-Schmiedeberg's Arch. Pharmacol. 356, 611-618.
28. Tong, X. & Patsalos, P. N. (2001) Br. J. Pharmacol. 133, 867-874.