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Volumn 11, Issue 1, 2012, Pages 52-64

Clinical pharmacology of non-steroidal anti-inflammatory drugs: A review

Author keywords

Adverse effects; Cancer; Cyclo oxygenases; Neuro inflammation; NSAIDs; Prostanoids; Safe NSAIDs

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; HYDROGEN SULFIDE; IBUPROFEN; INDOMETACIN; LICOFELONE; LIPOXYGENASE; LUMIRACOXIB; MELOXICAM; MF 63; NAPROXCINOD; NAPROXEN; NIMESULIDE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; SULINDAC; THROMBOXANE; TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1 ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84867491632     PISSN: 18715230     EISSN: 1875614X     Source Type: Journal    
DOI: 10.2174/187152312803476255     Document Type: Review
Times cited : (285)

References (175)
  • 1
    • 0026588059 scopus 로고
    • Prostaglandin endoper-oxide synthase gene structure: Identification of the transcriptional start site and 5'-flanking regulatory sequences
    • Kraemer, S.A.; Meade, E.A.; De Witt, D.L. Prostaglandin endoper-oxide synthase gene structure: Identification of the transcriptional start site and 5'-flanking regulatory sequences. Arch. Biochem. Byophys., 1992, 293, 391-400.
    • (1992) Arch. Biochem. Byophys , vol.293 , pp. 391-400
    • Kraemer, S.A.1    Meade, E.A.2    de Witt, D.L.3
  • 2
    • 4143107932 scopus 로고    scopus 로고
    • Ciclooxigenase Isozymes:The biology of Prostaglandin Synthesis and Inhibition
    • Simmons, D.L.; Botting, R.M.; Hla, T. Ciclooxigenase Isozymes:The biology of Prostaglandin Synthesis and Inhibition. Pharmacol. Rev., 2004, 56(3), 387-437.
    • (2004) Pharmacol. Rev , vol.56 , Issue.3 , pp. 387-437
    • Simmons, D.L.1    Botting, R.M.2    Hla, T.3
  • 3
    • 65249118795 scopus 로고    scopus 로고
    • The COXIB experience: A look in the rear-viewmirror
    • Marnett, L.J. The COXIB experience: A look in the rear-viewmirror. Ann. Rev. Pharmacol. Toxicol., 2009, 49, 26.
    • (2009) Ann. Rev. Pharmacol. Toxicol , vol.49 , pp. 26
    • Marnett, L.J.1
  • 5
    • 0024224535 scopus 로고
    • Pharmacokinetics ofnon-steroidal anti-inflammatory drugs
    • Day, R.O.; Graham, G.G.; Williams, K.M. Pharmacokinetics ofnon-steroidal anti-inflammatory drugs. Clin. Rheumatol., 1988, 2, 363-393.
    • (1988) Clin. Rheumatol , vol.2 , pp. 363-393
    • Day, R.O.1    Graham, G.G.2    Williams, K.M.3
  • 6
    • 0033594911 scopus 로고    scopus 로고
    • Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxigenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
    • Warner, T.D.; Giuliano, F.; Vojnovic, I.; Bukasa, A.; Mitchell, J. A.; Vane, J. R. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxigenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA, 1999, 96, 7563-7568.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7563-7568
    • Warner, T.D.1    Giuliano, F.2    Vojnovic, I.3    Bukasa, A.4    Mitchell, J.A.5    Vane, J.R.6
  • 8
    • 0034157957 scopus 로고    scopus 로고
    • Gastrointestinal complications of prescription and over-the-counter nonsteroidal anti-inflammatory drugs: A view from the ARAMIS database. Arthritis, rheumatism, and aging medical information system
    • Singh, G. Gastrointestinal complications of prescription and over-the-counter nonsteroidal anti-inflammatory drugs: a view from the ARAMIS database. Arthritis, rheumatism, and aging medical information system. Am. J. Ther., 2000, 7, 115-121.
    • (2000) Am. J. Ther , vol.7 , pp. 115-121
    • Singh, G.1
  • 9
    • 12344272630 scopus 로고    scopus 로고
    • Nonster-oidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: Meta-analysis of randomised placebo controlled trials
    • Bjordal, J.M.; Ljunggren, A.E.; Klovning, A.; Slordal, L. Nonster-oidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: Meta-analysis of randomised placebo controlled trials. B.M.J., 2004, 329, 1317.
    • (2004) B.M.J , vol.329 , pp. 1317
    • Bjordal, J.M.1    Ljunggren, A.E.2    Klovning, A.3    Slordal, L.4
  • 11
    • 33847283058 scopus 로고    scopus 로고
    • Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly
    • Lanas, A.; Ferrandez, A. Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly. Drugs Aging, 2007, 24, 121-131.
    • (2007) Drugs Aging , vol.24 , pp. 121-131
    • Lanas, A.1    Ferrandez, A.2
  • 12
    • 27744449725 scopus 로고    scopus 로고
    • Patterns of use andpublic perception of over-the-counter pain relievers: Focus on nonsteroidal antiinflammatory drugs
    • Wilcox, C.M.; Cryer, B.; Triadafilopoulos G. Patterns of use andpublic perception of over-the-counter pain relievers: Focus on nonsteroidal antiinflammatory drugs. J. Rheumatol., 2005, 32, 2218-2224.
    • (2005) J. Rheumatol , vol.32 , pp. 2218-2224
    • Wilcox, C.M.1    Cryer, B.2    Triadafilopoulos, G.3
  • 13
    • 44149106595 scopus 로고    scopus 로고
    • Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: A systematic review and economic evaluation
    • Chen, Y-F.; Jobanputra, P.; Barton, P.; Bryan, S.; Fry-Smith, A.; Harris, G.; Taylor, R.S. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: A systematic review and economic evaluation. Health Technol. Assess., 2008, 12, 1-278.
    • (2008) Health Technol. Assess , vol.12 , pp. 1-278
    • Chen, Y.-F.1    Jobanputra, P.2    Barton, P.3    Bryan, S.4    Fry-Smith, A.5    Harris, G.6    Taylor, R.S.7
  • 14
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism ofaction for aspirin-like drugs
    • Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism ofaction for aspirin-like drugs. Nat. New. Biol., 1971, 43, 232-235.
    • (1971) Nat. New. Biol , vol.43 , pp. 232-235
    • Vane, J.R.1
  • 15
    • 0017199955 scopus 로고
    • The mode of action of aspirin and similar compounds
    • Vane, J.R. The mode of action of aspirin and similar compounds. J. Allergy Clin. Immunol., 1976, 58, 691-712.
    • (1976) J. Allergy Clin. Immunol , vol.58 , pp. 691-712
    • Vane, J.R.1
  • 17
    • 0033791318 scopus 로고    scopus 로고
    • Cyclooxygenases:Structural, cellular, and molecular biology
    • Smith, W.L.; DeWitt, D.L.; Garavito, R.M. Cyclooxygenases:structural, cellular, and molecular biology. Ann. Rev. Biochem., 2000, 69, 145-182.
    • (2000) Ann. Rev. Biochem , vol.69 , pp. 145-182
    • Smith, W.L.1    Dewitt, D.L.2    Garavito, R.M.3
  • 18
    • 0035406938 scopus 로고    scopus 로고
    • Vascular endothelial growth factorinduces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor
    • Murphy, J.F.; Fitzgerald, D.J. Vascular endothelial growth factorinduces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor. FASEB J., 2001, 15, 1667-1669.
    • (2001) FASEB J , vol.15 , pp. 1667-1669
    • Murphy, J.F.1    Fitzgerald, D.J.2
  • 19
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: Advances in eicosa-noid biology
    • Funk, C.D. Prostaglandins and leukotrienes: Advances in eicosa-noid biology. Science, 2001, 294, 1871-1875.
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 21
    • 0033766398 scopus 로고    scopus 로고
    • COX-2 in brain and spinal cord implications fortherapeutic use
    • Hoffmann, C. COX-2 in brain and spinal cord implications fortherapeutic use. Curr. Med. Chem., 2000, 7, 1113-1120.
    • (2000) Curr. Med. Chem , vol.7 , pp. 1113-1120
    • Hoffmann, C.1
  • 22
    • 0028034970 scopus 로고
    • Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction
    • Harris, R.C.; McKanna, J.A.; Akai, Y.; Jacobson, H.R.; Dubois, R. N.; Breyer, M.D. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J. Clin. Invest., 1994, 94, 2504-2510.
    • (1994) J. Clin. Invest , vol.94 , pp. 2504-2510
    • Harris, R.C.1    McKanna, J.A.2    Akai, Y.3    Jacobson, H.R.4    Dubois, R.N.5    Breyer, M.D.6
  • 23
    • 0027468941 scopus 로고
    • Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
    • Jones, D.A.; Carlton, D.P.; McIntyre, T.M.; Zimmerman, G.A.; Prescott, S.M. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem., 1993, 268, 9049-9054.
    • (1993) J. Biol. Chem , vol.268 , pp. 9049-9054
    • Jones, D.A.1    Carlton, D.P.2    McIntyre, T.M.3    Zimmerman, G.A.4    Prescott, S.M.5
  • 24
    • 0030960506 scopus 로고    scopus 로고
    • Interferon gamma induces prostaglandin G/H synthase-2through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells
    • Asano, K.; Nakamura, H.; Lilly, C.M.; Klagsbrun, M.; Drazen, J.M. Interferon gamma induces prostaglandin G/H synthase-2through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells. J. Clin. Invest., 1997, 99, 1057-1063.
    • (1997) J. Clin. Invest , vol.99 , pp. 1057-1063
    • Asano, K.1    Nakamura, H.2    Lilly, C.M.3    Klagsbrun, M.4    Drazen, J.M.5
  • 25
    • 0030785484 scopus 로고    scopus 로고
    • Expression of functional luteinizing hormone (LH) receptor and its messenger ribonucleic acid in bovine uterine veins: LH induction of cyclooxygenase and augmentation of prostaglandin production in bovine uterine veins
    • Shemesh, M.; Gurevich, M.; Mizrachi, D.; Dombrovski, L.; Stram, Y.; Fields, M.J.; Shore, L.S. Expression of functional luteinizing hormone (LH) receptor and its messenger ribonucleic acid in bovine uterine veins: LH induction of cyclooxygenase and augmentation of prostaglandin production in bovine uterine veins. Endocrinology, 1997, 138, 4844-4851.
    • (1997) Endocrinology , vol.138 , pp. 4844-4851
    • Shemesh, M.1    Gurevich, M.2    Mizrachi, D.3    Dombrovski, L.4    Stram, Y.5    Fields, M.J.6    Shore, L.S.7
  • 26
    • 0036325931 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells
    • Tamura, M.; Sebastian, S.; Gurates, B., Yang, S.; Fang, Z.; Bulun, S. E. Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells. J. Clin. Endocrinol. Metab., 2002, 87, 3504-3507.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , pp. 3504-3507
    • Tamura, M.1    Sebastian, S.2    Gurates, B.3    Yang, S.4    Fang, Z.5    Bulun, S.E.6
  • 27
    • 0034676333 scopus 로고    scopus 로고
    • IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells
    • Di Popolo, A.; Memoli, A.; Apicella, A.; Tuccillo, C.; di Palma, A.; Ricchi, P.; Acquaviva, A.M.; Zarrilli, R. IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells. Oncogene, 2000, 19, 5517-5524.
    • (2000) Oncogene , vol.19 , pp. 5517-5524
    • Di Popolo, A.1    Memoli, A.2    Apicella, A.3    Tuccillo, C.4    Di Palma, A.5    Ricchi, P.6    Acquaviva, A.M.7    Zarrilli, R.8
  • 28
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones, M.K.; Wang, H.; Peskar, B.M.; Levin, E.; Itani, R.M.; Sar-feh, I.J.; Tarnawski, A.S. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing. Nat. Med., 1999, 5, 1418-1423.
    • (1999) Nat. Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3    Levin, E.4    Itani, R.M.5    Sar-Feh, I.J.6    Tarnawski, A.S.7
  • 29
    • 1842478183 scopus 로고    scopus 로고
    • Hypoxic regulation ofangiopoietin-2 expression in endothelial cells
    • Pichiule, P.; Chavez, J.C.; LaManna, J.C. Hypoxic regulation ofangiopoietin-2 expression in endothelial cells. J. Biol. Chem., 2004, 279, 12171-12180.
    • (2004) J. Biol. Chem , vol.279 , pp. 12171-12180
    • Pichiule, P.1    Chavez, J.C.2    Lamanna, J.C.3
  • 32
    • 0037108979 scopus 로고    scopus 로고
    • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
    • Chandrasekharan, N.V.; Dai, H.; Roos, K.L.; Evanson, N.K.; Tom-sik, J.; Elton, T.S.; Simmons, D.L. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc. Natl. Acad. Sci. USA, 2002, 99, 13926-13931.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13926-13931
    • Chandrasekharan, N.V.1    Dai, H.2    Roos, K.L.3    Evanson, N.K.4    Tom-Sik, J.5    Elton, T.S.6    Simmons, D.L.7
  • 33
    • 15544377692 scopus 로고    scopus 로고
    • Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3 in rat
    • Snipes, J.A.; Kis, B.; Shelness, G.S.; Hewett, J.A.; Busija, D.W. Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3 in rat. J. Pharmacol. Exp. Ther., 2005, 313, 668-676.
    • (2005) J. Pharmacol. Exp. Ther , vol.313 , pp. 668-676
    • Snipes, J.A.1    Kis, B.2    Shelness, G.S.3    Hewett, J.A.4    Busija, D.W.5
  • 34
    • 0035825152 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug prescribing: Past,present, and future
    • Jones, R. Nonsteroidal anti-inflammatory drug prescribing: past,present, and future. Am. J. Med., 2001, 110, 4-7.
    • (2001) Am. J. Med , vol.110 , pp. 4-7
    • Jones, R.1
  • 35
    • 0342561627 scopus 로고    scopus 로고
    • Association between non-steroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: An overview of epidemiologic studies published in the 1990s
    • Hernandez-Diaz, S.; Rodriguez, L.A. Association between non-steroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: An overview of epidemiologic studies published in the 1990s. Arch. Intern. Med., 2000, 160, 2093-9.
    • (2000) Arch. Intern. Med , vol.160 , pp. 2093-2099
    • Hernandez-Diaz, S.1    Rodriguez, L.A.2
  • 36
    • 0034644396 scopus 로고    scopus 로고
    • Gastrointestinal toxicity with celecoxib versus nonsteroidal anti inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib long-term arthritis safety study
    • Silverstein, F.E.; Faich, G.; Goldstein, J.L.; Simon, L.S.; Pincus, T.; Whelton, A. Gastrointestinal toxicity with celecoxib versus nonsteroidal anti inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib long-term arthritis safety study. JAMA, 2000, 284, 1247-1255.
    • (2000) JAMA , vol.284 , pp. 1247-1255
    • Silverstein, F.E.1    Faich, G.2    Goldstein, J.L.3    Simon, L.S.4    Pincus, T.5    Whelton, A.6
  • 37
    • 0034707105 scopus 로고    scopus 로고
    • Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
    • VIGOR Study Group
    • Bombardier, C.; Laine, L.; Reicin, A.; Shapiro, D.; BurgosVar-gas, R.; Davis, B. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N. Engl. J. Med., 2000, 343, 1520-8.
    • (2000) N. Engl. J. Med , vol.343 , pp. 1520-1528
    • Bombardier, C.1    Laine, L.2    Reicin, A.3    Shapiro, D.4    Burgosvar-Gas, R.5    Davis, B.6
  • 38
    • 4344661128 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: Randomised controlled trial
    • Schnitzer, T.J.; Burmester, G.R.; Mysler, E.; Hochberg, M. C.; Doherty, M.; Ehrsam, E. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: Randomised controlled trial. Lancet, 2004, 364, 665-74.
    • (2004) Lancet , vol.364 , pp. 665-674
    • Schnitzer, T.J.1    Burmester, G.R.2    Mysler, E.3    Hochberg, M.C.4    Doherty, M.5    Ehrsam, E.6
  • 39
    • 33847051340 scopus 로고    scopus 로고
    • Risk of upper gas-trointestinal complications among users of traditional NSAIDs and COXIBs in the general population
    • Garcìa Rodrìguez, L.A.; Barreales Tolosa, L. Risk of upper gas-trointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology, 2007, 132, 498-506.
    • (2007) Gastroenterology , vol.132 , pp. 498-506
    • Garcìa rodrìguez, L.A.1    Barreales, T.L.2
  • 40
    • 0029028590 scopus 로고
    • Immunocytochemical localization of cyclooxygenase-1and cyclooxygenase-2 in the rat stomach
    • Iseki, S. Immunocytochemical localization of cyclooxygenase-1and cyclooxygenase-2 in the rat stomach. Histochem. J., 1995, 27, 323-328.
    • (1995) Histochem. J , vol.27 , pp. 323-328
    • Iseki, S.1
  • 41
    • 0031693007 scopus 로고    scopus 로고
    • Constitu-tive cyclooxygenase-2 expression in healthy human and rabbit gastric mucosa
    • Zimmermann, K.C.; Sarbia, M.; Schror, K.; Weber, A.A. Constitu-tive cyclooxygenase-2 expression in healthy human and rabbit gastric mucosa. Mol. Pharmacol., 1998, 54, 536-40.
    • (1998) Mol. Pharmacol , vol.54 , pp. 536-540
    • Zimmermann, K.C.1    Sarbia, M.2    Schror, K.3    Weber, A.A.4
  • 43
    • 0033851568 scopus 로고    scopus 로고
    • NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2
    • Wallace, J.L.; McKnight, W.; Reuter, B.K.; Vergnolle, N. NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology, 2000, 119, 706-14.
    • (2000) Gastroenterology , vol.119 , pp. 706-714
    • Wallace, J.L.1    McKnight, W.2    Reuter, B.K.3    Vergnolle, N.4
  • 44
    • 0033524421 scopus 로고    scopus 로고
    • Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2
    • McAdam, B. F.; Catella-Lawson, F.; Mardini, I. A.; Kapoor, S.; Lawson, J. A.; FitzGerald, G. A. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2. Proc. Natl. Acad. Sci. USA, 1999, 96, 272-277.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 272-277
    • McAdam, B.F.1    Catella-Lawson, F.2    Mardini, I.A.3    Kapoor, S.4    Lawson, J.A.5    Fitzgerald, G.A.6
  • 46
    • 0035934070 scopus 로고    scopus 로고
    • Risk of cardiovascularevents associated with selective COX-2 inhibitors
    • Mukherjee, D.; Nissen, S. E.; Topol, E.J. Risk of cardiovascularevents associated with selective COX-2 inhibitors. JAMA, 2001, 286, 954-959.
    • (2001) JAMA , vol.286 , pp. 954-959
    • Mukherjee, D.1    Nissen, S.E.2    Topol, E.J.3
  • 47
    • 0033582464 scopus 로고    scopus 로고
    • Oxidative damage of cardiomyo-cytes is limited by extracellular regulated kinases 1/2 mediated induction of cyclooxygenanse-2
    • Adderley, S.R.; FitzGerald, D.J. Oxidative damage of cardiomyo-cytes is limited by extracellular regulated kinases 1/2 mediated induction of cyclooxygenanse-2. J. Biol. Chem., 1999, 274, 5038-5046.
    • (1999) J. Biol. Chem , vol.274 , pp. 5038-5046
    • Adderley, S.R.1    Fitzgerald, D.J.2
  • 48
    • 33644870565 scopus 로고    scopus 로고
    • COX isoforms in the cardiovascularsystem: Understanding the activities of nonsteroidal antiinflammatory drugs
    • Mitchell, J.A.; Warner, T.D. COX isoforms in the cardiovascularsystem: Understanding the activities of nonsteroidal antiinflammatory drugs. Nat. Rev. Drug. Dis., 2006, 5, 75-86.
    • (2006) Nat. Rev. Drug. Dis , vol.5 , pp. 75-86
    • Mitchell, J.A.1    Warner, T.D.2
  • 49
    • 55049100980 scopus 로고    scopus 로고
    • Role of dosepotency in the prediction of risk of myocardial infarction associated with nonsteroidal anti-inflammatory drugs in the general population
    • García Rodríguez, L.A.; Tacconelli, S.; Patrignani, P. Role of dosepotency in the prediction of risk of myocardial infarction associated with nonsteroidal anti-inflammatory drugs in the general population. J. Am. Coll. Cardiol., 2008, 52, 1628-36.
    • (2008) J. Am. Coll. Cardiol , vol.52 , pp. 1628-1636
    • García rodríguez, L.A.1    Tacconelli, S.2    Patrignani, P.3
  • 51
    • 33744976771 scopus 로고    scopus 로고
    • Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
    • Kearney, P.M.; Baigent, C.; Godwin, J.; Halls, H.; Emberson, J.R.; Patrono, C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ., 2006, 332, 1302-1308.
    • (2006) BMJ , vol.332 , pp. 1302-1308
    • Kearney, P.M.1    Baigent, C.2    Godwin, J.3    Halls, H.4    Emberson, J.R.5    Patrono, C.6
  • 52
    • 10744225128 scopus 로고    scopus 로고
    • Differential effects of selective cyclooxygenase2 inhibitors on endothelial function in salt-induced hypertension
    • Hermann, M.; Camici, G.; Fratton, A.; Hurlimann, D.; Tanner, F. C.; Hellermann, J.P. Differential effects of selective cyclooxygenase2 inhibitors on endothelial function in salt-induced hypertension. Circulation, 2003, 108, 2308-11.
    • (2003) Circulation , vol.108 , pp. 2308-2311
    • Hermann, M.1    Camici, G.2    Fratton, A.3    Hurlimann, D.4    Tanner, F.C.5    Hellermann, J.P.6
  • 53
    • 19944432721 scopus 로고    scopus 로고
    • The effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus
    • Sowers, J.R.; White, W.B.; Pitt, B.; Whelton, A.; Simon, L. S.; Winer, N. The effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus. Arch. Intern. Med., 2005, 165, 161-8.
    • (2005) Arch. Intern. Med , vol.165 , pp. 161-168
    • Sowers, J.R.1    White, W.B.2    Pitt, B.3    Whelton, A.4    Simon, L.S.5    Winer, N.6
  • 54
    • 33749337137 scopus 로고    scopus 로고
    • Adverse effects of cyclooxygenase2 inhibitors on renal and arrhythmia events: Meta-analysis of randomized trials
    • Zhang, J.; Ding, E.L.; Song, Y. Adverse effects of cyclooxygenase2 inhibitors on renal and arrhythmia events: Meta-analysis of randomized trials. JAMA, 2006, 296, 1619-32.
    • (2006) JAMA , vol.296 , pp. 1619-1632
    • Zhang, J.1    Ding, E.L.2    Song, Y.3
  • 55
    • 77954842850 scopus 로고    scopus 로고
    • NSAIDs and cardiovascular disease: Trasducing human pharmacology results into clinical read-outs in the general population
    • Capone, M.L.; Tacconelli, S.; Garcia Rodriguez, L.; Patrignani, P. NSAIDs and cardiovascular disease: Trasducing human pharmacology results into clinical read-outs in the general population. Pharmacological Reports, 2010, 62, 530-535.
    • (2010) Pharmacological Reports , vol.62 , pp. 530-535
    • Capone, M.L.1    Tacconelli, S.2    Garcia Rodriguez, L.3    Patrignani, P.4
  • 56
    • 33646415952 scopus 로고    scopus 로고
    • Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
    • Cheng, Y.; Wang, M.; Yu, Y.; Lawson, J.; Funk, C.D.; Fitzgerald, G. A. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J. Clin. Invest., 2006, 116, 1391-1399.
    • (2006) J. Clin. Invest , vol.116 , pp. 1391-1399
    • Cheng, Y.1    Wang, M.2    Yu, Y.3    Lawson, J.4    Funk, C.D.5    Fitzgerald, G.A.6
  • 58
    • 0035833502 scopus 로고    scopus 로고
    • The coxibs, selective inhibitors ofcyclooxygenase-2
    • Fitzgerald, G.A.; Patrono, C. The coxibs, selective inhibitors ofcyclooxygenase-2. N. Eng. J. Med., 2001, 345, 433-442.
    • (2001) N. Eng. J. Med , vol.345 , pp. 433-442
    • Fitzgerald, G.A.1    Patrono, C.2
  • 59
    • 33644851502 scopus 로고    scopus 로고
    • Expression and function of COX isoforms in renal medulla: Evidence for regulation of salt sensitivity and blood pressure
    • Ye, W.; Zhang, H.; Hillas, E.; Kohan, D.E.; Miller, R.L.; Nelson, R. D.; Honeggar, M.; Yang, T. Expression and function of COX isoforms in renal medulla: evidence for regulation of salt sensitivity and blood pressure. Am. J. Renal. Physiol., 2006, 290, 542-549.
    • (2006) Am. J. Renal. Physiol , vol.290 , pp. 542-549
    • Ye, W.1    Zhang, H.2    Hillas, E.3    Kohan, D.E.4    Miller, R.L.5    Nelson, R.D.6    Honeggar, M.7    Yang, T.8
  • 60
    • 61549118522 scopus 로고    scopus 로고
    • The management of hyperkalemia inpatients with cardiovascular disease
    • Khanna, A.; White, W.B. The management of hyperkalemia inpatients with cardiovascular disease. Am. J. Med., 2009, 122, 215-221.
    • (2009) Am. J. Med , vol.122 , pp. 215-221
    • Khanna, A.1    White, W.B.2
  • 63
    • 0038385271 scopus 로고    scopus 로고
    • Hepatotoxicity associated with non-steroidal anti-inflammatory drugs
    • Teoh, N.C.; Farrell, G.C. Hepatotoxicity associated with non-steroidal anti-inflammatory drugs. Clin. Liver Dis., 2003, 7, 401-413.
    • (2003) Clin. Liver Dis , vol.7 , pp. 401-413
    • Teoh, N.C.1    Farrell, G.C.2
  • 64
    • 34548168341 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugin-duced hepatotoxicity
    • Aithal, G.P.; Day, C.P. Nonsteroidal anti-inflammatory drugin-duced hepatotoxicity. Clin Liver Dis., 2007, 11, 563-575.
    • (2007) Clin Liver Dis , vol.11 , pp. 563-575
    • Aithal, G.P.1    Day, C.P.2
  • 65
    • 67651213715 scopus 로고    scopus 로고
    • FDA focuses on drugs and liver damage: Labelingand other changes for acetaminophen
    • Kuehn, B.M.; FDA focuses on drugs and liver damage: Labelingand other changes for acetaminophen. JAMA, 2009, 302, 369-71.
    • (2009) JAMA , vol.302 , pp. 369-371
    • Kuehn, B.M.1
  • 66
    • 59649106758 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: Results from a cohort study and a meta-analysis
    • Abnet, C.C.; Freedman, N.D.; Kamangar, F.; Leitzmann, M. F.; Hollenbeck, A.R.; Schatzkin, A. Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: Results from a cohort study and a meta-analysis. Br. J. Cancer, 2009, 100, 551-557.
    • (2009) Br. J. Cancer , vol.100 , pp. 551-557
    • Abnet, C.C.1    Freedman, N.D.2    Kamangar, F.3    Leitzmann, M.F.4    Hollenbeck, A.R.5    Schatzkin, A.6
  • 67
    • 34249673868 scopus 로고    scopus 로고
    • Aspirin and the risk of colorec-tal cancer in relation to the expression of COX-2
    • Chan, A.T.; Ogino, S.; Fuchs, C.S. Aspirin and the risk of colorec-tal cancer in relation to the expression of COX-2. N. Engl. J. Med., 2007, 356, 2131-2142.
    • (2007) N. Engl. J. Med , vol.356 , pp. 2131-2142
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 68
    • 54049109591 scopus 로고    scopus 로고
    • Breast cancerand use of nonsteroidal anti-inflammatory drugs: A meta-analysis
    • Takkouche, B.; Regueira-Méndez, C.; Etminan, M. Breast cancerand use of nonsteroidal anti-inflammatory drugs: A meta-analysis, J. Natl. Cancer Inst., 2008, 100, 1439-1447.
    • (2008) J. Natl. Cancer Inst , vol.100 , pp. 1439-1447
    • Takkouche, B.1    Regueira-Méndez, C.2    Etminan, M.3
  • 70
    • 66649135844 scopus 로고    scopus 로고
    • Asso-ciation of nonsteroidal anti-inflammatory drugs with lung cancer: Results from a large cohort study, Cancer Epidemiol
    • Slatore, C.G.; Au, D.H.; Littman, A.J.; Satia, J.A.; White, E. Asso-ciation of nonsteroidal anti-inflammatory drugs with lung cancer: results from a large cohort study, Cancer Epidemiol. Biomarkers Prev., 2009, 18, 1203-1207.
    • (2009) Biomarkers Prev , vol.18 , pp. 1203-1207
    • Slatore, C.G.1    Au, D.H.2    Littman, A.J.3    Satia, J.A.4    White, E.5
  • 73
    • 0037021658 scopus 로고    scopus 로고
    • Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosisinducing agents
    • Zhu, J.X.; Song, X.Q.; Lin, H. P.; Young, D.C.; Yan, S.Q.; Mar-quez, V.E.; Chen, C. S. Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosisinducing agents. J. Natl. Cancer Inst., 2002, 95, 1745-1757.
    • (2002) J. Natl. Cancer Inst , vol.95 , pp. 1745-1757
    • Zhu, J.X.1    Song, X.Q.2    Lin, H.P.3    Young, D.C.4    Yan, S.Q.5    Mar-Quez, V.E.6    Chen, C.S.7
  • 74
    • 33745238704 scopus 로고    scopus 로고
    • Cyclooxy-genase-2 (COX-2) independent anticarcinogenic effects of selective COX-2 inhibitors
    • Grösch, S.; Maier, T. J.; Schiffmann, S.; Geisslinger, G. Cyclooxy-genase-2 (COX-2) independent anticarcinogenic effects of selective COX-2 inhibitors. J. Natl. Cancer Inst., 2006, 98, 736-747.
    • (2006) J. Natl. Cancer Inst , vol.98 , pp. 736-747
    • Grösch, S.1    Maier, T.J.2    Schiffmann, S.3    Geisslinger, G.4
  • 75
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: A molecular target for colorec-tal cancer prevention
    • Brown, J.R.; DuBois, R.N. COX-2: a molecular target for colorec-tal cancer prevention, J. Clin. Oncol., 2005, 23, 2840-2855.
    • (2005) J. Clin. Oncol , vol.23 , pp. 2840-2855
    • Brown, J.R.1    Dubois, R.N.2
  • 76
    • 29244449354 scopus 로고    scopus 로고
    • Prostaglandins and cancer
    • Wang, D.; Dubois, R.N. Prostaglandins and cancer, Gut, 2006, 55,115-122.
    • (2006) Gut , vol.55 , pp. 115-122
    • Wang, D.1    Dubois, R.N.2
  • 77
    • 34748817976 scopus 로고    scopus 로고
    • Membrane pros-taglandin E synthase-1: A novel therapeutic target
    • Samuelsson, B.; Morgenstern, R.; Jakobsson, P.J. Membrane pros-taglandin E synthase-1: A novel therapeutic target. Pharmacol. Rev., 2007, 59,(3), 207-224.
    • (2007) Pharmacol. Rev , vol.59 , Issue.3 , pp. 207-224
    • Samuelsson, B.1    Morgenstern, R.2    Jakobsson, P.J.3
  • 79
    • 27544467455 scopus 로고    scopus 로고
    • Predis-position to colorectal cancer in rats with resolved colitis: Role of cyclooxygenase-2-derived prostaglandin d2
    • Zamuner, S.R.; Bak, A.W.; Devchand, P.R.; Wallace, J.L. Predis-position to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. Am. J. Pathol., 2005, 167, 1293-1300.
    • (2005) Am. J. Pathol , vol.167 , pp. 1293-1300
    • Zamuner, S.R.1    Bak, A.W.2    Devchand, P.R.3    Wallace, J.L.4
  • 81
    • 0035650943 scopus 로고    scopus 로고
    • COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxi
    • Grösch, S.; Tegeder, I.; Niederberger, E.; Bräutigam, L.; Geisslin-ger, G. COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxi. FASEB J., 2001, 15, 2742-2744.
    • (2001) FASEB J , vol.15 , pp. 2742-2744
    • Grösch, S.1    Tegeder, I.2    Niederberger, E.3    Bräutigam, L.4    Geisslin-Ger, G.5
  • 83
    • 22344439728 scopus 로고    scopus 로고
    • Aspirin,ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade (review)
    • Harris, R.E.; Beebe-Donk, J.; Doss, H.; Burr Doss, D. Aspirin,ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). Oncol. Rep., 2005, 13, 559-583.
    • (2005) Oncol. Rep , vol.13 , pp. 559-583
    • Harris, R.E.1    Beebe-Donk, J.2    Doss, H.3    Burr, D.D.4
  • 84
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials
    • Rothwell, P.M.; Fowkes, F.G.; Belch, J.F.; Ogawa, H.; Warlow, C. P.; Meade, T.W. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet, 2011, 377, 31-41.
    • (2011) Lancet , vol.377 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.2    Belch, J.F.3    Ogawa, H.4    Warlow, C.P.5    Meade, T.W.6
  • 85
    • 0036130051 scopus 로고    scopus 로고
    • NSAID inhibition of GIcancer growth: Clinical implications and molecular mechanisms of action
    • Husain, S.S.; Szabo, I.L.; Tamawski, A.S. NSAID inhibition of GIcancer growth: Clinical implications and molecular mechanisms of action. Am. J. Gastroenterol., 2002, 97, 542-553.
    • (2002) Am. J. Gastroenterol , vol.97 , pp. 542-553
    • Husain, S.S.1    Szabo, I.L.2    Tamawski, A.S.3
  • 86
    • 34249673868 scopus 로고    scopus 로고
    • Aspirin and the risk of colorec-tal cancer in relation to the expression of COX-2
    • Chan, A.T.; Ogino, S.; Fuchs, C.S. Aspirin and the risk of colorec-tal cancer in relation to the expression of COX-2. N. Engl. J. Med., 2007, 356, 2131-2142.
    • (2007) N. Engl. J. Med , vol.356 , pp. 2131-2142
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 87
    • 78650215449 scopus 로고    scopus 로고
    • Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    • Rothwell, P.M.; Wilson, M.; Elwin, C.E.; Norrving, B.; Algra, A.; Warlow, C.P.; Meade, T.W. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet, 2010, 376, 1741-1750.
    • (2010) Lancet , vol.376 , pp. 1741-1750
    • Rothwell, P.M.1    Wilson, M.2    Elwin, C.E.3    Norrving, B.4    Algra, A.5    Warlow, C.P.6    Meade, T.W.7
  • 88
    • 77952157424 scopus 로고    scopus 로고
    • Induction of apoptosis as a potential chemo-preventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis
    • Sanyal, S.N.; Kaur, J. Induction of apoptosis as a potential chemo-preventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis. J. Environ. Pathol. Toxicol. Oncol., 2010, 29, 41-53.
    • (2010) J. Environ. Pathol. Toxicol. Oncol , vol.29 , pp. 41-53
    • Sanyal, S.N.1    Kaur, J.2
  • 89
    • 77954692385 scopus 로고    scopus 로고
    • Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP
    • Fecker, L.F.; Stockfleth, E.; Braun, F.K.; Rodust, P.M.; Schwarz, C. Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP. J. Invest. Dermatol., 2010, 130, 2098-2109.
    • (2010) J. Invest. Dermatol , vol.130 , pp. 2098-2109
    • Fecker, L.F.1    Stockfleth, E.2    Braun, F.K.3    Rodust, P.M.4    Schwarz, C.5
  • 92
    • 33745238704 scopus 로고    scopus 로고
    • Cy-clooxygenase-2 (COX-2) Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors
    • Grösch, S.; Thorsten, J.M.; Schiffmann, S.; Geisslinger, G. Cy-clooxygenase-2 (COX-2) Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors. J. Natl. Cancer Inst., 2006, 98, 11.
    • (2006) J. Natl. Cancer Inst , vol.98 , pp. 11
    • Grösch, S.1    Thorsten, J.M.2    Schiffmann, S.3    Geisslinger, G.4
  • 95
    • 44349096269 scopus 로고    scopus 로고
    • Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parity
    • Wernli, K.J.; Newcomb, P.A.; Hampton, J.M.; Trentham-Dietz, A.; Egan K.M. Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parity. Br. J. Cancer, 2008, 98, 1781-1783.
    • (2008) Br. J. Cancer , vol.98 , pp. 1781-1783
    • Wernli, K.J.1    Newcomb, P.A.2    Hampton, J.M.3    Trentham-Dietz, A.4    Egan, K.M.5
  • 96
    • 0036154835 scopus 로고    scopus 로고
    • Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: Preclinical evaluation of NSAIDs as chemopreventive agents
    • Rodriguez-Burford, C.; Barnes, M.N.; Oelschlager, D.K.; Myers, R.B.; Talley, L.I. Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agents. Clin. Cancer Res., 2002, 8, 202-209.
    • (2002) Clin. Cancer Res , vol.8 , pp. 202-209
    • Rodriguez-Burford, C.1    Barnes, M.N.2    Oelschlager, D.K.3    Myers, R.B.4    Talley, L.I.5
  • 99
    • 42649084052 scopus 로고    scopus 로고
    • The role of interleu-kin-1 in neuroinflammation and Alzheimer disease: An evolving perspective
    • Shaftel, S.S.; Griffin, W.S.T.; O'Banion, M.K. The role of interleu-kin-1 in neuroinflammation and Alzheimer disease: An evolving perspective. J. Neuroinflamm., 2008, 5, 12.
    • (2008) J. Neuroinflamm , vol.5 , pp. 12
    • Shaftel, S.S.1    Griffin, W.S.T.2    O'Banion, M.K.3
  • 100
    • 53249131262 scopus 로고    scopus 로고
    • Therapeutic targets in prostaglandin E-2 signaling for neurologic disease
    • Cimino, P.J.; Keene, C.D.; Breyer, R.M.; Montine, K.S.; Montine, T. J. Therapeutic targets in prostaglandin E-2 signaling for neurologic disease. Curr. Med. Chem., 2008, 15, 1863-1869.
    • (2008) Curr. Med. Chem , vol.15 , pp. 1863-1869
    • Cimino, P.J.1    Keene, C.D.2    Breyer, R.M.3    Montine, K.S.4    Montine, T.J.5
  • 101
    • 0041784698 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration medi-ated by nitric oxide, glutamate, and mitochondria
    • Brown, G.C.; Bal-Price, A. Inflammatory neurodegeneration medi-ated by nitric oxide, glutamate, and mitochondria. Mol. Neurobiol., 2003, 27, 325-355.
    • (2003) Mol. Neurobiol , vol.27 , pp. 325-355
    • Brown, G.C.1    Bal-Price, A.2
  • 102
    • 0034304391 scopus 로고    scopus 로고
    • NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: The role of oxidant/antioxidant balance
    • Calabrese, V.; Bates, T.E.; Stella, A.M.G. NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: The role of oxidant/antioxidant balance. Neurochem. Res., 2000, 25, 1315-1341.
    • (2000) Neurochem. Res , vol.25 , pp. 1315-1341
    • Calabrese, V.1    Bates, T.E.2    Stella, A.M.G.3
  • 104
    • 0035690720 scopus 로고    scopus 로고
    • Glial activation in Alzheimer'sdisease: The role of Abeta and its associated proteins
    • Meda, L.; Baron, P.; Scarlato, G. Glial activation in Alzheimer'sdisease: The role of Abeta and its associated proteins. Neurobiol. Aging, 2001, 22, 885-893.
    • (2001) Neurobiol. Aging , vol.22 , pp. 885-893
    • Meda, L.1    Baron, P.2    Scarlato, G.3
  • 107
    • 0035693794 scopus 로고    scopus 로고
    • Downregulation of neuronalcyclooxygenase-2 expression in end stage Alzheimer's disease
    • Yermakova, A.V.; O'Banion, M.K. Downregulation of neuronalcyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol. Aging, 2001, 22, 823-836.
    • (2001) Neurobiol. Aging , vol.22 , pp. 823-836
    • Yermakova, A.V.1    O'Banion, M.K.2
  • 108
    • 0033927533 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 inhibitors: Rationale and thera-peutic potential for Alzheimer's disease
    • McGeer, P.L. Cyclo-oxygenase-2 inhibitors: Rationale and thera-peutic potential for Alzheimer's disease. Drugs Aging, 2000, 17, 1-11.
    • (2000) Drugs Aging , vol.17 , pp. 1-11
    • McGeer, P.L.1
  • 111
    • 44849140748 scopus 로고    scopus 로고
    • No effect of one-year treatment with indomethacin on Alzheimer's disease progression: A randomized controlled trial
    • De Jong, D.; Jansen, R.; Hoefnagels, W.; Jellesma-Eggenkamp, M.; Verbeek, M.; Borm, G.; Kremer, B. No effect of one-year treatment with indomethacin on Alzheimer's disease progression: A randomized controlled trial. PloS ONE, 2008, 3, e1475.
    • (2008) PloS ONE , vol.3
    • de Jong, D.1    Jansen, R.2    Hoefnagels, W.3    Jellesma-Eggenkamp, M.4    Verbeek, M.5    Borm, G.6    Kremer, B.7
  • 115
    • 0037046179 scopus 로고    scopus 로고
    • Randomized pilot studyof nimesulide treatment in Alzheimer's disease
    • Aisen, P.S.; Schmeidler, J.; Pasinetti, G.M. Randomized pilot studyof nimesulide treatment in Alzheimer's disease. Neurology, 2002, 58, 1050-1054.
    • (2002) Neurology , vol.58 , pp. 1050-1054
    • Aisen, P.S.1    Schmeidler, J.2    Pasinetti, G.M.3
  • 116
    • 33847339301 scopus 로고    scopus 로고
    • NSAIDs and Alzheimer disease:Epidemiological, animal model and clinical studies
    • McGeer, P.L.; McGeer, E.G. NSAIDs and Alzheimer disease:Epidemiological, animal model and clinical studies. Neurobiol. Aging, 2007, 28, 639-647.
    • (2007) Neurobiol. Aging , vol.28 , pp. 639-647
    • McGeer, P.L.1    McGeer, E.G.2
  • 117
    • 26444475416 scopus 로고    scopus 로고
    • Novel therapeutic opportunities forAlzheimer's disease: Focus on nonsteroidal anti-inflammatory drugs
    • Townsend, K.P.; Pratico, D. Novel therapeutic opportunities forAlzheimer's disease: Focus on nonsteroidal anti-inflammatory drugs. FASEB J., 2005, 19, 1592-1601.
    • (2005) FASEB J , vol.19 , pp. 1592-1601
    • Townsend, K.P.1    Pratico, D.2
  • 118
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's disease antiinflammatory prevention trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • Martin, B.K.; Szekely, C.; Brandt, J.; Piantadosi, S.; Breitner, J.C.S.; Craft, S.; Evans, D.; Green, R.; Mullan, M.; Grp, A.R. Cognitive function over time in the Alzheimer's disease antiinflammatory prevention trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neur., 2008, 65, 896-905.
    • (2008) Arch. Neur , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.S.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9    Grp, A.R.10
  • 119
    • 11144256197 scopus 로고    scopus 로고
    • Clinical trials: Halt of Celebrex study threatens drug'sfuture, other trials
    • Couzin, J. Clinical trials: Halt of Celebrex study threatens drug'sfuture, other trials. Science, 2004, 306, 2170-2170.
    • (2004) Science , vol.306 , pp. 2170
    • Couzin, J.1
  • 120
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer Dis-ease-A Brief Review of the Basic Science and Clinical Literature
    • Wyss-Coray, T; Joseph Rogers J. Inflammation in Alzheimer Dis-ease-A Brief Review of the Basic Science and Clinical Literature. Cold Spring Harb. Perspect. Med., 2012, 2, a006346.
    • (2012) Cold Spring Harb. Perspect. Med , vol.2
    • Wyss-Coray, T.1    Joseph, R.J.2
  • 122
    • 45149104720 scopus 로고    scopus 로고
    • COX-2, but not COX-1,activity is necessary for the induction of perforant path long-termpotentiation and spatial learning in vivo
    • Cowley, T.R.; Fahey, B.; O'Mara, S.M. COX-2, but not COX-1,activity is necessary for the induction of perforant path long-termpotentiation and spatial learning in vivo. Eur. J. Neurosci., 2008, 27, 2999-3008.
    • (2008) Eur. J. Neurosci , vol.27 , pp. 2999-3008
    • Cowley, T.R.1    Fahey, B.2    O'Mara, S.M.3
  • 123
    • 61349129035 scopus 로고    scopus 로고
    • Sexdependent effect of cyclooxygenase-2 inhibition on mouse spatialmemory
    • Guzman, C.B.; Graham, K.A.; Grace, L.A.; Moore, A.H. Sexdependent effect of cyclooxygenase-2 inhibition on mouse spatialmemory. Behav. Brain Rev., 2009, 199, 355-359.
    • (2009) Behav. Brain Rev , vol.199 , pp. 355-359
    • Guzman, C.B.1    Graham, K.A.2    Grace, L.A.3    Moore, A.H.4
  • 124
    • 0037432544 scopus 로고    scopus 로고
    • Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats
    • Rall, J.M.; Mach, S.A.; Dash, P.K. Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats. Brain Res., 2003, 968, 273-276.
    • (2003) Brain Res , vol.968 , pp. 273-276
    • Rall, J.M.1    Mach, S.A.2    Dash, P.K.3
  • 125
    • 15744402700 scopus 로고    scopus 로고
    • Post-training intrahippocampal infu-sion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats
    • Sharifzadeh, M.; Naghdi, N.; Khosrovani, S.; Ostad, S.N.; Sharifzadeh, K.; Roghani, A. Post-training intrahippocampal infu-sion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats. Eur. J. Pharmacol., 2005, 511, 159-166.
    • (2005) Eur. J. Pharmacol , vol.511 , pp. 159-166
    • Sharifzadeh, M.1    Naghdi, N.2    Khosrovani, S.3    Ostad, S.N.4    Sharifzadeh, K.5    Roghani, A.6
  • 126
    • 0036209131 scopus 로고    scopus 로고
    • Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation
    • Teather, L.A.; Packard, M.G.; Bazan, N.G. Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation. Learn.Memory, 2002, 9, 41-47.
    • (2002) Learn.Memory , vol.9 , pp. 41-47
    • Teather, L.A.1    Packard, M.G.2    Bazan, N.G.3
  • 127
    • 62949176283 scopus 로고    scopus 로고
    • The distinct roles of cyclooxygenase-1 and-2 in neuroinflammation: Implications for transla-tional research
    • Choi, S.H.; Aid, S.; Bosetti, F. The distinct roles of cyclooxygenase-1 and-2 in neuroinflammation: Implications for transla-tional research. Trends Pharmacol. Sci., 2009, 30, 174-181.
    • (2009) Trends Pharmacol. Sci , vol.30 , pp. 174-181
    • Choi, S.H.1    Aid, S.2    Bosetti, F.3
  • 128
    • 43149102747 scopus 로고    scopus 로고
    • Protectiveeffects of NSAIDs on the development of Alzheimer disease
    • Vlad, S.C.; Miller, D.R.; Kowall, N.W.; Felson, D.T. Protectiveeffects of NSAIDs on the development of Alzheimer disease. Neurology, 2008, 70, 1672-1677.
    • (2008) Neurology , vol.70 , pp. 1672-1677
    • Vlad, S.C.1    Miller, D.R.2    Kowall, N.W.3    Felson, D.T.4
  • 129
    • 73949105768 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs, Aspirin, and cognitive function in the Baltimore longitudinal study of aging
    • Waldstein, S.R.; Wendell, C.R.; Seliger, S.L.; Ferrucci, L.; Metter, E.J.; Zonderman, A.B. Nonsteroidal anti-inflammatory drugs, Aspirin, and cognitive function in the Baltimore longitudinal study of aging. J. Amer. Geriat. Soc., 2010, 58, 38-43.
    • (2010) J. Amer. Geriat. Soc , vol.58 , pp. 38-43
    • Waldstein, S.R.1    Wendell, C.R.2    Seliger, S.L.3    Ferrucci, L.4    Metter, E.J.5    Zonderman, A.B.6
  • 131
    • 0023789193 scopus 로고
    • Reactivemicroglia are positive for HLA-DR in the substantia nigra of parkinsons and alzheimers-disease brains
    • McGeer, P.L.; Itagaki, S.; Boyes, B.E.; McGeer, E.G. Reactivemicroglia are positive for HLA-DR in the substantia nigra of parkinsons and alzheimers-disease brains. Neurology, 1988, 38, 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 132
    • 75949087271 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson'sdisease: Its role in neuronal death and implications for therapeutic intervention
    • Tansey, M.G.; Goldberg, M.S. Neuroinflammation in Parkinson'sdisease: Its role in neuronal death and implications for therapeutic intervention. Neurobiol. Dis., 2010, 37, 510-518.
    • (2010) Neurobiol. Dis , vol.37 , pp. 510-518
    • Tansey, M.G.1    Goldberg, M.S.2
  • 136
    • 0037031609 scopus 로고    scopus 로고
    • Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1,2,3,6-tetrahydropyridineinduced damage of dopaminergic neurons in the substantia nigra
    • Feng, Z.H.; Wang, T.G.; Li, D.D.; Fung, P.; Wilson, B.C.; Liu, B.; Ali, S.F.; Langenbach, R.; Hong, J.S. Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1,2,3,6-tetrahydropyridineinduced damage of dopaminergic neurons in the substantia nigra. Neurosci. Lett., 2002, 329, 354-358.
    • (2002) Neurosci. Lett , vol.329 , pp. 354-358
    • Feng, Z.H.1    Wang, T.G.2    Li, D.D.3    Fung, P.4    Wilson, B.C.5    Liu, B.6    Ali, S.F.7    Langenbach, R.8    Hong, J.S.9
  • 137
    • 33746329652 scopus 로고    scopus 로고
    • Pathogenic role of glial cells inParkinson's disease
    • Przedborski, S.; Goldman, J.E. Pathogenic role of glial cells inParkinson's disease. Advan. Mol. Cell. Biol., 2004, 31, 967-982.
    • (2004) Advan. Mol. Cell. Biol , vol.31 , pp. 967-982
    • Przedborski, S.1    Goldman, J.E.2
  • 138
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease:A target for neuroprotection
    • Hirsch, E.C.; Hunot, S. Neuroinflammation in Parkinson's disease:A target for neuroprotection. Lancet Neurol., 2009, 8, 382-397.
    • (2009) Lancet Neurol , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 140
    • 0041653249 scopus 로고    scopus 로고
    • Nonsteroidal antiinflamma-tory drugs and the risk of Parkinson disease
    • Chen, H.; Zhang, S.M.; Hernan, M.A. Nonsteroidal antiinflamma-tory drugs and the risk of Parkinson disease. Arch. Neurol., 2006, 60, 1059-1064.
    • (2006) Arch. Neurol , vol.60 , pp. 1059-1064
    • Chen, H.1    Zhang, S.M.2    Hernan, M.A.3
  • 141
    • 28544451467 scopus 로고    scopus 로고
    • Nonsteroidal antiin-flammatory drug use and the risk for Parkinson's disease
    • Chen, H.; Jacobs, E.; Schwarzschild, M.A. Nonsteroidal antiin-flammatory drug use and the risk for Parkinson's disease. Ann. Neurol., 2005, 58, 963-967.
    • (2005) Ann. Neurol , vol.58 , pp. 963-967
    • Chen, H.1    Jacobs, E.2    Schwarzschild, M.A.3
  • 142
    • 69949164871 scopus 로고    scopus 로고
    • NSAID use and therisk of Parkinson's disease systematic review and meta-analysis of observational studies
    • Samii, A.; Etminan, M.; Wiens, M.O.; Jafari, S. NSAID use and therisk of Parkinson's disease systematic review and meta-analysis of observational studies. Drug Aging, 2009, 26, 769-779.
    • (2009) Drug Aging , vol.26 , pp. 769-779
    • Samii, A.1    Etminan, M.2    Wiens, M.O.3    Jafari, S.4
  • 143
  • 144
    • 13944259105 scopus 로고    scopus 로고
    • Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer antiinflammatory drugs
    • Whittle, B.J. Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer antiinflammatory drugs. Curr. Opin. Pharmacol., 2004, 4, 538-45.
    • (2004) Curr. Opin. Pharmacol , vol.4 , pp. 538-545
    • Whittle, B.J.1
  • 145
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology,pathophysiology, and pharmacology
    • Moncada, S.; Palmer, R.M.J.; Higgs, E.A. Nitric oxide: physiology,pathophysiology, and pharmacology. Pharmacol. Rev., 1991, 43, 109-42.
    • (1991) Pharmacol. Rev , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.J.2    Higgs, E.A.3
  • 146
    • 0033868029 scopus 로고    scopus 로고
    • Nitric oxide in mucosal defense: Alittle goes a long way
    • Wallace, J.L.; Miller, M.J.S. Nitric oxide in mucosal defense: alittle goes a long way. Gastroenterology, 2000, 119, 512-20.
    • (2000) Gastroenterology , vol.119 , pp. 512-520
    • Wallace, J.L.1    Miller, M.J.S.2
  • 148
    • 4644266226 scopus 로고    scopus 로고
    • Nitric oxide releasing drugs: From bench to bedside
    • Cirino, G. Nitric oxide releasing drugs: from bench to bedside. Dig.Liver Dis., 2003, 35, S2-8.
    • (2003) Dig.Liver Dis , vol.35 , pp. 2-8
    • Cirino, G.1
  • 149
    • 0036791714 scopus 로고    scopus 로고
    • Pharmacology and potential therapeuticapplications of nitric oxide-releasing non-steroidal antiinflammatory and related nitric oxide-donating drugs
    • Keeble, JE.; Moore, P.K. Pharmacology and potential therapeuticapplications of nitric oxide-releasing non-steroidal antiinflammatory and related nitric oxide-donating drugs. Br. J. Pharmacol., 2002, 137, 295-310.
    • (2002) Br. J. Pharmacol , vol.137 , pp. 295-310
    • Keeble, J.E.1    Moore, P.K.2
  • 150
    • 33847619273 scopus 로고    scopus 로고
    • Cyclo-oxygenase (COX) inhibiting nitricoxide donating (CINODs) drugs: A review of their current status
    • Fiorucci, S, Distrutti, E. Cyclo-oxygenase (COX) inhibiting nitricoxide donating (CINODs) drugs: a review of their current status. Curr. Top. Med. Chem., 2007, 7, 277-82.
    • (2007) Curr. Top. Med. Chem , vol.7 , pp. 277-282
    • Fiorucci, S.1    Distrutti, E.2
  • 151
    • 0031031097 scopus 로고    scopus 로고
    • NO-naproxen vs.naproxen: Ulcerogenic, analgesic and antiinflammatory effects
    • Davies, N.M.; Roseth, A.G.; Appleyard, C.B. NO-naproxen vs.naproxen: ulcerogenic, analgesic and antiinflammatory effects. Alimen. Pharmacol. Ther., 1997, 11, 69-79.
    • (1997) Alimen. Pharmacol. Ther , vol.11 , pp. 69-79
    • Davies, N.M.1    Roseth, A.G.2    Appleyard, C.B.3
  • 152
    • 0029100370 scopus 로고
    • A nitricoxide-releasing nonsteroidal antiinflammatory drug accelerates gastric ulcer healing in rats
    • Elliott, S.N.; McKnight, W.; Cirino, G.; Wallace, J.L. A nitricoxide-releasing nonsteroidal antiinflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology, 1995, 109, 524-30.
    • (1995) Gastroenterology , vol.109 , pp. 524-530
    • Elliott, S.N.1    McKnight, W.2    Cirino, G.3    Wallace, J.L.4
  • 153
    • 0031698343 scopus 로고    scopus 로고
    • Effects of cy-clooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach
    • Ukawa, H.; Yamakuni, H.; Kato, S.; Takeuchi, K. Effects of cy-clooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. Dig. Dis. Sci., 1998, 43, 2003-11.
    • (1998) Dig. Dis. Sci , vol.43 , pp. 2003-2011
    • Ukawa, H.1    Yamakuni, H.2    Kato, S.3    Takeuchi, K.4
  • 154
    • 0036268510 scopus 로고    scopus 로고
    • Nitric oxide-releasingdrugs: A novel class of effective and safe therapeutic agents
    • Burgaud, J.L.; Ongini, E.; Del Soldato, P. Nitric oxide-releasingdrugs: a novel class of effective and safe therapeutic agents. Ann.N. Y. Acad. Sci., 2002, 962, 360-71.
    • (2002) Ann.N. Y. Acad. Sci , vol.962 , pp. 360-371
    • Burgaud, J.L.1    Ongini, E.2    Del Soldato, P.3
  • 155
    • 0037373349 scopus 로고    scopus 로고
    • Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: A proof of concept endoscopic study
    • Fiorucci, S.; Santucci, L.; Gresele, P.; Faccino, R.M.; Del Soldato, P.; Morelli, A. Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. Gastroenterology, 2003, 124, 600-7.
    • (2003) Gastroenterology , vol.124 , pp. 600-607
    • Fiorucci, S.1    Santucci, L.2    Gresele, P.3    Faccino, R.M.4    Del Soldato, P.5    Morelli, A.6
  • 156
    • 0242329755 scopus 로고    scopus 로고
    • Gastrointestinal safety ofAZD3582, a cyclooxygenase inhibiting nitric oxide donator: Proof of concept study in humans
    • Hawkey, C.J.; Jones, J.I.; Atherton, C.T. Gastrointestinal safety ofAZD3582, a cyclooxygenase inhibiting nitric oxide donator: Proof of concept study in humans. Gut., 2003, 52, 1537-42.
    • (2003) Gut , vol.52 , pp. 1537-1542
    • Hawkey, C.J.1    Jones, J.I.2    Atherton, C.T.3
  • 157
    • 0842284226 scopus 로고    scopus 로고
    • The CINOD, AZD3582,exhibits an improved gastrointestinal safety profile compared with naproxen in healthy volunteers
    • Jonzon, B.; Bjarnason, I.; Hawkey, C. The CINOD, AZD3582,exhibits an improved gastrointestinal safety profile compared with naproxen in healthy volunteers. Inflammopharmacology, 2003, 11, 437-44.
    • (2003) Inflammopharmacology , vol.11 , pp. 437-444
    • Jonzon, B.1    Bjarnason, I.2    Hawkey, C.3
  • 158
    • 33751015422 scopus 로고    scopus 로고
    • Analgesic effects of the cyclooxygenase-inhibiting nitric oxide donor AZD3582 inpostoperative dental pain: Comparison with naproxen and rofecoxib in two randomized, double blind, placebo-controlled studies
    • Hill, M.; Sindet-Pederson, S.; Seymour, R.A. Analgesic effects of the cyclooxygenase-inhibiting nitric oxide donor AZD3582 inpostoperative dental pain: Comparison with naproxen and rofecoxib in two randomized, double blind, placebo-controlled studies. Clin. Ther., 2006, 28, 1279-95.
    • (2006) Clin. Ther , vol.28 , pp. 1279-1295
    • Hill, M.1    Sindet-Pederson, S.2    Seymour, R.A.3
  • 159
    • 34147113829 scopus 로고    scopus 로고
    • NO-Donor COX2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowedwith COX-2 Inhibitory and Vasodilator Properties
    • Chegaev, K.; Lazzarato, L.; Tosco, P. NO-Donor COX2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowedwith COX-2 Inhibitory and Vasodilator Properties. J. Med. Chem., 2007, 50, 1449-57.
    • (2007) J. Med. Chem , vol.50 , pp. 1449-1457
    • Chegaev, K.1    Lazzarato, L.2    Tosco, P.3
  • 160
    • 80051966203 scopus 로고    scopus 로고
    • COXIBs, CINODs and H2S-releasing NSAIDs: Current perspectives in the development of safer non ster-oidal anti-inflammatory drugs
    • Fiorucci, S.; Distrutti, E. COXIBs, CINODs and H2S-releasing NSAIDs: current perspectives in the development of safer non ster-oidal anti-inflammatory drugs. Curr. Med. Chem., 2011, 18, (23), 3494-505.
    • (2011) Curr. Med. Chem , vol.18 , Issue.23 , pp. 3494-3505
    • Fiorucci, S.1    Distrutti, E.2
  • 161
    • 84859478522 scopus 로고    scopus 로고
    • Apparao Satyam Part 3: Nitric Oxide-Releasing Prodrugs of Non-steroidal Anti-inflammatory Drugs
    • Namdev, B.; Asif Rahimkhan, P.; Somnath, H. Apparao Satyam Part 3: Nitric Oxide-Releasing Prodrugs of Non-steroidal Anti-inflammatory Drugs. Chem. Pharm. Bull., 2012, 60, (4), 465-481.
    • (2012) Chem. Pharm. Bull , vol.60 , Issue.4 , pp. 465-481
    • Namdev, B.1    Asif, R.P.2    Somnath, H.3
  • 162
    • 33745920516 scopus 로고    scopus 로고
    • The emergingroles of hydrogen sulfide in the gastrointestinal tract and liver
    • Fiorucci, S.; Distrutti, E.; Cirino, G.; Fallace, J.L. The emergingroles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology, 2006, 131, 259-71.
    • (2006) Gastroenterology , vol.131 , pp. 259-271
    • Fiorucci, S.1    Distrutti, E.2    Cirino, G.3    Fallace, J.L.4
  • 163
    • 33846184714 scopus 로고    scopus 로고
    • Gastrointestinal safety and antiinflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat
    • Wallace, J.L.; Caliendo, G.; Santagada, V.; Cirino, G.; Fiorucci, S.Gastrointestinal safety and antiinflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology, 2007, 132, 261-71.
    • (2007) Gastroenterology , vol.132 , pp. 261-271
    • Wallace, J.L.1    Caliendo, G.2    Santagada, V.3    Cirino, G.4    Fiorucci, S.5
  • 164
    • 84858289256 scopus 로고    scopus 로고
    • NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model
    • Chattopadhyay, M.; Kodela, R.; Olson, K.R.; Kashfi, K. NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model. Biochem. Biophys. Res. Commun., 2012, 419, 3, 523-528.
    • (2012) Biochem. Biophys. Res. Commun , vol.419 , Issue.3 , pp. 523-528
    • Chattopadhyay, M.1    Kodela, R.2    Olson, K.R.3    Kashfi, K.4
  • 165
    • 0042574211 scopus 로고    scopus 로고
    • Dual inhibition of cyclooxygenase-2(COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer nonsteroidal anti-inflammatory drugs
    • Charlier, C.; Michaux, C. Dual inhibition of cyclooxygenase-2(COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer nonsteroidal anti-inflammatory drugs. Eur. J. Med. Chem., 2003, 38, 645-659.
    • (2003) Eur. J. Med. Chem , vol.38 , pp. 645-659
    • Charlier, C.1    Michaux, C.2
  • 166
    • 33847657523 scopus 로고    scopus 로고
    • Licofelone a novel analgesic and anti-inflammatory agent Curr
    • Kulkarmi, S. K.; Singh, V.P. Licofelone a novel analgesic and anti-inflammatory agent Curr. Top. Med. Chem., 2007, 7, (3), 251-63.
    • (2007) Top. Med. Chem , vol.7 , Issue.3 , pp. 251-263
    • Kulkarmi, S.K.1    Singh, V.P.2
  • 167
    • 67449128722 scopus 로고    scopus 로고
    • Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: A first multicentre clinical trial using quantitative MRI
    • Raynauld, J.P.; Martel-Pelletier, J.; Bias, P.; Laufer, S.; Haraoui, B.; Choquette, D.; Beaulieu, A.D.; Abram, F.; Dorais, M.; Vignon, E.; Pelletier, J.P. Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: A first multicentre clinical trial using quantitative MRI. Ann. Rheum. Dis., 2009, 68, (6), 938-47.
    • (2009) Ann. Rheum. Dis , vol.68 , Issue.6 , pp. 938-947
    • Raynauld, J.P.1    Martel-Pelletier, J.2    Bias, P.3    Laufer, S.4    Haraoui, B.5    Choquette, D.6    Beaulieu, A.D.7    Abram, F.8    Dorais, M.9    Vignon, E.10    Pelletier, J.P.11
  • 169
    • 67650628023 scopus 로고    scopus 로고
    • Myrtucommu-lone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1
    • Koeberle, A.; Pollastro, F.; Northoff, H.; Werz, O. Myrtucommu-lone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1. Br. J. Pharmacol., 2009, 156, (6), 952-961.
    • (2009) Br. J. Pharmacol , vol.156 , Issue.6 , pp. 952-961
    • Koeberle, A.1    Pollastro, F.2    Northoff, H.3    Werz, O.4
  • 171
    • 53849098967 scopus 로고    scopus 로고
    • MF63 [2-(6-chloro-1Hphenanthro [9,10-d]imidazol-2-yl) isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation
    • Xu D.; Rowland S.E.; Clark P.; Giroux A.; Côté B.; Guiral S. MF63 [2-(6-chloro-1Hphenanthro [9,10-d]imidazol-2-yl) isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J. Pharmacol. Exp. Ther., 2008, 326, 754-63.
    • (2008) J. Pharmacol. Exp. Ther , vol.326 , pp. 754-763
    • Xu, D.1    Rowland, S.E.2    Clark, P.3    Giroux, A.4    Côté, B.5    Guiral, S.6
  • 172
    • 33749263692 scopus 로고    scopus 로고
    • Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
    • Wang M.; Zukas A.M.; Hui Y.; Ricciotti E.; Puré E.; Fitz Gerald G. A. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc. Natl. Acad. Sci. USA, 2006, 103, 14507-12.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 14507-14512
    • Wang, M.1    Zukas, A.M.2    Hui, Y.3    Ricciotti, E.4    Puré, E.5    Fitz, G.G.A.6
  • 173
    • 40549145155 scopus 로고    scopus 로고
    • Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation
    • Wang M.; Lee E.; Song W.; Ricciotti E.; Rader D.J.; Lawson J.A.; Pure E.; FitzGerald G.A. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation, 2008, 117, 1302-1309.
    • (2008) Circulation , vol.117 , pp. 1302-1309
    • Wang, M.1    Lee, E.2    Song, W.3    Ricciotti, E.4    Rader, D.J.5    Lawson, J.A.6    Pure, E.7    Fitzgerald, G.A.8
  • 175
    • 77954733524 scopus 로고    scopus 로고
    • Transient receptorpotential ankyrin 1 (TRPA1) chanel as emerging target for novel analgesic and anti-inflammatory agents
    • Baraldi P.G.; Preti D.; Materazzi S.; Geppetti P. Transient receptorpotential ankyrin 1 (TRPA1) chanel as emerging target for novel analgesic and anti-inflammatory agents. J. Med. Chem., 2010, 53, 5805-51.
    • (2010) J. Med. Chem , vol.53 , pp. 5805-5851
    • Baraldi, P.G.1    Preti, D.2    Materazzi, S.3    Geppetti, P.4


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