Nonpsychotropic plant cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), activate and desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) channels in vitro: Potential for the treatment of neuronal hyperexcitability

ACS Chemical Neuroscience

Volumn 5, Issue 11, 2014, Pages 1131-1141

  Iannotti, Fabio Arturo ^a   Hill, Charlotte L ^b   Leo, Antonio ^b,c   Alhusaini, Ahlam ^b   Soubrane, Camille ^b   Mazzarella, Enrico ^a   Russo, Emilio ^c   Whalley, Benjamin J ^b   Di Marzo, Vincenzo ^a   Stephens, Gary J ^b  

^a CNR   (Italy)

^b UNIVERSITY OF READING   (United Kingdom)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Cannabinoid; Epilepsy; Multi electrode arrays (MEAs); Patch clamp; TRP channels

Indexed keywords

CANNABIDIOL; CANNABIDIVARIN; CANNABINOID; CAPSAICIN; MAGNESIUM; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR 2; DITERPENE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; IODORESINIFERATOXIN; SLC17A7 PROTEIN, RAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPA1 PROTEIN, RAT; TRPV1 PROTEIN, RAT; TRPV2 PROTEIN, RAT; VANILLOID RECEPTOR; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DEPHOSPHORYLATION; DESENSITIZATION; EPILEPTIC DISCHARGE; HEK293 CELL LINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; NEURONAL HYPEREXCITABILITY; NONHUMAN; PATCH CLAMP TECHNIQUE; RAT; SPIKE WAVE; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL;

ANIMALS; CANNABINOIDS; CAPSAICIN; DITERPENES; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; IN VITRO TECHNIQUES; MAGNESIUM; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; TRANSFECTION; TRPC CATION CHANNELS; TRPV CATION CHANNELS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 84912567630     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5000524     Document Type: Article

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