메뉴 건너뛰기




Volumn 11, Issue 4 SUPPL. 1, 2011, Pages 15-19

Sativex® (tetrahydrocannabinol + cannabidiol), an endocannabinoid system modulator: Basic features and main clinical data

Author keywords

endocannabinoid system; multiple sclerosis; quality of life; Sativex ; spasticity

Indexed keywords

CANNABIS;

EID: 79953826032     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.11.27     Document Type: Conference Paper
Times cited : (34)

References (15)
  • 1
    • 41549121013 scopus 로고    scopus 로고
    • Cannabinoids in the management of diffcult to treat pain
    • Russo EB. Cannabinoids in the management of diffcult to treat pain. Ther. Clin. Risk Manag. 4, 245-249 (2008).
    • (2008) Ther. Clin. Risk Manag. , vol.4 , pp. 245-249
    • Russo, E.B.1
  • 2
    • 14844340153 scopus 로고    scopus 로고
    • The medicinal use of cannabis in the UK: Results of a nationwide survey
    • DOI 10.1111/j.1742-1241.2004.00271.x
    • Ware MA, Adams H, Guy GW. The medicinal use of cannabis in the UK: results of a nationwide survey. Int. J. Clin. Pract. 59, 291-295 (2005). (Pubitemid 40352745)
    • (2005) International Journal of Clinical Practice , vol.59 , Issue.3 , pp. 291-295
    • Ware, M.A.1    Adams, H.2    Guy, G.W.3
  • 4
    • 33749427038 scopus 로고    scopus 로고
    • Combined cannabinoid therapy via an oromucosal spray
    • Pérez J. Combined cannabinoid therapy via an oromucosal spray. Drugs Today 42, 495-501 (2006).
    • (2006) Drugs Today , vol.42 , pp. 495-501
    • Pérez, J.1
  • 5
    • 79953824225 scopus 로고    scopus 로고
    • A comparison of pharmacokinetic profles of inhaled?-9- tetrahydrocannabinol (THC) from smoked cannabis with Sativex® oromucosal spray in humans: Implications for possible symptomatic treatment in multiple sclerosis
    • Stott CG, Wright S, Guy GW. A comparison of pharmacokinetic profles of inhaled?-9-tetrahydrocannabinol (THC) from smoked cannabis with Sativex® oromucosal spray in humans: implications for possible symptomatic treatment in multiple sclerosis. Eur. J. Neurol. 15(Suppl. 3), 365 (2008).
    • (2008) Eur. J. Neurol. , vol.15 , Issue.SUPPL. 3 , pp. 365
    • Stott, C.G.1    Wright, S.2    Guy, G.W.3
  • 6
    • 39049124647 scopus 로고    scopus 로고
    • 9-THC and other cannabinoids in cannabis in England in 2005: Implications for psychoactivity and pharmacology
    • DOI 10.1111/j.1556-4029.2007.00603.x
    • Potter DJ, Clark P, Brown MB. Potency of 9-THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology. J. Forensic Sci. 53, 90-94 (2008). (Pubitemid 351239216)
    • (2008) Journal of Forensic Sciences , vol.53 , Issue.1 , pp. 90-94
    • Potter, D.J.1    Clark, P.2    Brown, M.B.3
  • 7
    • 28844489930 scopus 로고    scopus 로고
    • A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
    • DOI 10.1016/j.mehy.2005.08.026, PII S0306987705004317
    • Russo E, Guy GW. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med. Hypotheses 66, 234-246 (2006). (Pubitemid 41773895)
    • (2005) Medical Hypotheses , vol.66 , Issue.2 , pp. 234-246
    • Russo, E.1    Guy, G.W.2
  • 8
    • 33847766180 scopus 로고    scopus 로고
    • Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis
    • DOI 10.1111/j.1468-1331.2006.01639.x
    • Collin C, Davies P, Mutiboko IK, Ratcliffe S; for the Sativex Spasticity in MS Study Group. Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis. Eur. J. Neurol. 14, 290-296 (2007). (Pubitemid 46384865)
    • (2007) European Journal of Neurology , vol.14 , Issue.3 , pp. 290-296
    • Collin, C.1    Davies, P.2    Mutiboko, I.K.3    Ratcliffe, S.4
  • 9
    • 77952835462 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis
    • Collin C, Ehler E, Waberzinek G et al. A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis. Neurol. Res. 32, 451-459 (2010).
    • (2010) Neurol. Res. , vol.32 , pp. 451-459
    • Collin, C.1    Ehler, E.2    Waberzinek, G.3
  • 10
    • 79953822342 scopus 로고    scopus 로고
    • Arandomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
    • DOI: 10.1111/j.1468-1331.2010.03328.x Epub ahead of print
    • Novotna A, Mares J, Ratcliffe S et al. Arandomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Eur. J. Neurol. DOI: 10.1111/j.1468-1331.2010.03328.x (2011) (Epub ahead of print).
    • (2011) Eur. J. Neurol.
    • Novotna, A.1    Mares, J.2    Ratcliffe, S.3
  • 11
    • 79953828137 scopus 로고    scopus 로고
    • Trial period for new symptomatic treatments: Lessons learnt from a Sativex in MS spasticity clinical trial
    • Montalbán X, Wright S. Trial period for new symptomatic treatments: lessons learnt from a Sativex in MS spasticity clinical trial. Mult Scler. 15, S272 (2009).
    • (2009) Mult Scler. , vol.15
    • Montalbán, X.1    Wright, S.2
  • 12
    • 4344582253 scopus 로고    scopus 로고
    • Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients
    • DOI 10.1191/1352458504ms1082oa
    • Wade D, Makela P, Robson P, House H, Bateman C. Do cannabis-based medicinal extracts have general or specifc effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Mult. Scler. 10, 434-441 (2004). (Pubitemid 39117341)
    • (2004) Multiple Sclerosis , vol.10 , Issue.4 , pp. 434-441
    • Wade, D.T.1    Makela, P.2    Robson, P.3    House, H.4    Bateman, C.5
  • 13
    • 33745025055 scopus 로고    scopus 로고
    • Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis
    • DOI 10.1177/1352458505070618
    • Wade DT, Makela PM, House H, Bateman C, Robson P. Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis. Mult. Scler. 12, 639-645 (2006). (Pubitemid 46940638)
    • (2006) Multiple Sclerosis , vol.12 , Issue.5 , pp. 639-645
    • Wade, D.T.1    Makela, P.M.2    House, H.3    Bateman, C.4    Robson, P.5
  • 14
    • 79953820673 scopus 로고    scopus 로고
    • Results of an open-label extension trial of Sativex (THC:CBD) in patients with multiple sclerosis and symptoms of spasticity
    • Collin C, Serpell M, Potts R. Results of an open-label extension trial of Sativex (THC:CBD) in patients with multiple sclerosis and symptoms of spasticity. Mult Scler. 13, S129 (2007).
    • (2007) Mult Scler. , vol.13
    • Collin, C.1    Serpell, M.2    Potts, R.3
  • 15
    • 79953814690 scopus 로고    scopus 로고
    • Abuse potential of nabiximols oromucosal spray compared with dronabinol and placebo in recreational marijuana users
    • Schoedel K, Chen N, Guy GW et al. Abuse potential of nabiximols oromucosal spray compared with dronabinol and placebo in recreational marijuana users. Eur. Neuropsychopharmacol. 20(Suppl. 3), S587 (2010).
    • (2010) Eur. Neuropsychopharmacol. , vol.20 , Issue.SUPPL. 3
    • Schoedel, K.1    Chen, N.2    Guy, G.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.