-
1
-
-
33749011163
-
The NCI60 human tumour cell line anticancer drug screen
-
Shoemaker, R.H. The NCI60 human tumour cell line anticancer drug screen. Nat. Rev. Cancer 6, 813-823 (2006).
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 813-823
-
-
Shoemaker, R.H.1
-
2
-
-
33749335282
-
The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006).
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
-
3
-
-
77957044703
-
Discovery of drug mode of action and drug repositioning from transcriptional responses
-
Iorio, F. et al. Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc. Natl. Acad. Sci. USA 107, 14621-14626 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14621-14626
-
-
Iorio, F.1
-
4
-
-
84884200376
-
Characterization of drug-induced transcriptional modules: Towards drug repositioning and functional understanding
-
Iskar, M. et al. Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding. Mol. Syst. Biol. 9, 662 (2013).
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 662
-
-
Iskar, M.1
-
5
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607 (2012).
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
-
6
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
7
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio, T.A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
-
8
-
-
33747620519
-
Systems biology and combination therapy in the quest for clinical efficacy
-
Fitzgerald, J.B., Schoeberl, B., Nielsen, U.B. & Sorger, P.K. Systems biology and combination therapy in the quest for clinical efficacy. Nat. Chem. Biol. 2, 458-466 (2006).
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 458-466
-
-
Fitzgerald, J.B.1
Schoeberl, B.2
Nielsen, U.B.3
Sorger, P.K.4
-
9
-
-
0020075208
-
Alternating drug combinations in the treatment of advanced Hodgkin's disease
-
Santoro, A., Bonadonna, G., Bonfante, V. & Valagussa, P. Alternating drug combinations in the treatment of advanced Hodgkin's disease. N. Engl. J. Med. 306, 770-775 (1982).
-
(1982)
N. Engl. J. Med.
, vol.306
, pp. 770-775
-
-
Santoro, A.1
Bonadonna, G.2
Bonfante, V.3
Valagussa, P.4
-
10
-
-
33847377573
-
A robustness-based approach to systems-oriented drug design
-
Kitano, H. A robustness-based approach to systems-oriented drug design. Nat. Rev. Drug Discov. 5, 202-210 (2007).
-
(2007)
Nat. Rev. Drug Discov.
, vol.5
, pp. 202-210
-
-
Kitano, H.1
-
11
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
Borisy, A.A. et al. Systematic discovery of multicomponent therapeutics. Proc. Natl. Acad. Sci. USA 100, 7977-7982 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7977-7982
-
-
Borisy, A.A.1
-
12
-
-
36248965667
-
Combination drugs, an emerging option for antibacterial therapy
-
Cottarel, G. & Wierzbowski, J. Combination drugs, an emerging option for antibacterial therapy. Trends Biotechnol. 25, 547-555 (2007).
-
(2007)
Trends Biotechnol.
, vol.25
, pp. 547-555
-
-
Cottarel, G.1
Wierzbowski, J.2
-
13
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
Lehár, J. et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat. Biotechnol. 27, 659-666 (2009).
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 659-666
-
-
Lehár, J.1
-
14
-
-
33845762340
-
Multi-target therapeutics: When the whole is greater than the sum of the parts
-
Zimmermann, G.R., Lehár, J. & Keith, C.T. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov. Today 12, 34-42 (2007).
-
(2007)
Drug Discov. Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehár, J.2
Keith, C.T.3
-
15
-
-
84870902173
-
Targeted estrogen delivery reverses the metabolic syndrome
-
Finan, B. et al. Targeted estrogen delivery reverses the metabolic syndrome. Nat. Med. 18, 1847-1856 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1847-1856
-
-
Finan, B.1
-
16
-
-
84855272311
-
Prediction of drug combinations by integrating molecular and pharmacological data
-
Zhao, X.M., Iskar, M., Zeller, G., Kuhn, M., van Noort, V. & Bork, P. Prediction of drug combinations by integrating molecular and pharmacological data. PLoS Comput. Biol. 7, e1002323 (2011).
-
(2011)
PLoS Comput. Biol.
, vol.7
-
-
Zhao, X.M.1
Iskar, M.2
Zeller, G.3
Kuhn, M.4
Van Noort, V.5
Bork, P.6
-
17
-
-
59349083179
-
Mechanisms of drug combinations: Interaction and network perspectives
-
Jia, J. et al. Mechanisms of drug combinations: interaction and network perspectives. Nat. Rev. Drug Discov. 8, 111-128 (2009).
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 111-128
-
-
Jia, J.1
-
18
-
-
79959473110
-
An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data
-
Jin, G., Zhao, H., Zhou, X. & Wong, S.T. An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data. Bioinformatics 27, i310-i316 (2011).
-
(2011)
Bioinformatics
, vol.27
-
-
Jin, G.1
Zhao, H.2
Zhou, X.3
Wong, S.T.4
-
19
-
-
84896765811
-
A network-based approach for identifying effective drug combination
-
eds. Chen, L., Zhang, X.S., Wu, L.Y. & Wang, Y
-
Wu, Z., & Chen, L. A network-based approach for identifying effective drug combination. In (eds. Chen, L., Zhang, X.S., Wu, L.Y. & Wang, Y.) The Third International Symposium on Optimization and Systems Biology (OSB 09) 207-213 (2009).
-
(2009)
The Third International Symposium on Optimization and Systems Biology (OSB 09)
, pp. 207-213
-
-
Wu, Z.1
Chen, L.2
-
20
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins, A.L. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4, 682-690 (2008).
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
21
-
-
15044349115
-
The efficiency of multi-target drugs: The network approach might help drug design
-
Csermely, P., Agoston, V. & Pongor, S. The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol. Sci. 26, 178-182 (2005).
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, pp. 178-182
-
-
Csermely, P.1
Agoston, V.2
Pongor, S.3
-
22
-
-
12144258457
-
Multicomponent therapeutics for networked systems
-
Keith, C.T., Borisy, A.A. & Stockwell, B.R. Multicomponent therapeutics for networked systems. Nat. Rev. Drug Discov. 4, 71-78 (2005).
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 71-78
-
-
Keith, C.T.1
Borisy, A.A.2
Stockwell, B.R.3
-
23
-
-
0032858243
-
Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-smallcell lung cancer
-
Furuse, K. et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-smallcell lung cancer. J. Clin. Oncol. 17, 2692-2699 (1999).
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 2692-2699
-
-
Furuse, K.1
-
24
-
-
78651117965
-
A molecular mechanism of mitomycin action: Linking of complementary DNA strands
-
Iyer, V.N. & Szybalski, W. A molecular mechanism of mitomycin action: linking of complementary DNA strands. Proc. Natl. Acad. Sci. USA 50, 355-362 (1963).
-
(1963)
Proc. Natl. Acad. Sci. USA
, vol.50
, pp. 355-362
-
-
Iyer, V.N.1
Szybalski, W.2
-
25
-
-
0016301035
-
Sister chromatid exchanges, indices of human chromosome damage and repair: Detection by fluorescence and induction by mitomycin C
-
Latt, S.A. Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C. Proc. Natl. Acad. Sci. USA 71, 3162-3166 (1974).
-
(1974)
Proc. Natl. Acad. Sci. USA
, vol.71
, pp. 3162-3166
-
-
Latt, S.A.1
-
26
-
-
0023195303
-
Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide
-
Williams, S.D., Birch, R., Einhorn, L.H., Irwin, L., Greco, F.A. & Loehrer, P.J. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N. Engl. J. Med. 316, 1435-1440 (1987).
-
(1987)
N. Engl. J. Med.
, vol.316
, pp. 1435-1440
-
-
Williams, S.D.1
Birch, R.2
Einhorn, L.H.3
Irwin, L.4
Greco, F.A.5
Loehrer, P.J.6
-
27
-
-
0037050354
-
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer
-
Japan Clinical Oncology Group
-
Noda, K. et al.; Japan Clinical Oncology Group. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N. Engl. J. Med. 346, 85-91 (2002).
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 85-91
-
-
Noda, K.1
-
28
-
-
0036752261
-
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5
-
Maliga, Z., Kapoor, T.M. & Mitchison, T.J. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem. Biol. 9, 989-996 (2002).
-
(2002)
Chem. Biol.
, vol.9
, pp. 989-996
-
-
Maliga, Z.1
Kapoor, T.M.2
Mitchison, T.J.3
-
29
-
-
0034605123
-
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5
-
Kapoor, T.M., Mayer, T.U., Coughlin, M.L. & Mitchison, T.J. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J. Cell Biol. 150, 975-988 (2000).
-
(2000)
J. Cell Biol.
, vol.150
, pp. 975-988
-
-
Kapoor, T.M.1
Mayer, T.U.2
Coughlin, M.L.3
Mitchison, T.J.4
-
30
-
-
0037457808
-
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5
-
DeBonis, S. et al. Interaction of the mitotic inhibitor monastrol with human kinesin Eg5. Biochemistry 42, 338-349 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 338-349
-
-
Debonis, S.1
-
31
-
-
0024996768
-
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
-
Yoshida, M., Kijima, M., Akita, M. & Beppu, T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265, 17174-17179 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 17174-17179
-
-
Yoshida, M.1
Kijima, M.2
Akita, M.3
Beppu, T.4
-
32
-
-
0027217474
-
Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer
-
Murad, A.M., Santiago, F.F., Petroianu, A., Rocha, P.R., Rodrigues, M.A. & Rausch, M. Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer. Cancer 72, 37-41 (1993).
-
(1993)
Cancer
, vol.72
, pp. 37-41
-
-
Murad, A.M.1
Santiago, F.F.2
Petroianu, A.3
Rocha, P.R.4
Rodrigues, M.A.5
Rausch, M.6
-
33
-
-
0008632564
-
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
-
Ueda, K., Cardarelli, C., Gottesman, M.M. & Pastan, I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. USA 84, 3004-3008 (1987).
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 3004-3008
-
-
Ueda, K.1
Cardarelli, C.2
Gottesman, M.M.3
Pastan, I.4
-
34
-
-
0022355480
-
A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma
-
Shimaoka, K., Schoenfeld, D.A., DeWys, W.D., Creech, R.H. & DeConti, R. A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer 56, 2155-2160 (1985).
-
(1985)
Cancer
, vol.56
, pp. 2155-2160
-
-
Shimaoka, K.1
Schoenfeld, D.A.2
Dewys, W.D.3
Creech, R.H.4
Deconti, R.5
-
35
-
-
0021718634
-
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets
-
Kawamoto, S. & Hidaka, H. 1-(5-Isoquinolinesulfonyl)-2- methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets. Biochem. Biophys. Res. Commun. 125, 258-264 (1984).
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.125
, pp. 258-264
-
-
Kawamoto, S.1
Hidaka, H.2
-
36
-
-
0027223909
-
Protein kinase C is a tonic negative regulator of steroidogenesis and steroid hydroxylase gene expression in Y1 adrenal cells and functions independently of protein kinase A
-
Reyland, M.E. Protein kinase C is a tonic negative regulator of steroidogenesis and steroid hydroxylase gene expression in Y1 adrenal cells and functions independently of protein kinase A. Mol. Endocrinol. 7, 1021-1030 (1993).
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 1021-1030
-
-
Reyland, M.E.1
-
37
-
-
84867690864
-
Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
-
Winter, G.E. et al. Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML. Nat. Chem. Biol. 8, 905-912 (2012).
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 905-912
-
-
Winter, G.E.1
-
38
-
-
77951972600
-
BioNet: An R-Package for the functional analysis of biological networks
-
Beisser, D., Klau, G.W., Dandekar, T., Müller, T. & Dittrich, M.T. BioNet: an R-Package for the functional analysis of biological networks. Bioinformatics 26, 1129-1130 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 1129-1130
-
-
Beisser, D.1
Klau, G.W.2
Dandekar, T.3
Müller, T.4
Dittrich, M.T.5
|